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| 1 | 2D materials via liquid exfoliation:a review on fabrication and applications显示文摘Since graphene was discovered, the study of two-dimensional(2D) materials with atomic thickness has become a hot spot. To prepare different 2D materials,different methods have been groped, such as mechanical exfoliation, chemical vapor deposition(CVD), liquid-phase exfoliation. This review mainly introduced the sonication liquid-phase exfoliation, an effective method to prepare 2D materials. Compared with mechanical exfoliation and CVD methods, liquid-phase exfoliation is convenient and costeffective and provides high yield. We focused on both theoretical and experimental details of this method. This method was reviewed according to the development of 2D materials from graphene, h-BN to transition metal chalcogenides(TMDs) and black phosphorus nanosheets.We discussed the applications of liquid-exfoliated 2D materials including micro- and nanoelectrical devices,photoelectric devices, and energy storage devices. | Chengxue Huo Zhong Yan Xiufeng Song Haibo Zeng | 2015 | Science Bulletin2015，60，23： | 20 |
| 2 | Domain structure and defects of highly ordered Bi_4Si_3O_(12) micro-crystals显示文摘Highly ordered Bi4Si3O12 micro-crystals were prepared at normal atmosphere. Phase identification of the prepared crystals was accomplished by X-ray diffractometer (XRD). Domain structure and defects were characterized by environmental scanning electron microscopy (ESEM). XRD shows that the obtained micro-crystals are of eulytite structure with chemical formulation of Bi4Si3O12. A highly ordered growth pattern is confirmed due to the faster growth of the {124} faces than that of the {204} faces by ESEM. The growing process of the domain structure is of pollen parent and filial generation pattern. The filial generations of Bi4Si3O12 crystals are generated from the pollen parent. Cracks generate from the defect areas and propagate along the {124} faces due to their lower binding energy under a proper temperature gradient, contributing to the total transcrystalline fracture. It is confirmed that the generation and development of the voids in the crystal grains can be developed when unmatched dimensions of the two opposite faces are formed. And the development of the voids is dependent on the dimensions and orientations of the two opposite faces. | TIAN QingQuan, WANG XiuFeng, YU ChengLong, JIANG HongTao, ZHANG ZhengGuang, WANG Yan & LIN SheBao School of Materials Science and Engineering, Shaanxi University of Science & Technology, Xi’an 710021, China | 2009 | Science China(Technological Sciences)2009，52，8： | 8 |
| 3 | Transplantation of human umbilical cord blood mesenchymal stem cells to treat a rat model of traumatic brain injury显示文摘In the present study, human umbilical cord blood mesenchymal stem cells were injected into a rat model of traumatic brain injury via the tail vein. Results showed that 5-bromodeoxyuridine-labeled cells aggregated around the injury site, surviving up to 4 weeks post-transplantation. In addition, transplantation-related death did not occur, and neurological functions significantly improved. Histological detection revealed attenuated pathological injury in rat brain tissues following human umbilical cord blood mesenchymal stem cell transplantation. In addition, the number of apoptotic cells decreased. Immunohistochemistry and in situ hybridization showed increased expression of brain-derived neurotrophic factor, nerve growth factor, basic fibroblast growth factor, and vascular endothelial growth factor, along with increased microvessel density in surrounding areas of brain injury. Results demonstrated migration of transplanted human umbilical cord blood mesenchymal stem cells into the lesioned boundary zone of rats, as well as increased angiogenesis and expression of related neurotrophic factors in the lesioned boundary zone. | Junjian Zhao Naiyao Chen Na Shen Hui Zhao Dali Wang Jun Shi Yang Wang Xiufeng Cui Zhenyu Yan Hui Xue | 2012 | Neural Regeneration Research2012，7，10： | 5 |
