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| 1 | miR-210 over-expression enhances mesenchymal stem cell survival in an oxidative stress environment through antioxidation and c-Met pathway activation显示文摘microRNA-210(miR-210)has generally been reported to be associated with cell survival under hypoxia.However,there are few data regarding the role of miR-210 in the survival of mesenchymal stem cells(MSCs)under oxidative stress conditions.Thus,we sought to investigate whether miR-210 over-expression could protect MSCs against oxidative stress injury and what the primary mechanisms involved are.The results showed that over-expression of miR-210 significantly reduced the apoptosis of MSCs under oxidative stress,accompanied by obvious increases in cell viability and superoxide dismutase activity and remarkable decreases in malonaldehyde content and reactive oxygen species production,resulting in a noticeable reduction of apoptotic indices when compared with the control.Moreover,the above beneficial effects of miR-210 could be significantly reduced by c-Met pathway repression.Collectively,these results showed that miR-210 over-expression improved MSC survival under oxidative stress through antioxidation and c-Met pathway activation,indicating the potential development of a novel approach to enhance the efficacy of MSC-based therapy for injured myocardium. | XU JianFeng HUANG ZheYong LIN Li FU MingQiang GAO YanHua SHEN YunLi ZOU YunZeng SUN AiJun QIAN JuYing GE JunBo | 2014 | Science China(Life Sciences)2014，57，10： | 10 |
| 2 | Isolated laparoscopic resection of the hepatic caudate lobe显示文摘The caudate lobe (Couinaud's segment 1) is located at the posterior part of the liver.Isolated resection of caudate lobe is a major challenge1,2 especially when it is carried out laparoscopically.We report a case of successful total laparoscopic resection of caudate lobe using the technique of curettage and aspiration3 on a hepatic hemangioma which measured 7 cm ×5 cm.As far as we know,this is the first report from Asia on isolated laparoscopic resection of the hepatic caudate lobe. | Cai Xiujun Li Zheyong Yu Hong Liu Kun Liang Xiao Wang Yifan Liang Yuelong | 2014 | Chinese Medical Journal2014，，17： | 5 |
| 3 | Decorin accelerates the liver regeneration after partial hepatectomy in fibrotic mice显示文摘 | Ma Rui Chen Jiang Li Zheyong Tang Jiacheng Wang Yifan Cai Xiujun | 2014 | Chinese Medical Journal2014，，14： | 4 |
| 4 | Functional Analysis of a Rice Oxidosqualene Cyclase through Total Gene Synthesis显示文摘Dear Editor, Plants produce a large range of triterpenoids that serve as chemical defenses against pathogens.For example,β-amyrin synthase (AsbAS1) performs the initial enzymatic step in the biosynthesis of the potent antimicrobial avencins in oats (Haralampidis et al.,2001).Additionally,other triterpenoids such as glycyrrhizin and QS21 are known to have beneficial or detrimental effects for human health (Osbourn et al.,2011).For some time,heterologous expression of plant oxidosqualene cyclases (OSCs) in yeast has been a powerful methodology for the functional characterization of this important family of triterpene biosynthetic enzymes.The foundational work in this area employed the lanosterol-deficient Saccharomyces cerevisiae strain SMY1 to characterize the function of Arabidopsis thaliana cycloartenol synthase (CAS)(Corey et al.,1993). | Juncong Sun Xia Xu Zheyong Xue John Hugh Snyder Xiaoquan Qi | 2013 | Molecular Plant2013，6，5： | 4 |
| 5 | Limited value of recovery phase-limited ST segment depression of treadmill exercise test显示文摘 | Yang Hongbo Huang Zheyong Lou Yi Shen Yunli Qian Juying Ge Junbo | 2014 | Chinese Medical Journal2014，，4： | 3 |
| 6 | Laparoscopic liver resection and the learning curve: a 14-year, single-center experience显示文摘 | Xiujun Cai Zheyong Li Yale Zhang Hong Yu Xiao Liang Renan Jin Feng Luo | 2014 | Surgical Endoscopy2014，，4： | 2 |
| 7 | Decay estimate of the solutions to the magnetic - Semiconductor equations显示文摘 | Wang Yuanming Qiu zheyong Guan Ping | 1993 | Journal of southeast University1993，9，1： | 1 |
| 8 | Enhanced thermoelectric performance in three-dimensional superlattice of topological insulator thin films显示文摘 | Fan Zheyong Zheng Jiansen Wang Huiqiong | 2012 | Nanoscale Research Letters2012，7，1： | 1 |
