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| 1 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 2 | Gankyrin promotes tumor growth and metastasis through activation of IL‐6/STAT3 signaling in human cholangiocarcinoma显示文摘 | Tongsen Zheng Xuehui Hong Jiabei Wang Tiemin Pei Yingjian Liang Dalong Yin Ruipeng Song Xuan Song Zhaoyang Lu Shuyi Qi Jiaren Liu Boshi Sun Changming Xie Shangha Pan Yuejin Li Xiaohe Luo Shuai Li Xiang Fang Nishant Bhatta Hongchi Jiang Lianxin Liu | 2014 | Hepatology2014，，： | 2 |
| 3 | Seasonal changes in the effects of free-air CO 2 enrichment (FACE) on dry matter production and distribution of rice ( Oryza sativa L.)显示文摘 | Lianxin Yang Jianye Huang Hongjie Yang Guichun Dong Gang Liu Jianguo Zhu Yulong Wang | 2005 | Field Crops Research2005，，1： | 2 |
| 4 | Yield formation of CO 2 -enriched inter-subspecific hybrid rice cultivar Liangyoupeijiu under fully open-air field condition in a warm sub-tropical climate显示文摘 | Lianxin Yang Hongjiang Liu Yunxia Wang Jianguo Zhu Jianye Huang Gang Liu Guichun Dong Yulong Wang | 2008 | Agriculture Ecosystems and Environment2008，，1： | 1 |
| 5 | Yield formation of CO 2 -enriched hybrid rice cultivar Shanyou 63 under fully open-air field conditions显示文摘 | Hongjiang Liu Lianxin Yang Yulong Wang Jianye Huang Jianguo Zhu Wang Yunxia Guichun Dong Gang Liu | 2008 | Field Crops Research2008，，1： | 1 |
| 6 | The impact of free-air CO 2 enrichment (FACE) and nitrogen supply on grain quality of rice显示文摘 | Lianxin Yang Yulong Wang Guichun Dong Hui Gu Jianye Huang Jianguo Zhu Hongjian Yang Gang Liu Yong Han | 2007 | Field Crops Research2007，，2： | 1 |
| 7 | Re-detectable positive SARS-CoV-2 RNA tests in patients who recovered from COVID-19 with intestinal infection显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARSCoV-2),a novel coronavirus that causes Coronavirus Disease 2019(COVID-19)(Yang and Wang,2020),has spread to more than 200 countries and infected more than 9,000,000 people as of Jun 2020.Tens of thousands of patients with COVID-19 have recovered and been discharged from hospital.However,there are reports of recovered patients who subsequently tested positive for SARSCoV-2 after discharge(re-detectable positive,RP)(An et al.,2020;Lan et al.,2020),and this has led to increasing focus on the mechanism(s)underlying RP. | Wanyin Tao Xiaofang Wang Guorong Zhang Meng Guo Huan Ma Dan Zhao Yong Sun Jun He Lianxin Liu Kaiguang Zhang Yucai Wang Jianping Weng Xiaoling Ma Tengchuan Jin Shu Zhu | 2021 | Protein & Cell2021，12，3： | 1 |
| 8 | The impact of free-air CO 2 enrichment (FACE) and nitrogen supply on grain quality of rice显示文摘 | Lianxin Yang Yulong Wang Guichun Dong Hui Gu Jianye Huang Jianguo Zhu Hongjian Yang Gang Liu Yong Han | 2007 | Field Crops Research2007，，2： | 1 |
| 9 | 2009-18年西北太平洋区域海洋再分析CORA1.0产品研制及检验显示文摘在51年(1958-2008)西北太平洋区域海洋再分析CORA1.0产品的基础上,改进了模式配置和同化方法,研制了2009-18年的CORA产品并对其进行以下检验:(1)温盐和海表高度异常均方根误差分布检验;(2) 35°N处温度断面分布检验;(3)再分析流场和表漂浮标轨迹对比检验.结果显示,2009-18年的CORA产品可以再现海洋要素长时间序列,时空多尺度的变化特征,为研究特征海洋现象和过程提供背景信息. | Guofang Chao Xinrong Wu Lianxin Zhang Hongli Fu Kexiu Liu Guijun Han | 2021 | Atmospheric and Oceanic Science Letters2021，14，5： | 1 |
| 10 | Genistein potentiates the effect of arsenic trioxide against human hepatocellular carcinoma: Role of Akt and nuclear factor-κB显示文摘 | Yong Ma Jizhou Wang Lianxin Liu Huaqiang Zhu Xiaoning Chen Shangha Pan Xueying Sun Hongchi Jiang | 2010 | Cancer Letters2010，，1： | 1 |
| 11 | Impact of elevated CO 2 concentration on inter-subspecific hybrid rice cultivar Liangyoupeijiu under fully open-air field conditions显示文摘 | Lianxin Yang Hongjiang Liu Yunxia Wang Jianguo Zhu Jianye Huang Gang Liu Guichun Dong Yulong Wang | 2009 | Field Crops Research2009，，1： | 1 |
