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| 1 | 高渗氯化钠溶液治疗失血性休克的实验研究显示文摘目的 筛选出最佳氯化钠溶液浓度、最佳滴注速度和最佳剂量 ;了解高渗氯化钠溶液复苏后血浆渗透压及电解质的变化情况。 方法 45只犬 ,制成失血性休克模型 ,用不同浓度和剂量的氯化钠溶液在不同滴注速度下 ,对失血性休克犬进行复苏 ,比较其复苏效果。 结果 质量浓度为 75g/L的高渗氯化钠溶液为最佳浓度 ,2 0ml/min为最佳滴速 ,相当于放血量的 15 %(5 .71mg/kg体重 )为最佳剂量 ;复苏效果确切 ,使平均动脉压恢复到基础水平的 89% ,且维持时间至少 1h左右。 结论 以 2 0ml/min的滴速 ,用相当于失血量 15 %的 75g/L氯化钠溶液复苏失血性休克效果最佳。 | Cai Xiujun MOU Yiping HUANG Diyu 蔡秀军 牟一平 黄迪宇 彭淑牖 | 2001 | 中华创伤杂志2001，17，2： | 19 |
| 2 | maturity of associating liver partition and portal vein ligation for staged hepatectomy-derived liver regeneration in a rat model显示文摘AIM To establish a rat model for evaluating the maturity of liver regeneration derived from associating liver partition and portal vein ligation for staged hepatectomy(ALPPS).METHODS In the present study, ALPPS, partial hepatecotmy(PHx), and sham rat models were established initially, which were validated by significant increase of proliferative markers including Ki-67, proliferating cell nuclear antigen, and cyclin D1. In the setting of accelerated proliferation in volume at the second and fifth day after ALPPS, the characteristics of newborn hepatocytes, as well as specific markers of progenitor hepatic cell, were identified. Afterwards, the detection of liver function followed by cluster analysis of functional gene expression were performed to evaluate the maturity.RESULTS Compared with PHx and sham groups, the proliferation of f LR was significantly higher in ALPPS group(P = 0.023 and 0.001 at second day, P = 0.034 and P < 0.001 at fifth day after stage I). Meanwhile, the increased expression of proliferative markers including Ki-67, proliferating cell nuclear antigen, and cyclin D1 verified the accelerated liver regeneration derived from ALPPS procedure. However, ALPPS-induced Sox9 positive hepatocytes significantly increased beyond the portal triad, which indicated the progenitor hepatic cell was potentially involved. And the characteristics of ALPPSinduced hepatocytes indicated the lower expression of hepatocyte nuclear factor 4 and anti-tryptase in early proliferative stage. Both suggested the immaturity of ALPPS-derived liver regeneration. Additionally, the detection of liver function and functional genes expression confirmed the immaturity of renascent hepatocytes derived in early stage of ALPPS-derived liver regeneration.CONCLUSION Our study revealed the immaturity of ALPPS-derived proliferation in early regenerative response, which indicated that the volumetric assessment overestimated the functional proliferation. This could be convincing evidence that the stage Ⅱ of ALPPS should be performed prudently in patients with marginally adequate f LR, as the ALPPS-derived proliferation in volume lags behind the functional regeneration. | Yi-fan Tong Ning Meng Miao-qin Chen Han-ning Ying Ming Xu Billy Lu Jun-Jie Hong Yi-fan Wang Xiujun Cai | 2018 | World Journal of Gastroenterology2018，24，10： | 5 |
| 3 | Isolated laparoscopic resection of the hepatic caudate lobe显示文摘The caudate lobe (Couinaud's segment 1) is located at the posterior part of the liver.Isolated resection of caudate lobe is a major challenge1,2 especially when it is carried out laparoscopically.We report a case of successful total laparoscopic resection of caudate lobe using the technique of curettage and aspiration3 on a hepatic hemangioma which measured 7 cm ×5 cm.As far as we know,this is the first report from Asia on isolated laparoscopic resection of the hepatic caudate lobe. | Cai Xiujun Li Zheyong Yu Hong Liu Kun Liang Xiao Wang Yifan Liang Yuelong | 2014 | Chinese Medical Journal2014，，17： | 5 |
| 4 | CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1显示文摘Sorafenib is the first-line chemotherapeutic therapy for advanced hepatocellular carcinoma(HCC).However,sorafenib resistance significantly limits its therapeutic efficacy,and the mechanisms underlying resistance have not been fully clarified.Here we report that a circular RNA,circRNA-SORE(a circular RNA upregulated in sorafenib-resistant HCC cells),plays a significant role in sorafenib resistance in HCC.We found that circRNA-SORE is upregulated in sorafenib-resistant HCC cells and depletion of circRNA-SORE substantially increases the cell-killing ability of sorafenib.Further studies