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| 1 | Late Triassic sedimentary records in the northern Tethyan Himalaya:Tectonic link with Greater India显示文摘The Upper Triassic flysch sediments(Nieru Formation and Langjiexue Group)exposed in the Eastern Tethyan Himalayan Sequence are crucial for unraveling the controversial paleogeography and paleotectonics of the Himalayan orogen.This work reports new detrital zircon U-Pb ages and whole-rock geochemical data for clastic rocks from flysch strata in the Shannan area.The mineral modal composition data suggest that these units were mainly sourced from recycled orogen provenances.The chemical compositions of the sandstones in the strata are similar to the chemical composition of upper continental crust.These rocks have relatively low Chemical Index of Alteration values(with an average of 62)and Index of Compositional Variability values(0.69),indicating that they experienced weak weathering and were mainly derived from a mature source.The geochemical compositions of the Upper Triassic strata are similar to those of graywackes from continental island arcs and are indicative of an acidicintermediate igneous source.Furthermore,hornblende and feldspar experienced decomposition in the provenance,and the sediment became enriched in zircon and monazite during sediment transport.The detrital zircons in the strata feature two main age peaks at 225-275 Ma and 500-600 Ma,nearly continuous Paleoproterozoic to Neoproterozoic ages,and a broad inconspicuous cluster in the Tonian-Stenian(800-1200 Ma).The detrital zircons from the Upper Triassic sandstones in the study area lack peaks at 300-325 Ma(characteristic of the Lhasa block)and 1150-1200 Ma(characteristic of the Lhasa and West Australia blocks).Therefore,neither the Lhasa block nor the West Australia blocks likely acted as the main provenance of the Upper Triassic strata.Newly discovered Permian-Triassic basalt and mafic dikes in the Himalayas could have provided the 225-275 Ma detrital zircons.Therefore,Indian and Himalayan units were the main provenances of the flysch strata.The Tethyan Himalaya was part of the northern passive margin and was not an exotic terrane separated from India during the Permian to Early Cretaceous.This evidence suggests that the Neo-Tethyan ocean opened prior to the Late Triassic and that the Upper Triassic deposits were derived from continental crustal fragments adjacent to the northern passive continental margin of Greater India. | Huawen Cao Yong Huang Guangming Li Linkui Zhang Jianyang Wu Lei Dong Zuowen Dai Liu Lu | 2018 | Geoscience Frontiers2018，9，1： | 27 |
| 2 | pORF5 plasmid protein of Chlamydia trachomatis induces MAPK-mediated pro-inflammatory cytokines via TLR2 activation in THP-1 cells显示文摘Infection with Chlamydia trachomatis induces inflammatory pathologies in the urogenital tract that can lead to infertility and ectopic pregnancy.Pathogenesis of infection has been mostly attributed to excessive cytokine production.However,precise mechanisms on how C.trachomatis triggers this production,and which protein(s) stimulate inflammatory cytokines remains unknown.In the present study,the C.trachomatis pORF5 protein induced tumor necrosis factor alpha(TNF-α),interleukin-1 beta(IL-1β) and interleukin-8(IL-8) in dose-and time-dependent manners in the THP-1 human monocyte cell line.We found that intracellular p38/mitogen-activated protein kinase(MAPK) and extracellular signal-regulated kinase(ERK)/MAPK signaling pathways were required for the induction of TNF-α,IL-1β and IL-8.Blockade of toll-like receptor 2(TLR2) signaling reduced induction levels of TNF-α,IL-8 and IL-1β.We concluded that the C.trachomatis pORF5 protein might contribute to the inflammatory processes associated with chlamydial infections. | ZHOU Hui HUANG QiuLin LI ZhongYu WU YiMou XIE XiaoBing MA KangKang CAO WenJuan ZHOU Zhou LU ChunXue ZHONG GuangMing | 2013 | Science China(Life Sciences)2013，56，5： | 26 |