| 4 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 5 | COP9 signalosome subunit PfCsnE regulates secondary metabolism and conidial formation in Pestalotiopsis fici显示文摘The COP9 signalosome(CSN) is a highly conserved multiprotein complex in all eukaryotes and involved in regulation of organism development. In filamentous fungi, several lines of evidence indicate that fungal development and secondary metabolism(SM) are mediated by the fifth subunit of CSN, called CsnE. Here we uncover a connection with CsnE and conidial formation as well as SM regulation in the plant endophytic fungus Pestalotiopsis fici. A homology search of the P. fici genome with CsnE, involved in sexual development and SM in Aspergillus nidulans, identified PfCsnE. Deletion of PfcsnE resulted in a mutant that stopped conidial production, but the conidia are recovered in a PfcsnE complemented strain. This indicates that PfCsnE is required for the formation of conidia. Secondary metabolite analysis demonstrated that the ΔPfcsnE strain produced more chloroisosulochrin, less ficiolide A production in comparison to wild type(WT). Transcriptome analysis of WT andΔPfcsnE strains indicated that PfcsnE impacts the expression levels of 8.37% of 14,797 annotated genes. Specifically, nine biosynthetic gene clusters(BGCs) were up-regulated and three BGCs were down-regulated by PfCsnE. Our results suggest that PfCsnE plays major roles in SM regulation and conidial development in P. fici. | Yanjing Zheng Xiuna Wang Xiaoling Zhang Wei Li Gang Liu Shihua Wang Xiufeng Yan Huixi Zou Wen-Bing Yin | 2017 | Science China(Life Sciences)2017，60，6： | 4 |
| 6 | Bioinformatics analysis for structure and function of CPR of Plasmodium falciparum显示文摘Objective:To analyse the structure and function of NADPH-cytochrome p450 reductase(CYPOR or CPR) from Plasmodium falciparum(Pf),and to predict its’ drug target and vaccine target. Methods:The structure,function,drug target and vaccine target of CPR from Plasmodium falciparum were analyzed and predicted by bioinformatics methods.Results:PfCPR,which was older CPR,had close relationship with the CPR from other Plasmodium species,but it was distant from its hosts,such as Homo sapiens and Anopheles.PfCPR was located in the cellular nucleus of Plasmodium falciparum.335aa-352aa and 591aa - 608aa were inserted the interior side of the nuclear membrane,while 151aa-265aa was located in the nucleolus organizer regions.PfCPR had 40 function sites and 44 protein-protein binding sites in amino acid sequence.The teriary structure of laa-700aa was forcep-shaped with wings.15 segments of PfCPR had no homology with Homo sapien CPR and most were exposed on the surface of the protein.These segments had 25 protein-protein binding sites.While 13 other segments all possessed function sites. Conclusions:The evolution or genesis of Plasmodium falciparum is earlier than those of Homo sapiens.PfCPR is a possible resistance site of antimalarial drug and may involve immune evasion, which is associated with parasite of sporozoite in hepatocytes.PfCPR is unsuitable as vaccine target,but it has at least 13 ideal drug targets. | Zhigang Fan Lingmin Zhang Guogang Yan Qiang Wu Xiufeng Gan Saifeng Zhong Guifen Lin | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，2： | 3 |
| 7 | 为从变形体 berghei 的氮的氧化物 synthase 和类似的蛋白质的结构和功能的生物信息学分析和预言显示文摘 <正>Objective:To search and analyze nitric oxide synthase(NOS) and similar proteins from Plasmodium berghei(Pb).Methods:The structure and function of nitric oxide synthase and similar proteins from Plasmodium berghei were analyzed and predicted by bioinformatics. Results:P6NOS were not available,but nicotinamide adenine dinucleotide 2’-phosphate reduced tetrasodium(NADPH)-cytochrome p450 reductase(CPR) were gained.PiCPR was in the nucleus of Plasmodium berghei,while 134aa-229aa domain was localize in nucleolar organizer. The amino acids sequence of P6CPR had the closest genetic relationship with Plasmodium vivax showing a 73%homology.The tertiary structure of PbCPR displayed the forcep-shape with wings,but no wings existed in the tertiary structure of its’ host,Mus musculus(Mm).137aa-200aa, 201aa-218aa,220aa-230aa,232aa-248,269aa-323aa,478aa-501aa and 592aa-606aa domains of P6CPR showed no homology with MmCPRs’,and all domains were exposed on the surface of the protein.Conclusions:NOS can’t be found in Plasmodium berghei and other Plasmodium species.PbCPR may be a possible resistance site of antimalarial drug,and the targets of antimalarial drug and vaccine.It may be also one of the mechanisms of immune evasion.This study on Plasmodium berghei may be more suitable to Plasmodium vivax.And137aa-200aa, 201aa-218aa,220aa-230aa,232aa-248,269aa-323aa,478aa-501aa and 592aa-606aa domains of PbCPR are more ideal targets of antimalarial drug and vaccine. | Zhigang Fan Gang Lv Lingmin Zhang Xiufeng Gan Qiang Wu Saifeng Zhong Guogang Yan Guifen Lin | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，1： | 2 |
