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| 1 | Sonographic appearance of anal cushions of hemorrhoids显示文摘AIM To evaluate the diagnostic value of different sonographic methods in hemorrhoids.METHODSForty-two healthy volunteers and sixty-two patients with gradesⅠ-Ⅳhemorrhoids received two different sonographic examinations from January 2013 to January2016 at the First and Second Hospitals of Xinjiang Medical University in a prospective way.We analyzed the ultrasonographic findings of these participants and evaluated the outcomes.Resected gradesⅢandⅣhemorrhoid tissues were pathologically examined.The concordance of ultrasonographic results with pathologyresults was assessed with the Cohen’s kappa coefficient.RESULTS All healthy volunteers and all patients had no particular complications related to sonography.There were no statistically significant differences between the participants regarding age(P=0.5919),gender(P=0.4183),and persistent symptoms(P>0.8692).All healthy control participants had nospecial findings.However,30 patients with hemorrhoids showed blood signals around the dentate line on ultrasonography.When gradesⅠandⅡhemorrhoids were analyzed,there were no significant differences between transrectal ultrasound(TRUS),transperianal ultrasound(TPUS),and transvaginal ultrasound(TVUS)(P>0.05).GradesⅢandⅣhemorrhoids revealed blood flow with different directions which could be observed as a'mosaic pattern'.In patients with gradesⅢandⅣhemorrhoids,the number of patients with'mosaic pattern'as revealed by TRUS,TPUS and TVUS was 22,12,and 4,respectively.Patients with gradesⅢandⅣdisease presented with a pathologically abnormal cushion which usually appeared as a'mosaic pattern'in TPUS and an arteriovenous fistula in pathology.Subepithelial vessels of resected gradesⅢandⅣhemorrhoid tissues were manifested by obvious structural impairment and retrograde and ruptured changes of internal elastic lamina.Some parts of the Trietz’s muscle showed hypertrophy and distortion.Arteriovenous fistulas and venous dilatation were obvious in the anal cushion of hemorhoidal tissues.After pathological results with arteriovenous fistulas were taken as the standard reference,we evaluated the compatibility between the two methods according to the Cohen’s kappa coefficiency calculation.The compatibility(Cohein kappa co-efficiency value)between'mosaic pattern'in the TPUS and arteriovenous fistula in pathology was very good(?=0.8939).When compared between different groups,TRUS presented the advantage that the mosaic pattern could be confirmed in more patients,especially for group A.There was a statistical difference when comparing group A with group B or C(P<0.05 for both).There were obvious statistical differences between group A and group B with regard to the vessel diameter and blood flow velocity measured by TRUS(P<0.05).CONCLUSION Patients with gradesⅢandⅣhemorrhoids present with a pathologically abnormal cushion which usually appears as a'mosaic pattern'in sonography,which is in accord with an arteriovenous fistula in pathology.There are clearly different hemorrhoid structures shown by sonography.'Mosaic pattern'may be a parameter for surgical indication of gradesⅢandⅣhemorrhoids. | Adilijiang Aimaiti Ma Mu Ti Jiang A Ba Bai Ke Re Irshat Ibrahim Hui Chen Maimaitituerxun Tuerdi Mayinuer | 2017 | World Journal of Gastroenterology2017，23，20： | 11 |
