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| 1 | 1994年中国糖尿病患病率及其危险因素显示文摘为调查全国糖尿病及糖耐量低减(IGT)的患病率及糖尿病危险因素,对全国19省市年龄≥25岁的224251人群进行横向普查,根据1985年WHO标准,年龄在25~64岁的213515人群中,糖尿病患病率为2.51%,糖耐量低减患病率为3.20%(按1990年全国人口年龄标化后患病率);新诊断糖尿病的比例(70.33%)明显高于已确诊的糖尿病者。现患病率是10年前的3.0倍左右,其中农村患病率的增长高于城市。经多因素logistic逐步回归分析显示,年龄、体重指数或腰臀围比、糖尿病家族史、高血压、低体力活动、高收入为非胰岛素依赖型糖尿病(NIDDM)的独立危险因素,而且在高收入人群中,低文化程度也为NIDDM的独立危险因素。 | Pan Xiaoren *, Yang Wenying, Liu Juan, et al. *Department of Endocrinology, China Japan Friendship Hospital, Beijing 100029 | 1997 | 中华内科杂志1997，36，6： | 415 |
| 2 | Reappraisement and refinement of zircon U-Pb isotope and trace element analyses by LA-ICP-MS显示文摘A protocol was established for simultaneous measurements of zircon U-Pb ages and trace elements by LA-ICP-MS at spot sizes of 16 32 μm.This was accomplished by introducing N 2 into ICP to increase the sensitivity.The obtained U-Pb ages for zircon standards GJ-1,TEMORA and SK10-2 are consistent with the preferred values within about 1% uncertainty (2σ) by simple external calibration against zircon standard 91500.Different data reduction softwares could yield different uncertainties for calculation of U-Pb ages.The commercially available program GLITTER4.4 could apply an improper uncertainty calculation strategy,but it may yield artificial high precisions for single analyses.Our trace element analyses indicate that Si is not an ideal internal standard for zircon when calibrated against the NIST glasses.Calibration against the NIST glasses using Si as an internal standard,a systematic deviation of 10% 30% was found for most trace elements including Zr.However,the trace element compositions of zircon can be accurately measured by calibration against multiple reference materials with natural compositions (e.g.,BCR-2G,BHVO-2G and BIR-1G),or calibration against NIST SRM 610 and using Zr as an internal standard.Analyses of two pieces of GJ-1 demonstrate that it is relatively homogenous for most trace elements (except for Ti). | LIU YongSheng HU ZhaoChu ZONG KeQing GAO ChangGui GAO Shan XU Juan CHEN HaiHong | 2010 | Chinese Science Bulletin2010，55，15： | 1011 |
| 3 | Identification of plasma microRNA-21 as a biomarker for early detection and chemosensitivity of non-small cell lung cancer显示文摘Studies have shown cell-free microRNA(miRNA) circulating in the serum and plasma with specific expression in cancer,indicating the potential of using miRNAs as biomarkers for cancer diagnosis and therapy.This study was to investigate whether plasma miRNA-21(miR-21) can be used as a biomarker for the early detection of non-small cell lung cancer(NSCLC) and to explore its association with clinicopathologic features and sensitivity to platinum-based chemotherapy.We used real-time RT-PCR to investigate the expression of miR-21 in the plasma of 63 NSCLC patients and 30 healthy controls and correlated the findings with early diagnosis,pathologic parameters,and treatment.Thirty-five patients(stages IIIB and IV) were evaluable for chemotherapeutic responses:11 had partial response(PR);24 had stable and progressive disease(SD+PD).Plasma miR-21 was significantly higher in NSCLC patients than in age-and sex-matched controls(P<0.001).miR-21 was related to TNM stage(P<0.001),but not related to age,sex,smoking status,histological classification,lymph node status,and metastasis(all P>0.05).This marker yielded a receiver operating characteristic(ROC) curve area of 0.775(95% CI:0.681-0.868) with 76.2% sensitivity and 70.0% specificity.Importantly,miR-21 plasma levels in PR samples were several folds lower than that in SD plus PD samples(P=0.049),and were close to that in healthy controls(P=0.130).Plasma miR-21 can serve as a circulating tumor biomarker for the early diagnosis of NSCLC and is related to the sensitivity to platinum-base chemotherapy. | Juan Wei Wen Gao Cheng-Jun Zhu Yi-Qian Liu Zhu Mei Ting Cheng Yong-Qian Shu | 2011 | Chinese Journal of Cancer2011，30，6： | 63 |