| 8 | Genomic decoding of breeding history to guide breeding-by-design in rice显示文摘Deciphering the intrinsic molecular logic of empirical crop breeding from a genomic perspective is a decisive prerequisite for breeding-by-design(BbD),but remains not well established.Here,we decoded the historical features of past rice breeding by phenotyping and haplotyping 546 accessions covering the majority of cultivars bred in the history of Northeast China(NEC).We revealed that three groups founded the genetic diversities in NEC rice with distinct evolution patterns and traced and verified the breeding footprints to known or genome-wide association study(GWAS)-detected quantitative trait loci(QTLs),or introgressions from indica sub-species with chronological changes in allele frequencies.Then we summarized a rice breeding trend/principle in NEC,and combined with the successful example in breeding and application of Zhongkefa5 to demonstrate the guiding value of our conclusion for BbD in practice.Our study provides a paradigm for decoding the breeding history of a specific crop to guide BbD,which may have implications in different crop breeding. | Zhuo Chen Qingyun Bu Guifu Liu Maoqing Wang Hongru Wang Huazhao Liu Xiufeng Li Hong Li Jun Fang Yan Liang Zhenfeng Teng Sai Kang Hong Yu Zhukuan Cheng Yongbiao Xue Chengzhi Liang Jiuyou Tang Jiayang Li Chengcai Chu | 2023 | National Science Review2023，10，5： | 1 |
| 9 | Dirunal change of gas exchange of Rhodiola sachalinensis transplanted from different habitats in Changbai Moatain 显示文摘 | Yan Xiufeng Li Jing Wang Yujie | 2000 | J For Res2000，11，1： | 1 |
| 10 | Growth and thermal properties of YbVO4 single crystal显示文摘 | Yu Yonggui Cheng Yan Zhang Huaijin Wang Jiyang Cheng Xiufeng Xia Hairui | 2006 | Materials Letters2006，60，： | 1 |
| 11 | (25R)-Spirost-5-en-3-ol dimethyl sulfoxide solvate显示文摘 | Zhang Xiufeng Cui Yan Liu Yang | 2005 | Acta Crystallogr2005，61，： | 1 |
| 12 | Soil nutrient factors related to salidroside production of Rhodiola sachalinensis distributed in Chang Bai Mountain显示文摘 | Yan Xiufeng Wu Shuangxiu Wang Yang | 2004 | Environmental and Experimental Botany2004，52，3： | 1 |
| 13 | A 3D QSAR Study of Betulinic Acid Derivatives as Anti-Tumor Agents Using Topomer Co MFA:Model Building Studies and Experimental Verification显示文摘 | Ding Weimin Sun Miao Luo Shaman Xu Tao Cao Yibo Yan Xiufeng Wang Yang | 2013 | Molecules2013，18，10： | 1 |
| 14 | PCA-U-Net based breast cancer nest segmentation from microarray(jj)hyperspectral images显示文摘The incidence of breast cancer is tending younger globally,and tumor development,clinical treatment,and prognosis are largely influenced by histopathological diagnosis.For diagnosed patients,the distinction between the cancer nests and normal tissue is the basis of breast cancer treatment.Microscopic hyperspectral imaging technology has shown its potential in auxiliary pathological examinations due to the superior imaging modality and data characteristics.This paper presents a method for cancer nest segmentation from hyperspectral images of breast cancer tissue microarray samples.The scheme combines the strengths of the U-Net neural network and unsupervised principal component analysis,which reduces the amount of calculation and improves the recognition accuracy.The experimental accuracy of cancer nest segmentation reaches 87.14%.Furthermore,a set of quantitative pathological characteristic parameters reflects the degree of breast cancer lesions from multiple angles,providing a relatively comprehensive reference for the pathologist’s diagnosis.In-depth exploration of the combined development of deep learning and microscopic hyperspectral imaging technology is worthy to promote efficient diagnosis of breast tumors and concern for human health. | Jiansheng Wang Yan Wang Xiang Tao Qingli Li Li Sun Jiangang Chen Mei Zhou Menghan Hu Xiufeng Zhou | 2021 | Fundamental Research2021，1，5： | 1 |