| 2 | reatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs显示文摘气喘的发炎被一种类型调停 2 助手 T 房间(Th2 ) cytokine 反应,和堵住的 Th2 cytokine 生产被证明有一个有势力治疗学对气喘的发炎的效果。用 IL-4-green 荧光灯蛋白质(GFP ) 记者老鼠,我们表明了那 Bavachinin,从中国植物孤立的单个混合物,显著地禁止的 Th2 cytokine 生产包括 IL-4, IL-5 和 IL-13。尤其是,在 ovalbumin (卵) 的这复合几乎完全堵住的发炎敏化动物气喘模型。而且,我们证明这化学药品有选择地影响 GATA-3 的水平,由影响 GATA-3 mRNA 的稳定性最可能。第一次,我们的结果证明这单个混合物的潜在的治疗学的价值源于中国植物。 | Xi Chen Ti Wen Jun Wei Zhenzhou Wu Puyue Wang Zhangyong Hong Liqing Zhao Bin Wang Richard Flavell Shumei Gao Min Wang Zhinan Yin | 2013 | Cellular & Molecular Immunology2013，10，6： | 9 |
| 3 | Human fused NKG2D-IL-15 protein controls xenografted human gastric cancer through the recruitment and activation of NK cells显示文摘Interleukin (IL )-15 在生来的杀手(NK ) 和 CD8+T 房间增长和功能起一个重要作用并且是比为肿瘤免疫疗法的 IL-2 更有效的。由附近的房间的 IL-15 的 trans 演讲比它的可溶的 IL-15 为 NK 房间激活是更有效的。在这研究,熔化蛋白质 dsNKG2D-IL-15,由经由一个连接器联合到人的 IL-15 的人的 NKG2D 的二相同的细胞外的域组成了,在 Escherichia coli 被设计。DsNKG2D-IL-15 能高效地与二个 NKG2D 领域和 trans 礼品 IL-15 把人的肿瘤房间的链相关的蛋白质 A (云母) 绑在主要 histocompatibility 建筑群一级到 NK 或 CD8+ T 房间。我们移植了人的胃的癌症(SGC-7901 ) 房间进裸体老鼠和有进 C57BL/6 老鼠的云母(B16BL6 云母) 的宫外的表示的老鼠黑瘤房间。然后,我们学习了反肿瘤效果在二个 xenografted 肿瘤模特儿由 dsNKG2D-IL-15 调停了。人的 dsNKG2D-IL-15 在压制胃的癌症生长比 IL-15 展出了更高的效率。外长的人的 dsNKG2D-IL-15 集中地在老鼠肿瘤纸巾被散布基于在 vivo 实时成像。房间渗入了进跟随外部血 mononuclear 房间的注射进忍受人的胃的癌症的裸体老鼠的肿瘤纸巾的人的 CD56+ 的频率被人的 dsNKG2D-IL-15 治疗显著地增加。人的 dsNKG2D-IL-15 也由激活和招募的老鼠 NK 和 CD8+ T 房间推迟了移植黑瘤(B16BL6 云母) 的生长。在 C57BL/6 老鼠的人的 dsNKG2D-IL-15 的反黑瘤效果主要被减少由在里面老鼠 NK 房间的 vivo 弄空。这些数据热点为肿瘤的人的 dsNKG2D-IL-15 的潜在的使用治疗。 | Yan Chen Bei Chen Ti Yang Weiming Xiao Li Qian Yanbing Ding Mingchun Ji Xiaoqun Ge Weijuan Gong | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 4 | Proton pump inhibitor use increases mortality and hepatic decompensation in liver cirrhosis显示文摘BACKGROUND Proton pump inhibitors(PPIs)are widely prescribed,often without clear indications.There are conflicting data on its association with mortality risk and hepatic decompensation in cirrhotic patients.Furthermore,PPI users and PPI exposure in some studies have been poorly defined with many confounding factors.AIM To examine if PPI use increases mortality and hepatic decompensation and the impact of cumulative PPI dose exposure.METHODS Data from patients with decompensated liver cirrhosis were extracted from a hospital database between 2013 to 2017.PPI users were defined as cumulative defined daily dose(cDDD)≥28 within a landmark period,after hospitalisation for hepatic decompensation.Cox regression analysis for comparison was done after propensity score adjustment.Further risk of hepatic decompensation was analysed by Poisson regression.RESULTS Among 295 decompensated cirrhosis patients,238 were PPI users and 57 were non-users.PPI users had higher mortality compared to non-users[adjusted HR=2.10,(1.20-3.67);P=0.009].Longer PPI use with cDDD>90 was associated with higher mortality,compared to non-users[aHR=2.27,(1.10-5.14);P=0.038].PPI users had a higher incidence of hospitalization for hepatic decompensation[aRR=1.61,(1.30-2.11);P<0.001].CONCLUSION PPI use in decompensated cirrhosis is associated with increased risk of mortality and hepatic decompensation.Longer PPI exposure with cDDD>90 increases the risk of mortality. | Marianne Anastasia De Roza Lim Kai Jia Wen Kam Yiong Huak Chan Andrew Kwek Tiing Leong Ang John Chen Hsiang | 2019 | World Journal of Gastroenterology2019，25，33： | 6 |
