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| 1 | Immunotherapy of hepatocellular carcinoma: strategies for combinatorial intervention显示文摘Hepatocellular carcinoma(HCC) is the most frequent primary liver cancer,leading to 74.6 thousand deaths annually.The prognosis of HCC over the last few decades has remained unsatisfactory,and over half of patients with early-stage HCC develop recurrence by the time of follow-up.Immunotherapeutic intervention has emerged as a novel,effective treatment to delay the progression of aggressive tumors and suppress tumor recurrence and metastasis.However,few clinical immunotherapy trials have been conducted in HCC patients,and there is an unmet need for novel therapeutic strategies.The combination of conventional treatments with specific immunotherapeutic approaches may dramatically improve the efficacy of HCC treatment and the clinical outcome of HCC patients.In this review,we briefly summarize immunotherapy strategies and discuss new advances in combined immunotherapeutic approaches for the treatment of patients with liver cancer. | Mengxin Tian Yinghong Shi Weiren Liu Jia Fan | 2019 | Science China(Life Sciences)2019，62，9： | 12 |
| 2 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 3 | Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects显示文摘Using chemoproteomic techniques,we first identified EIF2AK2,eEF1A1,PRDX3 and VPS4B as direct targets of berberine(BBR)for its synergistically anti-inflammatory effects.Of them,BBR has the strongest affinity with EIF2AK2 via two ionic bonds,and regulates several key inflammatory pathways through EIF2AK2,indicating the dominant role of EIF2AK2.Also,BBR could subtly inhibit the dimerization of EIF2AK2,rather than its enzyme activity,to selectively modulate its downstream pathways including JNK,NF-κB,AKT and NLRP3,with an advantage of good safety profile.In EIF2AK2 gene knockdown mice,the inhibitory IL-1β,IL-6,IL-18 and TNF-a secretion of BBR was obviously attenuated,confirming an EIF2AK2-dependent anti-inflammatory efficacy.The results highlight the BBR's network mechanism on anti-inflammatory effects in which EIF2AK2 is a key target,and inhibition of EIF2AK2 dimerization has a potential to be a therapeutic strategy against inflammationrelated disorders. | Wei Wei Qingxuan Zeng Yan Wang Xixi Guo Tianyun Fan Yinghong Li Hongbin Deng Liping Zhao Xintong Zhang Yonghua Liu Yulong Shi Jingyang Zhu Xican Ma Yanxiang Wang Jiandong Jiang Danqing Song | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 2 |
| 4 | Anti-hypertensive and endothelia protective effects of Fufang Qima capsule(复方芪麻胶囊) on primary hypertension via adiponectin/adenosine monophosphate activated protein kinase pathway显示文摘OBJECTIVE:To investigate the potential mechanism of the vascular remodeling effect and provide additional information about anti-hypertension activity of Fufang Qima capsule(复方芪麻胶囊,QM).METHODS:Spontaneous hypertensive rats(SHRs)were used to study the underlying mechanism of the anti-hypertension activity of QM.In this study,SHRs were randomly divided into 5 groups:model group,Telmisartan group(7.2 mg/kg,p.o.),and three QM groups(0.9298,1.8596,and 3.7192 g/kg,p.o.).Wistar Kyoto rats(WKY)were used as normal control group.Blood pressure(BP),aorta,perivascular adipose tissue(PVAT)histology were investigated to evaluate the effect of QM.Nitric oxide(NO)and endothelial nitric oxide synthase(eNOS)phosphorylation were measured.Adiponectin(APN)secretion,as well as APN signal pathway proteins including APN,adiponectin receptors(R1 and R2)and adenosine 5’-monophosphate-activated protein kinase(AMPK)were all analyzed.RESULTS:QM significantly reduced BP and ameliorated the vascular pathological change,i.e.intima media thicken and collagen fiber hyperplasia.Meanwhile,QM increased concentration of NO and the phosphorylation of eNOS in the aorta.The anti-hypertensive and endothelia-protective effect of QM could be attributed to activating APN/AMPK pathway by up-regulating the expression of APN in PVAT and APN Receptor 2,AMPKαand phosphorylated AMPKαin the aorta.CONCLUSION:The QM alleviation effect mechanism for primary hypertension was via modulating the APN/AMPK signal pathway. | ZHAO Zhiyue SHI Zhenyu ZHANG Zhenzhen LI Yinghong ZENG Xiaohui CHEN Yuxing YAO Nan ZHOU Min SU Hui WANG Qinghai JIN LiLi | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 2 |