| 9 | Role of the Hedgehog pathway in hepatocellular carcinoma (Review)显示文摘 | Xin Zheng Wen Zeng Xiaohong Gai Qiuran Xu Chao Li Zheyong Liang Hang Tuo Qingguang Liu | 2013 | Oncology Reports2013，，5： | 1 |
| 10 | Decay estimate of the solutions to the magnet to semiconductor equations显示文摘 | Wang Yuangming Qiu Zheyong Guan Ping | 1993 | Journal of Southeast University1993，9，1： | 1 |
| 11 | Repeated laparoscopic liver resection using ICG fluorescent imaging for recurrent liver cancer显示文摘Objective:Liver cancer is very common in China,with cumulative five-year tumor recurrence rate after a microscopically margin-negative resection of hepatocellular carcinoma up to 70%.Postoperative recurrent hepatocellular carcinoma presents a challenge for surgeons because of the complexity of postoperative adhesion and the difficulty in of recognizing recurrent lesions.This study aims to introduce a method using an indocyanine green(ICG)fluorescent imaging technique to do repeated laparoscopic liver resection.Method:Patients received repeated laparoscopic liver resection using ICG fluorescent imaging between January 2017 and December 2019 in the Department of General Surgery of Sir Run Run Shaw Hospital were analyzed retrospectively.Basic information,intraoperative information,complications,and followup time were collected and analyzed.Results:Totally,35 patients with a median age of 59 years(ranged 38-82 years)were included.All of the patients received minimally invasive surgery.One case was performed robotically,and only two cases were converted to open surgery due to severe adhesion.The median operating time was 174 minutes,and the median blood loss during surgery was 100 mL.The median hospital stay after surgery was 5 days,with a range of 3e55 days.In total,32(91.4%)patients showed staining by ICG fluorescent imaging,and lesions were visible on fluorescent camera.The median follow-up time was 19.7 months,with a range of 1e40.2 months.The median relapse-free survival time was 18.5 months.Conclusion:Repeated laparoscopic liver resection using ICG fluorescent imaging is a safe and promising approach in the treatment of recurrent liver tumors in selected patients. | Zheyong Li Jingwei Cai Junhao Zheng Xiao Liang | 2022 | Laparoscopic, Endoscopic and Robotic Surgery2022，5，1： | 0 |
| 12 | Hippo pathway-manipulating neutrophil-mimic hybrid nanoparticles for cardiac ischemic injury via modulation of local immunity and cardiac regeneration显示文摘The promise of regeneration therapy for restoration of damaged myocardium after cardiac ischemic injury relies on targeted delivery of proliferative molecules into cardiomyocytes whose healing benefits are still limited owing to severe immune microenvironment due to local high concentration of proinflammatory cytokines.Optimal therapeutic strategies are therefore in urgent need to both modulate local immunity and deliver proliferative molecules.Here,we addressed this unmet need by developing neutrophil-mimic nanoparticles NM@miR,fabricated by coating hybrid neutrophil membranes with artificial lipids onto mesoporous silica nanoparticles(MSNs)loaded with microRNA-10b.The hybrid membrane could endow nanoparticles with strong capacity to migrate into infammatory sites and neutralize proinfammatory cytokines and increase the delivery efficiency of microRNA-1Ob into adult mammalian cardiomyocytes(CMs)by fusing with cell membranes and leading to the release of MSNs-miR into cytosol.Upon NM@miR administration,this nanoparticle could home to the injured myocardium,restore the local immunity,and efficiently deliver microRNA-1Ob to cardiomyocytes,which could reduce the activation of Hippo-YAP pathway mediated by excessive cytokines and exert the best proliferative effect of miR-1Ob.This combination therapy could finally improve cardiac function and mitigate ventricular remodeling.Consequently,this work offers a combination strategy of immunity modulation and proliferative molecule delivery to boost cardiac regeneration after injury. | Qiaozi Wang Yanan Song Jinfeng Gao Qiyu Li Jing Chen Yifang Xie Zhengmin Wang Haipeng Tan Hongbo Yang Ning Zhang Juying Qian Zhiqing Pang Zheyong Huang Junbo Ge | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
