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| 1 | Formaldehyde up-regulates TRPV1 through MAPK and PI3K signaling pathways in a rat model of bone cancer pain显示文摘Objective Our previous study showed that tumor tissue-derived formaldehyde at low concentrations plays an important role in bone cancer pain through activating transient receptor potential vanilloid subfamily member 1 (TRPV1). The present study further explored whether this tumor tissue-derived endogenous formaldehyde regulates TRPV1 expression in a rat model of bone cancer pain, and if so, what the possible signal pathways are during the development of this type of pain. Methods A rat model of bone cancer pain was established by injecting living MRMT-1 tumor cells into the tibia. The formaldehyde levels were determined by high performance liquid chromatography, and the expression of TRPV1 was examined with Western blot and RT-PCR. In primary cultured dorsal root ganglion (DRG) neurons, the expression of TRPV1 was assessed after treatment with 100 μmol/L formaldehyde with or without pre-addition of PD98059 [an inhibitor for extracellular signal-regulated kinase], SB203580 (a p38 inhibitor), SP600125 [an inhibitor for c-Jun N-terminal kinase], BIM [a protein kinase C (PKC) inhibitor] or LY294002 [a phosphatidylinositol 3-kinase (PI3K) inhibitor]. Results In the rat model of bone cancer pain, formaldehyde concentration increased in blood plasma, bone marrow and the spinal cord. TRPV1 protein expression was also increased in the DRG. In primary cultured DRG neurons, 100 μmol/L formaldehyde significantly increased the TRPV1 expression level. Pre-incubation with PD98059, SB203580, SP600125 or LY294002, but not BIM, inhibited the formaldehyde-induced increase of TRPV1 expression. Conclusion Formaldehyde at a very low concentration up-regulates TRPV1 expression through mitogen-activated protein kinase and PI3K, but not PKC, signaling pathways. These results further support our previous finding that TRPV1 in peripheral afferents plays a role in bone cancer pain. | Ying Han Yan Li Xlng Xlao Jia Liu Xiang-Ling Meng Feng-Yu Liu Guo-Gang Xing You Wan | 2012 | Neuroscience Bulletin2012，28，2： | 19 |
| 2 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 3 | Role of baicalin in regulating Toll-like receptor 2/4 after ischemic neuronal injury显示文摘 | LI Hui-ying YUAN Zhi-yi WANG Yu-gang WAN Hong-jiao HU Jun CHAI Yu-shuang LEI Fan XING Dong-ming DU Li-jun | 2012 | Chinese Medical Journal2012，，9： | 15 |
| 4 | Changes of p53 and Waf1p21 and cell proliferation in esophageal carcinogenesis显示文摘Changesofp53andWaf1p21andcelproliferationinesophagealcarcinogenesisWANGLiDong1,YANGWanCai1,ZHOUQi1,XINGYing1,JIAYunYing2a... | WANG Li Dong 1, YANG Wan Cai 1, ZHOU Qi 1, XING Ying 1,JIA Yun Ying 2 and ZHAO Xin 1 | 1997 | World Journal of Gastroenterology1997，3，2： | 15 |
| 5 | Breeding by design for future rice:Genes and genome technologies显示文摘1.Introduction Rice is a staple food for 3.2 billion people.The food security threat that shook many Asian countries in 2008 still looms,because farmers are facing the challenge of producing more rice with fewer resources of water,land,and inputs. | Jianlong Xu Yongzhong Xing Yunbi Xu Jianmin Wan | 2021 | The Crop Journal2021，9，3： | 10 |
