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| 1 | Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules显示文摘由病毒的 transduction 的四抄写因素 Oct4, Klf4, Sox2 和 c-Myc 的介绍能导致体的房间的 reprogramming 进导致的 pluripotent 干细胞(iPSCs ) ,但是 iPSCs 的使用被病毒的交货系统的使用妨碍。导致化学药品的 reprogramming 把一条新奇途径提供给没有任何病毒的基于向量的基因修正,产生 iPSCs。尽管,以前的报告证明几个小分子能代替一些 reprogramming 因素至少二个抄写因素, Oct4 和 Klf4,仍然被要求从老鼠产生 iPSCs 胚胎的成纤维细胞。这里,我们识别特定的化学联合,它是足够的面对一个单个抄写因素从胚胎的老鼠和成年成纤维细胞允许 reprogramming, Oct4 在 20 天以内,代替 Sox2, Klf4 和 c-Myc。用这个处理产生的 iPSCs 类似于胚胎的干细胞以全球基因表示介绍的老鼠,在 vitro 并且在 vivo 的 epigenetic 地位和 pluripotency。我们也发现那 8 天 Oct4 正式就职是足够的面对小分子启用导致 Oct4 的 reprogramming,它建议 reprogramming 在开始的 8 天以内被开始并且独立于连续外长的 Oct4 表示。没有基因修正,这些发现将帮助 iPSCs 的未来产生,以及阐明位于 reprogramming 过程下面的分子的机制。 | Yanqin Li Qiang Zhang Xiaolei Yin Weifeng Yang Yuanyuan Du Pingping Hou Jian Ge Chun Liu Weiqi Zhang Xu Zhang Yetao Wu Honggang Li Kang Liu Chen Wu Zhihua Song Yang Zhao Yan Shi Hongkui Deng | 2011 | Cell Research2011，21，1： | 51 |
| 2 | Development, chromosome location and genetic mapping of EST-SSR markers in wheat显示文摘A number of 151695 wheat expression sequence tags (ESTs) that originated from GenBank/dbEST from July 14, 2003 to August 24, 2004 were used to search for simple sequence repeats (SSRs) with motif 2―5 bp, and 2038 simple sequence repeats (EST-SSRs), which accounted for 1.34% of EST database, were identified. Based on these SSR sequences, 249 EST-SSR primer pairs and 166 amplified clear bands in various wheat cultivars were designed. These EST-SSR markers can be used as new molecular markers in wheat and related species. Using Chinese Spring nulli-tetrasomic lines, 93 EST-SSR primer pairs and 193 EST-SSR loci were located on 19 wheat chromosomes except for 4A and 4B. Forty-three loci were mapped on 11 chromosomes of the genetic frame- work map previously constructed using recombinant inbred lines. | CHEN Haimei LI Linzhi WEI Xianyun LI Sishen LEI Tiandong HU Haizhou WANG Honggang ZHANG Xiansheng | 2005 | Chinese Science Bulletin2005，50，20： | 48 |
| 3 | Efficient and Specific Modifications of the Drosophila Genome by Means of an Easy TALEN Strategy显示文摘技术开发总是是在生物医学的研究驾驶突破的力量之一。自从托马斯·摩根的时间起,一步一步地, Drosophilists 为操作并且机能上地把开发了强大的基因工具为改进这些技术并且开发新技术的果蝇染色体,而是房间仍然大,今天特别作为生物学家开始系统地学习不同模型有机体的功能的 genomics ,包括人,以一种高产量的方式。这里,我们报导,第一次在果蝇,为借助于改进抄写在很高的效率修改果蝇染色体的一个快速、容易、高度特定的方法像使活跃之物的受动器核酸酶(TALEN ) 策略。我们利用了最近发达的单位集会策略装配设计修改黄基因的二特定的 TALEN (在性染色体上) 并且新奇正染色体的基因。TALEN 的 mRNAs 随后被注入果蝇胚胎。从 31.2% 注射 F0 肥沃的苍蝇,我们检测了包含黄基因的可继承的修正。从到可继承的修正的察觉的特定的 TALEN 的建设的全部过程能在一个月以内被完成。在果蝇的这个调停 TALEN 的染色体修正方法的潜在的应用程序被讨论。 | Jiyong Liu Changqing Li Zhongsheng Yu Peng Huang Honggang Wu Chuanxian Wei Nannan Zhu Yan Shen Yixu Chen Bo Zhang Wu-Min Deng Renjie Jiao | 2012 | Journal of Genetics and Genomics2012，39，5： | 43 |
| 4 | A highly active oxygen evolution electrocatalyst: Ultrathin CoNi double hydroxide/CoO nanosheets synthesized via interface-directed assembly显示文摘成本效率、稳定的氧进化 electrocatalyst 为改进精力存储和变换效率是必要的。此处, 2D nanosheets 与随机 cross-linked CoNi 分层的双氢氧化物(LDH ) 并且小咕咕叫 nanocrystals 被设计并且综合经由在在空中的 situ 减小和 interfacedirected 汇编。CoNi LDH/CoO nanosheets 的形成被归因于界面的紧张驾驶的含水的 metaloxide 簇的强壮的挤出。获得了松开、多孔的 nanosheets 由于众多的缺点的存在展出了低 crystallinity。由于在金属 3d 和 O 2p 之间的轨道的杂交, orbitals,和电子在在场的 CoNi LDH 通过 NiOCo,很多个公司和 Ni 原子在金属原子之间转一个高 +3 原子价。在氧进化反应(OER ) 的高密度的这些唯一的特征结果活跃地点,改进与的亲密关系哦 和催化剂,并且为离子吸附和运输导致一个大可存取的表面区域和可渗透的隧道。因此,产生 nanosheets 向 OER 展出了高催化的活动。CoNi LDH/CoO 在碱的媒介展示了 1.48 V 的一个低发作潜力,并且在 10 妈据獥漠 ? 楬桧 ?L 潳灲楴湯漠 ? 桴 ? 的当前的密度要求了仅仅 300 mV 的过电位 ?? 潢瑴浯摥琠慲獮業瑴湡散吗?? | Jun Wu Zhiyu Ren Shichao Du Lingjun Kong Bowen Liu Wang Xi Jiaqing Zhu Honggang Fu | 2016 | Nano Research2016，9，3： | 25 |
| 5 | Composites of small Ag clusters confined in the channels of well-ordered mesoporous anatase TiO2 and their excellent solar-light-driven photocatalytic performance显示文摘 | Wei Zhou Ting Li Jianqiang Wang Yang Qu Kai Pan Ying Xie Guohui Tian Lei Wang Zhiyu Ren Baojiang Jiang Honggang Fu | 2014 | Nano Research2014，7，5： | 17 |