| 13 | Entanglement and nonlocality in a coupled-cavity system显示文摘No instrument is able to measure directly the quantum entanglement of a system. However, both theory and experiment, following the well-known Bell inequality, reveal the existence of the entanglement phenomenon in quantum mechanics. To examine the characterization of quantum entanglement, here we present a two-site cavity system, in which each cavity contains a Λ-type three-level atom and the two sites are identical and coupled with each other. We investigate and calculate the bipartite entanglement entropy of the system for the ground states. For photons of different types, corresponding to the two ground states of the atom, we investigate the correlations and violation of the Bell inequality. | ZHEYONG ZHANG JIANPING DING HUI-TIAN WANG | 2017 | Photonics Research2017，5，3： | 0 |
| 14 | The effect of cholecystectomy on the risk of colorectal cancer:A systematic review and meta-analysis显示文摘Objective:Some studies have found that cholecystectomy may increase the risk of colorectal cancer(CRC),while others have reached inconsistent conclusions.We thus performed a systematic review and meta-analysis to assess the incidence rate of CRC after cholecystectomy for patients with gallstones or gallbladder diseases,and whether the geographical location of the patients affected the results.Methods:We systematically searched PubMed,Embase,and Cochrane for studies reporting changes in the incidence rate of CRC after cholecystectomy published before January 12,2023.Our main endpoint wasthe occurrence of CRC Data were extracted and pooled,and the relative risk(RR)and 95%confidence interval(CI)were calculated.We assessed pooled data using a random-effects model.Results:In total,477 articles were identifled,and 6 articles were eligible,including 7 studies thatincluded 797,917 participants.Overall,the summarized research results showed that the risk of CRC was reduced in patients with gallbladder diseases who underwent cholecystectomy(RR:0.80,95%C:0.65 to0.99,p=0.040;I^(2)=85.0%).In the subgroup analysis based on different geographical locations,chole-cystectomy was not associated with the nisk of CRC in the Western population(RR:0.90,95%C:0.65 to 1.25.p=0.522;I^(2)=86.5%),but there was a negative corelation between cholecystectomy and the risk of CRC(RR:0,66,95%Cl:0.60 to 0,73,p=0.000)in the Chinese population Conclusions:Our findings support that for patients with gallstones or gallbladder diseases,the incidence of CRC after cholecystectomy is lower than that of patients who do not undergo cholecystectomy. | Zhuoneng Chen Chaohui Yu Zheyong Li | 2023 | Laparoscopic, Endoscopic and Robotic Surgery2023，6，4： | 0 |
| 15 | Early initiation of ARBs without blood pressure risk via neutrophil membrane-fused pH-sensitive liposomes to reduce cardiomyocyte apoptosis after acute myocardial infarction显示文摘Activation of the local renin-angiotensin system(RAS)promotes cardiomyocyte apoptosis and cardiac remodeling after acute myocardial infarction(AMI).As an anti-RAS drug,the effect of Valsartan in the early stage of acute MI is limited by its low drug concentration in the heart and low dosage.Here,by exploiting the inherent nature of neutrophils migrating to the injured myocardium and the local low-pH microenvironment caused by ischemia and hypoxia after myocardial infarction,we designed nanocarrier(NSLP)-hybridized neutrophil membranes and pH-sensitive liposomes(SLPs)for the delivery of Valsartan(NSLPVal).These functional nanocarriers could mimic neutrophils and are homed to the injured heart;they were also found to respond to a low-pH microenvironment.In the mouse model of MI,we found that NSLP-Val could target the infarct marginal zone and release Valsartan locally in the low-pH microenvironment without affecting hemodynamic stability.Further,locally released angiotensin receptor inhibitors reduced the infarct size and inflammatory response by inhibiting cardiomyocytes.Ultimately,NSLP-Val improved cardiac function and inhibited cardiac hypertrophy and fibrosis. | Jinfeng Gao Wusiman Yakufu Hongbo Yang Yanan Song Qiaozi Wang Qiyu Li Haipeng Tan Jing Chen Dili Sun Zhengmin Wang Jinyan Zhang Xueyi Weng Juying Qian Zhiqing Pang Qibing Wang Zheyong Huang Junbo Ge | 2023 | Nano Research2023，16，7： | 0 |
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