| 4 | Pathophysiological 角色和在糖尿病的 nephropathy 的发炎的治疗学的含意显示文摘 Diabetes mellitus and its complications are becoming one of the most important health problems in the world. Diabetic nephropathy is now the main cause of end-stage renal disease. The mechanisms leading tothe development and progression of renal injury are not well known. Therefore, it is very important to f ind new pathogenic pathways to provide opportunities for early diagnosis and targets for novel treatments. At the present time, we know that activation of innate immunity with development of a chronic low grade inflammatory response is a recognized factor in the pathogenesis of diabetic nephropathy. Numerous experimental and clinical studies have shown the participation of different inflammatory molecules and pathways in the pathophysiology of this complication. | Desirée Luis-Rodríguez Alberto Martínez-Castelao José Luis Górriz Fernando de lvaro Juan F Navarro-González | 2012 | World Journal of Diabetes2012，3，1： | 55 |
| 5 | Effects of vegetation type on soil microbial community structure and catabolic diversity assessed by polyphasic methods in North China显示文摘土壤微生物在生态的过程起一个主要作用并且仔细与被联系未葬植物群落。以便理解植被的效果在土壤的特征上打微生物引起的社区,土壤微生物引起的社区被板计数,磷脂脂肪酸( PLFA )和 Biolog 估计在五植物群落的微板技术,即,大豆地( SF ),人工的草地(在),人工的灌木(作为),自然灌木( NS ),和在 Jinan 的玉米地( MF ),山东省,诺思中国。结果证明那植物差异在微生物引起的生物资源上有小看得清的效果但是在 Biolog microplate.Legumes 的利用底层的平均上的积极影响能显著地提高文化微生物,微生物引起的生物资源,和社区的数字分解代谢的差异。除了荚统治的 SF ,真菌和微生物引起的社区的分解代谢的差异的生物资源比在在另外的 vegetationtypes.These 下面的经常扰乱的土壤结果证实植物种类的那个高数字在在 NS 下面的更少的扰乱的土壤是更高的,荚,并且到支持的自然植被 typest 结束与更高的功能玷污微生物引起的社区。现在的学习也发现了在有教养的细菌和细菌的社区的分解代谢的差异的数字之间的重要关联。不同研究方法在这研究导致了改变的结果。几条途径的联合为精确地在许多尊重描述微生物引起的社区的特征被推荐。 | HAN Xue-mei WANG Ren-qing LIU Jian WANG Meng-cheng ZHOU Juan GUO Wei-hua | 2007 | Journal of Environmental Sciences2007，19，10： | 60 |
| 6 | FIT interacts with AtbHLH38 and AtbHLH39 in regulating iron uptake gene expression for iron homeostasis in Arabidopsis显示文摘铁是为植物生长和开发的一个必要元素。在植物的铁动态平衡紧在 transcriptional 和 posttranscriptional 水平被调整。涉及铁动态平衡的几个 bHLH 抄写因素最近被识别了。然而,他们的规章的机制仍然保持未知。在这个工作,我们证明抄写因素适合与 AtbHLH38 和 AtbHLH39 交往了并且直接在 Arabidopsis 为铁动态平衡授与铁举起基因的表示规定。在 Arabidopsis 原物的酵母二混血儿的分析和短暂表示证明那 AtbHLH38 或 AtbHLH39 交往了与合适,在 Arabidopsis 涉及铁动态平衡的一个中央抄写因素。在酵母房间的 FIT/AtbHLH38 或 FIT/AtbHLH39 的表示激活铁的螯的 reductase (FRO2 ) 和铁的 transporter (IRT1 ) 驾驶的 GUS 表示倡导者。Overexpression 与在变换的工厂的 AtbHLH38 或 AtbHLH39 合适铁举起基因 FRO2 和 IRT1 从的表示导致了到组成。因为 IRT1 蛋白质累积和高铁的螯的 reductase 活动被检测在,进一步的分析表明 FRO2 和 IRT1 没在这些工厂在 posttranscriptional 水平被调整过去在铁缺乏和铁充足下面的表示工厂。在更积累的植物在表示任何一个 AtbHLH38 上比野生型或植物在他们的射击熨的表示上双, AtbHLH39 或合适。我们铁螯的 reductase FRO2 和铁运输的 IRT1 是三个抄写因素的目标和 FRO2 和 IRT1 的抄写的数据支持被 FIT/AtbHLH38 或 FIT/AtbHLH39 的建筑群直接调整。 | Youxi Yuan Huilan Wu Ning Wang Jie Li Weina Zhao Juan Du Daowen Wang Hong-QingLing | 2008 | Cell Research2008，18，3： | 57 |