| 3 | Superabsorbent Fibers for Comfortable Disposable Medical Protective Clothing显示文摘Disposable medical protective clothing for 2019-nCoV mainly consists of stacked layers with nanopore films,polymer coated nonwoven fabrics and melt-blown nonwoven fabrics against anti-microbial and anti-liquid penetration.However,such structures lack moisture permeability and breathability leading to an uncomfortable,stuffy wearing experience.Here,we propose a novel medical protective clothing material with a superabsorbent layer to enhance moisture absorption.Poly(acrylic acid-co-acrylamide)/polyvinyl alcohol superabsorbent fibers(PAAAM/PVA fibers)were prepared via wet spinning.And the superabsorbent composite layer was stacked from PAAAM/PVA fibers,bamboo pulp fibers(BPF)and ethylene-propyl-ene side by side fibers(ESF).The novel disposable medical protective composite fabric was obtained through gluing the superabsorbent layer to the inner surface of strong antistatic polypropylene nonwoven fabric.The resultant composite fabric possesses excellent absorption and retention capacity for sweat,up to 12.3 g/g and 63.8%,and a maximum hygroscopic rate of 1.04 g/h,higher than that of the conventional material(only 0.53 g/h).The moisture permeability of the novel material reached 12,638.5 g/(m^(2) d),which was 307.6%of the conventional material.The novel material can effectively reduce the humidity inside the protective clothing and significantly improve the comfort of medical staff. | Lin Yang Hong Liu Shuai Ding Jiawei Wu Yan Zhang Zhongzhen Wang Lili Wei Mingwei Tian Guangming Tao | 2020 | Advanced Fiber Materials2020，2，3： | 11 |
| 4 | Evolution of the Yellow River delta, China: Impacts of channel avulsion and progradation显示文摘The evolution of the Yellow River delta is characterized by heavy sediment load,rapid seaward migration,frequent avulsions,and intense anthropogenic disturbances.Evolution of the delta channel following avulsions is very complex and has not yet been thoroughly understood.In the research presented by this paper,we conducted comprehensive analyses of the changes in the water stages,slopes,longitudinal profiles,and the erosion and deposition in the Yellow River delta channels during a time period of over five decades.Results showed that,following each avulsion,channels migrated seaward at decaying rates and the slopes at the downstream of the avulsion point decreased exponentially with time and completed its major adjustment within about four to five years.A generalized geometric model was proposed to describe the changes in the longitudinal profiles of the delta channels.A calculation method to determine the characteristic water stages at the delta was proposed based on the geometric model and the delayed response model for the morphological responses of fluvial rivers to perturbations.Water stages corresponding to a discharge of 3000 m^3/s at Lijin and Xihekou during 1954 through 2012 were calculated by using the proposed method.The proposed method may be used to predict the evolution of the delta channels in response to artificial avulsions at the Yellow River delta in the future. | Shan Zheng Baosheng Wu Kairong Wang Guangming Tan Shasha Han Colin R. Thorne | 2017 | International Journal of Sediment Research2017，32，1： | 9 |
| 5 | Combined biologic aerated filter and sulfur/ceramisite autotrophic denitrification for advanced wastewater nitrogen removal at low temperatures显示文摘联合生物学的充气过滤器(BAF ) 和 sulfur/ceramisite-based 的一个创新先进废水处理过程为氮的可靠移动的自造营养物质的 denitrification (大量) 在这份报纸被建议。在大量反应堆, ceramisite 被用作过滤器和 Ca (HCO < 潜水艇 class= “ a-plus-plus ” > 3 ) 2 被用于供应碱度和碳来源。BAF 大量被用来对待第二等的处理自河。这进程的性能被调查,并且氮移动上的温度的影响被学习。结果证明联合系统甚至在低温度在氮移动是有效的(8 ?= 瑥 ? ? , | Tian WAN Guangming ZHANG Fcngwci DU Junguo HE Pan WU | 2014 | Frontiers of Environmental Science & Engineering2014，8，6： | 6 |
