|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Inhibiting effect of Astragalus polysaccharides on the functions of CD4+CD25^highTreg cells in the tumor microenvironment of human hepatocellular carcinoma显示文摘背景距骨多糖( APS ),从距骨 membranaceus 的主要活跃摘录(繁体中文药用的植物),与学习是在人的 hepatocellular 癌( HCC )的肿瘤微型环境在 Treg 房间的功能上检验 APS 的效果并且在肿瘤地点在 CD4+CD25highTreg 房间识别为反趋化性的活动负责的 APS 的 pharmacologic 机制的礼品的许多 immunomodulatory activities.The 目的被联系 HCC. | LI Qiang BAO Jian-min LI Xiao-li ZHANG Ti SHEN Xiao-hong | 2012 | Chinese Medical Journal2012，，5： | 57 |
| 2 | Effect of arsenic trioxide on rat hepatocarcinoma and its renal cytotoxicity显示文摘AIM: To study the effect of arsenic trioxide (As2O3) on rat experimental hepatocarcinoma and its renal cytotoxicity.METHODS: The hepatocarcinoma model was established by diethaylnitrosamine perfusion in stomach of 120 Wistar rats, and the treatment began at the end of 20 weeks.Before the treatment, the rat models were randomly divided into 5 groups. In the treatment groups, three doses of As2O3 were injected into rat abdominal cavity, the total time of drug administration was 4 weeks. Cisplatin control or the blank group was injected into abdominal cavity with equal amount of cisplatin or saline at the same time,respectively. On the 7th, 14th and 28th day after the treatment, the hepatocarcinoma nodules were obtained and the morphologic changes of hepatocarcinoma cells were observed under light and electron microscopes;Immunohistochemistry (S-P methods) was employed to detect the expression of bcl-2, bax and PCNA in hepatocarcinoma tissues; flow cytometry (TUNEL assay)was used to detect the apoptosis of liver cancer cells and the change of cytokinetics. On the 28th day, the kidneys were obtained and their histologic changes were observed under light microscope, and immunohistochemistry (SP stain) was also employed to detect the expression of bcl-2and PCNA. Cisplatin and saline solution were used as the control.RESULTS: As2O3 could induce the apoptosis of rat liver cancer cells and exhibited typical morphologic changes.The incidence of apoptosis of hapatocarcinoma cells was elevated (P=0.001). The elevation was the most higher in the group of middle-dose of As2O3 (1 mg.kg-1), significantly higher than that of the other arsenic groups and the controls (P=0.001). Large dose of As2O3 (5 mg.kg-1) was able to arise the incidence of apoptosis, but also produced a large amount of necrosis and inflammatory reaction. Middle dose of As2O3 dramatically increased the cell number in G2/M phase (P=0.0001), and apoptosis happened apparently.The expression of bcl-2 and bax was related to the dose of As2O3. With the up-regulation of apoptotic incidence, the ratio of bcl-2/bak decreased. But the incidence of apoptosis was not the highest status and the ratio of bcl-2/bax was at the lowest when the highest-dose of As2O3 was used.There was significant difference among the PCNA indexes (PCNA L1) of the five groups. Of them, three arsenic groups all showed decrease of different degrees, and this downregulation was most obvious in group A. There was significant difference among the three groups (P=0.016).Under the light microscope, the rat kidney in the cisplatin group exhibited tubular epithelium swelling and degeneration, protein casts in collecting tubules; While all arsenic groups didn't show the significant changes (P=0.013).In the arsenic groups, the expression of bcl-2 in the renal tubular epithelium was increased (P=0.005), no obvious changes happened to PCNA L1. But in the group of cisplatin,the PCNA L1 increased significantly (P=0.001).CONCLUSION: AS2O3 can induce apoptosis of rat hepatocellular carcinoma cells. And there is optimum dose;too high dose will induce the cytotoxic effect, while certain dose of As2O3 is able to block the cell cycle at G2/M phase.As2O3 had the most remarkable influence on G2/M cells,and it can also induce apoptosis to cells at other phases.As2O3 can restrain the proliferation of rat hepatocellular carcinoma cells, in a dose-time dependent manner.Compared with cisplatin, As2O3 didn't show obvious renal toxicity, which was related to the increasing expression of bcl-2 in renal tubular epithelium, the inhibition of apoptosis and the anti-oxidation effects. | Shao-Shan Wang Ti Zhang Xi-Lu Wang Li Hong Department of Surgery of Dagang Hospital 300270,Tianjin,China Qing-Hui Qi Department of Chinese and Western Integral Surgery of Master Hospital of Tianjin Medical University 300052,Tianjin,China | 2003 | World Journal of Gastroenterology2003，9，5： | 17 |