| 7 | Constitutive expression of pathogen-inducible OsWRKY31 enhances disease resistance and affects root growth and auxin response in transgenic rice plants显示文摘WRKY 抄写因素响应关於生命、不能生活的压力有许多规章的角色。在这研究,我们孤立被稻瘟病真菌 Magnaporthe grisea 和植物生长素导致的米饭 WRKY 基因(OsWRKY31 ) 。这基因编码 211 氨基酸的残余的多肽并且属于可能在单音的简易窄床和 dicot 植物的分叉以后发源的米饭 WRKY 基因家庭的亚群。OsWRKY31 被发现对洋葱外皮房间的原子核局部性短暂地表示 OsWRKY31-eGFP 熔化蛋白质。与一个 Gal4 DNA 有约束力的领域熔化的 OsWRKY31 和它的异种的分析显示 OsWRKY31 在酵母举办 transactivation 活动。OsWRKY31 基因的 Overexpression 被发现与 M 对感染提高抵抗。grisea,和展出的转基因的线减少了侧根形成和延伸与相比野类型并且 RNAi 植物。线与在表示上显示出许多防卫相关的基因的组成的表示例如 PBZ1 和 OsSci2,以及早植物生长素反应基因,例如 OsIAA4 和 OsCrl1 基因。而且,植物与对在高集中的外长地供应的 IBA, NAA 和 2,4-D 在表示上不太敏感,在 OsWRKY31 基因的表示上建议那可能改变植物生长素反应或运输。这些结果也建议 OsWRKY31 可能在米饭是在植物生长素反应和防卫反应的信号转导小径的一个普通部件。 | Juan Zhang Youliang Peng Zejian Guo | 2008 | Cell Research2008，18，4： | 60 |
| 8 | Diagnosis and management of bacterial infections in decompensated cirrhosis显示文摘Bacterial infections are one of the most frequent complications in cirrhosis and result in high mortality rates.Patients with cirrhosis have altered and impaired immunity,which favours bacterial translocation.Episodes of infections are more frequent in patients with decompensated cirrhosis than those with compensated liver disease.The most common and life-threatening infection in cirrhosis is spontaneous bacterial peritonitis followed by urinary tract infections,pneumonia,endocarditis and skin and soft-tissue infections.Patients with decompensated cirrhosis have increased risk of developing sepsis,multiple organ failure and death.Risk factors associated with the development of infections are severe liver failure,variceal bleeding,low ascitic protein level and prior episodes of spontaneous bacterial peritonitis (SBP).The prognosis of these patients is closely related to a prompt and accurate diagnosis.An appropriate treatment decreases the mortality rates.Preventive strategies are the mainstay of the management of these patients.Empirical antibiotics should be started immediately following the diagnosis of SBP and the first-line antibiotic treatment is third-generation cephalosporins.However,the efficacy of currently recommended empirical antibiotic therapy is very low in nosocomial infections including SBP,compared to community-acquired episodes.This may be associated with the emergence of infections caused by Enterococcus faecium and extended-spectrum β-lactamaseproducing Enterobacteriaceae,which are resistant to the first line antimicrobial agents used for treatment.The emergence of resistant bacteria,underlines the need to restrict the use of prophylactic antibiotics to patients with the greatest risk of infections.Nosocomial infections should be treated with wide spectrum antibiotics.Further studies of early diagnosis,prevention and treatment are needed to improve the outcomes in patients with decompensated cirrhosis. | Maria Pleguezuelo Jose Manuel Benitez Juan Jurado Jose Luis Montero Manuel De la Mata | 2013 | World Journal of Hepatology2013，5，1： | 44 |
| 9 | Effects of Long-Term Combined Application of Organic and Mineral Fertilizers on Microbial Biomass,Soil Enzyme Activities and Soil Fertility显示文摘土壤健康为陆上的生态系统的持续发展是重要的。在这篇论文,我们学习了在土壤质量和土壤之间的关系微生物引起的性质例如玷污微生物引起的生物资源和土壤酶活动以便说明功能作为土壤健康的简历指示物玷污微生物引起的性质。在这研究,微生物引起的生物资源 C 和 N 内容(Cmic 与 Nmic ) 。有不同化肥政体的土壤酶活动,和土壤肥力在 Changping 县在娼妓 Fluvo-aquic 土壤基于一个 15 年的长期的化肥实验被执行,中国北京。在这个地点, 7 个不同处理在 1991 被建立。他们也不在小麦玉米旋转正在收到化肥(CK ) 。矿质肥料(NPK ) 。有合并的麦秸(NPKW+) 的矿质肥料,有合并的增长麦秸(NPKW+) 的矿质肥料,加猪粪肥(NPKM ) 的矿质肥料,加增长的猪粪肥(NPKM+) 的矿质肥料或有合并的玉米秸秆(NPKS ) 的矿质肥料。在不同授精处理, Cmic 从 96.49 ~ 500.12 mg kg 变化了 ? 1,并且 Nmic 从 35.89 ~ 101.82 mg kg 变化了 ? 1。与 CK 相比,另外的处理增加了 Cmic 与 Nmic, Cmic/Corg (器官的 C ) 比率, Cmic/Nmic,脲酶活动,土壤有机物(SOM ) 。土壤总氮(STN ) ,和土壤总数磷(STP ) 。在有化肥输入 NPKM+ 的处理的所有这些性质最高。同时,有有机肥料或庄稼稻草的矿质肥料的长期的联合申请能显著地减少在 Fluvo-aquic 土壤(在这试验性的土壤的在 8.00 附近的 pH ) 的土壤 pH。一些土壤微生物引起的性质(Cmic/Nmic。脲酶活动) 断然与土壤营养素被相关。Cmic/Nmic 显著地与 SOM 和 STN 内容被相关。在过氧化氢酶活动和土壤营养素之间的关联不是重要的。除了过氧化氢酶活动,另外,在这个实验的土壤 pH 否定地与土壤被相关微生物引起的性质。在结论,微生物引起的性质反映的土壤土壤质量并且这样变化能被用作土壤健康的简历指示物。 | LI Juan ZHAO Bing-qiang LI Xiu-ying JIANG Rui-bo So Hwat Bing | 2008 | Agricultural Sciences in China2008，7，3： | 49 |