| 6 | Localization and characterization of the hypothetical protein CT440 in Chlamydia trachomatis-infected cells显示文摘The inclusion membrane proteins play potentially important roles in chlamydial biology and pathogenesis.Here we localized and characterized the hypothetical protein CT440 in Chlamydia trachomatis-infected cells.The open reading frame(ORF) encoding the CT440 protein from the C.trachomatis serovar D genome was cloned into the prokaryotic expression vector pGEX-6p and expressed as a glutathione-S-transferase(GST) fusion protein in E.coli XL1-Blue.The CT440 fusion protein was used to immunize mice to raise antigen-specific antibody.After verification by Western blot and immunofluorescence assay(IFA),the specific antibody was used to localize the endogenous CT440 protein and to detect its expression pattern in Chlamydia-infected cells.Cytosolic expression of CT440 in HeLa cells was also carried out to evaluate the effect of the CT440 protein on the subsequent chlamydial infection.The results showed that the hypothetical protein CT440 was localized in the C.trachomatis inclusion membrane,and was detectable 12 h after chlamydial infection.Expression of CT440 in the cytoplasm did not inhibit the subsequent chlamydial infection.In summary,we have identified a new inclusion membrane protein that may be an important candidate for understanding C.trachomatis pathogenesis. | LI ZhongYu HUANG QiuLin SU ShengMei ZHOU Zhou CHEN ChaoQun ZHONG GuangMing WU YiMou | 2011 | Science China(Life Sciences)2011，54，11： | 5 |
| 7 | Microelectronics-embedded channel bridging and signal regeneration of injured spinal cords显示文摘Due to the dificulty in spinal cord regeneration with biological methods,the microelectronic neural bridge,a new concept based on microelectronic technology,is presented.The microelectronic system has been realized in the forms of hybrid and integrated circuits.The integrated circuits forneural signal detection,stimulation,and regeneration are realized in a CMOS process.In animal experiments with 100 toads,48 rats,and 3 rabbits,nerve signals have been successfully detected from spinal cords and sciatic nerves,and functional electrical stimulation has been carried out for spinal cords and sciatic nerves.When the microelectronic system is bridged between the controlling and stimulated nerve,the relevant motion of legs and nerve signal waveforms,which are stimulated by the evoked or spontaneous nerve signal through such a system,have been observed.Therefore,the feasibility of the presented method was demonstrated. | Zhigong Wang Xiaosong Gu Xiaoying Lǔ Zhenglin Jiang Wenyuan Li Guangming Lǔ Yufeng Wang Xiaoyan Shen Xintai Zhao Huiling Wang Zhenyu Zhang Hongmei Shen Yang Wu Weixing Shen Jingyang Zhang Dong Chen Xiaoyi Mao Huaxiang Shen | 2009 | Progress in Natural Science:Materials International2009，19，10： | 5 |
| 8 | THE MANAGEMENT AND RESEARCH OF GEOGRAPHICAL NAMES USING GEOGRAPHICAL INFORMATION SYSTEM显示文摘Based on the combination of Geographical information system(GIS)with the research ofToponymy,some foundational problems of the Geographical Name Information System(GINS)are discussed in this paper.The present situation of Toponymical research is anal-ysed and the necessity of introducing the GIS tools to the research of Toponymy is demon-strated.The conceptual model of the GNIS and the structure of Geographical name Database(GND)are discussed.The basic functions of the GNIS software for management and re-search of geographical name are suggested.Some issues are stated such as the applicationand potential of the combination of GIS with CAD in the management and research of To-ponymy,the combination of GNIS with other spatial information system and sharing the in-formation with each other,the research and development of GNIS, etc. | Yu Guangming Chen Ping Wu Xuejin(Department of Geography) | 1992 | 湖北科技学院学报1992，23，3： | 4 |
| 9 | Preparation and Characterization of Silica Aerogels Derived from Ambient Pressure显示文摘硅石飞行器的胶化被大音阶的第五音胶化技术从工业硅衍生物准备(polyethoxydisiloxanes, E-40 ) ,由 silylation 列在后面并且在周围的压力下面弄干。比表面区域,毛孔尺寸分发和调查的硅石 aerogelswere 和结果的热电导率证明硅石粒子的直径是大约 6 nm 和硅石的平均毛孔尺寸飞行器的胶化是 14.7 nm。哪个是大约 1000 m^2 中心点 g~ 的比表面区域(-1) 和热传导性是大约 0.014 wm^(-1) 中心 dotK^( 在房间温度和 1.01 X10^5 Pa 的压力的 -1) 。Si-CH_3 组是也检测的在硅石的内部表面飞行器的胶化,它表演 hydrophobic。硅石飞行器的胶化由这种技术发源是低费用并且有宽应用。 | Jun SHEN Zhihua ZHANG Guangming WU Bin ZHOU Xingyuan NI Jue WANG | 2006 | Journal of Materials Science & Technology2006，22，6： | 4 |