| 6 | A structural view of the antibiotic degradation enzyme NDM-1 from a superbug显示文摘Gram-negative Enterobacteriaceae with resistance to carbapenem conferred by New Delhi metallo-β-lactamase 1(NDM-1)are a type of newly discovered antibioticresistant bacteria.The rapid pandemic spread of NDM-1 bacteria worldwide(spreading to India,Pakistan,Europe,America,and Chinese Taiwan)in less than 2 months characterizes these microbes as a potentially major global health problem.The drug resistance of NDM-1 bacteria is largely due to plasmids containing the blaNDM-1 gene shuttling through bacterial populations.The NDM-1 enzyme encoded by the blaNDM-1 gene hydrolyzes β-lactam antibiotics,allowing the bacteria to escape the action of antibiotics.Although the biological functions and structural features of NDM-1 have been proposed according to results from functional and structural investigation of its homologues,the precise molecular characteristics and mechanism of action of NDM-1 have not been clarified.Here,we report the threedimensional structure of NDM-1 with two catalytic zinc ions in its active site.Biological and mass spectroscopy results revealed that D-captopril can effectively inhibit the enzymatic activity of NDM-1 by binding to its active site with high binding affinity.The unique features concerning the primary sequence and structural conformation of the active site distinguish NDM-1 from other reported metallo-β-lactamases(MBLs)and implicate its role in wide spectrum drug resistance.We also discuss the molecular mechanism of NDM-1 action and its essential role in the pandemic of drug-resistant NDM-1 bacteria.Our results will provide helpful information for future drug discovery targeting drug resistance caused by NDM-1 and related metallo-β-lactamases. | Yu Guo Jing Wang Guojun Niu Wenqing Shui Yuna Sun Honggang Zhou Yaozhou Zhang Cheng Yang Zhiyong Lou Zihe Rao | 2011 | Protein & Cell2011，2，5： | 16 |
| 7 | A system dynamics approach for water resources policy analysis in arid land:a model for Manas River Basin显示文摘The Manas River Basin in Xinjiang Uygur autonomous region,similar to other arid regions,is facing water constraints which challenge decision-makers as to how to rationally allocate the available water resources to meet the demands from industries and natural ecosystems.Policies which integrate the supply and demand are needed to address the water stress issues.An object-oriented system dynamics model was developed to capture the interrelationships between water availability and increasing water demands from the growth of industries,agricultural production and the population through modeling the decision-making process of the water exploration explicitly,in which water stress is used as a major indicator.The model is composed of four sectors:1) natural surface and groundwater resources;2) water demand;3) the water exploitation process,including the decision to build reservoirs,canals and pumps;4) water stress to which political and social systems respond through increasing the supply,limiting the growth or improving the water use efficiency.The model was calibrated using data from 1949 to 2009 for population growth,irrigated land area,industry output,perceived water stress,groundwater resources availability and the drying-out process of Manas River;and simulations were carried out from 2010 to 2050 on an annual time step.The comparison of results from calibration and observation showed that the model corresponds to observed behavior,and the simulated values fit the observed data and trends accurately.Sensitivity analysis showed that the model is robust to changes in model parameters related to population growth,land reclamation,pumping capacity and capital contribution to industry development capacity.Six