revealed that circRNA-SORE binds the master oncogenic protein YBX1 in the cytoplasm,which prevents YBX1 nuclear interaction with the E3 ubiquitin ligase PRP19 and thus blocks PRP19-mediated YBX1 degradation.Moreover,our in vitro and in vivo results suggest that circRNA-SORE is transported by exosomes to spread sorafenib resistance among HCC cells.Using different HCC mouse models,we demonstrated that silencing circRNA-SORE by injection of siRNA could substantially overcome sorafenib resistance.Our study provides a proof-of-concept demonstration for a potential strategy to overcome sorafenib resistance in HCC patients by targeting circRNA-SORE or YBX1. | Junjie Xu Lin Ji Yuelong Liang Zhe Wan Wei Zheng Xiaomin Song Kirill Gorshkov Qiming Sun Hui Lin Xueyong Zheng Jiang Chen Ren-an Jin Xiao Liang Xiujun Cai | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 5 | Decorin accelerates the liver regeneration after partial hepatectomy in fibrotic mice显示文摘 | Ma Rui Chen Jiang Li Zheyong Tang Jiacheng Wang Yifan Cai Xiujun | 2014 | Chinese Medical Journal2014，，14： | 4 |
| 6 | CRISPR-Cas9-based genome-wide screening identified novel targets for treating sorafenib-resistant hepatocellular carcinoma:a cross-talk between FGF21 and the NRF2 pathway显示文摘The treatment of hepatocellular carcinoma(HCC)has been dominated by multikinase inhibitors for more than a decade.However,drug resistance can severely restrict the efficacy of these drugs.Using CRISPR/CAS9 genome library screening,we evaluated Kelch-like ECH-associated protein 1(KEAP1)as a key regulator of sorafenib’s susceptibility in HCC.We also investigated whether KEAP1’s knockdown can stabilize nuclear factor(erythroid-derived 2)-like 2(NRF2)protein levels that led to sorafenib’s resistance,including an NRF2 inhibitor that can synergize with sorafenib to abolish HCC’s growth in vitro and in vivo.Furthermore,we clarified that fibroblast growth factor 21(FGF21)is an important downstream regulator of NRF2 in HCC.Intriguingly,we observed that FGF21 bound to NRF2 through the C-terminus of FGF21,thereby stabilizing NRF2 by reducing its ubiquitination and generating a positive feedback loop in sorafenib-resistant HCC.These findings,therefore,propose that targeting FGF21 is a promising strategy to combat HCC sorafenib’s resistance. | Jiang Chen Shi Jiang Huijiang Shao Bixia Li Tong Ji Daniel Staiculescu Jiayan He Jie Zhao Liuxin Cai Xiao Liang Junjie Xu Xiujun Cai | 2022 | Science China(Life Sciences)2022，65，10： | 4 |
| 7 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 8 | Perioperative outcomes of laparoscopic versus open splenectomy for nontraumatic diseases: a meta-analysis显示文摘 | Chen Jiang Ma Rui Yang Shouzhang Lin Shuang He Shilin Cai Xiujun | 2014 | Chinese Medical Journal2014，，13： | 4 |
| 9 | Robotic single-incision left hemihepatectomy for intrahepatic bile duct stones by Da Vinci single-site surgical system: A case report with video显示文摘Minimally invasive surgery is a trend in hepatobiliary surgery.A 56-year-old female patient was admitted to our institution for intrahepatic lithiasis.The CT scan showed multiple calculi in the left liver,dilation of the left intrahepatic bile duct and liver atrophy of the left lobe.Robotic single-incision left hemihepatectomy by the single-site systemwas successfully applied.With the idea of enhanced recovery after surgery,the patient was discharged on the third day after the operation without any morbidity.Robotic single-incision surgery is more frequent in gynecologic and urological surgery.As far as we know,this is the first robotic single-incision left hemihepatectomy report in the world. | Xiao Liang Junhao Zheng Jiaqi Gao Yubin Sheng Tianyu Lin Xiujun Cai | 2021 | Laparoscopic, Endoscopic and Robotic Surgery2021，4，3： | 3 |
| 10 | Preoperative prediction of survival in resectable gallbladder cancer by a combined utilization of CA 19-9 and carcinoembryonic antigen显示文摘 | Yu Tunan Yu Hong Cai Xiujun | 2014 | Chinese Medical Journal2014，，12： | 3 |