| 3 | Shanghai Score: A Prognostic and Adjuvant Treatment-evaluating System Constructed for Chinese Patients with Hepatocellular Carcinoma after Curative Resection显示文摘 | Hui-Chuan Sun Lu Xie Xin-Rong Yang Wei Li Jian Yu Xiao-Dong Zhu Yong Xia Ti Zhang Yang Xu Bo Hu Li-Ping Du Ling-Yao Zeng Jian Ouyang Wei Zhang Tian-Qiang Song Qiang Li Ying-Hong Shi Jian Zhou Shuang-Jian Qiu Qian Liu Yi-Xue Li Zhao-You Tang Yu Shyr Feng Shen Jia Fan | 2017 | Chinese Medical Journal2017，，22： | 15 |
| 4 | Dairy Consumption and Associations with Nutritional Status of Chinese Children and Adolescents显示文摘Objective This study aimed to describe frequency and quantity of total dairy consumption of Chinese children and adolescents and explore the associations between dairy consumption and nutrition status, including stunting, wasting, overweight, and obesity. Methods Participants included 28,250 children and adolescents aged 6-17 years old. A food frequency questionnaire(FFQ) including 100 kinds of food was used to collect information about frequency and quantity of dairy consumption. Determination of stunting was with a height cutoff value for age and gender, and determination for wasting, overweight, and obesity was with BMI for age and gender. Results Of the total sample, 36.1% of children aged 6-17 reported consuming dairy food more than once per day(≥ 1/day). The average total dairy intake of all the participants was 126.7 g/day. For boys, dairy consumption had an inverse correlation with stunting and wasting after controlling for confounders. For girls, dairy consumption was negatively associated with stunting and obesity after controlling for confounders as above. Conclusion Dairy consumption in Chinese children and adolescents was relatively lower than that in developed countries, and was negatively associated with stunting and wasting for boys and with stunting and obesity for girls. | XU Pei Pei YANG Ti Ti XU Juan LI Li CAO Wei GAN Qian HU Xiao Qi PAN Hui ZHAO Wen Hua ZHANG Qian | 2019 | Biomedical and Environmental Sciences2019，32，6： | 9 |
| 5 | Combination therapy for advanced hepatocellular carcinoma:do we see the light at the end of the tunnel?显示文摘Importance:Combination therapies of anti-PD-1 and anti-angiogenesis regimens are emerging rapidly and exhibit more promising anti-tumor efficacy for advanced hepatocellular carcinoma(HCC),and consistently it is the hotspot in clinical studies.Objective:To elaborate several issues which are warranted further consideration as more regimens are being investigated in combination therapies.Evidence Review:We searched PubMed,MEDLINE,Cochrane Library and Google Scholar by 2021 February for publications on combination therapies for HCC.Findings:Several clinical issues are worth reconsidering,such as the evaluation on appropriate primary endpoints in phase III clinical trials as for different practical problems,the translation of surrogate endpoint objective response rate(ORR)benefits into overall survival(OS)benefits,and whether conversion surgery contributes to initial expectations of long-term survival or not.New concepts in novel immunotherapy and targeted therapy in combination with loco-regional therapies may improve overall survival for HCC.Conclusions and Relevance for Reviews:Comprehensive understanding of the mechanism of immunotherapy and targeted therapy contributes to better prognosis of advanced HCC and more explorative combination therapies are needed. | Ti Zhang Philippe Merle Huaqi Wang Haitao Zhao Masatoshi Kudo | 2021 | Hepatobiliary Surgery and Nutrition2021，10，2： | 7 |
