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| 1 | Studies on mechanism of Sialy Lewis-X antigen in liver metastases of human colorectal carcinoma显示文摘INTRODUCTIONSialyl Lewis-X antigen ,correlated with carcinoma, is a group of carbohydrate antigen containing oligosaccharide expressed of embryonic tisue and glycoproteins on cell surface of embryonic tissue[1].The SLeX antigen located on cell surface is synthesized principally by two enzymes ,al ,3fucosyltransfrease and a2, 3sialyctransferase.In adults ,SLeX antigen is expressed principally on the surfaces of granulocytic cells and some tumor cells . | Xiao Wei Li~1 Yan Qing Ding~1 Jun Jie Cai~1 Shao Qing Yang~2 Lian Bing An~3 Dong Fang Qiao~3 ~1Department of Pathology,Nanfang Hospital of the First Military Medical University,Guangzhou 510515,Guangdong Province,China ~2The Northern Hospital of PLA,Shenyang 110015,Liaoning Province,China ~3Department of Electronmicroscopy,First Military Medical University,Guangzhou 510515,Gangdong Province,ChinaDr.Xiao Wei Li graduated from the First Military Medical University with a MM degree in 1999.Physician in Charge of pathology,having 6 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 19 |
| 2 | EXPERIMENTAL STUDY OF FLOWFIELD STRUCTURE AROUND AN OGIVE-CYLINDER显示文摘The flowfield structure and their aerodynamic characteristics over an ogive cylinder were studied by means of flow visualization and surface pressure measurement in a water tunnel and a wind tunnel. The existence of multi asymmetric vortices over long slender bodies was experimentally confirmed at large angles of attack and in the subcritical Reynolds number range. The spatial 3 D characteristics of the multi vortices system were analyzed and a physical model was developed. The topological structure of different patterns in cross flow plane was studied and the mechanism governing the formation of asymmetric vortices and multi vortices was discussed from the viewpoint of stability of the topological structure. It was concluded that the maximum in the sectional side force distribution curve are not caused by the shedding of higher position vortex, but by the cross over to the symmetric plane of the lower position vortex. | Ph.D.Candidate:Wang Gang Fluid Mechanics Institute, Beijing University of Aeronautics and Astronautics, Beijing 100083, China,Supervisor: Deng Xue ying (Beijing University of Aeronautics and Astronautics) Members of Dissertation Defense Committee: Tong Bing gang (Graduate School of the Chinese Academy of Sciences),Chairman Gu Zhi fu (Peking University) Yang Qi de (China Aerodynamics Research and Development Center) Lv Zhi yong (Beijing University of Aeronautics and Astronautics) Liu Pei qing (Beijing University of Aeronautics and Astronautics) | 2003 | Journal of Hydrodynamics2003，15，5： | 18 |
| 3 | Additive Benefits of Twice Forest Bathing Trips in Elderly Patients with Chronic Heart Failure显示文摘长期的心失败(CHF ) ,源于各种各样的心血管的疾病(CVD ) 的后果的临床的症候群,逐渐地正在成为病态和死亡的一个全球原因。我们更早证明了洗旅行的一个 4 天的森林能在病人上向附属治疗学的影响提供 CHF。为了进一步调查影响和森林洗澡的最佳的频率的持续时间,与 CHF 在病人摔倒,我们招募了经历了在 4 个星期以后再洗旅行的第一个森林并且也就是,随机把他们分成了二个组的那些对象城市的控制组(城市)和洗组(森林)的森林。在洗旅行的第二个 4 天的森林以后,我们象氧化应力一样在大脑 natriuretic 肽层次,心失败的 biomarker,和稀释煽动性的回答观察了稳定的衰落。因此,这探索研究表明了添加剂好处两次,森林洗澡与 CHF 在老病人摔倒,它能进一步为在 CVD 分析如此的干预的效果铺平道路。 | MAO Gen Xiang CAO Yong Bao YANG Yan CHEN Zhuo Mei DONG Jian Hua CHEN Sha Sha WU Qing LYU Xiao Ling JIA Bing Bing YAN Jing WANG Guo Fu | 2018 | Biomedical and Environmental Sciences2018，31，2： | 18 |
