|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Glycerol carbonate synthesis from glycerol and dimethyl carbonate using guanidine ionic liquids显示文摘A large number of surplus glycerol from the biodiesel production can be used as renewable feedstock to produce glycerol carbonate. In this paper, a series of guanidine-based ionic liquids were synthesized to catalyze the transesterification of glycerol and dimethyl carbonate. The tunable basicity and the anion–cation cooperative effect were responsible for the obtained results. The [TMG][TFE] showed the best activity turnover frequency(TOF)of 1754.0 h^(-1), glycerol(GL) conversion of 91.8%, glycerol carbonate(GC) selectivity of 95.5%) at 80 °C with 0.1 mol% catalyst for 30 min. The reaction mechanism of the transesterification was also proposed. | Xingxing Wang Peng Zhang Penglei Cui Weiguo Cheng Suojiang Zhang | 2017 | Chinese Journal of Chemical Engineering2017，25，9： | 5 |
| 2 | A nanoporous oxide interlayer makes a better Pt catalyst on a metallic substrate: Nanoflowers on a nanotube bed显示文摘改进在铂催化剂和钛底层之间的接触, TiO 的层 < 潜水艇 class= “ a-plus-plus ” > 2 个 nanotube 数组在由脉搏电极淀积扔磅 nanoflowers 前被综合了。在 electrocatalytic 活动的戏剧的改进(3 ????????????? | Hongyi Li Jinshu Wang Man Liu Hong Wang Penglei Su JunshuWu Ju Li | 2014 | Nano Research2014，7，7： | 5 |
| 3 | PIP5k1β controls bone homeostasis through modulating both osteoclast and osteoblast differentiation显示文摘PIP5k1βis crucial to the generation of phosphotidylinosotol(4,5)P2.PIP5k1βparticipates in numerous cellular activities,such as B cell and platelet activation,cell phagocytosis and endocytosis,cell apoptosis,and cytoskeletal organization.In the present work,we aimed to examine the function of PIP5k1βin osteoclastogenesis and osteogenesis to provide promising strategies for osteoporosis prevention and treatment.We discovered that PIP5k1β deletion in mice resulted in obvious bone loss and that PIP5k1β was highly expressed during both osteoclast and osteoblast differentiation.Deletion of the gene was found to enhance the proliferation and migration of bone marrow-derived macrophage-like cells to promote osteoclast differentiation.PIP5k1β-/-osteoclasts exhibited normal cytoskeleton architecture but stronger resorption activity.PIP5kip deficiency also promoted activation of mitogen-activated kinase and Akt signaling,enhanced TRAF6 and c-Fos expression,facilitated the expression and nuclear translocation of NFATC1,and upregulated Grb2 expression,thereby accelerating osteoclast differentiation and function.Finally,PIP5k1β enhanced osteoblast differentiation by upregulating master gene expression through triggering smad1/5/8 signaling.Therefore,PIP5k1βmodulates bone homeostasis and remodeling. | Xiaoying Zhao Penglei Cui Guoli Hu Chuandong Wang Lei Jiang Jingyu Zhao Jiake Xu Xiaoling Zhang | 2020 | Journal of Molecular Cell Biology2020，12，1： | 4 |
| 4 | Efficient Extraction of Lithium Ions from High Mg/Li Ratio Brine through the Synergy of TBP and Hydroxyl Functional Ionic Liquids显示文摘of main observation and conclusion The extraction of Li^+from the high Mg/Li ratio brine was performed using hydroxyl functional ionic lic-uids(ILs)as the coextractant and tributyl phosphate(TBP)as the extractant.irsty the extractive system,1-2-hydroxyethyl-3-mnethylimidazolumbis(trifuoromethylsulfonyl)imide([HOEmim][NTf2])+TBP was proved to exhibit the highest extraction efficiency of Li^+(88.15%)from LiCl aqueous solutions among the extractants composed of differents TB P,and ls+TBP.Effects of various extraction parameters on the extraction eficiencies of Li^+and Mg^2+were then investigated.95.01%of Li^+was extracted and the Li^+/Mg^2+separation factor reached 405.76 in a singl-stage at 278.15 Kand O/A of 2:1.The extraction complexes were determined by the slope analysis method and ESI-MS analysis,and the metal complexes in the organic phase were indcated to be mainly[L-2TBP][NTf;J.The striping study showed that 92.86%of i*was stripped with 1.0 mol·L^-1 HCl.98%extraction capacity of the synergyextractants was remained after 5 regeneration cycles.The thermodynamic parameters(△G°,△H°,and△S°),together with the mechanism of the Li^+extraction were further demonstrated finally,According to the results,[HOEmim][NTf2]+TBP extraction system showed promising performance in extracting lithium from salt lake brine with high Mg/Li ratio. | Ruibing Bai Junfeng Wang Li Cui Shicheng Yang Wei Qian Penglei Cui Yanqiang Zhang | 2020 | Chinese Journal of Chemistry2020，38，12： | 4 |