| 5 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 6 | Ethnic Differences in Body Mass Index and Prevalence of Obesity in School Children of Urumqi City, Xinjiang, China显示文摘To investigate the prevalence of obesity and distribution of body mass index (BMI) in school children of four ethnic groups in Urumqi, Xinjiang, China, Methods A total of 55 508 school children of Han, Hui, Uygur and Kazak nationalities aged 8-18 years were selected by a cluster sampling from a districts of Urumqi City for anthropometric measurement and demographic survey. Prevalence of obesity and overweight and distribution of body mass index (BMI) by gender, age, and nationality were analyzed and compared. Cutoff points of BMI for defining obesity and overweight were based on the proposal set by the Working Group on Obesity in China (WGOC) to assess age-, gender- and nationality-specific prevalence of obesity and overweight. Results Prevalence of obesity was 5.34%, 6.78%, 3.39 %, and 1.22% for boys and 2.61%, 1.83%, 1.78%, and 1.40% for girls of Han, Hui, Uygur and Kazak nationalities, respectively. Prevalence of obesity tended to decrease with age overall, whereas that of overweight increased with age in Han children. Conclusions Prevalence of obesity in school children in Urumqi varies with their nationalities and is lower than that of an average national level and a level of western countries. Obesity is more prevalent in boys than in girls of Urmuqi overall, which is just the opposite in Kazak children. Han boys and Hui girls have the highest prevalence of obesity and Kazak boys and girls have the lowest ones. Prevalence of obesity decreases with age, but that of overweight shows a different trend. | WEI-LI YAN YU-JIAN ZHENG JUN WU SHU-FENG CHEN XIAO-KAI TI LING LI XIAO-RUI LIU | 2006 | Biomedical and Environmental Sciences2006，19，6： | 3 |
| 7 | Safety of endovascular therapy for symptomatic intracranial artery stenosis:a national prospective registry显示文摘Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown.The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis(CRTICAS)was a prospective,multicentre,real-world registry designed to assess these outcomes and the impact of centre experience.Methods 1140 severe,symptomatic intracranial arterial stenosis(ICAS)patients treated with endovascular therapy were included from 26 centres,further divided into three groups according to the annual centre volume of intracranial angioplasty and stent placement procedures over 2 years:(1)high volume for≥25 cases/year;(2)moderate volume for 10–25 cases/year and(3)low volume for<10 cases/year.Results The rate of 30-day stroke,transient ischaemic attack or death was 9.7%(111),with 5.4%,21.1%and 9.7%in high-volume,moderate-volume and low-volume centres,respectively(p<0.05).Multivariable logistic regression confirmed high-volume centres had a significantly lower primary endpoint compared with moderate-volume centres(OR=0.187,95%CI:0.056 to 0.627;p≤0.0001),while moderate-volume and low-volume centres showed no significant difference(p=0.8456).Conclusion Compared with the preceding randomised controlled trials,this real-world,prospective,multicentre registry shows a lower complication rate of endovascular treatment for symptomatic ICAS.Non-uniform utilisation in endovascular technology,institutional experience and patient selection in different volumes of centres may have an impact on overall safety of this treatment. | Yabing Wang Tao Wang Adam Andrew Dmytriw Kun Yang Liqun Jiao Huaizhang Shi Jie Lu Tianxiao Li Yujie Huang Zhenwei Zhao Wei Wu Jieqing Wan Qinjian Sun Bo Hong Yongli Li Liyong Zhang Jianfeng Chu Qiong Cheng Yiling Cai Pengfei Wang Qi Luo Hua Yang Baijing Dong Yang Zhang Jun Zhao Zuoquan Chen Wei Li Xiaoxin Bai Weiwen He Xueli Cai Maimai Ti Osama O Zaidat | 2022 | Stroke & Vascular Neurology2022，7，2： | 3 |