| 5 | A new approach of die shape optimization for sheet metal forming processes显示文摘 | Shi Xiaoxiang Chen Jun Peng Yinghong | 2004 | Journal of Materials Processing Technology2004，152，1： | 1 |
| 6 | Astrocyte elevated gene-1: a novel independent prognostic biomarker for metastatic ovarian tumors显示文摘 | Cong Li Kexin Chen Jianping Cai Qing-Tao Shi Yinghong Li Lejing Li Hongtao Song Huilei Qiu Yu Qin Jing-Shu Geng | 2014 | Tumor Biology2014，，4： | 1 |
| 7 | Comprehensive analysis of complement-associated molecular features in hepatocellular carcinoma显示文摘The complement cascade plays a“complementing”role in human immunity.However,the potential roles of complement system in impacting molecular and clinical features of hepatocellular carcinoma(HCC)remain unclear.In this study,eleven public datasets are analyzed to compare the complement status between normal and cancerous samples based on 18 classical complement-associated genes.The complement scores are constructed to quantify complement signatures of individual tumors.HCC patients in the The Cancer Genome Atlas(TCGA)cohort are focused to perform systematical analyses between complement status and immune infiltration,miRNA expression,DNA methylation,clinicopathological features,and drug response.The results show that the complement scores in normal tissues are dramatically higher than those of tumor tissues.Tumor samples in the TCGA cohort are classified into complement score-low and score-high groups.Pathway analysis reveals that tumor-promoting pathways are typically inhibited in complement score-high group.This study also shows that tumor-killing immune cells,such as CD8^(+)T cells and natural killer cells are abundant and tumor-suppressing miRNAs are upregulated in complement score-high samples.In addition,we identify that complement scores are negatively correlated with certain clinical features,including pathological grade,clinical-stage,and portal vein invasion.Moreover,various molecular features together with complement scores are found to be correlated with response to anti-cancer drugs.This study provides a comprehensive and multidimensional analysis conducive to understanding the role of complement in cancer. | Run Huang Guiqi Zhu Xiutao Fu Weiren Liu Chenyang Tao Jun Gao Weifeng Qu Yuan Fang Xifei Jiang Zhenbin Ding Jian Zhou Yinghong Shi Jia Fan Zheng Tang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，11： | 0 |
| 8 | Research Progress in the Application of Network Pharmacology in Traditional Chinese Medicine and Compound Prescriptions显示文摘Network pharmacology is a new discipline based on the theory of systems biology,mainly for network analysis of biological systems.It selects specific signal nodes for multi-target drug molecular design.This article summarizes the application of network pharmacology in traditional Chinese medicine and compound prescriptions in recent years from the research progress of network pharmacology,the current research status of single herbs,and the research and application of compound prescriptions. | Jiangcun WEI Zujie QIN Xiumei MA Wen ZHONG Zongxi SUN Liping QIN Yinghong HUANG Xianyi SHI | 2021 | Medicinal Plant2021，12，3： | 0 |
