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| 1 | Advances in the treatment of traumatic scars with laser,intense pulsed light,radiofrequency,and ultrasound显示文摘Traumatic scarring is one of the most common complications after soft tissue injury caused by burns and trauma,which affects tens of millions of people worldwide every year.Traumatic scars diminish the quality of life due to disfigurement,symptoms of pain and itch,and restricted motion.The pathogenesis and pathophysiology of traumatic scar remain elusive.The management for traumatic scars is comprised of surgical and non-surgical interventions such as pressure therapy,silicone,corticosteroid,and radiotherapy,which are chosen by clinicians based on the physical examinations of scars.Recently,great progress in treating traumatic scars has been achieved by the development of novel technologies including laser,intense pulsed light(IPL),radiofrequency,and ultrasound.The aim of this review article was to summarize the advances of these technologies for traumatic scars intervention. | Xiujun Fu Jiying Dong Shen Wang Min Yan Min Yao | 2019 | Burns & Trauma2019，7，1： | 12 |
| 2 | The role of P2X7 receptor in ATP-mediated human leukemia cell death: calcium influx-independent显示文摘P2X7 受体的激活导致阳离子的快速的、双向流动,引起包括 cytotoxicity 的生物回答的宽广范围。然而,调停 P2X7 的 cytotoxicity 的机制仍然保持大部分未经勘探。在我们的以前的学习,在正常条件下面的调停 P2X7 的钙反应的缺乏在 P2X7+ 造血的房间线被发现。在这研究,在房间的不同类型的调停 P2X7 的 cytotoxicity (P2X7 ? ,有钙反应的 P2X7+ ,和没有钙反应的 P2X7+) 被调查。我们的结果证明 P2X7 收缩筋,腺苷 5-triphosphate ( ATP )或2,3-O-( 4 benzoylbenzoyl )-ATP, dose-dependently 在测试的所有P2X7+房间减少了房间生存能力,包括为 调停P2X7 的钙反应否定的 J6-1 , LCL ,和 Namalva 房间,尽管这些效果比在有正常 P2X7 功能的 KG1a 房间观察的那些低。细胞毒素的效果能被 P2X7 对手,氧化 ATP 和 1- 堵住[N, O 二度(5-isoquinolinesulfonyl )-N-methyl-l-tyrosyl]-4-phenylpiperazine。另外, phosphatidylserine 的外表表现能以一种时间依赖者方式和 apoptotic 被检测词法变化能在 J6-1 房间在 P2X7 受体的激活以后被观察。而且,调停 P2X7 的毛孔形成能在低离子的条件下面,然而并非在低二价的条件下面在 KG1a 和 J6-1 房间被检测。这些效果不能在 P2X7 被观察吗?Ramos 房间。这些结果建议 P2X7 调停受体的细胞毒素的效果可以发生独立于钙反应。 | Xiujun Zhang Lijun Meng Baoling He Jing Chen Peng Liu Jie Zhao Yufen Zhang Ming Li Dong An | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 7 |
| 3 | Micro RNA profiles and potential regulatory pattern during the early stage of spermatogenesis in mice显示文摘Spermatogenesis is a complicated and poorly understood process that relies on the precise regulation of the self-renewal and differentiation of spermatogonia. In many organisms, micro RNAs(mi RNAs) are involved in multiple developmental processes as critical regulators of transcriptional and post-transcriptional gene silencing. This study investigated the expression pattern of mi RNAs in type B spermatogonia cells(BSc) and primary spermatocytes(PSc) of mice, using a high-throughput small RNA sequencing system. The results revealed that the expression levels of Let-7 family mi RNAs were remarkably high in both cell types. Furthermore, the expression levels of mi R-21, mi R-140-3p, mi R-103, mi R-30 a, mi R-101 b and mi R-99 b were decreased during the transformation from BSc to PSc. These mi RNAs target vital genes that participate in apoptosis, cell proliferation and differentiation, junction assembly and cell cycle regulation. These results highlight the indispensable role of mi RNAs in spermatogenesis. | LUO MengMeng HAO LiLi HU Fen DONG YaNan GOU LiXia ZHANG WenDian WANG Xin ZHAO YuHui JIA MengChun HU SongNian ZHANG XiuJun | 2015 | Science China(Life Sciences)2015，58，5： | 6 |
| 4 | Geohazard Recognition and Inventory Mapping Using Airborne LiDAR Data in Complex Mountainous Areas显示文摘Geohazard recognition and inventory mapping are absolutely the keys to the establishment of reliable susceptibility and hazard maps. However, it has been challenging to implement geohazards recognition and inventory mapping in mountainous areas with complex topography and vegetation cover. Progress in the light detection and ranging(Li DAR) technology provides a new possibility for geohazard recognition in such areas. Specifically, this study aims to evaluate the performances of the Li DAR technology in recognizing geohazard in the mountainous areas of Southwest China through visually analyzing airborne Li DAR DEM derivatives. Quasi-3 D relief image maps are generated based on the sky-view factor(SVF), which makes it feasible to interpret precisely the features of geohazard. A total of 146 geohazards are remotely mapped in the entire 135 km^(2) study area in Danba County, Southwest China, and classified as landslide, rock fall, debris flow based on morphologic characteristics interpreted from SVF visualization maps. Field validation indicate the success rate of Li DAR-derived DEM in recognition and mapping geohazard with higher precision and accuracy. These mapped