scenarios were designed to investigate the effectiveness of policy options in the area of reservoir relocation,urban water recycling,water demand control and groundwater pumping control.The simulation runs demonstrated that the technical solutions for improving water availability and water use efficiency are not sustainable.Acknowledging the carrying capacity of water resources and eliminating a growth-orientated value system are crucial for the sustainability of the Manas River Basin. | ShanShan DAI LanHai LI HongGang XU XiangLiang PAN XueMei LI | 2013 | Journal of Arid Land2013，5，1： | 14 |
| 8 | Therapeutic targets of Traditional Chinese Medicine for colorectal cancer显示文摘OBJECTIVE: To explore the role of Traditional Chinese Medicine(TCM) in the prevention and treatment of colorectal cancer and identify possible therapeutic targets of TCM to provide clues for the use of TCM for colorectal cancer prevention and treatment in the clinic and to find novel directions for new drug discovery for colorectal cancer.METHODS: We used Pub Med and Google to search for and collect scientific publications for a full evaluation of current evidence in the literature indicating the potential role of Chinese herbal medicines and their respective ingredients as effective candidatesforcolorectalcancerpreventionandtreatment.RESULTS: We extracted a detailed description of potential therapeutic Chinese herbal medicines and their constituent ingredients that target different mechanisms in colorectal cancer such as gene mutation, dysregulation of signaling pathways, metabolism disorders, and the inflammatory microenvironment, including both conventional and non-conventional approaches.CONCLUSION: TCM may be a promising complementary and alternative therapy for the treatment of colorectal cancer. | Li Weidong Li Chunsheng Zheng Honggang Chen Guohong Hua Baojin | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 14 |
| 9 | Quantitative trait loci(QTLs)for quality traits related to protein and starch in wheat显示文摘Quality traits in wheat (Triticum aestivum L.) were studied by quantitative trait locus (QTL) analysis in a recombinant inbred line (RIL) population, a set of 131 lines derived from Chuan 35050 × Shannong 483 cross (ChSh). Grains from RILs were assayed for 21 quality traits related to protein and starch. A total of 35 putative QTLs for 19 traits with a single QTL explaining 7.99–40.52% of phe- notypic variations were detected on 10 chromosomes, 1D, 2A, 2D, 3B, 3D, 5A, 6A, 6B, 6D, and 7B. The additive effects of 30 QTLs were positive, contributed by Chuan 35050, the remaining 5 QTLs were negative with the additive effect contributed by Shannong 483. For protein traits, 15 QTLs were obtained and most of them were located on chromosomes 1D, 3B and 6D, while 20 QTLs for starch traits were detected and most of them were located on chromosomes 3D, 6B and 7B. Only 7 QTLs for protein and starch traits were co-located in three regions on chromosomes 1D, 2A and 2D. These protein and starch trait QTLs showed a distinct distribution pattern in certain regions and chromosomes. Twenty-two QTLs were clustered in 6 regions of 5 chromosomes. Two QTL clusters for protein traits were located on chromosomes 1D and 3B, respectively, three clusters for starch traits on chromosomes 3D, 6B and 7B, and one cluster includ- ing protein and starch traits on chromosome 1D. | Haiyan Sun Jianhua Lü Yuding Fan Yan Zhao Fanmei Kong Rijun Li Honggang Wang Sishen Li | 2008 | Progress in Natural Science:Materials International2008，18，7： | 13 |