| 9 | Chitosan/Sodium Alginate Multilayer pH-Sensitive Films Based on Layer-by-Layer Self-Assembly for Intelligent Packaging显示文摘The abuse of plastic food packaging has brought about severe white pollution issues around the world.Developing green and sustainable biomass packaging is an effective way to solve this problem.Hence,a chitosan/sodium alginate-based multilayer film is fabricated via a layer-by-layer(LBL)self-assembly method.With the help of superior interaction between the layers,the multilayer film possesses excellent mechanical properties(with a tensile strength of 50 MPa).Besides,the film displays outstanding water retention property(blocking moisture of 97.56%)and ultraviolet blocking property.Anthocyanin is introduced into the film to detect the food quality since it is one natural plant polyphenol that is sensitive to the pH changes ranging from 1 to 13 in food when spoilage occurs.It is noted that the film is also bacteriostatic which is desired for food packaging.This study describes a simple technique for the development of advanced multifunctional and fully biodegradable food packaging film and it is a sustainable alternative to plastic packaging. | Mingxuan He Yahui Zheng Jiaming Shen Jiawei Shi Yongzheng Zhang Yinghong Xiao Jianfei Che | 2024 | Journal of Renewable Materials2024，12，2： | 0 |
| 10 | Associating liver partition and portal vein ligation for staged hepatectomy for colorectal liver metastasis:a single-center experience显示文摘Background:Associated liver partition and portal vein ligation for staged hepatectomy(ALPPS)is increasingly used for the treatment of primarily unresectable colorectal liver metastases(CRLM)because of the insufficient future liver remnant(FLR).The aim of this study was to share our experience with ALPPS for advanced CRLM and review the role of ALPPS in the management of patients with CRLM.Methods:Consecutive patients(n=10)with CRLM who underwent ALPPS at our center between December 2014 and October 2021 were retrospectively studied.Results:The median age of patients was 58 years(range 49–70 years).Five patients had metachronous CRLM and the other 5 patients had synchronous CRLM.Five patients had unilateral CRLM and the other 5 patients had bilateral CRLM.All patients previously underwent neoadjuvant chemotherapy.The FLR volume increased by 45.3%(35.8%–61.6%)over 14 days(range 7–21 days).The absolute and relative kinetic growth rates were 17.9 mL/day(range 7.5–32.1 mL/day)and 4.6%/day(range 2.3%–8.8%/day),respectively.Overall morbidity rates were 20%(2/10)and 40%(4/10)after ALPPS stage 1 and stage 2,respectively.The 30-day and 90-day mortality rates were 0%and 10%,respectively.R0 resection was achieved for all patients,and the median disease-free survival was 18.7 months.Conclusions:ALPPS is an effective treatment option for advanced CRLM.It enables rapid hypertrophy of the FLR and achieves a high R0 resection rate with an acceptable oncological outcome.However,ALPPS should be reserved for selected patients because of its relatively high morbidity and mortality. | Yuanfei Peng Feiyu Chen Zheng Wang Xiaoying Wang Yinghong Shi Zhenbing Ding Yongsheng Xiao Kang Song Lei Yu Jie Hu Min Tang Zhaoyou Tang Jia Fan Jian Zhou | 2022 | iLIVER2022，1，1： | 0 |
| 11 | Thin Layer Identification of Jiedu Shengxue Granules and Determination of Notoginsenoside R1 Content显示文摘[Objectives]To establish the quality standard of hospital preparation Jiedu Shengxue granules.[Methods]Scleromitrion diffusum and Prunella vulgaris in Jiedu Shengxue granules were qualitatively identified by thin layer chromatography(TLC).A high performance liquid chromatography(HPLC)was established to determine the content of notoginsenoside R1 in the granule.[Results]The traditional Chinese medicinal materials in Jiedu Shengxue granules could be identified by TLC,and the characteristic spots were stable and clear.Notoginsenoside R1 had a good linear relationship in the range of 10.45-104.5μg/mL,with an average recovery of 98.52%and RSD=2.36%.[Conclusions]TLC and HPLC,as the quality control methods of Jiedu Shengxue granules,have high accuracy and good repeatability,which lays a foundation for the quality control of this mixture. | Zhenying FU Bing QING Yinghong HUANG Xianyi SHI Meiyan QIU Xian PENG Jiangcun WEI Fengzhen LI Wen ZHONG | 2024 | Medicinal Plant2024，15，1： | 0 |