| 5 | Identification of subsurface damage of 4H-SiC wafers by combining photo-chemical etching and molten-alkali etching显示文摘In this work,we propose to reveal the subsurface damage(SSD)of 4H-SiC wafers by photo-chemical etching and identify the nature of SSD by molten-alkali etching.Under UV illumination,SSD acts as a photoluminescence-black defect.The selective photo-chemical etching reveals SSD as the ridge-like defect.It is found that the ridge-like SSD is still crystalline 4H-SiC with lattice distortion.The molten-KOH etching of the 4H-SiC wafer with ridge-like SSD transforms the ridge-like SSD into groove lines,which are typical features of scratches.This means that the underlying scratches under mechanical stress give rise to the formation of SSD in 4H-SiC wafers.SSD is incorporated into 4H-SiC wafers during the lapping,rather than the chemical mechanical polishing(CMP). | Wenhao Geng Guang Yang Xuqing Zhang Xi Zhang Yazhe Wang Lihui Song Penglei Chen Yiqiang Zhang Xiaodong Pi Deren Yang Rong Wang | 2022 | Journal of Semiconductors2022，43，10： | 2 |
| 6 | Nanoengineered hydrogels as 3D biomimetic extracellular matrix with injectable and sustained delivery capability for cartilage regeneration显示文摘The regeneration of articular cartilage remains a great challenge due to the difficulty in effectively enhancing spontaneous healing.Recently,the combination of implanted stem cells,suitable biomaterials and bioactive molecules has attracted attention for tissue regeneration.In this study,a novel injectable nanocomposite was rationally designed as a sustained release platform for enhanced cartilage regeneration through integration of a chitosan-based hydrogel,articular cartilage stem cells(ACSCs)and mesoporous SiO_(2)nanoparticles loaded with anhydroicaritin(AHI).The biocompatible engineered nanocomposite acting as a novel 3D biomimetic extracellular matrix exhibited a remarkable sustained release effect due to the synergistic regulation of the organic hydrogel framework and mesopore channels of inorganic mSiO_(2)nanoparticles(mSiO_(2)NPs).Histological assessment and biomechanical tests showed that the nanocomposites exhibited superior performance in inducing ACSCs proliferation and differentiation in vitro and promoting extracellular matrix(ECM)production and cartilage regeneration in vivo.Such a novel multifunctional biocompatible platform was demonstrated to significantly enhance cartilage regeneration based on the sustained release of AHI,an efficient bioactive natural small molecule for ACSCs chondrogenesis,within the hybrid matrix of hydrogel and mSiO_(2)NPs.Hence,the injectable nanocomposite holds great promise for use as a 3D biomimetic extracellular matrix for tissue regeneration in clinical diagnostics. | Penglei Cui Panpan Pan Ling Qin Xinluan Wang Xiaodong Chen Yonghui Deng Xiaoling Zhang | 2023 | Bioactive Materials2023，，1： | 2 |
| 7 | Synthesis of well-defined copper nanocubes by a one-pot solution process显示文摘 | Wang Yihai Chen Penglei Liu Minghua | 2006 | Nanotechnology2006，17，24： | 1 |
