|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Chronic hypoperfusion due to intracranial large artery stenosis is not associated with cerebralβ-amyloid deposition and brain atrophy显示文摘Background:Insufficient cerebral perfusion is suggested to play a role in the development of Alzheimer disease(AD).However,there is a lack of direct evidence indicating whether hypoperfusion causes or aggravates AD pathology.We investigated the effect of chronic cerebral hypoperfusion on AD-related pathology in humans.Methods:We enrolled a group of cognitively normal patients(median age:64 years)with unilateral chronic cerebral hypoperfusion.Regions of interest with the most pronounced hypoperfusion changes were chosen in the hypoperfused region and were then mirrored in the contralateral hemisphere to create a control region with normal perfusion.11C-Pittsburgh compound-positron emission tomography standard uptake ratios and brain atrophy indices were calculated from the computed tomography images of each patient.Results:The median age of the 10 participants,consisting of 4 males and 6 females,was 64 years(47-76 years).We found that there were no differences in standard uptake ratios of the cortex(volume of interest[VOI]:P=0.721,region of interest[ROI]:P=0.241)and grey/white ratio(VOI:P=0.333,ROI:P=0.445)and brain atrophy indices(Bicaudate,Bifrontal,Evans,Cella,Cella media,and Ventricular index,P>0.05)between the hypoperfused regions and contralateral normally perfused regions in patients with unilateral chronic cerebral hypoperfusion.Conclusion:Our findings suggest that chronic hypoperfusion due to large vessel stenosis may not directly induce cerebralβ-amyloid deposition and neurodegeneration in humans. | Dongyu Fan Huiyun Li Dongwan Chen Yang Chen Xu Yi Heng Yang Qianqian Shi Fangyang Jiao Yi Tang Qiming Li Fangyang Wang Shunan Wang Rongbing Jin Fan Zeng Yanjiang Wang | 2022 | Chinese Medical Journal2022，，5： | 1 |
| 2 | Explorations in Teaching Research by a Tutoring Institution in China显示文摘Purpose:This article focuses on rarely explored organizational practice of teaching research in China’s private tutoring industry.Taking a large private tutoring institution as an example,the article examines how private tutoring institutions understand and engage in educational explorations of standardization and informatization processes.Design/Approach/Methods:The article is based on a case study of one of the biggest tutoring companies in China.The study started with document analysis of the institutional history,supplemented by interviews with personnel who have worked in the institution since it was founded.Next,the researchers collected empirical data using mixed methods.Quantitative data were obtained from the user database owned by the institution.Qualitative data were collected directly by the researchers through interviews and participant observation.Both qualitative and quantitative data were analyzed from multiple perspectives.Findings:Teaching research in private tutoring institutions commonly differs from that in public schooling.In this particular case,it is technology-driven,student-tailored,and processstandardized.Utilized well,it can supplement the mainstream public education system and promote education innovation and equity throughout the country.Originality/Value:It is hoped that this article could give some insights into the possibility of the cooperation between formal schools and tutoring institutions in the areas of teaching research and other in-class and off-campus activities.The article can also draw public attention to the necessity and benefits of adopting technical methods in the teaching process. | Yunfeng Bai Xueli Tang Xingfang Li Shunan Fan | 2019 | ECNU Review of Education2019，2，1： | 1 |
| 3 | Animal models for COVID-19:advances,gaps and perspectives显示文摘COVID-19,caused by SARS-CoV-2,is the most consequential pandemic of this century.Since the outbreak in late 2019,animal models have been playing crucial roles in aiding the rapid development of vaccines/drugs for prevention and therapy,as well as understanding the pathogenesis of SARS-CoV-2 infection and immune responses of hosts.However,the current animal models have some deficits and there is an urgent need for novel models to evaluate the virulence of variants of concerns(VOC),antibodydependent enhancement(ADE),and various comorbidities of COVID-19.This review summarizes the clinical features of COVID-19 in different populations,and the characteristics of the major animal models of SARS-CoV-2,including those naturally susceptible animals,such as non-human primates,Syrian hamster,ferret,minks,poultry,livestock,and mouse models sensitized by genetically modified,AAV/adenoviral transduced,mouse-adapted strain of SARS-CoV-2,and by engraftment of human tissues or cells.Since understanding the host receptors and proteases is essential for designing advanced genetically modified animal models,successful studies on receptors and proteases are also reviewed.Several improved alternatives for future mouse models are proposed,including the reselection of alternative receptor genes or multiple gene combinations,the use of transgenic or knock-in method,and different strains for establishing the next generation of genetically modified mice. | Changfa Fan Yong Wu Xiong Rui Yuansong Yang Chen Ling Susu Liu Shunan Liu Youchun Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员