| 12 | Impact of elevated ozone concentration on yield of four Chinese rice cultivars under fully open-air field conditions显示文摘 | Guangyao Shi Lianxin Yang Yunxia Wang Kazuhiko Kobayashi Jianguo Zhu Haoye Tang Shiting Pan Tao Chen Gang Liu Yulong Wang | 2009 | Agriculture Ecosystems and Environment2009，，3： | 1 |
| 13 | Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a highly infectious respiratory disease that continues to pose a serious global public health emergency.The disease shows a high infection rate,long incubation period,and rapidly emerging variants,which have led to its rapid spread worldwide(Krammer 2020).Many vaccines have been developed for the control of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the virus responsible for COVID-19,including vaccines based on messenger RNA(mRNA)(Polack et al.2020),viral vectors(Zhu et al.2020),recombinant proteins(Yang et al.2020),and inactivated SARS-CoV-2(Zhang et al.2021). | Dali Tong Mei Zhang Yunru Yang Han Xia Haiyang Tong Huajun Zhang Weihong Zeng Muziying Liu Yan Wu Huan Ma Xue Hu Weiyong Liu Yuan Cai Yanfeng Yao Yichuan Yao Kunpeng Liu Shifang Shan Yajuan Li Ge Gao Weiwei Guo Yun Peng Shaohong Chen Juhong Rao Jiaxuan Zhao Juan Min Qingjun Zhu Yanmin Zheng Lianxin Liu Chao Shan Kai Zhong Zilong Qiu Tengchuan Jin Sandra Chiu Zhiming Yuan Tian Xue | 2023 | Protein & Cell2023，14，1： | 0 |
| 14 | A core epitope targeting antibody of SARS-CoV-2显示文摘Dear Editor,Tremendous efforts have been made globally to develop therapeutics and prophylactics against severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)which has caused thousands of millions of infections and deaths worldwide.A series of potent neutralizing antibodies with defined epitopes targeting RBD have been recently identified with different strategies.However,being an RNA virus,the instability of the SARS-CoV-2 genome results in numerous S-protein variants with altered viral phenotypes. | Simeng Zhao Fengjiang Liu Shizhen Qiu Qiaoshuai Lan Yiran Wu Wei Xu Junzi Ke Jie Yang Xiaoyan Liu Kun Wang Hangtian Guo Shuai Xia Fangfang Zhang Jiabei Wang Xiaowen Hu Lu Lu Shibo Jiang Suwen Zhao Lianxin Liu Youhua Xie Xiuna Yang Haopeng Wang Guisheng Zhong | 2023 | Protein & Cell2023，14，1： | 0 |
| 15 | Expert consensus on organizing the multidisciplinary team(MDT) diagnosis and treatment of hepato-pancreato-biliary diseases in China显示文摘Multidisciplinary team(MDT) discussion has been well established in some European countries and widely carried out in various clinical professional fields(Festen et al.,2021;Fleissig et al.,2006).Many studies have reported the benefits of MDT,including improving survival and quality of cancer care(Munro et al.,2015;Nixon et al.,2021;Tsai et al.,2020). | Binhao Zhang Jian Zhou Weifen Xie Kaishan Tao Shichun Lu Xianglin Yuan Lianxin Liu Weilin Wang Yilei Mao Ping Bie Jingfeng Liu Xinyu Bi Zhiwei Zhang Changhong Liang Jianqiang Cai Zhixiang Jian Yi Lv Peng Zhu Wei Zhang Hongqiang Yang Weiping Zhou Bixiang Zhang Xiaoping Chen | 2022 | Science China(Life Sciences)2022，65，5： | 0 |
| 16 | Activities of Liquid Crystals in Acupuncture Points显示文摘0IntroductionThephysiologicalfunctionsoftheMeridianssystemplayanessentialroleinhumanlifeactivi-ties.TraditionalChineseMedicin... | Ma, Wentao Liu, Shaoan Liu, Nai Hu, Jiming Cao, Lianxin | 1998 | Wuhan University Journal of Natural Sciences1998，3，3： | 0 |