| 4 | Impact of alanyl-glutamine dipeptide on severe acute pancreatitis in early stage显示文摘AIM:To evaluate the therapeutic effect of alanyl- glutamine dipeptide (AGD) in the treatment of severe acute pancreatitis (SAP) in early and advanced stage. METHODS: Eighty patients with SAP were randomized and received 100 mL/d of 20% AGD intravenously for 10 d starting either on the day of (early treatment group) or 5 d after (late treatment group) admission. Groups had similar demographics, underlying diseases, Ranson score, Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ) score, and Balthazar’s computed tomography (CT) score at the beginning of the study and underwent similar other medical and nutritional management. RESULTS: The duration of acute respiratory distress syndrome (2.7 ± 3.3 d vs 12.7 ± 21.0 d, P < 0.01), renal failure (1.3 ± 0.5 d vs 5.3 ± 7.3 d, P < 0.01), acute hepatitis (3.2 ± 2.3 d vs 7.0 ± 7.1 d, P < 0.01), shock (1.7 ± 0.4 d vs 4.8 ± 3.1 d, P < 0.05), encephalopathy (2.3 ± 1.9 d vs 9.5 ± 11.0 d, P < 0.01) and enteroparalysis (2.2 ± 1.4 d vs 3.5 ± 2.2 d, P < 0.01) and hospital stay (28.8 ± 9.4 d vs 45.2 ± 27.1 d, P < 0.01) were shorter in the early treatment group than in the late treatment group. The 15-d APACHE Ⅱ score was lower in the early treatment group than in the late treatment group (5.0 ± 2.4 vs 8.6 ± 3.6, P < 0.01). The infection rate (7.9% vs 26.3%, P < 0.05), operation rate (13.2% vs 34.2%, P < 0.05) and mortality (5.3% vs 21.1%, P < 0.05) in the early treatment group were lower than in the late treatment group.CONCLUSION: Early treatment with AGD achieved a better clinical outcome in SAP patients. | Ping Xue Li-Hui Deng Qing xia Zhao-Da Zhang Wei-Ming Hu Xiao-Nan Yang Bing Song Zong-Wen Huang | 2008 | World Journal of Gastroenterology2008，14，3： | 15 |
| 5 | A Cross-sectional Survey Assessing Carriage of Streptococcus pneumoniae in a Healthy Population in Xinjiang Uygur Autonomous Region of China显示文摘链球菌 pneumoniae 的车厢率和 serotype 分发(S。pneumoniae ) 在在中国遗体的一张健康人口不清楚。在这研究,我们在 Xinjiang 从 513 个个人收集了 oropharyngeal 拖把,中国。指向 lytA 基因和 12 serotypes 的实时 PCR 被估计识别 S。pneumoniae 马车。S 的全部的车厢率。pneumoniae 是 70.4%(361/513 ) 。最流行的 serotypes 是 19B/F, 18B/C, 5,并且 6A/B。S 的最高的车厢率。pneumoniae 6-10 年(88.6%) 在孩子被注意,它应得进一步的注意。二的合作殖民率或更多的 S。pneumoniae serotypes 是 79.8%(264/331 ) 。这研究试图在中国在健康个人之中调查基线 pneumococcal 马车率改进我们 S 的传染病学的理解。pneumoniae。 | XIE Na CHEN Zhao Yun CHEN Tao ZHU Bing Qing XU Li GAO Yuan ZHANG Ai Yu ZHAO Pan LIU Ji Wen SHAO Zhu Jun | 2018 | Biomedical and Environmental Sciences2018，31，3： | 15 |
| 6 | Cloning and characterization of a potato StAN11 gene involved in anthocyanin biosynthesis regulation显示文摘Anthocyanins are a class of products of plant secondary metabolism and are responsible for tubers color in potato.The biosynthesis of anthocyanins is a complex Researchbiological process,in which multiple genes are involved including structural genes and regulatory genes.In this study,StAN11,a WD40-repeat gene,was cloned from potato cultivar Chieftain(Solanum tuberosum L.).StAN11(HQ599506)contained no intron and its open reading frame(ORF)was 1,029 bp long,encoding a putative protein of 342 amino acids.In order to verify its role in anthocyanin biosynthesis,StAN11 was inserted behind the CaMV-35S promoter of pCMBIA1304 and the recombination vector was introduced into the potato cultivar Désirée plants by Agrobacterium-mediated transformation.The color of transgenic tuber skin was significantly deepened,compared to the wild-type control,which was highly consistent