| 6 | Propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits显示文摘The present study established a rabbit model of global cerebral ischemia using the 'six-vessel' method,which was reperfused after 30 minutes of ischemia.Rabbits received intravenous injection of propofol at 5 mg/kg prior to ischemia and 20 mg/kg per hour after ischemia until samples were prepared.Results revealed that propofol inhibited serum interleukin-8,endothelin-1 and malondialdehyde increases and promoted plasma superoxide dismutase activity after cerebral ischemia/reperfusion.In addition,cerebral cortex edema was attenuated with little neuronal nuclear degeneration and pyknosis with propofol treatment.The cross-sectional area of neuronal nuclei was,however,increased following propofol treatment.These findings suggested that propofol could improve anti-oxidant activity and inhibit synthesis of inflammatory factors to exert a protective effect on cerebral ischemia/reperfusion injury. | Xiaodong Wei Xing Wan Bo Zhao Jiabao Hou Min Liu Bangchang Cheng | 2012 | Neural Regeneration Research2012，7，11： | 8 |
| 7 | Biology,invasion and management of the agricultural invader:Fall armyworm,Spodoptera frugiperda(Lepidoptera:Noctuidae)显示文摘The fall armyworm(FAW),Spodoptera frugiperda(J.E.Smith),is native to the Americas.It has rapidly invaded 47 African countries and 18 Asian countries since the first detection of invasion into Nigeria and Ghana in 2016.It is regarded as a super pest based on its host range(at least 353 host plants),its inherent ability to survive in a wide range of habitats,its strong migration ability,high fecundity,rapid development of resistance to insecticides/viruses and its gluttonous characteristics.The inherently superior biological characteristics of FAW contribute to its invasiveness.Integrated pest management(IPM)of FAW has relied on multiple applications of monitoring and scouting,agricultural control,chemical pesticides,viral insecticides,sex attractants,bio-control agents(parasitoids,predators and entomopathogens)and botanicals.Knowledge gaps remain to be filled to:(1)understand the invasive mechanisms of S.frugiperda;(2)understand how to prevent its further spread and(3)provide better management strategies.This review summarizes the biological characters of FAW,their association with its invasiveness and IPM strategies,which may provide further insights for future management. | Jing WAN HUANG Cong LI Chang-you ZHOU Hong-xu REN Yong-lin LI Zai-yuan XING Long-sheng ZHANG Bin QIAO Xi LIU Bo LIU Cong-hui XI Yu LIU Wan-xue WANG Wen-kai QIAN Wan-qiang Simon MCKIRDY WAN Fang-hao | 2021 | Journal of Integrative Agriculture2021，20，3： | 7 |
| 8 | Enhanced Anticorrosion Properties of Epoxy Coatings from Al and Zn Based Pigments显示文摘 | WAN Kail LI Changcheng XING Cuijuan ZHAO Haizhou YU Liangmin | 2015 | Chemical Research in Chinese Universities2015，31，4： | 7 |
| 9 | Impact of Fuzheng Huayu tablet on antiviral effect of entecavir in patients with hepatitis B cirrhosis显示文摘Background:Fuzheng Huayu tablet is a traditional Chinese medicine(TCM)used for the treatment of liver fibrosis and cirrhosis.However,whether the combination with Fuzheng Huayu tablet could affect the antiviral efflcacy of nucleos(t)ide remains a concern.The objective of this trial was to explore the impact of Fuzheng Huayu tablet on antiviral effect of entecavir in patients with hepatitis B cirrhosis.Methods:A prospective,randomized control