| 6 | A PILOT TRIAL FOR SEVERE ,REFRACTORY SYSTEMIC AUTOIMMUNE DISEASE WITH STEM CELL TRANSPLANTATION显示文摘Objective To evaluate the feasibility, efficacy, and safety of high dose immunosuppressive therapy (HDIT) and autolo- gous hemopoietic stem cell transplantation (HSCT) with CD34+ cell selection in patients with severe, refractory autoim- mune diseases. Methods Twenty-six patients with persistent systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), primary Sjgren’s syndrome (pSS), or systemic sclerosis (SSc) who had been treated unsuccessfully with conventional treatment were enrolled in the trial in Peking Union Medical College Hospital from September 1999 to June 2004. The patients received HDIT with 200 mg/kg cyclophosphamide followed by an infusion of autologous stem cells that were CD34 selected. Disease acti- vity, adverse effect, hemopoietic and immune reconstitution, and time to recurrence of disease were monitored. Results Overall treatment related mortality was 7.7% (2/26) with 1 patient died of cytomegalovirus infection and an- other of severe pneumonia. Relapse occurred in 3 SLE patients (17.6%) in 37, 26, and 19 months posttransplantation respectively, and 1 RA patient in 15 months posttransplantation. SLE Disease Activity Index (SLEDAI) scores of SLE survivors decreased significantly (P < 0.01). RA patients recorded a drop of Disease Activity Score 28 (DAS 28). The pSS patient remained symptoms free up to now, more than 50 months after the transplantation. Conclusion HSCT can be performed relative safely in patients with severe autoimmune disease. Short-term effect of HSCT is promising. However treatment related mortality and relapse were observed in a subset of patients. | Xiao-mei Leng Yan Zhao Dao-bing Zhou Huifen Situ Tai-sheng Li Ti Shen Yong-qiang Zhao Xiao-feng Zeng Feng-chun Zhang Yi Dong Fu-lin Tang | 2005 | Chinese Medical Sciences Journal2005，20，3： | 4 |
| 7 | Sorafenib Combined with Cryoablation to Treat Unresectable Hepatocellular Carcinoma显示文摘Objective:To evaluate the efficacy and tolerability of sorafenib combined with cryoablation in treating unresectable hepatocellular carcinoma (HCC).Methods:Patients with unresectable advanced HCC received cryoablation and sorafenib at a dose of 400 mg twice daily in 4-week cycles on the same day of the cryoablation.Tumor response,median overall survival and the median time to radiological progression were calculated and the toxicity was evaluated.Results:Seventy-eight patients with unresectable HCC were involved in this study.The median age was 52 years (range,22-81 years).The Eastern Cooperative Oncology Group (ECOG) performance status scores were 0 (39.7%),1 (55.1%),and 2 (5.1%).Nine (11.5%) patients were at Barcelona clinic liver cancer (BCLC) stage A,twenty-four (30.8%) patients were at stage B and 45 (57.7%) patients were at stage C.Five (6.4%) achieved partial responses,and 34 (43.6%) achieved stable disease.The median time to progression (TTP) for all enrolled patients was 6.6 months and the median overall survival (OS) was 12.2 months.Conclusion:Cryoablation combined with sorafenib demonstrates good efficacy and acceptable tolerability in treating unresectable advanced HCC patients. | Hong Ni Mao Yang Zhi Guo Ti Zhang | 2011 | Chinese Journal of Cancer Research2011，23，3： | 4 |
| 8 | Apatinib as an alternative therapy for advanced hepatocellular carcinoma显示文摘Angiogenesis plays an important role in the occurrence and development of tumors.Registered tyrosine kinase inhibitors targeting vascular endothelial growth factor reduce angiogenesis.Apatinib,a tyrosine kinase inhibitor,can specifically inhibit vascular endothelial growth factor receptor 2,showing encouraging anti-tumor effects in a variety of tumors including advanced hepatocellular carcinoma(HCC).This article intends to review the clinical research and application prospects of apatinib in the field of HCC. | Xi-Hao Zhang Man-Qing Cao Xiu-Xiu Li Ti Zhang | 2020 | World Journal of Hepatology2020，12，10： | 4 |
| 9 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 10 | Multi-Period Optimal Distribution Model of Energy Medium and Its Application显示文摘A mathematical model of optimal energy medium distribution in steelmaking process is formulated.In this model,three kinds of important energy mediums including byproduct gases,steam and electricity are considered,and the objective function accounts for both the change of generation and consumption of the byproduct gases and the demand of low(or middle)pressure steam and electricity for each period to maximize the benefit of products cost and minimize the consumption of energy.The results indicate that the optimal distribution scheme of byproduct gases,middle pressure steam,low pressure steam and electricity is achieved and case study shows that 6% of operation cost is reduced by using the proposed model comparing with the previous model. | ZHANG Qi TI Wei CAI Jiu-ju DU Tao WANG Ai-hua | 2011 | Journal of Iron and Steel Research(International)2011，18，8： | 3 |
