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| 1 | A new unconventional HLA-A2-restricted epitope from HBV core protein elicits antiviral cytotoxic T lymphocytes显示文摘细胞毒素的 T 房间(CTL ) 在肝炎 B 的控制起一个关键作用病毒(HBV ) 感染和病毒的清理。然而,大多数识别 CTL epitopes 从遗传型 A 和 D 的 HBV 被导出,并且很少在在亚洲更流行的遗传型 B 和 C 的病毒被定义。因为 HBV 核心蛋白质(HBc ) 是最保守、产生免疫性的部件,在这研究,我们使用了盖住 HBc 屏蔽并且识别特定的 CTL epitopes 的一个重叠 9-mer 肽水池。异乎寻常的 HLA-A2-restricted epitope HBc141149 被结晶化分析发现,在结构上描绘了。immunogenicity 和 anti-HBV 活动进一步在 HBV 和 HLA-A2 被决定转基因的老鼠。最后,我们证明在 HBc141149 epitope 的变化与病毒的参数被联系,在 HBV 的疾病前进感染了病人。我们的数据因此提供卓见进这异乎寻常的 epitope 绑定的结构特征给 MHC-I 分子,以及 epitope 特定的 CTL 活动在 HBV 安排 T 房间反应和有免疫力的避免感染的病人。 | Lu Sun Yu Zhang Bao Zhao Mengmeng Deng Jun Liu Xin Li Junwei Hou Mingming Gui Shuijun Zhang Xiaodong Li George F. Gao Songdong Meng | 2014 | Protein & Cell2014，5，4： | 7 |
| 2 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 3 | Analysis on CO2 Emissions Transferred from Developed Economies to China through Trade显示文摘 | Wencheng Zhang Shuijun Peng | 2016 | China & World Economy2016，24，2： | 3 |
| 4 | Core antigen tests for hepatitis C virus: a meta-analysis显示文摘 | Shuijun Gu Jun Liu Huijun Zhang Baoluo Gu Hanjiang Lai Hongliang Zhou Chaoqi He Yingying Chen | 2012 | Molecular Biology Reports2012，，8： | 2 |
| 5 | Norcantharidin enhances ABT-737-induced apoptosis in hepatocellular cainoma cells by transcriptional repression of Mcl-1 显示文摘 | SHUIJUN ZHANG GONGQUAN L I XIUXIAN M A | 2012 | Ellular Signalling2012，24，： | 1 |
| 6 | Role of Leptin Receptor ( LEPR ) Gene Polymorphisms and Haplotypes in Susceptibility to Hepatocellular Carcinoma in Subjects with Chronic Hepatitis B Virus Infection显示文摘 | Zhen Li Weitang Yuan Shijie Ning Jie Li Wenlong Zhai Shuijun Zhang | 2012 | Molecular Diagnosis & Therapy2012，，6： | 1 |
| 7 | Surgical therapy of Budd-Chiari syndrome:Report of 528 cases显示文摘 | Xu peiqin Zhao yongfu Zhang shuijun | 1998 | Journal of Henan Medical University1998，33，5： | 1 |
| 8 | Determination of melamine and cyanuric acid in human urine by a liquid chromatography tandem mass spectrometry显示文摘 | Mengqi Zhang Shuijun Li Chengyin Yu Gangyi Liu Jingying Jia Chuan Lu Jian He Yinghua Ma Jianmin Zhu Chen Yu | 2010 | Journal of Chromatography B2010，，9： | 1 |
| 9 | Polymorphisms of DNA repair gene XRCC1 and hepatocellular carcinoma risk among East Asians: a meta-analysis显示文摘 | Jie Li Zhenzhen Li Liushun Feng Wenzhi Guo Shuijun Zhang | 2013 | Tumor Biology2013，，1： | 1 |
| 10 | The Effect of FOXP3^(+) Regulatory T Cells on Infectious and Inflammatory Diseases显示文摘CD4^(+)CD25^(+)FOXP3^(+)regulatory T cells(Tregs)contribute to the maintenance of immune homeostasis and tolerance in the body.The expression levels and functional stability of FOXP3 control the function and plasticity of Tregs.Tregs critically impact infectious diseases,especially by regulating the threshold of immune responses to pathogenic microorganisms.The functional regulatory mechanism and cell-specific surface markers of Tregs in different tissues and inflammatory microenvironments have been investigated in depth,which can provide novel ideas and strategies for immunotherapies targeting infectious diseases. | Yakun Bai Fang Gao Dan Li Suyuan Ji Shuijun Zhang Wenzhi Guo Bin Li | 2021 | Infectious Microbes & Diseases2021，3，4： | 1 |
| 11 | Norcantharidin enhances ABT-737-induced apoptosis in hepatocellular carcinoma cells by transcriptional repression of Mcl-1显示文摘 | Shuijun Zhang Gongquan Li Xiuxian Ma Yu Wang Guangzhi Liu Liushun Feng Yongfu Zhao Gong Zhang Yang Wu Xuexiang Ye Baoming Qin Jianfeng Lu | 2012 | Cellular Signalling2012，，9： | 1 |