| 8 | Model predictive control of rigid spacecraft with two variable speed control moment gyroscopes显示文摘In this paper, an attitude maneuver control problem is investigated for a rigid spacecraft using an array of two variable speed control moment gyroscopes(VSCMGs)with gimbal axes skewed to each other. A mathematical model is constructed by taking the spacecraft and the gyroscopes together as an integrated system, with the coupling interaction between them considered. To overcome the singular issues of the VSCMGs due to the conventional torque-based method, the first-order derivative of gimbal rates and the second-order derivative of the rotor spinning velocity, instead of the gyroscope torques, are taken as input variables. Moreover, taking external disturbances into account,a feedback control law is designed for the system based on a method of nonlinear model predictive control(NMPC). The attitude maneuver can be realized fast and smoothly by using the proposed controller in this paper. | Pengcheng WU Hao WEN Ti CHEN Dongping JIN | 2017 | Applied Mathematics and Mechanics(English Edition)2017，38，11： | 3 |
| 9 | Whole-body physiology-based pharmacokinetics of caspofungin for general patients, intensive care unit patients and hepatic insufficiency patients显示文摘Caspofungin 是抗真菌的代理人在病人为侵略 candidiasis 作为首要的治疗准许了与的 echinocandin 对到 azoles 的严重的病或最近的暴露中等。在这研究,我们开发了一个整个身体的基于生理学的 pharmacokinetics (WB-PBPK ) 模型预言 caspofungin 的 pharmacokinetics (PK ) ,并且与蒙特卡罗模拟(MCS ) 结合了在病人的不同类型优化 caspofungin 的临床的剂量政体。caspofungin 的一个 WB-PBPK 模型从一般病人,的 4 以前的试用与未加工的数据被造并且验证有孩子呸 B 的特别护理单位(ICU ) 病人,连续肾的代替治疗上的 ICU 病人,温和、中等的肝的 insuffciency (嗨) 病人。MCS 被用来在这些病人优化 caspofungin 的临床的剂量政体。90% 的价值被考虑是为完成最佳的实验治疗的最小的反应(CFR ) 的累积部分。WB-PBPK 模型的模仿的结果在对所有试用的观察价值的好同意。为有 caspofungin 70/50 mg 的将军和 ICU 病人, AUC 和 Cmax 随身体重量(BW ) 的增加被减少并且显示出大变化。MCS 证明所有一般病人不管 BW 完成了 CFR90% 。然而并非有更高的 BW (70 kg ) 的所有 ICU 病人能完成 CFR90% 。与在一般病人的标准剂量政体相比,在有孩子呸 B 的 ICU 病人的 caspofungin 70/35 mg 完成了显著地减少的 AUC 和 Cmax,但是获得了类似的 AUC 和 Cmax 在中等嗨有孩子呸 B 的病人。caspofungin 的 WB-PBPK 模型能正确地预言所有人口的 PK。有 MCS 的联合 WB-PBPK 模型能成功地在所有耐心的人口优化 caspofungin 的临床的剂量政体。 | Qian-ting YANG Ya-jing ZHAI Lu CHEN Tao ZHANG Yan YAN Ti MENG Lei-chao LIU Li-mei CHEN Xue WANG Ya- lin DONG | 2018 | Acta Pharmacologica Sinica2018，39，9： | 3 |
| 10 | The Beneficial Effect of Regular Endurance Exercise Training on Blood Pressure and Quality of Life in Patients with Hypertension显示文摘 | Jen‐Chen Tsai Hung‐Yu Yang Wei‐Hsin Wang Ming‐Hsiung Hsieh Pei‐Ti Chen Ching‐Chiu Kao Pai‐Feng Kao Chia‐Hui Wang Paul Chan | 2004 | Clinical and Experimental Hypertension2004，，3： | 2 |
| 11 | A Single-legged Robot Inspired by the Jumping Mechanism of Click Beetles and Its Hopping Dynamics Analysis显示文摘The click beetle can jump up with a hinge when it is on the dorsal side.This jumping mechanism is simple and suitable as an inspiration for designing a simple,small,and reliable hopping robot.We report a single-legged robot inspired by the jumping mechanism of click beetles.It is 85 mm high,60 mm long,and 41 mm wide,and weighs about 49 g.The robot has good hopping performance that the hopping height is about 4 times-4.3 times of its body height.It is capable for rescue missions that require to enter enclosed spaces through cracks and narrow channels.In addition,hopping dynamics of the robot is important to understand its jumping mechanism and improve the robot’s hopping performance.But existing dynamic study does not complete the analysis including all stages in the hopping which are pre-hopping,take-off,and air-flying.We propose the decomposition method to study dynamics of the three stages separately,and synthesize them with related parameters.The dynamic synthesis of multi-motion states in a hopping cycle of the single-legged hopping robot is implemented.The hopping performance and dynamic synthesis theory of the robot are verified by simulations and experiments.Our study helps lay the foundation for design and hopping control of simple hopping robot systems. | Gang Chen Jiajun Tu Xiaocong Ti Huosheng Hu | 2020 | Journal of Bionic Engineering2020，17，6： | 2 |
