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| 1 | Dapper1 promotes autophagy by enhancing the Beclinl -Vps34-Atg14L complex formation显示文摘 | Benvu Ma Weipeng Cao Wenxia Li Chan Gao Zhen Qi Yan Zhao Jun Du Hua Xue Junya Peng Jun Wen Hua Chen Yuanheng Ning Lei Huang Hong Zhang Xiang Gao Li Yu Ye-Guang Chen | 2014 | Cell Research2014，24，8： | 12 |
| 2 | Oral bacteria colonize and compete with gut microbiota in gnotobiotic mice显示文摘The oral microbiota is associated with oral diseases and digestive systemic diseases.Nevertheless,the causal relationship between them has not been completely elucidated,and colonisation of the gut by oral bacteria is not clear due to the limitations of existing research models.The aim of this study was to develop a human oral microbiota-associated (HOMA) mouse model and to investigate the ecological invasion into the gut.By transplanting human saliva into germ-free (GF) mice,a HOMA mouse model was first constructed.16S rRNA gene sequencing was used to reveal the biogeography of oral bacteria along the cephalocaudal axis of the digestive tract.In the HOMA mice,84.78% of the detected genus-level taxa were specific to the donor.Principal component analysis (PCA) revealed that the donor oral microbiota clustered with those of the HOMA mice and were distinct from those of specific pathogen-free (SPF) mice.In HOMA mice,OTU counts decreased from the stomach and small intestine to the distal gut.The distal gut was dominated by Streptococcus,Veillonella,Haemophilus,Fusobacterium,Trichococcus and Actinomyces.HOMA mice and human microbiota-associated (HMA) mice along with the GF mice were then cohoused.Microbial communities of cohoused mice clustered together and were significantly separated from those of HOMA mice and HMA mice.The Source Tracker analysis and network analysis revealed more significant ecological invasion from oral bacteria in the small intestines,compared to the distal gut,of cohoused mice.In conclusion,a HOMA mouse model was successfully established.By overcoming the physical and microbial barrier,oral bacteria colonised the gut and profiled the gut microbiota,especially in the small intestine. | Bolei Li Yang Ge Lei Cheng Benhua Zeng Jinzhao Yu Xian Peng Jianhua Zhao Wenxia Li Biao Ren Mingyun Li Hong Wei Xuedong Zhou | 2019 | International Journal of Oral Science2019，11，3： | 7 |
| 3 | Fatigue crack propagation behavior of Ni-based superalloys after overloading at elevated temperatures显示文摘The fatigue crack propagation behavior of three superalloys subjected to a single overloading at elevated temperatures was investigated. The fatigue crack propagation rate FCPR versus stress intensity factor range data da/dN—ΔK were calculated using the two-point secant method. It was found that the crack growth rates of the investigated materials were retarded after overloading with an overload ratio R OL=1.6. The size of the plastic zone in the front of the crack tip and its relation to loading level were discussed. The overload retardation effects are attributed to crack closure. The fatigue damage in the plastic zone can also be a factor to explain the overload retardation. | Xinyue Huang Liang Wang Yunming Hu Guangping Guo David Salmon Ying Li Wenxia Zhao | 2016 | Progress in Natural Science:Materials International2016，26，2： | 4 |
| 4 | Phase Ⅲ Clinical Trials of the Cell Differentiation Agent-2 (CDA-2): Therapeutic Efficacy on Breast Cancer, Non-Small Cell Lung Cancer and Primary Hepatoma显示文摘 | Fengyi Feng Qing Lu Changquan Ling Yang Zhang Fengzhan Qin Huaqing Wang Wenxia Huang Shunchang Jiao Qiang Chen Mingzhong Li Yunzhong Zhu Meizhen Zhou Jun Ren Yetao Gao Jingpo Zhao Rongsheng Zheng Wenhua Zhao Zhiqiang Meng Fang Li Qizhong Zhang Dongli Zhao Liyan Xu Yongqiang Zhang Yanjun Zhang Zhenjiu Wang Shuonqi Liu Ming C. Liau | 2005 | Chinese Journal of Clinical Oncology2005，2，4： | 3 |