| 17 | Silicon Mitigates Aluminum Toxicity of Tartary Buckwheat by Regulating Antioxidant Systems显示文摘Aluminum (Al) toxicity is a considerable factor limiting crop yield and biomass in acidic soil. Tartary buckwheatgrowing in acidic soil may suffer from Al poisoning. Here, we investigated the influence of Al stress on the growthof tartary buckwheat seedling roots, and the alleviation of Al stress by silicon (Si), as has been demonstrated inmany crops. Under Al stress, root growth (total root length, primary root length, root tips, root surface area, androot volume) was significantly inhibited, and Al and malondialdehyde (MDA) accumulated in the root tips. At thesame time, catalase (CAT) and ascorbate peroxidase activities, polyphenols, flavonoids, and 1,1-diphenyl-2-picrylhydrazyl(DPPH) and 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulphonate) (ABTS) free-radical scavenging abilitywere significantly decreased. After the application of Si, root growth, Al accumulation, and oxidative damage wereimproved. Compared to Al-treated seedlings, the contents of ·O2− and MDA decreased by 29.39% and 25.22%,respectively. This was associated with Si-induced increases in peroxidase and CAT enzyme activity, flavonoidcompounds, and free-radical scavenging (DPPH and ABTS). The application of Si therefore has positive effectson Al toxicity in tartary buckwheat roots by reducing Al accumulation in the roots and maintaining oxidationhomeostasis. | Anyin Qi Xiaonan Yan Yuqing Liu Qingchen Zeng Hang Yuan Huange Huang Chenggang Liang Dabing Xiang Liang Zou Lianxin Peng Gang Zhao Jingwei Huang Yan Wan | 2024 | Phyton-International Journal of Experimental Botany2024，93，1： | 0 |
| 18 | Panoramic comparison between NK cells in healthy and cancerous liver through single-cell RNA sequencing显示文摘Objective:NK cells play crucial roles in the immune defense mechanisms against viral infections and transformed cells.However,the developmental progression,transcriptomic landscape,and functional subtypes of liver NK cells are not well defined.Hepatocellular carcinoma(HCC)accounts for approximately 80%of primary liver cancer worldwide,yet the biological characteristics of NK cells in the HCC environment are unclear.Therefore,we aimed to determine these cells’roles in tumorigenesis and prognosis.Methods:We compared the single-cell RNA sequencing profiles of NK cells purified from blood(n=1),healthy liver tissues(n=3),HCC tumor tissues(n=4),and peritumor liver tissues(n=1)to identify NK cell subsets.Furthermore,we performed bioinformatics analysis by using The Cancer Genome Atlas(TCGA)data to identify prognostic biomarkers simultaneously overexpressed in the blood and tumor tissues of patients with HCC.Results:Transcriptomic analysis revealed 5 NK cell subsets(L1-NK-CD56bright,L2-NK-CD56dim,L3-NK-HLA,L4-LrNK-FCGR3A,and L5-LrNK-XCL1)in the healthy liver tissues.However,the transitional L3 subset and the CXCR6+CD16+L4 subset with strong anti-tumor activity were absent in the HCC and peritumor liver tissues.Furthermore,4 common prognosis-associated genes(RHOB,TALDO1,HLA-DPA1,and TKT)were significantly overexpressed in the paired tumor tissue and blood.Conclusions:Our study revealed 5 specific subsets of NK cells in healthy human liver tissues.However,only 3 of the 5 NK cell subsets were present in HCC and peritumor tissues.The cytotoxic NK cell subsets were absent in HCC tissues.Furthermore,we identified 4 potential non-invasive prognostic biomarkers in patients with HCC. | Huan Liu Ronghua Zhao Rongrong Qin Haoyu Sun Qiang Huang Lianxin Liu Zhigang Tian Björn Nashan Cheng Sun Rui Sun | 2022 | Cancer Biology & Medicine2022，19，9： | 0 |
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