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| 1 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 2 | A mussel-inspired supramolecular hydrogel with robust tissue anchor for rapid hemostasis of arterial and visceral bleedings显示文摘In recent years,the developed hemostatic technologies are still difficult to be applied to the hemostasis of massive arterial and visceral hemorrhage,owing to their weak hemostatic function,inferior wet tissue adhesion,and low mechanical properties.Herein,a mussel-inspired supramolecular interaction-cross-linked hydrogel with robust mechanical property(308.47±29.20 kPa)and excellent hemostatic efficiency(96.5%±2.1%)was constructed as a hemostatic sealant.Typically,we combined chitosan(CS)with silk fibroin(SF)by cross-linking them through tannic acid(TA)to maintain the structural stability of the hydrogel,especially for wet tissue adhesion ability(shear adhesive strength=29.66±0.36 kPa).Compared with other materials reported previously,the obtained CS/TA/SF hydrogel yielded a lower amount of blood loss and shorter time to hemostasis in various arterial and visceral bleeding models,which could be ascribed to the synergistic effect of wound closure under wet state as well as intrinsic hemostatic activity of CS.As a superior hemostatic sealant,the unique hydrogel proposed in this work can be exploited to offer significant advantages in the acute wound and massive hemorrhage with the restrictive access of therapeutic moieties. | Ziwen Qiao Xueli Lv Shaohua He Shumeng Bai Xiaochen Liu Linxi Hou Jingjing He Dongmei Tong Renjie Ruan Jin Zhang Jianxun Ding Huanghao Yang | 2021 | Bioactive Materials2021，6，9： | 14 |
| 3 | Cold hardiness estimation of Pinus densiflora var. zhangwuensis based on changes in ionic leakage, chlorophyll fluorescence and other physiological activities under cold stress显示文摘Pinus densiflora var. zhangwuensis grows fast,and its drought and salinity resistance are better than Pinus sylvestris var. mongolica. We compared cold hardiness and mechanisms of cold hardiness between the two species, to provide a theoretical basis for promoting and applying P.densiflora var. zhangwuensis in cold regions. A cold stress experiment was carried out on 3-year-old plantlets of P.densiflora var. zhangwuensis and P. sylvestris var. mongolica after hardening at five temperature regimes, 5,-10,-20,-40, and-60℃, respectively. Some indices of needle samples for both species were measured, such as relative conductivity(REL), maximum photochemical efficiency(F_v/F_m), malondialdehyde(MDA), catalase(CAT), proline(Pro), soluble sugar(SS), and stomata density. REL and MDA values of both species after hardening had the same trend of increasing, but the trend was opposite in F_v/F_mvalue with increasing cold stress. Compared with P. sylvestris var. mongolica, the P. densiflora var. zhangwuensis had smaller increases in REL and MDA,and a smaller decline in F_v/F_mduring cold stress. Compared to the control, REL growth of P. densiflora var.zhangwuensis and P. sylvestris var. mongolica at-60℃ were 0.41 and 0.60, and MDA growth was 29.94 mol g^-1FW and 47.80 mol g^-1FW, and F_v/F_mdeclines were 0.08 and 0.27. Half-lethal temperatures(LT_50) calculated by logistic equation for P. densiflora var. zhangwuensis and P.sylvestris var. mongolica were-58.23 and-50.34℃,respectively. These data suggest that cold resistance of P.densiflora var. zhangwuensis is stronger than that of P.sylvestris var. mongolica. Cold-resistance mechanisms of the two species differed. In response to cold stress, P.sylvestris var. mongolica had strong osmotic adjustment ability because of higher Pro and SS content, while P.densiflora var. zhangwuensis had strong antioxidant ability due to stronger CAT activity. Stomata density and diameter of P. densiflora var. zhangwuensis were smaller, as were single leaf area and number of leaves per plant, both characteristics promoting survival in a cold environment.Greater shoot height and total biomass of seedlings of P.densiflora var. zhangwuensis might be another reason for its stronger cold tolerance. | Peng Meng Xuefeng Bai Hongdan Li Xiaodong Song Xueli Zhang | 2015 | Journal of Forestry Research2015，26，3： | 8 |