| 10 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 11 | Microstructure Control of Nanoporous Silica Thin Film Prepared by Sol-gel Process显示文摘Nanoporous 硅石电影被大音阶的第五音胶化过程与底准备,酸 andbase/acid 二拍子的圆舞催化作用。传播电子显微镜(TEM ) 和粒子尺寸分析器被用来描绘微观结构和粒子尺寸 sols.Scanningelectron 显微镜学(SEM ) 的分发,原子力量显微镜学(AFM ) 和分光镜的 ellipsometer 被用来描绘表面微观结构和硅石电影的光性质。大音阶的第五音的稳定性在长期的存储期间被调查。而且,硅石电影的光常数的分散关系,和微观结构的控制和由在大音阶的第五音胶化期间改变催化作用条件的电影的性质处理也被讨论。 | Yiqun XIAO Jun SHEN Zhiyong XIE Bin ZHOU Guangming WU | 2007 | Journal of Materials Science & Technology2007，23，4： | 4 |
| 12 | A high quality image reconstruction method based on nonconvex decoding显示文摘The article proposes a fast reconstruction algorithm for l0≤p≤1 norm nonconvex model,called Gradient projection nonconvex sparse recovery(GPNSR),which makes a good performance in high-quality image reconstruction.We apply the GPNSR into canonical multiple description coding theory and propose a robust high-quality compressed sensing-based coding method.Combined with iterative weighted technique and fast gradient descent method,the proposed method implicitly implements matrix inverse operations to highly reduce the storage pressure.Also the weighted norm method is taken to optimize the descent steps,which highly increases convergent speed of the algorithm.Taking an image has sparse Fourier representations as an example,the paper presents the detailed image sparse coding and fast reconstruction procedure.By integrating the compressive sensing multi-description coding framework,the simulation demonstrates the superior reconstruction performance of the proposed algorithm.Most importantly,with p close to zero,the reconstruction performance of GPNSR can approximate that of l0 norm optimization result. | ZHAO GuangHui SHEN FangFang WANG ZhengYang WU WeiJia SHI GuangMing LIU DanHua | 2013 | Science China(Information Sciences)2013，56，11： | 3 |
| 13 | Fecal microbiota transplantation through mid‐gut for refractory C rohn’s disease: Safety, feasibility, and efficacy trial results显示文摘 | Bota Cui Qiang Feng Honggang Wang Min Wang Zhaoyuan Peng Pan Li Guangming Huang Zheng Liu Ping Wu Zhining Fan Guozhong Ji Xin Wang Kaichun Wu Daiming Fan Faming Zhang | 2015 | J Gastroenterol Hepatol2015，，1： | 3 |
| 14 | Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation显示文摘Although monkeys and pigs can be infected with SARS-Co V-2,they generally have a long growth cycle and a large size that is difficult to handle in large quantities.However,the readily available rats and mice are not susceptible to SARSCo V-2 because of differences in ACE2(angiotensin-converting enzyme 2),the receptor mediating cell entry of SARSCo V-2[1].Thus,the key to establishing a mouse model of COVID-19 is to make the mice express human ACE2 protein,and therefore become SARS-Co V-2 susceptible.Recently reported COVID-19 mouse models using a random insertion transgene approach[2,3]or adenoviral approach to express h ACE2[4],lack the tissue-specificity of h ACE2 expression and might not replicate COVID-19 precisely,limiting their applications in certain studies. | Feng-Liang Liu Kaixin Wu Jiaoyang Sun Zilei Duan Xiongzhi Quan Junqi Kuang Shilong Chu Wei Pang Han Gao Ling Xu Ying-Chang Li Hai-Lin Zhang Xue-Hui ang Rong-Hua Luo Xiao-Li Feng Hans RScholer Xinwen Chen Duanqing Pei Guangming Wu Yong-Tang Zheng Jiekai Chen | 2021 | National Science Review2021，8，2： | 3 |
| 15 | Enhancement of Rhodobacter sphaeroides growth and carotenoid production through biostimulation显示文摘Bacillus thuringiensis/cereus L2 was added as a biostimulant to enhance the biomass accumulation and carotenoid yield of Rhodobacter sphaeroides using wastewater as the culturing medium. Results showed that biostimulation could significantly enhance the R. sphaeroides biomass production and carotenoid yield. The optimal biostimulant proportion was 40 μL(about 6.4 × 105CFU). Through the use of biostimulation, chemical oxygen demand removal, R. sphaeroides biomass production, carotenoid concentration, and carotenoid yield were improved by 178%, 67%, 214%, and 70%, respectively. Theoretical