with the accumulation of anthocyanin and expression of StAN11 in transgenic lines tuber skin.Further analysis on the expression of Flavonone-3-hydroxylase(F3H),Dihydroflavonol reductase(DFR),Anthocyanidin synthase(ANS),and Flavonoid 3-O-glucosyl transferase(3GT)in transgenic plants revealed that only DFR was upregulated.This result suggested that StAN11 regulated anthocyanin biosynthesis in potato by controlling DFR expression and accumulation of anthocyanin could be increased through overexpression of StAN11 in the tubers with the genetic background of anthocyanin biosynthesis. | Wang Li Bing Wang Man Wang Min Chen Jing-Ming Yin Ghullam Murtaza Kaleri Rui-Jie Zhang Tie-Niu Zuo Xiong You Qing Yang | 2014 | Journal of Integrative Plant Biology2014，56，4： | 13 |
| 7 | Epidemiological Data of Work-Related Musculoskeletal Disorders—China,2018–2020显示文摘Summary What is already known about this topic?In recent decades,work-related musculoskeletal disorders(WMSDs)have become increasingly prominent and have become an important issue that is of universal concern and an urgent need to be solved in all countries of the world.What is added by this report?The top three industries or occupational groups with the highest standardized prevalence rate of WMSDs were flight attendants,medical staff,and vegetable greenhouses in that order.Women workers were 1.5 times more likely to suffer from WMSDs than men workers. | Ning Jia Huadong Zhang Ruijie Ling Yimin Liu Gang Li Zaoliang Ren Yan Yin Hua Shao Hengdong Zhang Bing Qiu Meibian Zhang Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang | 2021 | China CDC weekly2021，3，18： | 13 |
| 8 | Investigation on Work-Related Musculoskeletal Disorders--China, 2018−2019显示文摘What is already known about this topic?Work-related musculoskeletal disorders(WMSDs)have a high prevalence and seriously harmful,which has attracted extensive attention in various countries in the world.Currently,the occurrence and rules of WMSDs in key industries are not known in China.What is added by this report?The prevalence of WMSDs is relatively high among professional populations in key industries in China,with the most commonly affected body parts concentrated in neck,shoulders,and low back and increasing with age and working years.What are the implications for public health practice?This study determined the prevalence and distribution characteristics of WMSDs in key industries in China and provided scientific evidence to recommend for inclusion of WMSDs in the new revision of the list of occupational diseases in China. | Ning Jia Huadong Zhang Ruijie Ling Yimin Liu Gang Li Zaoliang Ren Yan Yin Hua Shao Hengdong Zhang Bing Qiu Meibian Zhang Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang | 2020 | China CDC weekly2020，2，18： | 11 |
| 9 | Functional protection of pentoxifylline against spinal cord ischemia/reperfusion injury in rabbits: necrosis and apoptosis effects显示文摘背景很少对跟随学习试图对 injury.Methods 兔子支撑了针的绳索局部缺血列在后面的针的绳索 ischemia/reperfusion (I/R ) 调查 pentoxifylline (图画) 的保护的效果的在场的针的绳索 ischemia.The 的 neuronal 死亡机制被知道 infrarenal aorta.Experimental 组 45 分钟夹钳十字花科植物如下:第一组动物(假冒, n=8 ) 独自经历了剖腹术并且担任了假冒的组;第二个组(I/R, n=20 ) 接待了搬运人(3 ml 盐溶液) 并且担任了控制组;第三个组(PTX -- 一, n=20 ) 静脉内地收到了 PTX 在局部缺血以前的 10 分钟;并且第四组织( PTX-B , n=20 )收到的 PTX 静脉内地在 reperfusion.Rabbits 的发作被评估因为有在 48 hours.Serum 的 Tarlov 得分系统的后部手足的马达功能是有为肿瘤坏死因素(TNF-)的连接酶的 immunosorbent 试金的 assayed ,针的绳索为 myeloperoxidase (军邮局)被收获活动,组织病理学说的分析,终端 deoxynucleotidyl transferase ( TdT )调停了标记染色的 dUTP 刻痕结束, platelet/endothelial 房间粘附 molecule-1 ( PECAM-1 ) | ZHU Dan-jie XIA Bing BI Qing ZHANG Shui-jun QIU Bin-song ZHAO Chen | 2008 | Chinese Medical Journal2008，，23： | 10 |