| 11 | The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells显示文摘Pancreatic adenocarcinoma(PAAD) is one of the most lethal malignancies. Although gemcitabine(GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C(Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not been investigated since it was isolated. Our research is the first to indicate that Sec C is a broad-spectrum anticancer agent and could exhibit potently similar anticancer activity both in GEM-resistant and GEM-sensitive PAAD cells. Interestingly, Sec C exerted a rapid growth-inhibiting effect(80% death at 6 h), which might be beneficial for patients who need rapid tumor shrinkage before surgery. Liquid chromatography/mass spectrometry and N-acetyl-L-cysteine(NAC) reverse assays show that Sec C sulfates cysteines to disrupt disulfide-bonds formation in endoplasmic reticulum(ER) proteins to cause protein misfolding, leading to ER stress and disorder of lipid biosynthesis. Microarray data and subsequent assays show that ER stress-mediated ER-associated degradation(ERAD) ubiquitinates anddownregulates YAP to enhance ER stress via destruction complex(YAP-Axin-GSK-βTr CP), which also elucidates a unique degrading style for YAP. Potent anticancer activity in GEM-resistant cells and low toxicity make Sec C a promising anti-PAAD candidate. | Junxia Wang Minghua Chen Mengyan Wang Wenxia Zhao Conghui Zhang Xiujun Liu Meilian Cai Yuhan Qiu Tianshu Zhang Huimin Zhou Wuli Zhao Shuyi Si Rongguang Shao | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 2 |
| 12 | Changes of the colonic physiologic functions after colonic anastomosis with a degradable stent in a porcine model显示文摘 | Feng Xu Liang Xiao Wang Yifan He Shilin Cai Xiujun | 2014 | Chinese Medical Journal2014，，18： | 2 |
| 13 | Printability during projection-based 3D bioprinting显示文摘Since projection-based 3D bioprinting(PBP)could provide high resolution,it is well suited for printing delicate structures for tissue regeneration.However,the low crosslinking density and low photo-crosslinking rate of photocurable bioink make it difficult to print fine structures.Currently,an in-depth understanding of the is lacking.Here,a research framework is established for the analysis of printability during PBP.The gelatin methacryloyl(GelMA)-based bioink is used as an example,and the printability is systematically investigated.We analyze the photo-crosslinking reactions during the PBP process and summarize the specific requirements of bioinks for PBP.Two standard quantized models are established to evaluate 2D and 3D printing errors.Finally,the better strategies for bioprinting five typical structures,including solid organs,vascular structures,nerve conduits,thin-wall scaffolds,and micro needles,are presented. | Kang Yu Xinjie Zhang Yuan Sun Qing Gao Jianzhong Fu Xiujun Cai Yong He | 2022 | Bioactive Materials2022，7，5： | 2 |
| 14 | Laparoscopic liver resection and the learning curve: a 14-year, single-center experience显示文摘 | Xiujun Cai Zheyong Li Yale Zhang Hong Yu Xiao Liang Renan Jin Feng Luo | 2014 | Surgical Endoscopy2014，，4： | 2 |
| 15 | Completed Laparoscopic Pancreaticoduodenectomy显示文摘 | Xiujun Cai Yifan Wang Hong Yu Xiao Liang Bin Xu Shuyou Peng | 2008 | Surgical Laparoscopy, Endoscopy & Percutaneous Techniques2008，，4： | 1 |
| 16 | Experimental study of colonic anastomosis with a degradable stent in a porcine model显示文摘 | YiFan Wang XiuJun Cai HuanJie Cai YueLong Liang DiYu Huang Xiao Liang | 2010 | The American Journal of Surgery2010，，6： | 1 |
| 17 | Sutureless primary repair of colonic perforation with a degradable stent in a porcine model of fecal peritonitis显示文摘 | Kun Liu Hong Yu Minghui Zhang Yichen Yu Yifan Wang Xiujun Cai | 2012 | International Journal of Colorectal Disease2012，，12： | 1 |
| 18 | What is the best technique in parenchymal transection in laparoscopic liver resection? Comprehensive review for the clinical question on the 2nd International Consensus Conference on Laparoscopic Liver Resection显示文摘 | Yuichiro Otsuka Hironori Kaneko Sean P. Cleary Joseph F. Buell Xiujun Cai Go Wakabayashi | 2015 | J Hepatobiliary Pancreat Sci2015，，5： | 1 |
| 19 | Lap- aroscopic hepatectomy for hepatolithiasis: a feasibility and safety study in 29 patients 显示文摘 | Xiujun Cai Yifan Wang Hong Yu Xiao Liang Shuyou Peng | 2007 | Surg Endosc2007，21，： | 1 |
| 20 | Laparoscopic hepatectomy for hepatolithiasis: a feasibility and safety study in 29 patients显示文摘 | Xiujun Cai Yifan Wang Hong Yu | 2007 | Surgical Endoscopy2007，21，7： | 1 |
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