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| 1 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 2 | Dynamic Modeling and Experiment of a New Type of Parallel Servo Press Considering Gravity Counterbalance显示文摘The large capacity servo press is traditionally realized by means of redundant actuation,however there exist the over-constraint problem and interference among actuators,which increases the control difficulty and the product cost.A new type of press mechanism with parallel topology is presented to develop the mechanical servo press with high stamping capacity.The dynamic model considering gravity counterbalance is proposed based on the virtual work principle,and then the effect of counterbalance cylinder on the dynamic performance of the servo press is studied.It is found that the motor torque required to operate the press is a lot less than the others when the ratio of the counterbalance force to the gravity of ram is in the vicinity of 1.0.The stamping force of the real press prototype can reach up to 25 MN on the position of 13 mm away from the bottom dead center.The typical deep-drawing process with 1200 mm stroke at 8 strokes per minute is proposed by means of five order polynomial.On this process condition,the driving torques are calculated based on the above dynamic model and the torque measuring test is also carried out on the prototype.It is shown that the curve trend of calculation torque is consistent to the measured result and that the average error is less than 15%.The parallel mechanism is introduced into the development of large capacity servo press to avoid the over-constraint and interference of traditional redundant actuation,and its dynamic characteristics with gravity counterbalance are presented. | HE Jun GAO Feng BAI Yongjun WU Shengfu | 2013 | Chinese Journal of Mechanical Engineering2013，26，6： | 4 |
| 3 | Selection of water source for water transfer based on algal growth potential to prevent algal blooms显示文摘Water transfer is becoming a popular method for solving the problems of water quality deterioration and water level drawdown in lakes. However, the principle of choosing water sources for water transfer projects has mainly been based on the effects on water quality, which neglects the influence in the variation of phytoplankton community and the risk of algal blooms. In this study, algal growth potential(AGP) test was applied to predict changes in the phytoplankton community caused by water transfer projects. The feasibility of proposed water transfer sources(Baqing River and Jinsha River) was assessed through the changes in both water quality and phytoplankton community in Chenghai Lake, Southwest China. The results showed that the concentration of total nitrogen(TN) and total phosphorus(TP) in Chenghai Lake could be decreased to 0.52 mg/L and 0.02 mg/L respectively with the simulated water transfer source of Jinsha River. The algal cell density could be reduced by 60%, and the phytoplankton community would become relatively stable with the Jinsha River water transfer project, and the dominant species of Anabaena cylindrica evolved into Anabaenopsis arnoldii due to the species competition. However, the risk of algal blooms would be increased after the Baqing River water transfer project even with the improved water quality. Algae gained faster proliferation with the same dominant species in water transfer source. Therefore, water transfer projects should be assessed from not only the variation of water quality but also the risk of algal blooms. | Yongjun Song Jing Qi Le Deng Yaohui Bai Huijuan Liu Jiuhui Qu | 2021 | Journal of Environmental Sciences2021，33，5： | 3 |
| 4 | Ordered arrays of semi-crown ligands on an Au(111) electrode surface: in situ STM study显示文摘In situ scanning tunneling microscopy (STM) and cyclic voltammetry were employed to investigate the adsorption structures of three semi-crown ligands on an Au(111) surface under the potential control. It is found that all the molecules formed ordered arrays in 0.1 mol/L HClO4 solution, although their geometric structures are complex and asymmetric. The driving force was supposed to come from the balance between intermolecular and molecule-substrate interactions. High resolution STM images revealed internal molecular structures, orientations and packing arrangements in the ordered adlayers. The results are useful for preparing ordered arrays of transition metal-mediated nanostructures. | PAN Gebo LI Huijing YUAN Qunhui CHEN Yongjun WAN Lijun BAI Chunli | 2004 | Science China Chemistry2004，47，4： | 1 |