| 10 | Component azimuths of the CEArray stations estimated from P-wave particle motion显示文摘The recently built China Digital Seismic Network consists of the China National Digital Seismic Network (CNDSN),31 regional seismic networks and several small aperture arrays with more than 1 000 stations including 850+ broadband stations.It forms a gigantic seismic array that provides an unprecedented opportunity to study the Earth's deep interior besides its routine task of seismic monitoring.Many modern seismic studies rely on rotation of vertical and horizontal components in order to separate different types of seismic waves.Knowledge of the orientations of the two horizontal components thus is important to perform a correction rotation.We analyzed particle motions of teleseismic P waves recorded by the network and used them to estimate the northcomponent azimuth of each station.An SNR-weighted-multi-event method was introduced to obtain component azimuths that best explain the P-wave particle motions of all the events recorded at a station.The method provides robust estimates including a measurement error calculated from background noise levels.We found that about one third of the stations have some sort of problems,including misorientation of the two horizontal components,mislabeling and polarity reversal in one or more components.These problems need to be taken into account for any rotation based seismic studies. | Fenglin Niu Juan Li | 2011 | Earthquake Science2011，24，1： | 43 |
| 11 | New insights into the roles of CHOP-induced apoptosis in ER stress显示文摘Endoplasmic 蜂窝胃应力(嗯应力) 在 ER 由于动态平衡的损失被触发,在 ER 腔导致累积 ofmisfolded 蛋白质。嗯因为 ER 的展开的蛋白质 response.Perturbation 是抄写因素 C/EBP 相应蛋白质(砍) 的强大的 inducer,应力激活知道的一系列适应机制。尽管它过时的人或物证明到 ER 的过多或不利的应力触发 apoptosis,由砍位于这些 processesinduced 下面的特定的机制仍然保持不清楚。现在,导致砍的 apoptosis 在嗯应力在众多的人的疾病被含有例如 neurodegenerative 疾病,糖尿病, ischemic 疾病,肿瘤等等。在这评论,我们从实验室在几疾病的发展总结了砍的角色的 currentunderstanding 到诊所。 | Yiming Li Yunshan Guo Juan Tang Jianli Jiang Zhinan Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，8： | 45 |
| 12 | 血浆同型半胱氨酸水平升高与心血管疾病及各种死亡风险因子的meta分析(英文)显示文摘目的:探讨普通人群血浆同型半胱氨酸水平升高是否能独立预测死亡风险。创新点:通过汇总12篇前瞻性研究,定量分析血浆同型半胱氨酸水平升高与心血管疾病及各种死亡风险因子的关系。方法:通过检索Pub Med和Embase数据库,收集普通人群中血浆同型半胱氨酸水平与死亡关系的前瞻性观察性研究,采用STATA统计软件进行meta分析。结论:血浆同型半胱氨酸水平升高是心血管疾病及各种原因死亡风险增加的一个独立预测因素,在老年人群中尤为明显。 | Hui-yong PENG Chang-feng MAN Juan XU Yu FAN | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，1： | 46 |
| 13 | Clinical and procedural predictors of no-ref low in patients with acute myocardial infarction after primary percutaneous coronary intervention显示文摘BACKGROUND: The treatment of acute myocardial infarction(AMI) is thought to restore antegrade blood flow in the infarct-related artery(IRA) and minimize ischemic damage to the myocardium as soon as possible. The present study aimed to identify possible clinical predictors for no-refl ow in patients with AMI after primary percutaneous coronary intervention(PCI).METHODS: A total of 312 consecutive patients with AMI who had been treated from January 2008 to December 2010 at the Cardiology Department of East Hospital, Tongji University School of Medicine were enrolled in this study. Inclusion criteria were:(i) patients underwent successfully primary PCI within 12 hours after the appearance of symptoms; or(ii) patients with ischemic chest pain for more than 12 hours after