| 12 | Author correction to‘Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects’[Acta Pharmaceutica Sinica B 13(2023)2138-2151]显示文摘The authors regret that there are some misplaced figure numbers in the body of this article due to negligence in the layout and proofreading of the figures.Although it does not affect the conclusion,it is an obvious error.The authors have now modified as below.The authors apologize for any inconvenience caused to the journal and readers. | Wei Wei Qingxuan Zeng Yan Wang Xixi Guo Tianyun Fan Yinghong Li Hongbin Deng Liping Zhao Xintong Zhang Yonghua Liu Yulong Shi Jingyang Zhu Xican Ma Yanxiang Wang Jiandong Jiang Danqing Song | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 13 | Multiomics analysis reveals metabolic subtypes and identifies diacylglycerol kinase α (DGKA) as a potential therapeutic target for intrahepatic cholangiocarcinoma显示文摘Background:Intrahepatic cholangiocarcinoma(iCCA)is a highly heteroge-neous and lethal hepatobiliary tumor with few therapeutic strategies.The metabolic reprogramming of tumor cells plays an essential role in the develop-ment of tumors,while the metabolic molecular classification of iCCA is largely unknown.Here,we performed an integrated multiomics analysis and metabolic classification to depict differences in metabolic characteristics of iCCA patients,hoping to provide a novel perspective to understand and treat iCCA.Methods:We performed integrated multiomics analysis in 116 iCCA samples,including whole-exome sequencing,bulk RNA-sequencing and proteome anal-ysis.Based on the non-negative matrix factorization method and the protein abundance of metabolic genes in human genome-scale metabolic models,the metabolic subtype of iCCA was determined.Survival and prognostic gene analy-ses were used to compare overall survival(OS)differences between metabolic subtypes.Cell proliferation analysis,5-ethynyl-2’-deoxyuridine(EdU)assay,colony formation assay,RNA-sequencing and Western blotting were performed to investigate the molecular mechanisms of diacylglycerol kinaseα(DGKA)in iCCA cells.Results:Three metabolic subtypes(S1-S3)with subtype-specific biomarkers of iCCA were identified.These metabolic subtypes presented with distinct prog-noses,metabolic features,immune microenvironments,and genetic alterations.The S2 subtype with the worst survival showed the activation of some special metabolic processes,immune-suppressed microenvironment and Kirsten ratsar-coma viral oncogene homolog(KRAS)/AT-rich interactive domain 1A(ARID1A)mutations.Among the S2 subtype-specific upregulated proteins,DGKA was further identified as a potential drug target for iCCA,which promoted cell proliferation by enhancing phosphatidic acid(PA)metabolism and activating mitogen-activated protein kinase(MAPK)signaling.Conclusion:Viamultiomics analyses,we identified three metabolic subtypes of iCCA,revealing that the S2 subtype exhibited the poorest survival outcomes.We further identified DGKA as a potential target for the S2 subtype. | Weiren Liu Huqiang Wang Qianfu Zhao Chenyang Tao Weifeng Qu Yushan Hou Run Huang Zimei Sun Guiqi Zhu Xifei Jiang Yuan Fang Jun Gao Xiaoling Wu Zhixiang Yang Rongyu Ping Jiafeng Chen Rui Yang Tianhao Chu Jian Zhou Jia Fan Zheng Tang Dong Yang Yinghong Shi | 2024 | Cancer Communications2024，44，2： | 0 |
| 14 | 3D‑Printed Carbon‑Based Conformal Electromagnetic Interference Shielding Module for Integrated Electronics显示文摘Electromagnetic interference shielding(EMI SE)modules are the core com-ponent of modern electronics.However,the tra-ditional metal-based SE modules always take up indispensable three-dimensional space inside electronics,posing a major obstacle to the integra-tion of electronics.The innovation of integrating 3D-printed conformal shielding(c-SE)modules with packaging materials onto core electronics offers infinite possibilities to satisfy ideal SE func-tion without occupying additional space.Herein,the 3D printable carbon-based inks with