analysis revealed that there were two possible reasons for such increases. One was that biostimulation enhanced the R. sphaeroides wastewater treatment efficiency. The other was that biostimulation significantly decreased the peroxidase activity in R. sphaeroides. The results showed that the highest peroxidase activity dropped by 87% and the induction ratio of the RSP_3419 gene was 3.1 with the addition of biostimulant. The enhanced carotenoid yield in R. sphaeroides could thus be explained by a decrease in peroxidase activity. | Shuli Liu Guangming Zhang Xiangkun Li Pan Wu Jie Zhang | 2015 | Journal of Environmental Sciences2015，27，7： | 3 |
| 16 | Observation of a bi-critical point between antiferromagnetic and superconducting phases in pressurized single crystal Ca0.73La0.27FeAs2显示文摘One of the most strikingly universal features of the high-temperature superconductors is that the superconducting phase emerges in the close proximity of the antiferromagnetic phase, and the interplay between these two phases poses a long-standing challenge. It is commonly believed that, as the antiferromagnetic transition temperature is continuously suppressed to zero, there appears a quantum critical point, around which the existence of antiferromagnetic fluctuation is responsible for the development of the superconductivity. In contrast to this scenario, we report the observation of a bi-critical point identified at 2.88 GPa and 26.02 K in the pressurized high-quality single crystal Ca_(0.73)La_(0.27)FeAs_2 by complementary in-situ high pressure measurements. At the critical pressure, we find that the antiferromagnetism suddenly disappears and superconductivity simultaneously emerges at almost the same temperature, and that the external magnetic field suppresses the superconducting transition temperature but hardly affects the antiferromagnetic transition temperature. | Yazhou Zhou ShanJiang Qi wu Vladimir A.Sidorov Jing Guo Wei Yi Shan Zhang Zhe Wang HonghongWang shu Cai Ke Yang Sheng Jiang Aiguo Li Ni Ni Guangming Zhang Liling Sun Zhongxian Zhao | 2017 | Science Bulletin2017，62，12： | 3 |
| 17 | Mg^(2+) improves biomass production from soybean wastewater using purple non-sulfur bacteria显示文摘Soybean wastewater was used to generate biomass resource by use of purple non-sulfur bacteria(PNSB). This study investigated the enhancement of PNSB cell accumulation in wastewater by Mg2+under the light-anaerobic condition. Results showed that with the optimal Mg2+dosage of 10 mg/L, biomass production was improved by 70% to 3630 mg/L,and biomass yield also was improved by 60%. Chemical Oxygen Demand(COD) removal reached above 86% and hydraulic retention time was shortened from 96 to 72 hr. The mechanism analysis indicated that Mg2+could promote the content of bacteriochlorophyll in photosynthesis because Mg2+is the bacteriochlorophyll active center, and thus improved adenosine triphosphate(ATP) production. An increase of ATP production enhanced the conversion of organic matter in wastewater into PNSB cell materials(biomass yield) and COD removal, leading to more biomass production. With 10 mg/L Mg2+, bacteriochlorophyll content and ATP production were improved by 60% and 33% respectively. | Pan Wu Guangming Zhang Jianzheng Li | 2015 | Journal of Environmental Sciences2015，27，2： | 3 |
| 18 | Effect of Calcium Aluminate Cement Variety on the Hydration of Portland Cement in Blended System显示文摘Two kinds of CACs with different monocalcium aluminate(CA) contents were used in the PC/CAC(PAC) mixtures. Effects of CA and CACs on the properties of PAC were analyzed by setting times and the compressive strength tests, and also by means of calorimetry, XRD, DTA-TG and ESEM. The experimental results show that the compressive strength of the PAC mortars decreases with increasing content of CAC while it declines sharply with a higher content of CA in CAC. Compared with neat PC paste, the content of calcium hydroxide in hydrates of PAC paste decreases significantly, and the hydration time of PC is prominently prolonged. Additionally, the higher the content of CA in CAC, the more obviously the hydration of PC is delayed, confi rming that the CA phase in CAC plays an important role in the delay of PC hydration. | 徐玲琳 王培铭 Geert DE SCHUTTER WU Guangming | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，4： | 3 |