| 4 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 5 | Safety of endovascular therapy for symptomatic intracranial artery stenosis:a national prospective registry显示文摘Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown.The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis(CRTICAS)was a prospective,multicentre,real-world registry designed to assess these outcomes and the impact of centre experience.Methods 1140 severe,symptomatic intracranial arterial stenosis(ICAS)patients treated with endovascular therapy were included from 26 centres,further divided into three groups according to the annual centre volume of intracranial angioplasty and stent placement procedures over 2 years:(1)high volume for≥25 cases/year;(2)moderate volume for 10–25 cases/year and(3)low volume for<10 cases/year.Results The rate of 30-day stroke,transient ischaemic attack or death was 9.7%(111),with 5.4%,21.1%and 9.7%in high-volume,moderate-volume and low-volume centres,respectively(p<0.05).Multivariable logistic regression confirmed high-volume centres had a significantly lower primary endpoint compared with moderate-volume centres(OR=0.187,95%CI:0.056 to 0.627;p≤0.0001),while moderate-volume and low-volume centres showed no significant difference(p=0.8456).Conclusion Compared with the preceding randomised controlled trials,this real-world,prospective,multicentre registry shows a lower complication rate of endovascular treatment for symptomatic ICAS.Non-uniform utilisation in endovascular technology,institutional experience and patient selection in different volumes of centres may have an impact on overall safety of this treatment. | Yabing Wang Tao Wang Adam Andrew Dmytriw Kun Yang Liqun Jiao Huaizhang Shi Jie Lu Tianxiao Li Yujie Huang Zhenwei Zhao Wei Wu Jieqing Wan Qinjian Sun Bo Hong Yongli Li Liyong Zhang Jianfeng Chu Qiong Cheng Yiling Cai Pengfei Wang Qi Luo Hua Yang Baijing Dong Yang Zhang Jun Zhao Zuoquan Chen Wei Li Xiaoxin Bai Weiwen He Xueli Cai Maimai Ti Osama O Zaidat | 2022 | Stroke & Vascular Neurology2022，7，2： | 3 |
| 6 | Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy显示文摘Despite great success in cancer immunotherapy,immune checkpoint-targeting drugs are not the most popular weapon in the armory of cancer therapy.Accumulating evidence suggests that the tumor immune microenvironment plays a critical role in anticancer immunity,which may result in immune checkpoint blockade therapy being ineffective,in addition to other novel immunotherapies in cancer patients.In the present review,we discuss the deficiencies of current cancer immunotherapies.More importantly,we highlight the critical role of tumor immune microenvironment regulators in tumor immune surveillance,immunological evasion,and the potential for their further translation into clinical practice.Based on their general targetability in clinical therapy,we believe that tumor immune microenvironment regulators are promising cancer immunotherapeutic targets.Targeting the tumor immune microenvironment,alone or in combination with immune checkpoint-targeting drugs,might benefit cancer patients in the future. | Tianyu Tang Xing Huang Gang Zhang Zhengtao Hong Xueli Bai Tingbo Liang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 3 |
| 7 | Multiplex imaging reveals the architecture of the tumor immune microenvironment显示文摘The tumor immune microenvironment(TME)is composed of a variety of components,such as tumor cells,immune cells,and the extracellular matrix.The TME has been studied through transcriptomic,proteomic,metabolomic,and phosphoproteomic approaches,which have provided researchers with a wealth of TME-related molecular information. | Junlei Zhang Jinyuan Song Jianpeng Sheng Xueli Bai Tingbo Liang | 2021 | Cancer Biology & Medicine2021，18，4： | 2 |
| 8 | Spatial distribution of arbuscular mycorrhizal fungi, glomalin and soil enzymes under the canopy of Astragalus adsurgens Pall. in the Mu Us sandland, China显示文摘 | Chunming Bai Xueli He Hongliang Tang Baoqin Shan Lili Zhao | 2009 | Soil Biology and Biochemistry2009，，： | 2 |
| 9 | Critical Exponent for Parabolic System with Time-Weighted Sources in Bounded Domain显示文摘 | BAI Xueli ZHENG Sining WANG Wei | 2013 | Journal of Functional Analysis2013，265，6： | 1 |
| 10 | A Semilinear Parabolic System with Coupling Variable Exponents 显示文摘 | Xueli Bai Sining Zhcng | 2011 | Annali di Mathematic Pura ed Application2011，，190： | 1 |
| 11 | A semilinear parabolic system with coupling variable exponents显示文摘 | Xueli Bai and Sining Zheng | 2011 | Annali di Mathematic Pura ed Application2011，190，3： | 1 |
| 12 | Spatial distribution of arbuscular mycorrhizal fungi, glomalin and soil enzymes under the canopy of Astragalus adsurgens Pall in the Mu Us sandland, China显示文摘 | BAI chunming HE Xueli TANG Hongliang | 2009 | Soil Biology and Biochemistry2009，41，： | 1 |