| 10 | Enhancing effect of natural borneol on the absorption of geniposide in rat via intranasal administration显示文摘Both geniposide (Ge) and natural borneol (NB) are bioactive substances derived from traditional Chinese herbs. The effect of NB on the pharmacokinetics of Ge in rat via intranasal administration was investigated. The concentrations of Ge in plasma were determined by reversed-phase high-performance liquid chromatography (HPLC) after intranasal administration of Ge (4 mg/kg) alone and combined with different doses (0.08, 0.8, and 8 mg/kg) of NB. The intravenous administration was given as a reference (4 mg/kg of Ge and 8 mg/kg of NB). Compared with the intravenous administration, the absolute bioavailability of Ge was 76.14% through intranasal administration combined with NB. Compared with the intranasal administration of Ge alone, Ge could be absorbed rapidly in the nasal cavity combined with NB; the peak time of Ge in the plasma became shorter (3-5 min vs. 40 min); the peak concentration became higher (1.32-4.25 μg/ml vs. 0.67 μg/ml); and, the relative bioavailability of Ge combined with NB was 90.3%-237.8%. The enhancing effect was attenuated as the dose of NB decreased. The results indicated that NB can accelerate the absorption of Ge dose-dependently in the nasal cavity. | Yang LU Shou-ying DU Xiao-lan CHEN Qing WU Xiao SONG Bing XU Yong-song ZHAI | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，2： | 8 |
| 11 | Super stable CsPbBr3@SiO2 tumor imaging reagent by stress-response encapsulation显示文摘Great photoelectric properties can herald the high potentials of CsPbBr3 nanocrystals(NCs)to function as the fluorescent probes for early tumor diagnosis.However,the intrinsic water vulnerability of CsPbBr3 NCs highly restricts their biomedical applications.To conquer this challenge,we herein introduce a nature inspired'stress-response'method to tightly encapsulate CsPbBr3 into SiO2 nano-shells that can dramatically improve the water stability of CsPbBr3@SiO2 nanoparticles for over 48 h.We further highlighted the advantageous features of CsPbBr3@SiO2 by using them as the fluorescent probes for CT26 tumor cell imaging with their high water stability,biocompatibility,and low cytotoxicity.Our work for the first time exhibited the potential of lead halide perovskite NCs for tumor diagnosis,and can highly anticipate the further in vivo biomedical applications that light up live cells. | Wentao Song Yiming Wang Bing Wang Yingfang Yao Wenguang Wang Jinhui Wu Qing Shen Wenjun Luo Zhigang Zou | 2020 | Nano Research2020，13，3： | 7 |
| 12 | Retrograde approach for the recanalization of coronary chronic total occlusion: preliminary experience of a single center显示文摘为开运河不戏剧性地有的长期的全部的吸藏(CTO ) 的 antegrade 途径的成功率增加了的背景,特别在复杂 CTO 子集。retrograde 技术可以保持大诺言。这份报告试图描述我们的经验后退为 CTO 的开运河,集中于它的安全和可行性。我们识别了在 CTO 经历了 revascularization 与的 42 个病人的方法后退在我们的 center.Results 的 2009 年 11 月的从 2005 年 7 月的途径三种策略被使用:作为主要策略(50.0%) 后退,在 antegrade 失败(26.2%) 以后立即后退并且重复在以前的 antegrade 失败(23.8%) 以后的过程。氏族的担保更经常被用作 retrograde 存取线路(92.9%) 。全面成功率是 88.1% 。在病人与成功后退电线十字路口担保隧道到 CTO 的远侧的帽子,开运河的成功率是 94.1% 。在有失败到的病人穿过担保,成功率是 62.5% 。八种不同类型后退技术被使用:吻的电线技术(35.3%),套住的电线和套住的反向的电线技术(17.6%),后端汽球和 microcatherer 颠倒技术(14.7%),控制 antegrade 并且后退追踪的 subintimal (大车)技术(8.8%),反向的大车和修改颠倒运技术(8.8%),后退电线十字路口技术(2.9%)。有 4 复杂并发症没有在里面医院,发生了主要不利心脏的事件(向) 。在里面医院向是 7.7% 。所有他们是 non-Q 挥动心肌的梗塞。没有死亡的盒子或指向 retrograde 途径能是的容器 revascularization,任何一个外科或 percutaneous.Conclusions 为在复杂 CTO 增加开运河的成功率的一个有效工具。保证由富有经验的操作员处理的途径,小心的盒子选择和设备的成功和安全是必要的。 | GE Lei QIAN Ju-ying LIU Xue-bo QIN Qing CUI Shan-jing YAO Kang SHEN Li MA Jian-ying HUANG Dong XU Shi-kun ZHANG Feng WANG Xiang-fei WANG Qi-bing FAN Bing YAN Yan FENG Qi WANG Hao SHEN An ZHU Ming-hui GE Jun-bo | 2010 | Chinese Medical Journal2010，，7： | 7 |