| 5 | The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells显示文摘Pancreatic adenocarcinoma(PAAD) is one of the most lethal malignancies. Although gemcitabine(GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C(Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not been investigated since it was isolated. Our research is the first to indicate that Sec C is a broad-spectrum anticancer agent and could exhibit potently similar anticancer activity both in GEM-resistant and GEM-sensitive PAAD cells. Interestingly, Sec C exerted a rapid growth-inhibiting effect(80% death at 6 h), which might be beneficial for patients who need rapid tumor shrinkage before surgery. Liquid chromatography/mass spectrometry and N-acetyl-L-cysteine(NAC) reverse assays show that Sec C sulfates cysteines to disrupt disulfide-bonds formation in endoplasmic reticulum(ER) proteins to cause protein misfolding, leading to ER stress and disorder of lipid biosynthesis. Microarray data and subsequent assays show that ER stress-mediated ER-associated degradation(ERAD) ubiquitinates anddownregulates YAP to enhance ER stress via destruction complex(YAP-Axin-GSK-βTr CP), which also elucidates a unique degrading style for YAP. Potent anticancer activity in GEM-resistant cells and low toxicity make Sec C a promising anti-PAAD candidate. | Junxia Wang Minghua Chen Mengyan Wang Wenxia Zhao Conghui Zhang Xiujun Liu Meilian Cai Yuhan Qiu Tianshu Zhang Huimin Zhou Wuli Zhao Shuyi Si Rongguang Shao | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 2 |
| 6 | What triggered the Asian elephant’s northward migration across southwestern Yunnan?显示文摘The Asian elephant(Elephas maximus),an endangered species on the International Union for Conservation of Nature Red List,is the largest terrestrial animal living in Asia.They require a relatively large space to live in.In China,the wild Asian elephants exist only in XiShuangBanNa,Pu’Er,and LinCang of southern Yunnan Province,with 95%of the wild population residing in the XiShuangBanNa National Nature Reserve.In recent years,territorial conflicts have arisen between humans and elephants around the national nature reserve.A herd of wild Asian elephants roamed north,venturing over 500 km from the largest area of the reserve,MengYang(998 km^(2),600–1,500 m above sea level[ASL]in altitude),in March of 2020 to KunMing(the capital of Yunnan Province,ca.2000 m ASL in altitude)in early June 2021(Figure 1A).These elephants,traipsing north through fields,highways,villages,and towns,have stepped into the international spotlight,not only because such long-distance migration never happened in the past half a century but also because the United Nations Biodiversity Conference will be held in KunMing in the coming October.However,no one knows exactly why this has happened,as elephant migration,a complex ecological process,can be of varied duration,distance,timing,and driver. | Haijun Wang Puze Wang Xu Zhao Wenxia Zhang Jing Li Chi Xu Ping Xie | 2021 | The Innovation2021，2，3： | 2 |
| 7 | EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer显示文摘Tyrosine kinase inhibitors for epidermal growth factor receptor(EGFR TKIs)greatly improved clinical outcomes of patients with non-small cell lung cancer(NSCLC).Unfortunately,primary and acquired resistance limits their clinical benefits.To overcome such resistance,new generations of EGFR TKIs have been developed by targeting newly identified mutations in EGFR.However,much less effort has been put into alternative strategies,such as targeting the intrinsic protective responses to EGFR TKIs.In this study,we found that EGFR TKIs,including gefitinib and AZD9291,impaired lysosome-dependent degradation of SQSTM1,thus compromising their anti-cancer efficiency.By accumulating in the lysosome lumen,gefitinib and AZD9291 attenuated lysosomal acidification and impaired autolysosomal degradation of SQSTM1 owing to their intrinsic alkalinity.As a result,SQSTM1 protein was stabilized in response to gefitinib and AZD9291 treatment and conferred EGFR TKI resistance.Depleting SQSTM1 significantly increased the sensitivity of NSCLC cells to gefitinib and AZD9291 both in vitro and in vivo.Furthermore,a chemically modified gefitinib analog lacking alkalinity displayed stronger inhibitory effects on NSCLC cells.Therefore,targeting accumulated SQSTM1 or chemically modified EGFR TKIs may represent new strategies to increase the effectiveness of EGFR targeted therapy. | Lixian Yang Shilong Ying Shiman Hu Xiangtong Zhao Muchun Li Miaoqin Chen Yiran Zhu Ping Song Liyuan Zhu Tingting Jiang Huimin An Neelum Aziz Yousafzai Wenxia Xu Zhiguo Zhang Xian Wang Lifeng Feng Hongchuan Jin | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 2 |