geohazards lie along both sides of the river, and their spatial distributions are related highly to human engineering activities, such as road excavation and slope cutting. The minimum geohazard that can be recognized in the 0.5 m resolution DEM is about 900 m^(2). Meanwhile, the SVF visualization method is demonstrated to be a great alternative to the classical hillshaded DEM method when it comes to the determination of geomorphological properties of geohazard. Results of this study highlight the importance of Li DAR data for creating complete and accurate geohazard inventories, which can then be used for the production of reliable susceptibility and hazard maps and thus contribute to a better understanding of the movement processes and reducing related losses. | Chen Guo Qiang Xu Xiujun Dong Weile Li Kuanyao Zhao Huiyan Lu Yuanzhen Ju | 2021 | Journal of Earth Science2021，32，5： | 6 |
| 5 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 6 | Isolation and Characterization of Melanin Pigment from Yesso Scallop Patinopecten yessoensis显示文摘Melanin is one of the essential compounds in the pigments of molluscan shells.However,the effects of melanin on color variations in molluscs are largely unknown.Our previous study suggests that Yesso scallop Patinopecten yessoensis might contain melanin pigment in the dark brown shell.We therefore isolated melanin from the pigmented shells using hydrochloric acid method,and characterized the types of melanin pigments by spectrophotometry.The purified melanin,which was verified by spectrophotometry scanning and HPLC analysis,showed the typical characteristics of melanin absorption spectra and HPLC chromatograms.The contents of pheomelanin and eumelanin in pigmented shells,which were determined by the linear standard curve of melanin at 405 nm and 350 nm absorbance,were 48.23 ? 1.350 and 157.65 ? 5.905 mg,respectively.The present results indicate that the brown-pigmented shells of scallops comprise approximately 76.6% of eumelanin and 23.4% of pheomelanin,which supports the presence of eumelanin-rich pigment in scallop shells.Therefore,the combination of hydrochloric acid extraction and spectrophotometric quantification is a rapid and efficient method to isolate and quantify melanin in shells.This will facilitate the melanin studies related to shell color polymorphism and the selective breeding of bivalves with different shell colors. | SUN Xiujun WU Biao ZHOU Liqing LIU Zhihong DONG Yinghui YANG Aiguo | 2017 | Journal of Ocean University of China2017，16，2： | 2 |
| 7 | An experimental research into endostatin microbubble combined with focused ultrasound for anti-tumor angiogenesis in colon cancer显示文摘Objective:to evaluate the therapeutic effect of targeted endostatin-loaded microbubbles,combined with improved,focused,directional ultrasound radiation for inhibition of subcutaneous translocation in situ colon tumor angiogenesis in colon cancer.Methods:65 BALB/c nude mice with subcutaneous translocation in situ colon tumors were randomly divided into five groups.Group A was the control group,without any treatments.In Group B,the mouse was treated with ultrasonic radiation.In Group C,the mouse was treated with ultrasonic radiation combined with empty SonoVue microbubbles.In Group D,the mouse was treated with ultrasonic radiation combined with empty Targestar-SA microbubbles.In Group E,the mouse was treated with ultrasonic radiation combined with endostatin microbubbles.The tumor size was measured before and 1,14,and 28 days after irradiation.The peak intensity(PI),regional blood volume(RBV)and regional blood flow(RBF)were recorded using contrast-enhanced ultrasound.The tumor tissue was removed for pathological examination;the tumor necrosis area and microvascular density(MVD)were evaluated by immunohistochemistry.Results:Tumors in Groups C,D and E were significantly smaller than in Groups A and B at 28 days after irradiation,with Group E the smallest.PI,RBF and RBV of Groups C,D,and E were significantly decreased 28 days after radiation with Group E the lowest,and significantly lower than Groups A and B(all P<0.05).The tumor tissue necrosis area of Group E was clearly greater while MVD was obviously lower than the other groups(all P<0.01)at 28 days after treatment.Conclusion:The targeted endostatin microbubbles,combined with focused,directional ultrasound radiation can damage tumor microvasculature of subcutaneous colon translocation in situ colon cancer,as well as inhibit the tumor angiogenesis. | Xiufeng Zhang Guangen Yang Ying Zhang Pintong Huang Jianming Qiu Yu Sun Zhong Shen Xiujun Liao Hongsheng Xia Shuxian Shao Dong Wang | 2014 | Gastroenterology Report2014，2，1： | 0 |
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