| 12 | Experimental study on the establishment and maintenance of brain death model with pigs显示文摘It remains controversial that after the transplantation of using grafts from brain-dead donors,organs injury and rejection can influence the effects of transplantation.This study sought to explore methods of establishing a stable brain death(BD)model using Bama mini pigs and to maintain the brain-dead state for a comparatively long period to provide a model for investigating changes in brain death.Sixteen anesthetized Bama mini pigs were randomized into a control group(n=5)and a BD group(n=11).Intracranial pressure(ICP)was increased in a modified,slow,and intermittent way to establish BD.Respiration and circulation were sustained during the brain-dead state.Hemodynamic changes were monitored during the experiment.In the BD group,10 pigs met the requirements for brain death and 1 died of cardiopulmonary complications following an increase in ICP.Brain death was maintained for more than 48 hours with artificial life support.During the experiment,the heart rate and blood pressure showed characteristic changes due to increased ICP.Prior to BD being established,a“tic reaction”inevitably occurred.We used an improved method of increasing ICP to establish a stable BD model.The BD state could be maintained for more than 48 hours with effective respiratory and circulatory support.Disappearance of the tic reaction was considered to be one of the verified indexes for BD via encephalic pressure increase. | ZHANG Shuijun SHI Jihua ZHAI Wenlong SONG Yan CHEN Shi | 2007 | Frontiers of Medicine2007，1，2： | 0 |
| 13 | Stratified Analysis of Survival Benefit for ABO-incompatible Deceased-donor Liver Transplantation:Multicenter Propensity Score-matched Study显示文摘Background and Aims:Liver transplantation(LT)using ABO-incompatible(ABOi)grafts can extend the donor pool to a certain extent and hence reduce the waiting time for transplantation.However,concerns of the impending prognosis associated with this option,especially for patients with liver failure and higher model for end-stage liver disease(MELD)scores,who tend to be more fragile during the waiting period before LT.Methods:Recipients undergoing LT for acute-onchronic liver failure or acute liver failure were retrospectively enrolled at four institutions.Overall survival was compared and a Cox regression analysis was performed.Propensity score matching was performed for further comparison.Patients were stratified by MELD score and cold ischemia time(CIT)to determine the subgroups with survival benefits.Results:Two hundred ten recipients who underwent ABOi LT and 1,829 who underwent ABO compatible(ABOc)LT were enrolled.The 5-year overall survival rate was significantly inferior in the ABOi group compared with the ABOc group after matching(50.6%vs.75.7%,p<0.05).For patients with MELD scores≤30,using ABOi grafts achieved a comparable overall survival rate as using ABOc grafts(p>0.05).Comparison of the survival rates revealed no statistically significant difference for patients with MELD scores≥40(p>0.05).For patients with MELD scores of 31-39,the overall survival rate was significantly inferior in the ABOi group compared with the ABOc group(p<0.001);however,the rate was increased when the liver graft CIT was<8 h.Conclusions:For recipients with MELD scores≤30,ABOi LT had a prognosis comparable to that of ABOc LT and can be regarded as a feasible option.For recipients with MELD scores≥40,ABOi should be adopted with caution in emergency cases.For recipients with MELD scores of 31-39,the ABOi LT prognosis was worse.However,those patients benefited from receiving ABOi grafts with a CIT of<8 h. | Mengfan Yang Xuyong Wei Abdul Rehman Khan Qiang Wei Rui Wang Binhua Pan Kun Wang Zhisheng Zhou Di Lu Beini Cen Shuijun Zhang Wenzhi Guo Shusen Zheng Yang Yang Xiao Xu | 2023 | Journal of Clinical and Translational Hepatology2023，11，4： | 0 |
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