| 5 | Effects of grain boundary diffusion of PrCu alloy on microstructure and coercivity of hot deformed(Nd,Ce)-Fe-B magnets显示文摘The technology of using high abundance rare earth element Ce in permanent magnets has attracted many concerns.In this work,the magnetic properties and microstructures of hot deformed(Nd_(1-x)Ce_(x))_(13.8)Fe_(76.1)Co_(4)Ga_(0.5)B_(5.6) magnets and a selective magnet treated with PrCu grain boundary diffusion process(GBDP) were investigated systematically.It is found that Ce is beneficial to improving the plastic deformation ability of NdFeB magnets.The strongest c-axis orientation is achieved in the HD magnets with Ce concentration of x=0.3,resulting in good comprehensive magnetic properties of B_(r)=13.00 kGs,H_(cj)=10.12 kOe,(BH)_(max)=38.42 MGOe.Based on that,the GBDP was implemented on the magnets with the best orientation using Pr_(68)Cu_(32) ribbons and the magnetic properties of B_(r)=12.87 kGs,H_(cj)=15.65 kOe,(BH)_(max)=37.48 MGOe were obtained.The results of composition distribution and Curie temperature test of the GBDPed magnets illustrate that Pr diffuses into the(Nd,Ce)_(2)(Fe,Co)_(14)B grains to substitute Ce,which not only improves the Curie temperature of the grains,but also enhances the magnetic performance of the magnets.Through GBDP,the thermal stability of magnets has also been improved. | Haijun Peng Dunbo Yu Xinyuan Bai Xiao Lin Yongjun Mao Zilong Wang Yang Luo | 2021 | Journal of Rare Earths2021，39，8： | 1 |
| 6 | Heat-treated glassy carbon under pressure exhibiting superior hardness,strength and elasticity显示文摘Glassy carbon(GC)is a type of non-graphitizing disordered carbon material at ambient pressure and high temperatures,which has been widely used due to its excellent mechanical properties.Here we report the changes in the microstructure and mechanical properties of GC treated at high pressures(up to 5 GPa)and high temperatures.The formation of intermediate sp2-sp3 phases is identified at moderate treatment temperatures before the complete graphitization of GC,by analyzing synchrotron X-ray diffraction,Raman spectra,and transmission electron microscopy images.The intermediate metastable carbon materials exhibit superior mechanical properties with hardness reaching up to 10 GPa and compressive strength reaching as high as 2.5 GPa,nearly doubling those of raw GC,and improving elasticity and thermal stability.The synthesis pressure used in this study can be achieved in the industry on a commercial scale,enabling the scalable synthesis of this type of strong,hard,and elastic carbon materials. | Meng Hu Shuangshuang Zhang Bing Liu Yingju Wu Kun Luo Zihe Li Mengdong Ma Dongli Yu Lingyu Liu Yufei Gao Zhisheng Zhao Yoshio Kono Ligang Bai Guoyin Shen Wentao Hu Yang Zhang Ralf Riedel Bo Xu Julong He Yongjun Tian | 2021 | Journal of Materiomics2021，7，1： | 1 |
| 7 | Incomplete β-Ketone Processing as a Mechanism for Polyene Structural Variation in the FR-008/Candicidin Complex显示文摘 | Yongjun Zhou Jialiang Li Jing Zhu Shi Chen Linquan Bai Xiufen Zhou Houming Wu Zixin Deng | 2008 | Chemistry & Biology2008，，： | 1 |
| 8 | Partially charged single-atom Ru supported on ZrO_(2) nanocrystals for highly efficient ethylene hydrosilylation with triethoxysilane显示文摘Homogeneous noble metal catalysts used in alkene hydrosilylation reactions to manufacture organosilicon compounds commercially often suffer from difficulties in catalyst recovering and recycling,undesired disproportionation reactions,and energyintensive purification of products.Herein,we report a heterogeneous 0.5Ruδ+/ZrO_(2) catalyst with partially charged single-atom Ru(0.5 wt.%Ru)supported on commercial ZrO_(2) nanocrystals synthesized by the simple impregnation method followed by H2 reduction.When used in the ethylene hydrosilylation with triethoxysilane to produce the desired ethyltriethoxysilane,0.5Ruδ+/ZrO_(2) showed excellent catalytic performance with the maximum Ru atom utilization and good recyclability,even superior to homogeneous catalyst(RuCl3·H2O).Structural characterizations and density functional theory calculations reveal the atomic dispersion of the active Ru species and their unique electronic properties distinct from the homogeneous catalyst.The reaction route over this catalyst is supposed to follow the typical Chalk-Harrod mechanism.This highly efficient and supported singleatom Ru catalyst has the potential to replace the current homogeneous catalyst for a greener hydrosilylation industry. | Mingyan Li Shu Zhao Jing Li Xiao Chen Yongjun Ji Haijun Yu Dingrong Bai Guangwen Xu Ziyi Zhong Fabing Su | 2022 | Nano Research2022，15，7： | 0 |