| 8 | An ultrasound-triggered cation chelation and reassembly route to one-dimensional Ni-rich cathode material enabling fast charging and stable cycling of Li-ion batteries显示文摘Ni-rich oxides,LiNixMnyCozO2(NMC),are among leading candidates for cathode materials in Li-ion batteries.However,they are mostly fabricated by coprecipitation approach under complex conditions,which usually produces large secondary particles composed of aggregated primary particles.Undesirable cation mixing and crack propagation upon cycling block ion and electron transport,result in fast capacity fading and poor rate capability.Herein,we present an ultrasound-triggered cation chelation and reassembly route for synthesizing one-dimensional precursor with homogeneous element distribution at the atomic level.This process is accomplished by the synergistic combination of ultrasound and surfactant,which can disperse reactants and remove hydration shells surrounding cations so as to accelerate chelating reaction,and then separate and assemble chelates into one dimensional structure.The whole synthesis time is only 20 min(8.9 min of ultrasonic working time)in an open vessel under natural ambient conditions.One-dimensional LiNi0.6Mn0.2Co0.2O2 has a high reversible capacity(184 mAh·g^−1 at 0.1 C)and long cycling stability(95.1%and 82.4%capacity retention for 100 and 1000 cycles,respectively).The short charging time of 76 s is realized at super high current rate of 20 C,which is very important to improve the competitiveness of electric vehicles relative to fuel vehicles.Our synthetic approach can provide a general strategy for the growth of mixed-metal-EDTA chelate precursors by changing the feeding ratio of Ni2+,Mn2+and Co2+cations in reaction for fabricating NMC cathode materials with other compositions. | Yongjian Lai Zhaojie Li Wenxia Zhao Xiaoning Cheng Shuo Xu Xiao Yu Yong Liu | 2020 | Nano Research2020，13，12： | 2 |
| 9 | Hyperactive PI3Kδ predisposes naive T cells to activation via aerobic glycolysis programs显示文摘Activated phosphoinositide 3-kinaseδsyndrome(APDS)is an autosomal-dominant combined immunodeficiency disorder resulting from pathogenic gain-of-function(GOF)mutations in the PIK3CD gene.Patients with APDS display abnormal T cell homeostasis.However,the mechanisms by which PIK3CD GOF contributes to this feature remain unknown.Here,with a cohort of children with PIK3CD GOF mutations from multiple regions of China and a corresponding CRISPR/Cas9 gene-edited mouse model,we reported that hyperactive PI3Kδdisrupted TNaive cell homeostasis in the periphery by intrinsically promoting the growth,proliferation,and activation of TNaive cells.Our results showed that PIK3CD GOF resulted in loss of the quiescence-associated gene expression profile in naive T cells and promoted naive T cells to overgrow,hyperproliferate and acquire an activated functional status.Naive PIK3CD GOF T cells exhibited an enhanced glycolytic capacity and reduced mitochondrial respiration in the resting or activated state.Blocking glycolysis abrogated the abnormal splenic T cell pool and reversed the overactivated phenotype induced by PIK3CD GOF in vivo and in vitro.These results suggest that enhanced aerobic glycolysis is required for PIK3CD GOF-induced overactivation of naive T cells and provide a potential therapeutic approach for targeting glycolysis to treat patients with APDS as well as other immune disorders. | Yanjun Jia Qiuyun Yang Yanping Wang Wenyan Li Xuemei Chen Tao Xu Zhirui Tian Minxuan Feng Liang Zhang Wenjing Tang Na Tian Lina Zhou Wenxia Song Xiaodong Zhao | 2021 | Cellular & Molecular Immunology2021，18，7： | 2 |
| 10 | Influence of different extraction methods of tea polyphenols on proportions of catechins显示文摘 | LAI Ronghui LAI Xingfei ZHAO Wenxia | | 0，，： | 1 |
| 11 | Effects of Liuwei Dihuang decoction on ion channels and synaptic transmission in cultured hippocampal neuron of rat显示文摘 | Sheng Yang Wenxia Zhou Yongxiang Zhang Cunyu Yan Yimin Zhao | 2006 | Journal of Ethnopharmacology2006，，2： | 1 |
| 12 | Phase inversion of TiO:e nanoparticle stabilized emulsions of alkenyl sue- cinic anhydride显示文摘 | Zhao Zhenhuan Liu Wenxia Liu Zongyin | 2013 | Chemical Engineering Science2013，87，24： | 1 |
| 13 | Inhibition effect on tobacco mosaic virus and regulation effect on calreticulin of oligochitosan in tobacco by induced Ca2+influx显示文摘 | Lu Hang Zhao Xiaoming Wang Wenxia | 2010 | Carbohydrate Polymers2010，82，1： | 1 |
| 14 | Multiple positive solutions for boundary value problems of second order delay differential equations with one- dimensional p - Laplacian显示文摘 | WANG Youyu ZHAO Wenxia GE Weigao | 2007 | J Math Anal Appl2007，326，1： | 1 |
| 15 | Multiple positive solutions for boundary value problems of second order delay differential equations with one-dimensional p-Laplacian 显示文摘 | WANG Youyu ZHAO Wenxia GE Weigao | 2007 | Journal of Mathematical Analysis and Applications2007，326，1： | 1 |