| 12 | MicroRNA-27a/b regulates cellular cholesterol efflux, influx and esterification/hydrolysis in THP-1 macrophages显示文摘 | Min Zhang Jian-Feng Wu Wu-Jun Chen Shi-Lin Tang Zhong-Cheng Mo Yan-Yan Tang Yuan Li Jia-Lin Wang Xiang-Yu Liu Juan Peng Kong Chen Ping-Ping He Yun-Cheng Lv Xin-Ping Ouyang Feng Yao Deng-Pei Tang Francisco S. Cayabyab Da-Wei Zhang Xi-Long Zheng Guo-Ping Ti | 2014 | Atherosclerosis2014，，1： | 2 |
| 13 | Adaptive T cell immunotherapy in cancer显示文摘Impaired tumor-specific effector T cells contribute to tumor progression and unfavorable clinical outcomes. As a compensatoryT cell-dependent cancer immunoediting strategy, adoptive T cell therapy (ACT) has achieved encouraging therapeutic results,and this strategy is now on the center stage of cancer treatment and research. ACT involves the ex vivo stimulation and expansionof tumor-infiltrating lymphocytes (TILs) with inherent tumor reactivity or T cells that have been genetically modified to expressthe cognate chimeric antigen receptor or T cell receptor (CAR/TCR), followed by the passive transfer of these cells into alymphodepleted host. Primed T cells must provide highly efficient and long-lasting immune defense against transformed cellsduring ACT. Anin-depth understanding of the basic mechanisms of these living drugs can help us improve upon currentstrategies and design better next-generation T cell-based immunotherapies. From this perspective, we provide an overview ofcurrent developments in different ACT strategies, with a focus on frontier clinical trials that offer a proof of principle. Meanwhile,insights into the determinants of ACT are discussed, which will lead to more rational, potent and widespread applicationsin the future. | Dongdong Ti Miaomiao Bai Xiaolei Li Jianshu Wei Deyun Chen Zhiqiang Wu Yao Wang Weidong Han | 2021 | Science China(Life Sciences)2021，64，3： | 2 |
| 14 | An anthraquinone from Hedyotis diffusa显示文摘 | Ho TI Chen G P Lin Y C | 1986 | PHytochem1986，25，8： | 1 |
| 15 | Carbon nanotubes promote neuron differentiation from human embryonic stem cells 显示文摘 | Chao TI Xiang S Chen CS | 2009 | Biochem Biophys Res Commun2009，384，4： | 1 |
| 16 | Molecular recognition and complexation thermodynamics of dye guest mole-cules by modified cyclodextrins and calixarenesulfonates显示文摘 | LIU Yu HAN Bao Hang CHEN Yun Ti | 2002 | J Phys Chem B2002，106，： | 1 |
| 17 | Electrochemical preparation, characterization, and electrocatalytic studies of nation ruthenium oxide modified glassy carbon electrode 显示文摘 | TI C C KUMAR S A CHEN S M | 2009 | Joumal of Solid State Electrochemistry2009，13，39： | 1 |
| 18 | Cardiac metabolism, inflammation, and peroxisome proliferator-activated receptors modulated by 1, 25-di- hydroxyvitamirt D3 in diabetic rats 显示文摘 | Lee TI Kao YH Chen YC | 2014 | Int I Cardiol2014，176，： | 1 |
| 19 | A comparison of the effectiveness of dexmedetomidine versus propofol target-controlled infusion for sedationduring fibreoptic nasotracheal intubation显示文摘 | Tsai CJ Chu KS Chen TI | 2010 | Anaesthesia2010，65，3： | 1 |
| 20 | Degradation of high-methoxyl pectin by dynamic high pressure microfluidization and its mechanism显示文摘 | Jun Chen Rui-Hong Liang Wei Liu Cheng-Mei Liu Ti Li Zong-Cai Tu Jie Wan | 2011 | Food Hydrocolloids2011，，1： | 1 |
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