| 10 | Distribution,Frequency and Variation of Stripe Rust Resistance Loci Yr10,Lr34/Yr18 and Yr36 in Chinese Wheat Cultivars显示文摘Wheat stripe rust is a devastating disease in many regions of the world.In wheat,49 resistance genes for stripe rust have been officially documented,but only three genes are cloned,including the race-specific resistance Yr10 candidate gene(Yr10_(CG)) and slow-rusting genes Lr34/Yr18(hereafter designated as Yr18) and Yr36.In this study,we developed gene-specific markers for these genes and used them to screen a collection of 659 wheat accessions,including 485 Chinese cultivars.Thirteen percent and eleven percent of the tested Chinese cultivars were positive for the markers for Yr10_(CG) and Yr18_(RH)(the resistant haplotype of Yr18),respectively,but none were positive for the Yr36 marker.Since there is a limited use of the Yr10 gene in Chinese wheat,the relatively high frequency of wheat varieties with the Yr10_(CG) marker suggests that the identity of the Yr10 gene is unknown.With regards to the Yr18 gene,29%of the tested cultivars that are used in the Middle and Lower Yangtze Valleys' winter wheat zone were positive for Yr18_(RH) markers.A non-functional allele of Yr18_(RH) was identified in 'Mingxian 169',a commonly used susceptible check for studying stripe rust.The data presented here will provide useful information for marker-assisted selection for wheat stripe rust resistance. | Cuiling Yuan Hui Jiang Honggang Wang Kun Li Heng Tang Xianbin Li Daolin Fu | 2012 | Journal of Genetics and Genomics2012，39，11： | 12 |
| 11 | Deep structure at northern margin of Tarim Basin显示文摘In this paper, a 2D velocity structure of the crust and the upper mantle of the northern margin of the Tarim Basin (TB) has been obtained by ray tracing and theoretical seismogram calculation under the condition of 2D lateral inhomogeneous medium using the data of seismic wide angle reflection/refraction profile from Baicheng to Da Qaidam crossing the Kuqa Depression (KD) and Tabei Uplift (TU). And along the Baicheng to Da Qaidam profile, 4 of the 10 shot points are located in the northern margin of the TB. The results show that the character of the crust is uniform on the whole between the KD and TU, but the depth of the layers, thickness of the crust and the velocity obviously vary along the profile. Thereinto, the variation of the crust thickness mainly occurs in the middle and lower crust. The Moho has an uplifting trend near the Baicheng shot point in KD and Luntai shot point in TU, and the thickness of the crust reduces to 42 km and 47 km in these two areas, respectively. The transition zone between the KD and TU has a thickest crust, up to 52 km. In this transition zone, there are high velocity anoma-lies in the upper crust, and low velocity anomalies in the lower crust, these velocity anomalies zone is near vertical, and the sediment above them is thicker than the other areas. According to the velocity distributions, the profile can be divided into three sections:KD, TU and transition zone between them. Each section has a special velocity structural feature, the form of the crystalline basement and the relationship between the deep structure and the shallow one. The differences of velocity and tectonic between eastern and western profile in the northern margin of the Tarim Basin (NMTB) may suggest different speed and intensity of the subduction from the Tarim basin to the Tianshan orogenic belt (TOB). | ZHAO JunMeng CHENG HongGang PEI ShunPing LIU HongBing ZHANG JianShi LIU BaoFeng | 2008 | Chinese Science Bulletin2008，53，10： | 10 |