various proportions of graphene and carbon nanotube nanoparticles are well-formulated by manipulating their rheological peculiarity.Accordingly,the free-constructed architectures with arbitrarily-customized structure and multifunctionality are created via 3D printing.In particular,the SE performance of 3D-printed frame is up to 61.4 dB,simultaneously accompanied with an ultralight architecture of 0.076 g cm^(-3) and a superhigh specific shielding of 802.4 dB cm3 g^(-1).Moreover,as a proof-of-concept,the 3D-printed c-SE module is in situ integrated into core electronics,successfully replacing the traditional metal-based module to afford multiple functions for electromagnetic compatibility and thermal dissipa-tion.Thus,this scientific innovation completely makes up the blank for assembling carbon-based c-SE modules and sheds a brilliant light on developing the next generation of high-performance shielding materials with arbitrarily-customized structure for integrated electronics. | Shaohong Shi Yuheng Jiang Hao Ren Siwen Deng Jianping Sun Fangchao Cheng Jingjing Jing Yinghong Chen | 2024 | Nano-Micro Letters2024，16，5： | 0 |
| 15 | Lessons from Transient “Triumphalism” in China's Neighboring Diplomacy显示文摘This article aims to identify some lessons from China’s neighboring diplomacy in the two years prior to the 18th National Congress of the CPC(November 8-14,2012).Angered by the legally absurd and politically provocative Doctrine of Seiji Maehara(former Japanese foreign minister,September | Shi Yinghong Ma Zongshi | 2013 | Contemporary International Relations2013，23，6： | 0 |
| 16 | Discovery and development of tricyclic matrinic derivatives as anti-diabetic candidates by AMPKαactivation显示文摘We found compound 12N-p-trifluoromethylbenzenesulfonyl matrinane(1)was a potent anti-diabetic agent.Thirty-five tricyclic matrinic derivatives were synthesized and determined for their stimulatory effects on glucose consumption in L6 myotubes,taking 1 as the lead.In high-fat diet(HFD)and STZ induced diabetic mice,9a significantly lowers blood glucose,improves glucose tolerance,and especially alleviates diabetic nephropathy and islet damage.Mechanism study indicates that 9a simultaneously targets mitochondrial complex I to increase AMP/ATP ratio,as well as liver kinase B1(LKB1)and calcium/calmodulindependent protein kinase(Ca MKK),which synergistically activates AMPKαand then stimulates glucose transporter 4(GLUT4)membrane translocation and 2-deoxyglucose(2-DG)uptake to exert anti-diabetic efficacy.Therefore,compound 9a with a novel structure is a promising anti-diabetic candidate with the advantage of multiple-target mechanism,worthy of further investigation. | Yinghong Li Yuanhui Zhang Tianyu Niu Yudong Pang Yulong Shi Qingxuan Zeng Jingpu Zhang Jingyang Zhu Xiuli Zhong Yanxiang Wang Yan Wang Sheng Tang Weijia Kong Danqing Song Jiandong Jiang | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
| 17 | Emergent hybrid-dual-graft liver transplantation:a life-saving strategy for a patient with inadequate living donor graft during the COVID-19 pandemic显示文摘Introduction Liver transplantation(LT)benefits patients with decompensated liver cirrhosis,acute liver failure,or hepatocellular carcinoma.The greatest challenge in LT is the insufficient number of donors for the growing number of transplantation candidates.Various surgical strategies have been adopted to overcome the increasing donor-recipient disparity,including sequential/“domino”transplantation,split LT,use of marginal livers,and living donor LT(LDLT).To ensure the safety of donors and recipients,dual-graft LT may be considered(1).Herein,we describe the first successful hybrid-dual-graft LT in an obese patient requiring urgent LT,which involved transplantation of an otherwise-wasted resected liver lobe from a patient with a benign hepatic tumor and an inadequate-size living donor graft from the recipient’s father. | Yongsheng Xiao Xiaowu Huang Yinghong Shi Zheng Wang Xiaoying Wang Yifeng He Ting Wang Jian Sun Kang Song Zhenbin Ding Yinghao Shen Yuanfei Peng Zaozhuo Shen Lei Yu Kai Zhu Hui Li Di Zhou Changhong Miao Yuan Ji Liuxiao Yang Yingyong Hou Xudong Qu Jia Fan Jian Zhou | 2022 | Hepatobiliary Surgery and Nutrition2022，11，5： | 0 |