| 15 | Process of Assembling Component Based on Domain Ontology显示文摘 | Yan Wang Xiufeng Cao | 2013 | Journal of Networks2013，，10： | 1 |
| 16 | Tissue-specific and developmental regulation of camptothecin and 10-hydroxycamptothecin levels in Camptotheca acuminata显示文摘 | Yan Xiufeng Wang Yang Zhang Yuhong | 2005 | Botanical Bullelin of Academia Sinica2005，46，： | 1 |
| 17 | Evaluation of antioxidant activities of water-soluble polysaccharides from brown alga Hizikia fusiforme显示文摘 | MINGJIANG WU YUE WU XIUFENG YAN | 2013 | International Journal of Biological Macromolecules2013，56，： | 1 |
| 18 | Bioinformatic analysis of molecular network of glucosinolate biosynthesis 显示文摘 | Yazhou Chen Xiufeng Yan Sixue Chen | 2011 | Computa- tional Biology and Chemistry2011，35，1： | 1 |
| 19 | Pluripotent Embryonic Stem Cells Developed into Medulloepithelioma in Nude Mice Eyes显示文摘Purpose: The pluripotent embryonic stem cells can differentiate into various kinds offormal tissues. There is no previous report on the differentiation of embryonic stem cellin the intraocular environment. In this paper, the authors tried to investigate theintraocular growth character of mice embryonic stem cells in nude mice.Methods: Murine embryonic stem cells were cultured and maintained in anundifferentiated state in vitro. They were transplanted into the right eyes of 20 nude miceby microinjection under operating microscope. Animal eye observation, light microscopeand immunohistochemical examinations were implemented.Results: Two to three days after transplantation, small pieces of gray-white materialcould be viewed in the vitreous cavity. Between the 15th and 20th day, the gray-whitemass grew into the anterior chamber in 4 nude mice eyes. Then, the mass at the anteriorchamber extended extraocularly. On the 30th day, a remarkable proptosis was observedin two of the four nude mice. In 6 to 45 days, the mice were executed for morphologicalexamination which showed the following typical structures: (1) Undifferentiated cellswith prominent nucleolius. (2) Flexner-Wintersteiner-like rosettes. (3) Medulloepithe-lioma-like structure: the cells were arranged in sheets, cords, tubes, and cysts. (4) Large,spindle-or astrocyte-like cells. (5) Cartilage-like structure. Immunohistochemically, mostof the cells were highly positive in NSE staining and a few cells were moderately positivein GFAP staining.Conclusions: Both animal eye findings and morphologic examinations certificated thatthe transplanted embryonic stem cells could grow in the eyes of nude mice anddifferentiate into intraocular medulloepithelioma. | Yongping Li , Xiufeng Zhong , Jianhua Yan , Jianxian Lin, Song Tan Xuan Wu, Shulong Li, Guanguang Feng, Yuzhen Yi Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China Department of Pathophysiology, Sun Yat-sen University, Guangzhou | 2002 | Eye Science2002，18，1X： | 0 |
| 20 | High-speed high-resolution laser diode-based photoacoustic microscopy for in vivo microvasculature imaging显示文摘Laser diodes(LDs)have been considered as cost-effective and compact excitation sources to overcome the requirement of costly and bulky pulsed laser sources that are commonly used in photoacoustic microscopy(PAM).However,the spatial resolution and/or imaging speed of previously reported LD-based PAM systems have not been optimized simultaneously.In this paper,we developed a high-speed and high-resolution LD-based PAM system using a continuous wave LD,operating at a pulsed mode,with a repetition rate of 30 kHz,as an excitation source.A hybrid scanning mechanism that synchronizes a one-dimensional galvanometer mirror and a two-dimensional motorized stage is applied to achieve a fast imaging capability without signal averaging due to the high signal-to-noise ratio.By optimizing the optical system,a high lateral resolution of 4.8μm has been achieved.In vivo microvasculature imaging of a mouse ear has been demonstrated to show the high performance of our LD-based PAM system. | Xiufeng Li Victor T C Tsang Lei Kang Yan Zhang Terence T W Wong | 2021 | Visual Computing for Industry,Biomedicine,and Art2021，4，1： | 0 |
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