a successful primary PCI within 24 hours after appearance of symptoms. Exculsion criteria were:(i) coronary artery spasm;(ii) diameter stenosis of the culprit lesion was ≤50% and coronary blood f low was normal;(iii) patients with severe left main coronary or multivessel disease, who had to require emergency revascularization. According to thrombolysis in myocardial infarction(TIMI), the patients were divided into a reflow group and a no-reflow group. The clinical data, angiography f indings and surgical data were compared between the two groups. Univariate and multivariate logistic regressions were used to determine the predictors for no-ref low.RESULTS: Fifty-four(17.3%) of the patients developed NR phenomenon after primary PCI. Univariate analysis showed that age, time from onset to reperfusion, systolic blood pressure(SBP) on admission, Killip class of myocardial infarction, intra-aortic balloon pump(IABP) use before primary PCI, TIMI flow grade before primary PCI, type of occlusion, thrombus burden on baseline angiography, target lesion length, reference luminal diameter and method of reperfusion were correlated with no-reflow(P<0.05 for all). Multiple logistic regression analysis identified that age >65 years [OR=1.470, 95% confi dence interval(CI) 1.460–1.490, P=0.007], long time from onset to reperfusion >6 hours(OR=1.270, 95%CI 1.160–1.400, P=0.001), low SBP on admission <100 mmHg(OR=1.910, 95%CI 1.018–3.896, P=0.004), IABP use before PCI(OR= 1.949, 95%CI 1.168–3.253, P=0.011), low(≤1) TIMI fl ow grade before primary PCI(OR=1.100, 95%CI 1.080–1.250, P<0.001), high thrombus burden(OR=1.600, 95%CI 1.470–2.760, P=0.030), and long target lesion(OR=1.948, 95%CI 1.908–1.990, P=0.019) on angiography were independent predictors of no-refl ow.CONCLUSION: The occurrence of no-refl ow after primary PCI for acute myocardial infarction can predict clinical, angiographic and procedural features. | Hua Zhou Xiao-yan He Shao-wei Zhuang Juan Wang Yan Lai Wei-gang Qi Yi-an Yao Xue-bo Liu | 2014 | World Journal of Emergency Medicine2014，5，2： | 46 |
| 14 | Different strategies of treatment for uterine cervical carcinoma stage ⅠB2-ⅡB显示文摘Uterine cervical cancer is the second most common gynecological malignancy. It is estimated that over 35% of tumors are diagnosed at locally advanced disease, stage ⅠB2-ⅡB with an estimated 5-year overall survival of 60%. During the last decades, the initial treatment for these women has been debated and largely varies through different countries. Thus, radical concurrent chemoradiation is the standard of care in United Sated and Canada, and neoadjuvant chemotherapy followed by radical surgery is the first line of treatment in some institutions of Europe, Asia and Latin America. Until today, there is no evidence of which strategy is better over the other. This article describe the evidence as well as the advantages and disadvantages of the main strategies of treatment for women affected by uterine cervical cancer stage ⅠB2-ⅡB. | Lucas Minig María Guadalupe Patrono Nuria Romero Juan Francisco Rodríguez Moreno Jesús Garcia-Donas | 2014 | World Journal of Clinical Oncology2014，5，2： | 46 |