| 12 | Weighted Markov chains for forecasting and analysis in Incidence of infectious diseases in jiangsu Province,China显示文摘This paper first applies the sequential cluster method to set up the classification standard of infectious disease incidence state based on the fact that there are many uncertainty characteristics in the incidence course.Then the paper presents a weighted Markov chain,a method which is used to predict the future incidence state.This method assumes the standardized self-coefficients as weights based on the special characteristics of infectious disease incidence being a dependent stochastic variable.It also analyzes the characteristics of infectious diseases incidence via the Markov chain Monte Carlo method to make the long-term benefit of decision optimal.Our method is successfully validated using existing incidents data of infectious diseases in Jiangsu Province.In summation,this paper proposes ways to improve the accuracy of the weighted Markov chain,specifically in the field of infection epidemiology. | Zhihang Peng Changjun Bao Yang Zhao Honggang Yi Letian Xia Hao Yu Hongbing Shen Feng Chen | 2010 | The Journal of Biomedical Research2010，24，3： | 10 |
| 13 | Automatic Malware Classification via PRICoLBP显示文摘Creating effective features is a critical issue in malware analysis. It requires a proper tradeoff between discriminative power and invariance. Previous studies have shown that it is fairly effective to design features based on the binary code. However, the current existing binary-based features seldom take into consideration the problem of obfuscation, such as relocated sections, incomplete code and redundant operations. In this paper, we propose a novel Pairwise rotation invariant co-occurrence local binary pattern(PRICo LBP) feature, and further extend it to incorporate the Term frequency-inverse document frequency(TFIDF) transform. Different from other static analysis techniques, our method not only achieves better linear separability, but also appears to be more resilient to obfuscation. In addition, we evaluate PRICo LBPTFIDF comprehensively on three datasets from different perspectives, e.g., classification performance, classifier selection and performance against obfuscation. What's more,we compare our PRICoLBP-TFIDF method with other techniques, and demonstrate that PRICo LBP-TFIDF is quite an efficient and effective tradeoff between discriminative power and invariance. | YAN Hanbing ZHOU Hao ZHANG Honggang | 2018 | Chinese Journal of Electronics2018，27，4： | 10 |
| 14 | Chromosomal Constitutions and Reactions to Powdery Mildew and Stripe Rust of Four Novel Wheat-Thinopyrum intermedium Partial Amphiploids显示文摘As a staple food crop for one-third of the world's population,common wheat(Triticum aestivum L.,2n=6x=42,AABBDD)plays an important role in humans'food security.However,the genetic variation of cultivated wheat has been dramatically narrowed by genetic erosion under the modern cultivation system,resulting in vulnerability to biotic and abiotic stresses(Jiang et al.,1994;Friebe et al.,1996).The wild relatives of wheat | Yinguang Bao Xia Wu Chao Zhang Xingfeng Li Fang He Xiaolei Qi Honggang Wang | 2014 | Journal of Genetics and Genomics2014，41，12： | 10 |
| 15 | Small-sized tungsten nitride anchoring into a 3D CNT- rGO framework as a superior bifunctional catalyst for the methanol oxidation and oxygen reduction reactions显示文摘直接甲醇燃料房间(DMFC ) 的申请被磅催化剂被高费用,低活动,和差的公司忍耐妨碍。此处,我们由抛锚的钨设计了一个花式的 3D 混血儿氮化物(WN ) nanoparticles (NP ) 在尺寸的大约 3 nm,进 3D 碳用一条集会线路的减少 nanotube 的 graphene 氧化物框架(CNT-rGO ) 。在扔磅以后,联系了并且强烈联合了 PtWN NP 被形成,从磅导致电子转移到 WN。3D PtWN/CNT-rGO 混血儿能为两甲醇氧化反应(粗腐殖质) 和氧减小反应(ORR ) 被用作 bifunctional electrocatalyst。在粗腐殖质,催化剂显示出优秀公司忍耐和 702.4 妈慰物漠的一项高集体的活动吗? | Haijing Yan Meichen Meng Lei Wang Aiping Wu Chungui Tian Lu Zhao Honggang Fu | 2016 | Nano Research2016，9，2： | 9 |
| 16 | Diffusion bonding of AlCoCrFeNi2.1 eutectic high entropy alloy to TiAl alloy显示文摘High entropy alloys have special microstructure and remarkable properties.To explore their potential engineering application in high temperature structures,the microstructure evolution of bonding interface,the elemental diffusion behavior and mechanical property of the diffusion bonded joint between AlCoCrFeNi2.1eutectic high entropy alloy(EHEA)and TiAl alloy were investigated.Four reaction layers(rodlike B2 phase,Al(Co,Ni)2Ti,τ3-Al3NiTi2+TiAl,τ3-Al3NiTi2+TiAl+Ti3Al)formed in the diffusion