| 16 | In vivo inducing collagen regeneration of biodegradable polymer microspheres显示文摘Biodegradable polymer particles have been used as dermal fillers for pre-clinical and clinical trials.The impact of material properties of polymers is very important to develop products for aesthetic medicine such as dermal fillers.Herein,eight biodegradable polymers with different molecular weights,chemical compositions or hydrophilic-hydrophobic properties were prepared and characterized for systematical study for aesthetic medicine applications.Polymer microspheres with 20-100 lmwere prepared.The in vitro degradation study showed that poly(L-lactic-co-glycolic acid)75/25 microspheres degraded the fastest,whereas poly(L-lactic acid)(PLLA)microspheres with intrinsic viscosity of 6.89([g]¼6.89)with the highest molecular weight showed the slowest degradation rate.After these microspheres were fabricated dermal fillers according to the formula of SculptraVR,they were injected subcutaneously into the back skin of rabbits.In vivo results demonstrated that the degradation rate of microspheres strongly correlated with the foreign body reaction and collagen regeneration was induced by microspheres.The microspheres with faster degradation rate induced inflammatory response and the collagen regeneration maintained in shorter time.PLLA([g]¼3.80)microsphere with a moderate molecular weight and degradation rate could strongly regenerate Type I and III collagen to maintain a long-term aesthetic medicine effect.These properties of size,morphology and degradation behavior would influence the foreign body reaction and collagen regeneration. | Yixin Zhang Hanwen Liang Qian Luo Jianlin Chen Nan Zhao Wenxia Gao Yuji Pu Bin He Jing Xie | 2021 | Regenerative Biomaterials2021，8，5： | 1 |
| 17 | Change in Precipitation over the Tibetan Plateau Projected by Weighted CMIP6 Models显示文摘Precipitation over the Tibetan Plateau(TP)is important to local and downstream ecosystems.Based on a weighting method considering model skill and independence,changes in the TP precipitation for near-term(2021-40),mid-term(2041-60)and long-term(2081-2100)under shared socio-economic pathways(SSP1-1.9,SSP1-2.6,SSP2-4.5,SSSP3-7.0,SSP5-8.5)are projected with 27 models from the latest Sixth Phase of the Couple Model Intercomparison Project.The annual mean precipitation is projected to increase by 7.4%-21.6%under five SSPs with a stronger change in the northern TP by the end of the 21st century relative to the present climatology.Changes in the TP precipitation at seasonal scales show a similar moistening trend to that of annual mean precipitation,except for the drying trend in winter precipitation along the southern edges of the TP.Weighting generally suggests a slightly stronger increase in TP precipitation with reduced model uncertainty compared to equally-weighted projections.The effect of weighting exhibits spatial and seasonal differences.Seasonally,weighting leads to a prevailing enhancement of increase in spring precipitation over the TP.Spatially,the influence of weighting is more remarkable over the northwestern TP regarding the annual,summer and autumn precipitation.Differences between weighted and original MMEs can give us more confidence in a stronger increase in precipitation over the TP,especially for the season of spring and the region of the northwestern TP,which requires additional attention in decision making. | Yin ZHAO Tianjun ZHOU Wenxia ZHANG Jian LI | 2022 | Advances in Atmospheric Sciences2022，39，7： | 1 |
| 18 | Roles of short amine in preparation and sizing performance of partly hydrolyzed ASA emul- sion stabilized by Laponite particles 显示文摘 | Ding Pengxiang Liu Wenxia Zhao Zhenghuan | 2011 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2011，384，3： | 1 |
| 19 | Multiple positive solutions for boundary value problems of second order delay differential equations with one-dimensional p-Laplaeian 显示文摘 | Wang Youyu Zhao Wenxia Ge Weigao | 2007 | Journal of Mathematical Analysis and Applications2007，326，1： | 1 |
| 20 | Roles of short amine in preparation and sizing performance of partly hydrolyzed ASA emul- sion stabilized by Laponite particles 显示文摘 | Ding Pengxiang Liu Wenxia Zhao Zhenghuan | 2011 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2011，384，13： | 1 |
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