| 9 | Nucleolus localization of SpyCas9 affects its stability and interferes with host protein translation in mammalian cells显示文摘The CRISPR/Cas9 system,originally derived from the prokaryotic adaptive immune system,has been developed as efficient genome editing tools.It enables precise gene manipulation on chromosomal DNA through the specific binding of programmable sgRNA to target DNA,and the Cas9 protein,which has endonuclease activity,will cut a double strand break at specific locus.However,Cas9 is a foreign protein in mammalian cells,and the potential risks associated with its introduction into mammalian cells are not fully understood.In this study,we performed pull-down and mass spectrometry(MS)analysis of Streptococcus pyogenes Cas9(SpyCas9)interacting proteins in HEK293T cells and showed that the majority of Cas9-associated proteins identified by MS were localized in the nucleolus.Interestingly,we further discovered that the Cas9 protein contains a sequence encoding a nucleolus detention signal(NoDS).Compared with wild-type(WT)Cas9,NoDS-mutated variants of Cas9(mCas9)are less stable,although their gene editing activity is minimally affected.Overexpression of WT Cas9,but not mCas9,causes general effects on transcription and protein translation in the host cell.Overall,identification of NoDS in Cas9 will improve the understanding of Cas9's biological function in vivo,and the removal of NoDS in Cas9 may enhance its safety for future clinical use. | Renke Tan Wenhao Du Yiyang Liu Xiaoji Cong Meirong Bai Chenxiao Jiang Zengxia Li Minjia Tan Dengke K.Ma Qiang Huang Wei Jiang Yongjun Dang | 2022 | Genes & Diseases2022，9，3： | 0 |
| 10 | GmNMHC5 may promote nodulation via interaction with GmGAI in soybean显示文摘Soybean(Glycine max[L.]Merr.)is a food and oil crop whose growth and yield are influenced by root and nodule development.In the present study,Gm NMHC5 was found to promote the formation of nodules in overexpressing mutants.In contrast,the number of nodules in Gmnmhc5 edited with CRISPR/Cas9 decreased sharply.In 35 S:Gm NMHC5 mutants,expression levels of genes involved in nodulation were significantly up-regulated.Both in vitro and in vivo biochemical analyses showed that Gm NMHC5 directly interacted with Gm GAI(a DELLA protein),and the content of gibberellin 3(GA_(3))in overexpressing mutants was lower than that in the wild type.These results revealed that Gm NMHC5 participates in the classical GA signaling pathway,and may regulate the content of GA_3 to match the optimal concentration required for nodule formation,thereby promoting nodulation by directly interacting with Gm GAI.A model illustrating the mechanism by which Gm NMHC5 promotes soybean nodulation is presented. | Wenting Wang Zhili Wang Wensheng Hou Li Chen Bingjun Jiang Wenya Ma Lijuan Bai Wenwen Song Cailong Xu Tianfu Han Yongjun Feng Cunxiang Wu | 2022 | The Crop Journal2022，10，1： | 0 |
| 11 | Pyrolysis of Rice Husk in a Fluidized Bed Reactor:Evaluate the Characteristics of Fractional Bio-Oil and Particulate Emission of Carbonaceous Aerosol(CA)显示文摘Bio-oil production via pyrolysis is one of promising technologies for renewable energy production from bio-wastes.However,the complicated biooil is still a challenge for high-valued application and during biomass pyrolysis,the emission of non-cleaned aerosol,the potential emission,namely carbonaceous aerosol(CA)increased the difficulty of the commercial promotion.In this study,Rice husk pyrolysis was performed in a semi-continuous fluidized bed reactor coupled with fractional condensers.The effects of pyrolysis and condensation temperature on the properties of bio-oil and emission of CAwere investigated systemically.Results