zone near FCC phase of EHEA,but three layers(Al(Co,Ni)2Ti,τ3-Al3Ni Ti2+Ti Al,τ3-Al3Ni Ti2+Ti Al+Ti3Al)formed near B2 phase.Al and Ni controlled the reaction diffusion of EHEA and TiAl alloy,coarsened the acicular precipitated B2 phase and turned Ti Al phase into Al(Co,Ni)2Ti andτ3-Al3NiTi2 phases.All these reaction layers grew in a parabolic manner as a function of bonding temperature.Rodlike B2 phase has the lowest growth activation energy of 125.2 kJ/mol,and the growth activation energy ofτ3-Al3Ni Ti2+TiAl layer near B2 phase is much lower than that near FCC phase.The penetration phenomenon and convex structure formed in the diffusion zone,which resulted in interlocking effect and enhanced the strength of resultant joints.The highest shear strength of 449 MPa was achieved at 950℃.And the brittle fracture generally initiated at the interface between Al(Co,Ni)2Ti andτ3-Al3NiTi2+TiAl layers. | Peng Li Shuai Wang Yueqing Xia Xiaohu Hao Honggang Dong | 2020 | Journal of Materials Science & Technology2020，42，10： | 8 |
| 17 | Influence of zeta potential on the flocculation of cyanobacteria cells using chitosan modified soil显示文摘Using chitosan modified soil to flocculate and sediment algal cells has been considered as a promising strategy to combat cyanobacteria blooms in natural waters. However, the flocculation efficiency often varies with algal cells with different zeta potential(ZP) attributed to different growth phases or water conditions. This article investigated the relationship between ZP of Microcystis aeruginosa and its influence to the flocculation efficiency using chitosan modified soil. Results suggested that the optimal removal efficiency was obtained when the ZP was between- 20.7 and- 6.7 m V with a removal efficiency of more than 80% in 30 min and large floc size of > 350 μm. When the algal cells were more negatively charged than- 20.7 m V, the effect of chitosan modified soil was depressed(< 60%) due to the insufficient charge density of chitosan to neutralize and destabilize the algal suspension. When the algal cells were less negative than- 6.7 m V or even positively charged, a small floc size(< 120 μm) was formed, which may be difficult to sink under natural water conditions. Therefore, manipulation of ZP provided a viable tool to improve the flocculation efficiency of chitosan modified soil and an important guidance for practical engineering of cyanobacteria bloom control. | Liang Li Honggang Zhang Gang Pan | 2015 | Journal of Environmental Sciences2015，27，2： | 8 |
| 18 | In-situ structure reconstitution of NiCo2Px for enhanced electrochemical water oxidation显示文摘Gaining insight into the structure evolution of transition-metal phosphides during anodic oxidation is significant to understand their oxygen evolution reaction(OER) mechanism, and then design highefficiency transition metal-based catalysts. Herein, NiCo_2P_x nanowires(NWs) vertically grown on Ni foam were adopted as the target to explore the in-situ morphology and chemical component reconstitution during the anodic oxidation. The major factors causing the transformation from NiCo_2P_x into the hierarchical NiCo_2P_x@CoNi(OOH)_x NWs are two competing reactions: the dissolution of NiCo_2P_x NWs and the oxidative re-deposition of dissolved Co^(2+) and Ni^(2+) ions, which is based primarily on the anodic bias applied on NiCo2 Px NWs. The well balance of above competing reactions, and local pH on the surface of NiCo_2P_x NW modulated by the anodic oxidation can serve to control the anodic electrodeposition and rearrangement of metal ions on the surface of NiCo_2P_x NWs, and the immediate conversion into CoNi(OOH)_x. Consequently, the regular hexagonal CoNi(OOH)_x nanosheets grew around NiCo_2P_x NWs.Benefiting from the active catalytic sites on the surface and the sufficient conductivity, the resultant NiCo_2P_x@CoNi(OOH)_x arrays also display good OER activity, in terms of the fast kinetics process, the high energy conversion efficiency, especially the excellent durability. The strategy of in-situ structure reconstitution by electrochemical reaction described here offers a reliable and valid way to construct the highly active systems for various electrocatalytic applications. | Xue Bai Zhiyu Ren Shichao Du Huiyuan Meng Jun Wu Yuzhu Xue Xiaojun Zhao Honggang Fu | 2017 | Science Bulletin2017，62，22： | 8 |