| 15 | The economic burden of influenza-associated outpatient visits and hospitalizations in China: a retrospective survey显示文摘Background:The seasonal influenza vaccine coverage rate in China is only 1.9%.There is no information available on the economic burden of influenza-associated outpatient visits and hospitalizations at the national level,even though this kind of information is important for informing national-level immunization policy decision-making.Methods:A retrospective telephone survey was conducted in 2013/14 to estimate the direct and indirect costs of seasonal influenza-associated outpatient visits and hospitalizations from a societal perspective.Study participants were laboratory-confirmed cases registered in the National Influenza-like Illness Surveillance Network and Severe Acute Respiratory Infections Sentinel Surveillance Network in China in 2013.Patient-reported costs from the survey were validated by a review of hospital accounts for a small sample of the inpatients.Results:The study enrolled 529 outpatients(median age:eight years;interquartile range[IQR]:five to 20 years)and 254 inpatients(median age:four years;IQR:two to seven years).Among the outpatients,22.1%(117/529)had underlying diseases and among the inpatients,52.8%(134/254)had underlying diseases.The average total costs related to influenza-associated outpatient visits and inpatient visits were US$155(standard deviation,SD US$122)and US$1,511(SD US$1,465),respectively.Direct medical costs accounted for 45 and 69%of the total costs related to influenza-associated outpatient and inpatient visits,respectively.For influenza outpatients,the mean cost per episode in children aged below five years(US$196)was higher than that in other age groups(US$129–153).For influenza inpatients,the mean cost per episode in adults aged over 60 years(US$2,735)was much higher than that in those aged below 60 years(US$1,417–1,621).Patients with underlying medical conditions had higher costs per episode than patients without underlying medical conditions(outpatients:US$186 vs.US$146;inpatients:US$1,800 vs.US$1,189).In the baseline analysis,inpatients reported costs were 18%higher than those found in the accounts review(n=38).Conclusion:The economic burden of influenza-associated outpatient and inpatient visits in China is substantial,particularly for young children,the elderly,and patients with underlying medical conditions.More widespread influenza vaccination would likely alleviate the economic burden of patients.The actual impact and cost-effectiveness analysis of the influenza immunization program in China merits further investigation. | Juan Yang Mark Jit Kathy S.Leung Ya-ming Zheng Lu-zhao Feng Li-ping Wang Eric H.Y.Lau Joseph T.Wu Hong-jie Yu | 2015 | Infectious Diseases of Poverty2015，4，1： | 44 |
| 16 | Contribution of additives Cu to its accumulation in pig feces: study in Beijing and Fuxin of China显示文摘猪粪肥的巨大的数量被集中的猪农场在中国生产,猪粪肥的 andthe 作文由于使用改变了大部分喂 additives.However ,关于准确 Cu (铜)的小 isknown 在 137 喂的 feces.One 和 142 烘便的 samplesfrom 作为在猪的沾染物喂的添加剂或礼品和 theresidues 喂 48 个猪农场在 1999 和 2005 在北京和 Fuxin 城市被收集, Cu 的 respectively.Theconcentrations 在 6.86-395 的范围。 | LI Yan-xia LI Wei WU Juan XU Li-chao SU Qiu-hong XIONG Xiong | 2007 | Journal of Environmental Sciences2007，19，5： | 38 |
| 17 | Current Trends of the Prevalence of Childhood Asthma in Three Chinese Cities: A Multicenter Epidemiological Survey显示文摘Objective To analyze the prevalence of asthma and asthma related symptoms among children aged 0-14 years in three Chinese cities and to obtain a crude estimation of the trend of childhood asthma prevalence in China. Methods A cross-sectional, population-based survey of prevalence of asthma was conducted in children aged from 0 to 14 years in 3 major cities of China (Beijing, Chongqing, and Guangzhou) with different geographic locations. All the subjects were randomly selected by a multi-stage sampling method. Three to five schools and kindergartens