| 13 | Auto-intestine transplantation for pancreatic tumors with mesenteric root involvement:a systematic review and survival-based analysis显示文摘To analyze a long-term survival outcome of an auto-intestine transplantation(aINTx)for the patients with locally advanced pancreatic tumor and identify the potential prognostic factors,databases were carefully searched for the studies reporting the patients with a locally advanced pancreatic tumor which typically underwent aINTx.We performed a database search using PubMed,the Cochrane Library,EMBASE,and MEDLINE to identify multiple case series of the patients who had pancreatic tumors with mesenteric root involvement and underwent aINTx,to evaluate the treatment outcomes,and calculated the patient survival using the Kaplan–Meier method and Cox proportional hazard regression analysis to properly identify an independent predictor of the survival.A total of 9 retrospective studies with a total of 29 patients were included in our study.The calculated 1-,2-,and 3-year survival rates for the patients with pancreatic cancer and benign or low grade pancreatic tumors were 49.64%,22.06%,and 0%versus 100%,100%,and 80%,respectively.The corresponding median survival time was 13.4months and 84months,respectively.Moreover,when stratifying the pancreatic cancer patients undergoing aINTx on the basis of neoadjuvant chemotherapy(aINTx+neoadjuvant vs aINTx-neoadjuvant)there was a significant difference in the survival(P=0.01).The 1-and 2-year survival rates were 75%and 75%versus 34.1%and 0%,respectively.Corresponding median survival times were 24months and 10months,respectively.Our analysis shows the long-term survival benefit with acceptable morbidity and mortality of pancreatoduodenectomy and aINTx for the pancreatic tumors with the mesenteric root involvement that are otherwise unresectable by the conventional surgical techniques.However,from an oncological point of view,a larger study with the control group is required to determine its safety compared to less aggressive surgical treatment. | Dipesh Kumar Yadav Xing Huang Qi Zhang Gang Zhang Xueli Bai Tingbo Liang | 2021 | Journal of Pancreatology2021，4，4： | 1 |
| 14 | Erianin suppresses constitutive activation of MAPK signaling pathway by inhibition of CRAF and MEK1/2显示文摘Constitutive activation of RAS-RAF-MEK-ERK signaling pathway(MAPK pathway)frequently occurs in many cancers harboring RAS or RAF oncogenic mutations.Because of the paradoxical activation induced by a single use of BRAF or MEK inhibitors,dual-target RAF and MEK treatment is thought to be a promising strategy.In this work,we evaluated erianin is a novel inhibitor of CRAF and MEK1/2 kinases,thus suppressing constitutive activation of the MAPK signaling pathway induced by BRAF V600E or RAS mutations.KinaseProfiler enzyme profiling,surface plasmon resonance(SPR),isothermal titration calorimetry(ITC),cellular thermal shift assay,computational docking,and molecular dynamics simulations were utilized to screen and identify erianin binding to CRAF and MEK1/2.Kinase assay,luminescent ADP detection assay,and enzyme kinetics assay were investigated to identify the efficiency of erianin in CRAF and MEK1/2 kinase activity.Notably,erianin suppressed BRAF V600E or RAS mutant melanoma and colorectal cancer cell by inhibiting MEK1/2 and CRAF but not BRAF kinase activity.Moreover,erianin attenuated melanoma and colorectal cancer in vivo.Overall,we provide a promising leading compound for BRAF V600E or RAS mutant melanoma and colorectal cancer through dual targeting of CRAF and MEK1/2. | Penglei Wang Xuechao Jia Bingbing Lu Han Huang Jialin Liu Xuejiao Liu Qiong Wu Yamei Hu Pan Li Huifang Wei Tingting Liu Dengyun Zhao Lingwei Zhang Xueli Tian Yanan Jiang Yan Qiao Wenna Nie Xinli Ma Ruihua Bai Cong Peng Zigang Dong Kangdong Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 15 | Blocking PD-L1 for anti-liver cancer immunity:USP22 represents a critical cotarget显示文摘MULTIPLE LEVELS OF PD-L1 REGULATION IN CANCER IMMUNOTHERAPY To date,the PD-1/PD-L1 blockade strategy has been tested in a variety of cancer types.However,only bladder cancer,melanoma,mismatch repair-deficient colorectal cancer,and certain hematopoietic malignancies have been highly responsive in terms of clinical outcomes.1,2 It is presumed that the expression level of the PD-L1 protein largely determines the therapeutic efficacy of PD-1/PD-L1-targeted cancer immunotherapy.3,4 Previous studies have shown that several transcriptional factors are involved in the upregulation of PD-L1 by directly binding to its promoter region.5 For instance,individual activation of STAT1,NF-κB,HIF-1α,c-Myc,or MAPK increased PD-L1 transcription and immune evasion of tumor cells.On the other hand,oncogenic RAS signaling reportedly stabilizes PD-L1 mRNA to promote tumor immunoresistance. | Xing Huang Xiaozhen Zhang Xueli Bai Tingbo Liang | 2020 | Cellular & Molecular Immunology2020，17，7： | 1 |