| 19 | Microstructure and Mechanical Properties of Pulse MIG Welded 6061/A356 Aluminum Alloy Dissimilar Butt Joints显示文摘The microstructure and mechanical properties of pulse metal inert-gas(MIG) welded dissimilar joints between 4 mm thick wrought 6061-T6 and cast A356-T6 aluminum alloy plates were investigated. The tensile strength of the joints reached 235 MPa, which is 83% of that of 6061 aluminum alloy, and then decreased with the increase of travel speed while keeping other welding parameters constant. The microstructure, composition and fractography of joints were examined by the optical microscopy(OM),scanning electron microscopy(SEM) and electron probe microanalysis(EPMA). Grain boundary liquation and segregation occurred in the partially melted zone(PMZ) on 6061 aluminum alloy side, and brittle Fe-rich phases were observed in partially melted zone on A356 aluminum alloy side. The minimum microhardness appeared in heat-affected zone(HAZ) near A356 aluminum alloy substrate. The samples during tensile test failed mainly in PMZ and HAZ on A356 aluminum alloy side through mixed fracture mode with quasi cleavage and dimples on fracture surface. | Fuheng Nie Honggang Dong Su Chen Peng Li Leyou Wang Zhouxing Zhao Xintao Li Hai zhang | 2018 | Journal of Materials Science & Technology2018，34，3： | 8 |
| 20 | High-Resolution Genome-wide Association Study Identifies Genomic Regions and Candidate Genes for Important Agronomic Traits in Wheat显示文摘Wheat(Triticum aestivum)is a major staple food crop worldwide.Genetic dissection of important agronomic traits is essential for continuous improvement of wheat yield to meet the demand of the world's growing population.We conducted a large-scale genome-wide association study(GWAS)using a panel of 768 wheat cultivars that were genotyped with 327609 single-nucleotide polymorphisms generated by genotyping-by-sequencing and detected 395 quantitative trait loci(QTLs)for 12 traits under 7 environments.Among them,273 QTLs were delimited to≤1.0-Mb intervals and 7 of them are either known genes(Rht-D,Vrn-B1,and Vrn-D1)that have been cloned or known QTLs(TaGA2ox8,APO1,TaSus1-7B,and Rht12)that were previously mapped.Eight putative candidate genes were identified for three QTLs that enhance spike seed setting and grain size using gene expression data and were validated in three bi-parental populations.Protein sequence analysis identified 33 putative wheat orthologs that have high identity with rice genes in QTLs affecting similar traits.Large r^2 values for additive effects observed among the QTLs for most traits indicated that the phenotypes of these identified QTLs were highly predictable.Results from this study demonstrated that significantly increasing GWAS population size and marker density greatly improves detection and identification of candidate genes underlying a QTL,solidifying the foundation for large-scale QTL fine mapping,candidate gene validation,and developing functional markers for genomics-based breeding in wheat. | Yunlong Pang Chunxia Liu Danfeng Wang Paul St.Amand Amy Bernardo Wenhui Li Fang He Linzhi Li Liming Wang Xiufang Yuan Lei Dong Yu Su Huirui Zhang Meng Zhao Yunlong Liangi Hongze Jia Xitong Shen Yue Lu Hongming Jiang Yuye Wu Anfei Li Honggang Wang Lingrang Kong Guihua Bai Shubing Liu | 2020 | Molecular Plant2020，13，9： | 8 |
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