in 2 urban districts in each city were randomly selected for the survey, and a validated questionnaire that included the core questions of the International Study of Asthma and Allergies in Childhood, Phase Ⅲ questionnaire and several additional questions were used. All questionnaires were completed by parents or guardians of the selected children. Children whose parents responded affirmatively to the question' Has your child ever been diagnosed as asthma by a doctor' were recognized as victims of asthma. Results The prevalence of asthma in Beijing, Chongqing, and Guangzhou was 3.15%, 7.45%, and 2.09%, respectively. These values were significantly higher than those obtained 10 years ago in the national epidemiological survey in 2000 which used the same method of investigation and the same diagnotic criteria (χ2 =3.938, P=0.047; χ2 =73.506, P≤0.001; χ2 =11.956, P=0.001, in each city). Of the asthmatic children 57.21%, 69.91%, and 60.00% had their first attack before the age of 3 in Beijing, Chongqing, and Guangzhou, respectively. Wheezing was the primary clinical manifestation for all asthmatic children , followed by persistent cough and repeated respiratory infections. Both the prevalence of asthma and asthma-related symptoms were statistically higher in males than in females. Conclusion The prevalence of childhood asthma is statistically higher than that 10 years ago in the three Chinese cities. | JUAN BAI JiNG ZHAO KUN-LING SHEN LI XIANG AI-HUAN CHEN SUI HUANG YING HUANG JIAN-SHENG WANG RONG-WEI YE | 2010 | Biomedical and Environmental Sciences2010，23，6： | 37 |
| 18 | Locking plate fixation combined with iliac crest bone autologous graft for proximal humerus comminuted fracture显示文摘 | Zhu Lian Liu Yueju Yang Zongyou Li Han Wang Juan Zhao Changping Chen Xiao Zhang Yingze | 2014 | Chinese Medical Journal2014，，9： | 40 |
| 19 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 20 | Update on the treatment of type 2 diabetes mellitus显示文摘To achieve good metabolic control in diabetes and keep long term, a combination of changes in lifestyle and pharmacological treatment is necessary. Achieving near-normal glycated hemoglobin significantly, decreases risk of macrovascular and microvascular complications. At present there are different treatments, both oral and injectable, available for the treatment of type 2 diabetes mellitus(T2DM). Treatment algorithms designed to reduce the development or progression of the complications of diabetes emphasizes the need for good glycaemic control. The aim of this review is to perform an update on the benefits and limitations of different drugs, both current and future, for the treatment of T2 DM. Initial intervention should focus on lifestyle changes. Moreover, changes in lifestyle have proven to be beneficial, but for many patients is a complication keep long term. Physicians should be familiar with the different types of existing drugs for the treatment of diabetes and select the most effective, safe and better tolerated by patients. Metformin remains the first choice of treatment for most patients. Other alternative or second-line treatment options should be individualized depending on the characteristics of each patient. This article reviews the treatments available for patients with T2 DM, with an emphasis on agents introduced within the last decade. | Juan Jose Marin-Penalver Iciar Martin-Timon Cristina Sevillano-Collantes Francisco Javier del Canizo-Gomez | 2016 | World Journal of Diabetes2016，7，17： | 37 |
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