| 18 | Translational medicine in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is a highly complex disease that is generally resistant to commonly used chemotherapy and radiotherapy.Consequently,there is an urgent need for the development of new treatment strategies for this devastating disease.In the past decade,tremendous progress has been achieved in the molecular stratification of HCCs for diagnosis,prognosis,and therapeutic decision-making.To date,the molecular classification of HCCs has been carried out through transcriptomic,genetic and epigenetic profiling of tumors.Such research has led to identification of several potential molecular targets in HCC,and subsequently,development of novel systemic agents for the treatment of HCC has begun in earnest.In this article,we review the current knowledge of the molecular pathogenesis of HCC and outline potential areas for application of this knowledge in a clinical setting.As a typical virus and inflammation-associated cancer,both host immune response and tumor microenvironment have crucial roles in HCC pathogenesis.In addition,we examine the potential of immunotherapy and strategies targeting various components of the tumor microenvironment,as well as novel molecular and cellular targets in HCC such as cancer stem cells. | Qiang Gao Yinghong Shi Xiaoying Wang Jian Zhou Shuangjian Qiu Jia Fan | 2012 | Frontiers of Medicine2012，6，2： | 0 |
| 19 | Research Progress and Application Prospect of Chengyin Decoction (Granule)显示文摘Research and development of Chengyin detoxification prescription are taken as research objects. Starting from preparation research and development, clinical research, urgency and market demand, and significance for industrial development, the relevant research of Chengyin detoxification prescription is systematically reviewed, and the application prospect of the ethnic medicine preparations is looked forward to. | Qingmei DENG Jiangcun WEI Xiumei MA Jingrong LU Xianyi SHI Yinghong HUANG Bing QING Wen ZHONG Zujie QIN | 2023 | Medicinal Plant2023，14，4： | 0 |
| 20 | Establishment of a Method for the Determination of Emodin in Wudajiangjun Liquor显示文摘[Objectives]To establish a method for the determination of emodin in Wudajiangjun liquor,a hospital preparation.[Methods]A high-performance liquid chromatography(HPLC)method for the determination of emodin in Rhizoma Polygontum Cuspidatum in hospital preparation Wudajiangjun liquor was established.Using HPLC method,octadecylsilane chemically bonded silica gel was used as filler for the chromatographic column[Inertsil-C 18 chromatographic column(5μm,4.6 mm×250 mm)].Methanol-0.1%phosphoric acid water(76∶24)was used as mobile phase.The flow rate was 1.0 mL/min,the column temperature was 30℃,the detection wavelength was 254 nm,and the injection volume was 10μL.[Results]The content of emodin in Wudajiangjun liquor was determined by reversed-phase high performance liquid chromatography(RP-HPLC).When the injection volume of emodin was in the range of 5.45-54.5μg/mL,there was a good linear relationship between the injection volume and the peak area.The regression equation is Y=42.952-15.068(r=0.9998),the average recovery rate is 98.23%,and RSD=1.45%.[Conclusions]A method for the determination of emodin in Wudajiangjun liquor by HPLC was established.This method can be used as a quality control method for Wudajiangjun liquor with high accuracy and good repeatability,which lays a foundation for the quality control of the medicinal liquor. | Wen ZHONG Zongxi SUN Yinghong HUANG Xianyi SHI Xian PENG Meiyan QIU Jiangcun WEI Wei TIAN Guodong HUANG | 2021 | Medicinal Plant2021，12，1： | 0 |
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