| 8 | Effect of high pressure sintering and annealing on microstructure and thermoelectric properties of nanocrystalline Bi_2Te_(2.7)Se_(0.3) doped with Gd显示文摘Bi2Te2.7Se0.3of high performance doped with Gd bulk materials was prepared by a high pressure(6.0 GPa) sintering(HPS) method at 593 K,633 K, 673 K and 693 K. The sample was then annealed for 36 h in a vacuum at 633 K. The phase composition, crystal structure and morphology of the sample were analyzed by X-ray diffraction and scanning electron microscopy. The electric conductivity, Seebeck coefficient, and thermal conductivity aspects of the sample were measured from 298 K to 473 K. The results show that high pressure sintering and the doping with Gd has a great effect on the crystal structure and the thermoelectric properties of the samples. The samples are consisted of nanoparticles before and after annealing, and these nanostructures have good stability at high temperature. HPS together with annealing can improve the TE properties of the sample by decreasing the thermal conductivity of the sample with nanostructures. The maximum ZT value of 0.74 was obtained at 423 K for the sample, which was sintered at 673 K and then annealed at 633 K for 36 h. Compared with the zone melting sample, it was increased by 85% at423 K. Hence the temperature of the maximum of figure of merit was increased. The results can be applied to the field of thermoelectric power generation materials. | Ping Zou Guiying Xu Song Wang Penglei Chen Fengzhu Huang | 2014 | Progress in Natural Science:Materials International2014，24，3： | 1 |
| 9 | Erianin suppresses constitutive activation of MAPK signaling pathway by inhibition of CRAF and MEK1/2显示文摘Constitutive activation of RAS-RAF-MEK-ERK signaling pathway(MAPK pathway)frequently occurs in many cancers harboring RAS or RAF oncogenic mutations.Because of the paradoxical activation induced by a single use of BRAF or MEK inhibitors,dual-target RAF and MEK treatment is thought to be a promising strategy.In this work,we evaluated erianin is a novel inhibitor of CRAF and MEK1/2 kinases,thus suppressing constitutive activation of the MAPK signaling pathway induced by BRAF V600E or RAS mutations.KinaseProfiler enzyme profiling,surface plasmon resonance(SPR),isothermal titration calorimetry(ITC),cellular thermal shift assay,computational docking,and molecular dynamics simulations were utilized to screen and identify erianin binding to CRAF and MEK1/2.Kinase assay,luminescent ADP detection assay,and enzyme kinetics assay were investigated to identify the efficiency of erianin in CRAF and MEK1/2 kinase activity.Notably,erianin suppressed BRAF V600E or RAS mutant melanoma and colorectal cancer cell by inhibiting MEK1/2 and CRAF but not BRAF kinase activity.Moreover,erianin attenuated melanoma and colorectal cancer in vivo.Overall,we provide a promising leading compound for BRAF V600E or RAS mutant melanoma and colorectal cancer through dual targeting of CRAF and MEK1/2. | Penglei Wang Xuechao Jia Bingbing Lu Han Huang Jialin Liu Xuejiao Liu Qiong Wu Yamei Hu Pan Li Huifang Wei Tingting Liu Dengyun Zhao Lingwei Zhang Xueli Tian Yanan Jiang Yan Qiao Wenna Nie Xinli Ma Ruihua Bai Cong Peng Zigang Dong Kangdong Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 10 | Epigenetic regulation of hematopoietic stem cell homeostasis显示文摘As one of the best characterized adult stem cells,hematopoietic stem cell(HSC)homeostasis is of great importance to hematopoiesis and immunity due to HSC’s abilities of self-renewal and multi-lineage differentiation into functional blood cells.However,excessive self-renewal of HSCs can lead to severe hematopoietic malignancies like leukemia,whereas deficient selfrenewal of HSCs may result in HSC exhaustion and eventually apoptosis of specialized cells,giving rise to abnormalities such as immunodeficiency or anemia.How HSC homeostasis is maintained has been studied for decades and regulatory factors can be generally categorized into two classes:genetic factors and epigenetic factors.Although genetic factors such as signaling pathways or transcription factors have been well explored,recent studies have emerged the indispensable roles of epigenetic factors.In this review,we have summarized regulatory mechanisms of HSC homeostasis by epigenetic factors,including DNA methylation,histone modification,chromatin remodeling,non-coding RNAs,and RNA modification,which will facilitate applications such as HSC ex vivo expansion and exploration of novel therapeutic approaches for many hematological diseases. | Penglei Jiang Hui Wang Jiachen Zheng Yingli Han He Huang Pengxu Qian | 2019 | Blood Science2019，1，1： | 1 |