trial was conducted.Patients with compensated hepatitis B cirrhosis were randomly divided into the treatment group(entecavir capsule plus Fuzheng Huayu tablet)and the control group(entecavir capsule plus simulant of Fuzheng Huayu),and followed up for 48 weeks.The dynamic changes of HBV DNA load,the rate of serological conversion of HBeAg,liver function,renal function and liver stiffness measurement(LSM)were monitored.The general clinical data and adverse events were also recorded.Results:There was no significant difference in the rate of virological response and cumulative virological response between the treatment group and the control group(P>0.05).After 48 weeks of treatment,the HBeAg seroconversion rate,biochemical response rate and LSM value were 21.05%and 4.76%(P=0.164),86.96%and 65.96%(P=0.017),9.5 kpa and 10.6 kpa(P=0.827)in the treatment group and the control group,respectively.No serious adverse events related to the study therapy occurred during the trial.Conclusions:The antiviral entecavir combined with Fuzheng Huayu tablet did not affect the antiviral efflcacy of entecavir,but could improve the rate of biochemical response,and had a tendency to improve the rate of serological conversion of HBeAg and liver fibrosis in patients with hepatitis B cirrhosis.Fuzheng Huayu tablet is clinically safe for patients with hepatitis B cirrhosis. | Dan-Ying Cheng Zhi-Min Zhao Gang Wan Huan-Wei Zheng Jia-Quan Huang Cheng-Hai Liu Hui-Chun Xing | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，5： | 6 |
| 10 | Comparison of preoperative TN staging of gastric carcinoma by endoscopic ultrasonography with CT examination显示文摘ComparisonofpreoperativeTNstagingofgastriccarcinomabyendoscopicultrasonographywithCTexaminationGUOWen1,ZHANGYaLi1,LIGuoXin... | GUO Wen1, ZHANG YaLi1, LI GuoXing2, ZHOU DianYuan1 and ZHANG WanDai1 | 1997 | World Journal of Gastroenterology1997，3，4： | 5 |
| 11 | Formaldehyde increases intracellular calcium concentration in primary cultured hippocampal neurons partly through NMDA receptors and T-type calcium channels显示文摘在高集中的客观甲醛是一个贡献者让污染通风。它也是在房间的一个内长的新陈代谢的产品,并且什么时候在生理的集中以外,在神经原上有病理学的效果。甲醛在癌症疼痛模型导致外部 nociceptive 神经原的记忆功能,以及刺激的 neuronal 字形物蛋白质,海马趾的 neuronal apoptosis,认知缺陷和损失的合拢 mis 和聚集。细胞内部的钙([Ca2+] 我) 是一个重要细胞内部的送信人,并且在许多病理学的过程起一个关键作用。现在的学习试图调查甲醛的效果在上[Ca2+] i 和 N-methyl-D-aspartate 受体(NMDAR ) 和房间膜上的 T 类型 Ca2+ 隧道的可能的参与。把主要有教养的海马趾的神经原用作一个模型,的方法变化[Ca2+] 我被共焦的激光扫描面对在低集中的甲醛检测显微镜学。在近似加倍的 1 mmol/L 的结果甲醛[Ca2+] 我。( 2R ) -amino-5-phosphonopentanoate ( AP5 , 25 mol/L ,一个 NMDAR 对手)并且 mibefradil ( MIB , 1 mol/L ,T类型Ca2+隧道 blocker ),在甲醛灌注以后给 5 min ,部分各禁止了导致甲醛的增加[Ca2+]我,并且这禁止的效果被 AP5 和 MIB 的联合申请增强。什么时候在甲醛灌注前使用了 3 min, AP5 (甚至在 50 mol/L ) 没禁止导致甲醛的增加[Ca2+] 我,而是 MIB (1 mol/L ) 显著地在 70% 禁止了这增加。这些结果在低集中建议那甲醛的结论增加[Ca2+] 在有教养的海马趾的神经原的 i;NMDAR 和 T 类型 Ca2+ 隧道可以涉及这个过程。 | Ye-Nan Chi Xu Zhang Jie Cai Feng-Yu Liu Guo-Gang Xing You Wan | 2012 | Neuroscience Bulletin2012，28，6： | 4 |