| 16 | Explorations in Teaching Research by a Tutoring Institution in China显示文摘Purpose:This article focuses on rarely explored organizational practice of teaching research in China’s private tutoring industry.Taking a large private tutoring institution as an example,the article examines how private tutoring institutions understand and engage in educational explorations of standardization and informatization processes.Design/Approach/Methods:The article is based on a case study of one of the biggest tutoring companies in China.The study started with document analysis of the institutional history,supplemented by interviews with personnel who have worked in the institution since it was founded.Next,the researchers collected empirical data using mixed methods.Quantitative data were obtained from the user database owned by the institution.Qualitative data were collected directly by the researchers through interviews and participant observation.Both qualitative and quantitative data were analyzed from multiple perspectives.Findings:Teaching research in private tutoring institutions commonly differs from that in public schooling.In this particular case,it is technology-driven,student-tailored,and processstandardized.Utilized well,it can supplement the mainstream public education system and promote education innovation and equity throughout the country.Originality/Value:It is hoped that this article could give some insights into the possibility of the cooperation between formal schools and tutoring institutions in the areas of teaching research and other in-class and off-campus activities.The article can also draw public attention to the necessity and benefits of adopting technical methods in the teaching process. | Yunfeng Bai Xueli Tang Xingfang Li Shunan Fan | 2019 | ECNU Review of Education2019，2，1： | 1 |
| 17 | Urinary podocalyxin positive-element occurs in the early stage of diabetic nephropathy and is correlated with a clinical diagnosis of diabetic nephropathy显示文摘 | Hui Ye Xueli Bai Hua Gao Li Li Chunxiao Wu Xinping Sun Chunzhi Zhang Yajuan Shen Jian Zhang Zhiming Lu | 2014 | Journal of Diabetes and Its Complications2014，，1： | 1 |
| 18 | A semilinear parabolic system with coupling variable exponents显示文摘 | Xueli Bai and Sining Zheng | 2011 | Annali di Mathematic Pura ed Application2011，190，3： | 1 |
| 19 | Eating self for not be eaten:Pancreatic cancer suppresses selfimmunogenicity by autophagy-mediated MHC-I degradation显示文摘In a recent study in Nature,1 Yamamoto et al.reported that MHC-I is a selective substrate of autophagy in tumor immune evasion.Furthermore,it was reported that autophagy-mediated lysosomal degradation of MHC-I suppresses pancreatic cancer immunogenicity and the effectiveness of immunotherapy.These findings indicate the potential of autophagy inhibition as a strategy to activate anti-pancreatic cancer immunity. | Xing Huang Xiaozhen Zhang Xueli Bai Tingbo Liang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 20 | Analysis of Food Safety Supervision and Spot-Check in Sichuan Province in 2019显示文摘Through the analysis on 211614 batches of samples from 35 categories of food safety supervision and inspection in Sichuan Province by Administration for Market Regulation of Sichuan Province in 2019,four suggestions were finally put forward.The analysis results showed that in 2019,the overall trend of food safety in Sichuan Province was stable and improved.A total of 30 categories of unqualified samples were detected,and a total of 12135 batches of unqualified samples were detected,with an average sample unqualified rate of 5.73%.Among them,the main problems of unqualified samples were as follows:the use of food additives beyond the scope and limit,accounting for 40.17%of the total number of unqualified samples,microbial contamination in food,accounting for 23.61%of the total unqualified samples,the residue index of agricultural and veterinary drugs in food not meeting the standard,accounting for 15.61%of the total unqualified samples,the quality index in food not meeting the standard,accounting for 8.51%of the total number of unqualified samples,and heavy metals and other pollutants in food exceeding the standard,accounting for 7.10%of the total unqualified samples. | Pengyu CHEN Wei WANG Xueli WU Lili JI Jiamin ZHANG Zhipin ZHAO Rui ZHANG Ting BAI Bo HOU Yixi YANG Lin CHEN | 2022 | Agricultural Biotechnology2022，11，2： | 0 |
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