indicated that the in-situ separation of vapors was accomplished via condensers of different temperatures(85℃and−10℃).The bio-oil with different physiochemical properties were obtained in the high content of phenols and lower acids of BO1 and high content of acids and better liquidity.The size distribution of CA was found primarily classified as sub-micrometer grade particles,which have a diameter of less than 1.1μm.In particular,CA existed in three representative forms:bead,granular aggregate,and liquidoid.The results of light absorption of total organic carbon(TOC)and non-volatile organic carbon(NVOC)indicated that the absorption per mass increased in the single temperature with the decrement of wavelength and it improved as the pyrolysis temperature increased at the specified wavelength.The absorption per mass was to maximum value(3.7 m^(2)/g)at 360 nm wavelength and 600℃.TOC demonstrated a strong light absorption and a wide spectral range dependence(AAE:5.08-10.05)which enhanced the light absorption in the ultra-violet and low-visible regions. | Ning Li Weiming Yi Zhihe Li Lihong Wang Yongjun Li Xueyuan Bai Mei Jiang | 2020 | Journal of Renewable Materials2020，8，3： | 0 |
| 12 | Attenuation of Chlorinated Contamination in Three Different Depths of Aquifers at Remediation Site显示文摘The cleanup of carbon tetrachloride(CCl4)in groundwater is challenging due to its high volatility and tendency to form a dense nonaqueous liquid phase.From the engineering applications perspective,the pump-and-treat(PAT)technology has substantial advantages owing to its large-scale implementation ability to solve groundwater contamination.However,few studies focused on the variation in chloride contaminants in remediation sites after the contaminated groundwater was pumped and treated.Herein,we monitored the changes in chlorinated contamination in groundwater from 12 aquifers at the field level for 6 months.Considering that the natural attenuation of chlorinated contamination is inseparable from the action of microorganisms,the major environmental factors influencing biodegradation were also evaluated.A redundancy analysis(RDA)showed that inorganic salts(DS,DN,and DF)were the most important factor(>60%)affecting the concentration of chloride contaminants,including the negative correlation between DN and the degradation of contaminants in shallow aquifers.In deep aquifers,DS,DF,and pH explained most of the degradation of chloride contaminants.For bedrock layers,DCl was positively relevant to the chloride contaminants in wells PTJ2 and PTJ10.In addition,EC and DS accounted for 73.2%and 92.4%of the contaminant’s variance in wells PTJ4 and PTJ8,respectively.Moreover,the concentrations of the corresponding contaminations and physicochemical variation in three different depths of aquifers were compared;the shallower aquifers showed a higher biodegradation.The in situ monitoring and analysis of contaminated groundwater in remediation sites under PAT will promote practical wastewater treatment technologies in engineering applications. | Sun Shaodong Li Weisi Huang Yongjun Jiang Qing Bai Yu Wang Kunhua Xue Jianliang Wang Bo Yan Dongdong Xu Conghai | 2023 | China Petroleum Processing & Petrochemical Technology2023，25，1： | 0 |
| 13 | Experimental evidence of surface copper boride显示文摘To validate the crystal structure and elucidate the formation mechanism of the unexpected surface copper boride,a systematic scanning tunneling microscope,X-ray photoelectron spectroscopy,angle-resolved photoemission spectroscopy,and aberrationcorrected scanning transmission electron microscopy investigations were conducted to confirm the structure of copper-rich boride Cu_(8)B_(14)after depositing boron on single-crystal Cu(111)surface under ultrahigh vacuum.First-principles calculations with defective surface models further indicate that boron atoms tend to react with Cu atoms near terrace edges or defects,which in turn shapes the intermediate structures of copper boride and leads to the formation of stable Cu-B monolayer via large-scale surface reconstruction eventually. | Xiao-Ji Weng Jie Bai Jingyu Hou Yi Zhu Li Wang Penghui Li Anmin Nie Bo Xu Xiang-Feng Zhou Yongjun Tian | 2023 | Nano Research2023，16，7： | 0 |
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