| 11 | Safety of endovascular therapy for symptomatic intracranial artery stenosis:a national prospective registry显示文摘Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown.The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis(CRTICAS)was a prospective,multicentre,real-world registry designed to assess these outcomes and the impact of centre experience.Methods 1140 severe,symptomatic intracranial arterial stenosis(ICAS)patients treated with endovascular therapy were included from 26 centres,further divided into three groups according to the annual centre volume of intracranial angioplasty and stent placement procedures over 2 years:(1)high volume for≥25 cases/year;(2)moderate volume for 10–25 cases/year and(3)low volume for<10 cases/year.Results The rate of 30-day stroke,transient ischaemic attack or death was 9.7%(111),with 5.4%,21.1%and 9.7%in high-volume,moderate-volume and low-volume centres,respectively(p<0.05).Multivariable logistic regression confirmed high-volume centres had a significantly lower primary endpoint compared with moderate-volume centres(OR=0.187,95%CI:0.056 to 0.627;p≤0.0001),while moderate-volume and low-volume centres showed no significant difference(p=0.8456).Conclusion Compared with the preceding randomised controlled trials,this real-world,prospective,multicentre registry shows a lower complication rate of endovascular treatment for symptomatic ICAS.Non-uniform utilisation in endovascular technology,institutional experience and patient selection in different volumes of centres may have an impact on overall safety of this treatment. | Yabing Wang Tao Wang Adam Andrew Dmytriw Kun Yang Liqun Jiao Huaizhang Shi Jie Lu Tianxiao Li Yujie Huang Zhenwei Zhao Wei Wu Jieqing Wan Qinjian Sun Bo Hong Yongli Li Liyong Zhang Jianfeng Chu Qiong Cheng Yiling Cai Pengfei Wang Qi Luo Hua Yang Baijing Dong Yang Zhang Jun Zhao Zuoquan Chen Wei Li Xiaoxin Bai Weiwen He Xueli Cai Maimai Ti Osama O Zaidat | 2022 | Stroke & Vascular Neurology2022，7，2： | 3 |
| 12 | Whole-body physiology-based pharmacokinetics of caspofungin for general patients, intensive care unit patients and hepatic insufficiency patients显示文摘Caspofungin 是抗真菌的代理人在病人为侵略 candidiasis 作为首要的治疗准许了与的 echinocandin 对到 azoles 的严重的病或最近的暴露中等。在这研究,我们开发了一个整个身体的基于生理学的 pharmacokinetics (WB-PBPK ) 模型预言 caspofungin 的 pharmacokinetics (PK ) ,并且与蒙特卡罗模拟(MCS ) 结合了在病人的不同类型优化 caspofungin 的临床的剂量政体。caspofungin 的一个 WB-PBPK 模型从一般病人,的 4 以前的试用与未加工的数据被造并且验证有孩子呸 B 的特别护理单位(ICU ) 病人,连续肾的代替治疗上的 ICU 病人,温和、中等的肝的 insuffciency (嗨) 病人。MCS 被用来在这些病人优化 caspofungin 的临床的剂量政体。90% 的价值被考虑是为完成最佳的实验治疗的最小的反应(CFR ) 的累积部分。WB-PBPK 模型的模仿的结果在对所有试用的观察价值的好同意。为有 caspofungin 70/50 mg 的将军和 ICU 病人, AUC 和 Cmax 随身体重量(BW ) 的增加被减少并且显示出大变化。MCS 证明所有一般病人不管 BW 完成了 CFR90% 。然而并非有更高的 BW (70 kg ) 的所有 ICU 病人能完成 CFR90% 。与在一般病人的标准剂量政体相比,在有孩子呸 B 的 ICU 病人的 caspofungin 70/35 mg 完成了显著地减少的 AUC 和 Cmax,但是获得了类似的 AUC 和 Cmax 在中等嗨有孩子呸 B 的病人。caspofungin 的 WB-PBPK 模型能正确地预言所有人口的 PK。有 MCS 的联合 WB-PBPK 模型能成功地在所有耐心的人口优化 caspofungin 的临床的剂量政体。 | Qian-ting YANG Ya-jing ZHAI Lu CHEN Tao ZHANG Yan YAN Ti MENG Lei-chao LIU Li-mei CHEN Xue WANG Ya- lin DONG | 2018 | Acta Pharmacologica Sinica2018，39，9： | 3 |
| 13 | A randomized, controlled trial of postoperative adjuvant cytokine-induced killer cells immunotherapy after radical resection of hepatocellular carcinoma显示文摘 | Dong Hui Li Qiang Wang Jian Zhang Ti Kong Da-Lu | 2008 | Digestive and Liver Disease2008，，1： | 2 |