| 13 | Etiology and prevalence of abnormal serum alanine aminotransferase levels in a general population in Northeast China显示文摘背景长期的肝疾病是在 China.Alanine aminotransferase (中高音)的主要负担能被用作 hepatocyte damage.In 的指示物这研究,我们在吉林在一张成年人口决定了提高的中高音的流行和病原学, 4072 个个人的一个总数在 18 和 79 年之间变老的 China.Methods 首先被会见,然后经历提高的中高音的流行是的 ultrasonography 和血 tests.Results 17.53% .The | ZHANG Hong JIANG Yan-fang HE Shu-mei SUN Jie GU Qing FENG Xiang-wei DU Bing WANG Wei SHI Xiao-dong WANG Chun-yan ZHANG Si-qi LI Wan-yu NIU Jun-qi | 2011 | Chinese Medical Journal2011，，17： | 6 |
| 14 | Synthesis and characterization of phosphate-modified LiMn_2O_4 cathode materials for Li-ion battery显示文摘LiMn2O4 尖晶石阴极材料与 2 wt.% LiMPO4 被修改(M = 公司, Ni, Mn ) 由 polyol 合成方法。修改表面的 LiMn2O4 阴极材料身体上是的磷酸盐由 X 光检查衍射(XRD ) 描绘了,扫描电子显微镜学(SEM ) 和精力散 X 光检查光谱学(版本) 。chargedischarge 测试证明骑车和 LiMn2O4 阴极材料的率能力被与磷酸盐稳定电极表面显著地提高。 | Qing Lai Jiang Ke Du Yan Bing Cao Zhong Dong Peng Guo Rong Hu Ye Xiang Liu | 2010 | Chinese Chemical Letters2010，21，11： | 6 |
| 15 | Potent Dendritic Cell Vaccine Loaded with Latent Membrane Protein 2A (LMP2A)显示文摘Epstein-Barr virus (EBV), a potential oncogenic herpesvirus, has been found to be associated with several malignancies. It's critical to elicit cellular immunity of the body to fight against EBV-associated tumor development. Using dendritic cells (DCs) loaded with latent membrane protein 2A (LMP2A) to elicit T cell response against tumor may be one of the most direct and safest immunotherapy approaches. The present study aimed to develop DCs-based cancer vaccine (DC loaded with LMP2A protein) and study its biological characteristics and immune functions. Purified LMP2A protein was extracted from a cell line L929/LMP2A stably expressing LMP2A. LMP2A could be loaded on DCs with no significant changes of the DC surface markers and cytomorphology. The percentage of DCs loaded with LMP2A was above 80%. LMP2A-loaded DCs markedly enhanced the proliferation of antigen-specific CD8+ T and CD4+ T cells by 3H-TdR incorporation assay. Besides, the specific cytotoxicity of the CTLs against LMP2A target cells was also significantly increased. These results indicated that DC-based vaccine loaded with virus antigen could elicit potent CTL response and provide a foundation for further study on the DC-based immunotherapy for nasopharygeal carcinoma and other EBV associated tumors. | Yun Chen Kun Yao Bing Wang Jian Qing Genyan Liu | 2008 | Cellular & Molecular Immunology2008，5，5： | 6 |
| 16 | Current Status of Forest Medicine Research in China显示文摘In recent years,due to regional pollution and deteriorating environment,combined with intense social competition and heavier life pressure,an increasing number of people are affected by lifestyle-related diseases and remain in a state of being sub-healthy.Therefore,health issue has been receiving unprecedented attention.It is well known that the forest environment | HUANG Qing Dong WU Qing MAO Gen Xiang WANG San Ying JIA Bing Bing WANG Guo Fu | 2018 | Biomedical and Environmental Sciences2018，31，7： | 5 |