| 12 | Neurotoxicity of intrathecal injections of dexmedetomidine into the rat spinal dorsal horn显示文摘To investigate the neurotoxicity of intrathecal injections of dexmedetomidine,Sprague-Dawley rats were intrathecally injected with dexmedetomidine at doses of 0.75,1.50 and 3.00μg/kg into the spinal dorsal horn.We found that c-Fos expression in the rat spinal dorsal horn peaked at 7 hours following the 3.00μg/kg dexmedetomidine injection,while the levels of c-Fos expression following 0.75 and 1.50μg/kg dexmedetomidine were similar to those in the spinal dorsal horn of normal rats. At 48 hours following administration,the level of c-Fos expression was similar to normal levels.In addition,the intrathecal injections of dexmedetomidine increased paw withdrawal mechanical thresholds and prolonged thermal tail flick latencies.These results indicate that dexmedetomidine has pronounced antinociceptive effects.However,dexmedetomidine appears to have neurotoxic effects in the spinal cord because it increased c-Fos expression in the spinal dorsal horn within 7 hours following administration. | Jiabao Hou Zhongyuan Xia Xingpeng Xiao Xing Wan Bo Zhao | 2012 | Neural Regeneration Research2012，7，23： | 4 |
| 13 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 14 | Arabidopsis Blue Light Receptor Phototropin 1 Undergoes Blue Light-Induced Activation in Membrane Microdomains显示文摘Phototropin (辐透) 调停了发信号由蓝光(BL ) 开始了在在植物在血浆膜(下午) 优化光合的轻俘获起一个关键作用。然而,响应 BL 在 PM 位于辐透活动的规定下面的机制仍然保持大部分不清楚。在这研究,由单个粒子的追踪和 phot1-GFP 蛋白质的逐步的 photobleaching 分析,我们在黑暗 phot1 表明了那 ? 蛋白质留在一个不活跃的状态并且主要作为单体存在。Dimerization 和 phot1-GFP 的散开率响应 BL 以一种剂量依赖者方式增加了。相反, BL 没影响 kinase 不活跃的 phot1 D806N -GFP?but 确实提高了它的 dimerization,建议那 phot1 dimerization 独立于 phosphorylation。F ? rster 回声精力转移荧光一生成像显微镜学 ? 分析表明在 phot1-GFP 和充满甾醇的类脂化合物环境的一个标记之间的相互作用, AtRem1.3-mCherry,与 BL 处理的增加的时间被提高。然而,这个 BL 依赖的相互作用不在植物共同表示是明显的 phot1 D806N -GFP 和 AtRem1.3-mCherry,显示那 BL 便于功能的 phot1-GFP 的 translocation 进标记 AtRem1.3 的 microdomains 激活调停辐透的发信号。相反地,甾醇弄空稀释了 phot1-GFP 动力学, dimerization,和 phosphorylation。一起拿,这些结果显示膜 microdomains 充当在 PM 组织为激活的 phot1 的合适的功能必要的平台。 | Yiqun Xue Jingjing Xing Yinglang Wan Xueqin Lv Lusheng Fan Yongdeng Zhang Kai Song Li Wang Xiaohua Wang Xin Deng Frantisek Baluska John M. Christie Jinxing Lin | 2018 | Molecular Plant2018，11，6： | 4 |
| 15 | Optimization of Approximate Solution of Integral Equations of Several Variables | Wan MA Xing Hua WANG Department of Mathematics, Zhejiang University. Hangzhou 310028, P. R. China | 2002 | Acta Mathematica Sinica,English Series2002，18，3： | 4 |
| 16 | Salidroside Reduces PDE2A Expression by Down-regulating p53 in Human Embryonic Lung Fibroblasts显示文摘Salidroside(SAL) is a glucoside of tyrosol and a key constituent of Rhodiola rosea L. The diverse pharmacological activities of SAL include anti-inflammatory, cardioprotective, and neuroprotective effects(1)Our previous investigation showed that the anti-aging effects of SAL involve reductions of the levels of advanced glycation end products in a D-galactose induced mouse model(2)Additionally. | XING Wen Min CHEN Sha Sha WANG San Ying GAO Wen Yan WAN Xiao Qing SU Hui Li YANG Yi ZHANG Jing YAN Jing MAO Gen Xiang | 2019 | Biomedical and Environmental Sciences2019，32，2： | 3 |
| 17 | A new error-controllable method for smoothing the G01 commands显示文摘In real machining, the tool paths are composed of a series of short line segments, which constitute groups of sharp corners correspondingly leading to geometry discontinuity in tangent. As a result, high acceleration with high fluctuation usually occurs. If these kinds of tool paths are directly used for machining, the feedrate and quality will be greatly reduced. Thus, generating continuous tool paths is strongly desired. This paper presents a new error-controllable method