| 19 | A mathematical modeling study of the HIV epidemics at two rural townships in the Liangshan Prefecture of the Sichuan Province of China显示文摘Background:As a response to a severe HIV epidemic in the Liangshan Prefecture,one of the worst in China,population based HIV interventions,including two population-wide HIV screening,have been carried out since 2005 at two townships in a remote mountainous region of Liangshan.The objective of our mathematical modeling study is to assess the temporal dynamics of the HIV epidemic in the two townships based on the data collected in the study area during the period 2005e2010.Methods:A mathematical model was set up to describe the population dynamics of HIV transmission in study area.The model was calibrated by fitting it to the HIV testing and treatment data from 2005 to 2008.Validation of the model was done by comparing its predicted value of HIV prevalence in 2010 to the prevalence data obtained in the 2010 population wide HIV testing.The validated model was used to produce estimation of HIV incidence,prevalence and death.Results:Our model estimations show that population-based HIV interventions have significantly slowed down the rise of the HIV epidemic in the two townships.Over the five-year period from 2005 to 2010,the year-over-year rate of increase in HIV incidence,prevalence,and death has declined by 91.5%,28.7%,and 52.3%,respectively.Conclusion:Mathematical models,when integrated with epidemiological and surveillance data,can be an effective tool for predicting the temporal dynamics of HIV and assessing the impacts of HIV interventions. | Zhimin Su Caiting Dong Ping Li Hongxia Deng Yuhan Gong Shiyong Zhong Min Wu Yuhua Ruan Guangming Qin Wen Yang Yiming Shao Michael Li | 2016 | Infectious Disease Modelling2016，1，1： | 2 |
| 20 | Effects of silver nanoparticles with different dosing regimens and exposure media on artificial ecosystem显示文摘Due to the wide use of silver nanoparticles(AgNPs) in various fields, it is crucial to explore the potential negative impacts on the aquatic environment of AgNPs entering into the environment in different ways. In this study, comparative experiments were conducted to investigate the toxicological impacts of polyvinylpyrrolidone-coated silver nanoparticles(PVP-AgNPs) with two kinds of dosing regimens, continuous and one-time pulsed dosing, in different exposure media(deionized water and XiangJiang River water). There were a number of quite different experimental results(including 100% mortality of zebrafish,decline in the activity of enzymes, and lowest number and length of adventitious roots) in the one-time pulsed dosing regimen at high PVP-AgNP concentration exposure(HOE)compared to the three other treatments. Meanwhile, we determined that the concentration of leached silver ions from PVP-AgNPs was too low to play a role in zebrafish death. Those results showed that HOE led to a range of dramatic ecosystem impacts which were more destructive than those of other treatments. Moreover, compared with the continuous dosing regimen, despite the fact that higher toxicity was observed for HOE, there was little difference in the removal of total silver from the aquatic environment for the different dosing regimens. No obvious differences in ecological impacts were observed between different water columns under low concentration exposure. Overall, this work highlighted the fact that the toxicity of Ag NPs was impacted by different dosing regimens in different exposure media, which may be helpful for assessments of ecological impacts on aquatic environments. | Jingwen Zeng Piao Xu Guiqiu Chen Guangming Zeng Anwei Chen Liang Hu Zhenzhen Huang Kai He Zhi Guo Weiwei Liu Jing Wu Jiangbo Shi | 2019 | Journal of Environmental Sciences2019，31，1： | 2 |
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