| 11 | Synthesis of well-defined copper nanocubes by a one-pot solution process 显示文摘 | WANG Yihai CHEN Penglei LIU Minghua | 2006 | Nanotechnology2006，17，： | 1 |
| 12 | Application of principal component analysis to evaluation of black soil degradation in Jilin显示文摘Principal Component Analysis(PCA) can simplify the structure of database by replacing multi-dimensional parameters with relatively less comprehensive variables in order to ensure the minimum lost in initial data.In this paper,eighteen black soil samples from different sites were tested and thirteen distinctive indexes were chosen to evaluate the degeneration of black soil.By using principal component analysis,variables of thirteen dimensions can be diminished to six unrelated principal indexes.Analysis shows that the soluble salt content,Fulvic acids(FA) and aggregation degree have a high weighing coefficient,indicating these three indexes are the major parts for the evaluation of black soil degradation.It also provides a new path to the degenerated black soil treatment in Northeast China. | NIU Cencen WANG Qing WEN Xiuyu GUO Yuan ZHAGN Penglei ZHU Rongyue HE Xianhui | 2011 | Global Geology2011，14，1： | 1 |
| 13 | DSFA: cross-scene domain style and feature adaptation for landslide detection from high spatial resolution images显示文摘Rapid and accurate landslide inventory mapping is significant for emergency rescue and post-disaster reconstruction.Nowadays,deep learning methods exhibit excellent performance in supervised landslide detection.However,due to differences between cross-scene images,the performance of existing methods is significantly degraded when directly applied to another scene,which limits the application of rapid landslide inventory mapping.In this study,we propose a novel Domain Style and Feature Adaptation(DSFA)method for cross-scene landslide detection from high spatial resolution images,which can leverage labeled source domain images and unlabeled target domain images to mine robust landslide representations for different scenes.Specifically,we mitigate the large discrepancy between domains at the dataset level and feature level.At the dataset level,we introduce a domain style adaptation strategy to shift landslide styles,which not only bridges the domain gap,but also increases the diversity of landslide samples.At the feature level,adversarial learning and domain distance minimization are integrated to narrow large feature distribution discrepancies for learning domain-invariant information.In addition,to avoid information omission,we improve the U-Net3+model.Extensive experimental results demonstrate that DSFA has superior detection capability and outperforms other methods,showing its great application potential in unsupervised landslide domain detection. | Penglei Li Yi Wang Tongzhen Si Kashif Ullah Wei Han Lizhe Wang | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
| 14 | SARS-CoV-2 N protein potentiates host NPM1-snoRNA translation machinery to enhance viral replication显示文摘Dear Editor,COVID-19(Coronavirus Disease 2019)is causing an unprecedented public health crisis.Protein translation is crucial for virus lifecycle.Nucleocapsid(N)protein is among the most abundant SARS-CoV-2 proteins and highly conserved across coronavirus genus.1 However,its function in subverting host translation machinery is still elusive. | Hui Wang Danrong Shi Penglei Jiang Zebin Yu Yingli Han Zhaoru Zhang Peihui Wang He Huang Hangping Yao Pengxu Qian | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员