| 17 | Feiji Recipe inhibits the growth of lung cancer by modulating T-cell immunity through indoleamine-2,3-dioxygenase pathway in an orthotopic implantation model显示文摘Objective: Escape from the body's immune response is a basic characteristic of lung cancer, and indoleamine-2,3-dioxygenase(IDO) plays a key role in mediating immune escape of non-small-cell lung cancer, which leads to recurrence and metastasis. Feiji Recipe, a compound Chinese herbal medicine, has the effect of stabilizing lesions and prolonging survival in patients with lung cancer. The purpose of this study was to investigate the mechanisms underlying the anticancer properties of Feiji Recipe.Methods: An orthotopic transplant model of mouse Lewis lung cancer, with stable expression of IDO gene, was established in C57 BL/6 mice. Optical imaging was used to observe the effects of Feiji Recipe in the treatment of lung cancer in vivo. The effects of Feiji Recipe on the proliferation of mouse Lewis lung cancer cell line 2 LL, 2 LL-enhanced green fluorescent protein(2 LL-EGFP) and 2 LL-EGFP-IDO were investigated, and the apoptosis of T-cells was examined by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2 H-tetra zolium bromide using flow cytometry. Chemical composition of Feiji Recipe was validated by highperformance liquid chromatography.Results: Compared to the control group, the survival of animals treated with Feiji Recipe was significantly prolonged(P = 0.0074), and the IDO protein level decreased(P = 0.0072); moreover, the percentages of CD4+CD25+T-cells and Foxp3+T-cells were significantly decreased(P < 0.05). The molecular mechanism of Feiji Recipe against lung cancer may relate to the regulation of immune cells, such as T-cells and regulatory T-cells.Conclusion: The molecular mechanism of Feiji Recipe in treatment of lung cancer is to restore the function of T-cells in the cancer microenvironment through interfering with the IDO pathway. | Bin Luo Zu-jun Que Zhi-yi Zhou Qing Wang Chang-sheng Dong Yi Jiang Bing Hu Hui Shi Yu Jin Jian-wen Liu He-gen Li Lin Wang Jian-hui Tian | 2018 | Journal of Integrative Medicine2018，16，4： | 5 |
| 18 | Pharmacokinetics and radiation dosimetry of ^(99m)Tc-3PRGD_2 in healthy individuals:A pilot study显示文摘99mTc-3PRGD2 is a new SPECT radiotracer for several tumor imaging with high uptake where integrinαvβ3 is highly expressed.This pilot study was to assess the safety,biodistribution and radiation dosimetry of 9,mTc-3PRGD2 in healthy volunteers.The 10 healthy male volunteers were injected with 99mTc-3PRGD2(786.7±55.8 MBq,19.1-24.2 mCi).Baseline measurements of vital signs,laboratory safety tests and 12-lead electrocardiogram were recorded before and after injection.Blood and urine samples were collected and radiation counts were obtained at various time points.Whole-body scans and ROIs of identified organs were used for visual analysis and estimating the radiation dosimetry.No adverse reactions were found during the study.99mTc-3PRGD2 exhibited a rapid clearance from the blood with less than 45%of the initial dosage at 10 min after injection and gradual increasing radioactivity in urine with(52.9±6)%of original dose at 1440 min.The whole-body imaging showed high radioactive accumulation in bladder.And the highest 99mTc-3PRGD2 uptake was found in the kidneys(3.50×10-2 mSv/MBq).The 99mTc-3PRGD2 exhibited good pharmacokinetic properties and little radiation burden.This study showed that 99mTc-3PRGD2 would be a safe and attractive SPECT agent in clinic applications. | CHENG Guanghui GAO Shi JI Tiefeng MA Qingjie JIA Bing CHEN Zuowei WANG Qing | 2012 | Nuclear Science and Techniques2012，23，6： | 5 |