| 14 | Conjugated Polymers as Hole Transporting Materials for Solar Cells显示文摘In principle,conjugated polymers can work as electron donors and thus as low-cost p-type organic semiconductors to transport holes in photovoltaic devices.With the booming interests in high-efficiency and low-cost solar cells to tackle global climate change and energy shortage,hole transporting materials(HTMs)based on conjugated polymers have received increasing attention in the past decade.In this perspective,recent advances in HTMs for a range of photovoltaic devices including dye-sensitized solar cells(DSSCs),perovskite solar cells(PSCs),and silicon(Si)/organic heterojunction solar cells(HSCs)are summarized and perspectives on their future development are also presented. | Dan Ti Kun Gao Zhi-Pan Zhang Liang-Ti Qu | 2020 | Chinese Journal of Polymer Science2020，38，5： | 2 |
| 15 | Comparison Structure Forms Between Isogrid and Orthogrid of C/E Composite Trellis Wound Structure Based on Calculation of Load-Carrying显示文摘This paper calculated load-carrying of isogrid and orthogrid of carbon-epoxy composite trellis wound structure(C/E CTWS) using non-linear finite element method.Based on the analysis,test cases were designed and tests of axial compression were carried.Analysis result and test result fit well.In order to be used in the project,this kind of structure cut-out repairing was calculated.The method presented in this paper has been proved and can be used to solve complicated engineering problems.According to calculations and experimental results combined with application,a principle of choosing wound structure is obtained and principle could be applied to engineering. | Ti Yafeng Zhang Duo Wang Lipeng Dong Bo | 2010 | 宇航材料工艺2010，40，5： | 2 |
| 16 | Structure Optimization of Wheel Force Transducer Based on Natural Frequency and Comprehensive Sensitivity显示文摘The current research of wheel force transducer(WFT) mainly focuses on test signal processing and decoupling methods based on signal itself, while the WFT structure optimization research related to decreasing the mass and increase the natural frequency and comprehensive sensitivity is not enough. In order to improve the WFT test accuracy, a structure optimization method based on natural frequency and comprehensive sensitivity indicators is put forward. The WFT with 8-beam elastic body is used for the finite element modeling(FEM), in which the following variations are taken into consideration: the connection type of elastic body with modified rim, the number of connection holes, and the respects of strain beam including the shape, the cross sectional area and the length,etc.. The test results shows that the natural frequency of the connecting block type is increased by 65.5% compared with the connecting seat type of elastic body & modified rim, and the main channel sensitivity is improved as well.The results show that the connecting block type will achieve the best comprehensive performance when the number of connecting holes between the elastic body and the modified rim is 20. And the thinner and longer strain beam with smaller cross section area is preferable within the scope of elastic body mechanical strength. This research proposes a novel structure optimization method for WFT which contributes to improve the measurement performance of WFT. | Xiao-Long Zhang Ti Wu Yan Shao Jian Song | 2017 | Chinese Journal of Mechanical Engineering2017，30，4： | 2 |
| 17 | MicroRNA-27a/b regulates cellular cholesterol efflux, influx and esterification/hydrolysis in THP-1 macrophages显示文摘 | Min Zhang Jian-Feng Wu Wu-Jun Chen Shi-Lin Tang Zhong-Cheng Mo Yan-Yan Tang Yuan Li Jia-Lin Wang Xiang-Yu Liu Juan Peng Kong Chen Ping-Ping He Yun-Cheng Lv Xin-Ping Ouyang Feng Yao Deng-Pei Tang Francisco S. Cayabyab Da-Wei Zhang Xi-Long Zheng Guo-Ping Ti | 2014 | Atherosclerosis2014，，1： | 2 |
| 18 | Free and bound phenolic profiles and antioxidant activity of milled fractions of different indica rice varieties cultivated in southern China显示文摘 | TI H LI Q ZHANG R | 2014 | Food Chemistry2014，159，： | 1 |
| 19 | Free and bound phenolic profiles and antioxidant activity of milled fractions of different indica rice varieties cultivated in southern China显示文摘 | TI Huihui LI Qing ZHANG Ruifen | 2014 | Food Chemistry2014，159，0： | 1 |
| 20 | Free and bound phenolic profiles and antioxidant activity of milled fractions of different indica rice varieties cultivated in southern China 显示文摘 | Ti Huihui Li Qing Zhang Ruifen | 2014 | Food Chemistry2014，159，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员