for generating continuous tool path. Different from the traditional method focusing on fitting the cutter locations, the proposed method realizes globally smoothing the tool path in an error-controllable way. Concretely, it does the smoothing by approaching the newly produced curve to the linear tool path by taking the tolerance requirement as a constraint. That is, the error between the desired tool path and the G01 commands are taken as a boundary condition to ensure the finally smoothed curve being within the given tolerance. Besides, to improve the smoothing ability in case of small corner angle, an improved local smoothing method is also proposed by symmetrically assigning the control points to the two adjacent linear segments with the constrains of tolerance and G3 continuity. Experiments on an open five-axis machine are developed to verify the advantages of the proposed methods. | Min WAN Wan-Jing XING Yang LIU Qun-Bao XIAO Wei-Hong ZHANG | 2019 | Chinese Journal of Aeronautics2019，32，7： | 3 |
| 18 | Solution-processable graphene mesh transparent electrodes for organic solar cells显示文摘有好电导率和透明性的 Graphene 网孔电极(GME ) 被标准工业影印石版术和 O2 血浆蚀刻过程用 graphene 答案制作了。器官光电( OPV )用 GME 的房间作为有poly-( 3-hexylthiophene )的混合的透明电极, /phenyl-C61-butyric 酸甲基酉旨( P3HT/PC61BM )作为活跃的层被制作了并且展出2.04%的力量变换效率( PCE ),为透明基于电极的太阳能电池迄今为止报导了的处理答案的 graphene 的最高的 PCE 。 | Qian Zhang Xiangjian Wan Fei Xing Lu Huang Guankui Long Ningbo Yi Wang Ni Zhibo Liu Jianguo Tian Yongsheng Chen | 2013 | Nano Research2013，6，7： | 3 |
| 19 | Divergence-degenerate spatial multiplexing towards future ultrahigh capacity,low error-rate optical communications显示文摘Spatial mode(de)multiplexiing of orbital angular momentum(OAM)beams is a promising solution to address future bandwidth issues,but the rapidly increasing divergence with the mode order severely limits the practically addressable number of OAM modes.Here we present a set of multi-vortex geometric beams(MVGBs)as high-dimensional information carriers for free-space optical communication,by virtue of three independent degrees of freedom(DoFs)including central OAM,sub-beam OAM,and coherent-state phase.The novel modal basis set has high divergence degeneracy,and highly consistent propagation behaviors among all spatial modes,capable of increasing the addressable spatial channels by two orders of magnitude than OAM basis as predicted.We experimentally realize the tri-DoF MVGB mode(de)multiplexing and data transmission by the conjugated modulation method,demonstrating lower error rates caused by center offset and coherent background noise,compared with OAM basis.Our work provides a potentially useful basis for the next generation of large-scale dense data communication. | Zhensong Wan Yijie Shen Zhaoyang Wang Zijian Shi Qiang Liu Xing Fu | 2022 | Light(Science & Applications)2022，11，6： | 3 |
| 20 | Fabrication and biocompatible characterization of magnetic hollow capsules显示文摘Monodispersed Fe3O4/polypyrrole (PPy ) 空粒子被综合经由可控制在原处 poly 使用的免职和聚合技术(styrene-co-acrylic )(PSA ) 乳胶是模板。地依赖者磁化阴谋说明囊是在 300 K 的 superparamagnetic。FTIR 光谱证实实质上在 Fe3O4/PPy 空粒子的表面上吸附的肌球素(Mb ) 分子保留它的本国的结构。而且, Mb 的直接电气化学能在 Fe3O4/PPy 囊上被认识到修改了 pyrolytic 石墨磁盘电极,它显示磁性的传导性的聚合物囊能支持蛋白质的电子转移。 | Hong Zhang Xing Long Gong Ling Yun Hao Wan Quan Jiang | 2008 | Chinese Chemical Letters2008，19，7： | 3 |
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