| 19 | Clinical and experimental study of therapeutic effect of Weixibaonizhuan pills on gastric precancerous lesions显示文摘ClinicalandexperimentalstudyoftherapeuticefectofWeixibaonizhuanpilsongastricprecancerouslesionsZHANGXuChen1,GAORuiFeng2,LI... | ZHANG XuChen1, GAO RuiFeng2, LI BingQing2, MA LianSheng3, MEI LiXin1, WU YuZhen2, LIU FengQin2 and Liao ZhengLin2 | 1998 | World Journal of Gastroenterology1998，4，1： | 5 |
| 20 | Real world effectiveness of PCSK-9 inhibitors combined with statins versus statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease in China(RWE-PCSK study)显示文摘BACKGROUND The efficacy and safety of proprotein convertase subtilisin/kexin type 9(PCSK-9) inhibitors were confirmed by several clinical trials, but its effectiveness in routine clinical practice in China has not been evaluated. This study aims to describe the real world effectiveness of PCSK-9 inhibitors combined with statins compared with statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease(ASCVD).METHODS This is a multi-center observational study, enrolled patients from 32 hospitals who underwent percutaneous coronary intervention(PCI) from January to June in 2019. There are 453 patients treated with PCSK-9 inhibitors combined with statins in PCSK-9 inhibitor group and 2,610 patients treated with statins-based lipid lowering therapies in statins-based group. The lipid control rate and incidence of major adverse cardiovascular events(MACE) over six months were compared between two groups.A propensity score-matched(PSM) analysis was used to balance two groups on confounding factors. Survival analysis using Kaplan-Meier methods was applied for MACE.RESULTS In a total of 3,063 patients, 89.91% of patients had received moderate or high-intensity statins-based therapy before PCI, but only 9.47% of patients had low-density lipoprotein cholesterol(LDL-C) levels below 1.4 mmol/L at baseline. In the PSM selected patients, LDL-C level was reduced by 42.57% in PCSK-9 inhibitor group and 30.81%(P < 0.001) in statins-based group after six months. The proportion of LDL-C ≤ 1.0 mmol/L increased from 5.29% to 29.26% in PCSK-9 inhibitor group and 0.23% to 6.11% in statins-based group, and the proportion of LDL-C ≤ 1.4 mmol/L increased from 10.36% to 47.69% in PCSK-9 inhibitor group and 2.99% to 18.43% in statins-based group(P < 0.001 for both). There was no significant difference between PCSK-9 inhibitor and statins-based treatment in reducing the risk of MACE(hazard ratio = 2.52, 95% CI: 0.49-12.97, P = 0.250).CONCLUSIONS In the real world, PCSK-9 inhibitors combined with statins could significantly reduce LDL-C levels among patients with very high risk of ASCVD in China. The long-term clinical benefits for patients received PCSK-9 inhibitor to reduce the risk of MACE is still unclear and requires further study. | Yu-Qi LIU Dan-Dan LI Meng CHAI Hong-Liang CONG Xiao-Qiang CONG Jun DAI Rong-Pin DU Ming GAO Jin-Cheng GUO Yan-Qing GUO Xiao-Jian HONG Rong-Chong HUANG Feng-Shun JIA Jia-Yu LI Qing LI Jia-Mei LIU Xin-Ping LIU Yu-Guo LIU Hong-Gang NIE Bing SHAO Xiao-Yu SHEN Hai-Qing SONG Yi-Jun SONG Li-Jun WANG Shuo WANG Dong-Mei WU Jing XIA Zhi-Yong YANG Hong-Ying YU Hui ZHANG Tie-Mei ZHANG Ji-Yi ZHAO Liang-Chen ZHAO Ming-Qi ZHENG Yun-Dai CHEN | 2021 | Journal of Geriatric Cardiology2021，18，4： | 5 |
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