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| 1 | World-class Xincheng gold deposit: An example from the giant Jiaodong gold province显示文摘The Jiaodong gold deposits are currently the most important gold resources(with Au reserves of>4000 t) in China,and the leading gold-producing country globally(with Au production of ~428 t in2013).Jiaodong is also considered as perhaps the only world-class to giant gold accumulation on the planet where relatively young gold ores(ca.130-120 Ma) were deposited in rocks that are 2 Ga older.The Xincheng world-class high-grade gold deposit,with a proven reserve of >200 t gold,is one of the largest deposits in the giant gold province of the Jiaodong Peninsula.It is located in the northwestern part of the jiaobei Uplift,and hosted by ca.132-123 Ma Xincheng quartz monzonites and monzogranites.Ore zones are structurally controlled by the NE-trending and NW-dipping Jiaojia Fault and subsidiary faults,and are mainly restricted to the footwall of the fault.The dominant disseminated- and stockworkstyle ores are associated with strong sericitization,silicification,sulfidation and K-feldspathization,and minor carbonate wallrock alteration halos.The four mineralization stages are pyrite-quartz-sericite(stage 1),quartz-pyrite(stage 2),quartz-polysulfide(stage 3) and quartz-carbonate(stage 4).Gold occurs dominantly as electrum,with lesser amounts of sulfide-hosted native gold and rare native silver and argentite,normally associated with pyrite,chalcopyrite,galena and sphalerite:the latter with proven resources of about 105 t Ag,713 t Cu,and 5100 t S.There are three types of ore-related fluid inclusions:type 1 aqueous-carbonate(H_2O-CO_2),type 2aqueous(liquid H_2O+vapor H_2O),and type 3 CO_2(liquid CO_2 and vapor CO_2) inclusions.Homogenization temperatures range from 221 to 304℃ for type 1 inclusions,with salinities of 2.4-13.3 wt.%NaCl eq.,and bulk densities of 0.858-1.022 g/cm^3.The δ^(34)S_(CDT) values of hydrothermal sulfides are 4.3-10.6‰and δ^(18)O values of hydrothermal quartz have a median value of 13.0‰.δD values of fluid inclusions in hydrothermal quartz have a median value of-75‰.Calculated δ^(18)Owater has a median value of 5.2‰.The timing of gold mineralization at the Xincheng gold deposit is younger than 123±1 Ma,and likely between 120.9 and 119.9 Ma.A minerals system genetic model for the probable epizonal orogenic Xincheng deposit suggests an initial medium temperature,CO_2-rich,and low salinity H_2O-CO_2 deeply sourced metamorphic ore fluid associated with dehydration and decarbonization of subducting Paleo-Pacific lithosphere.The Jiaojia Fault constrained the migration of ore-forming fluids and metals at the brittle-ductile transition.Fluid immiscibility,caused by episodic pressure drops,led to significant high-grade gold deposition in the giant Xincheng gold deposit. | Liqiang Yang Jun Deng Ruipeng Guo Lin'nan Guo Zhongliang Wang Binghan Chen XudongWang | 2016 | Geoscience Frontiers2016，7，3： | 14 |
| 2 | Water regime-nitrogen fertilizer incorporation interaction:Field study on methane and nitrous oxide emissions from a rice agroecosystem in Harbin, China显示文摘Water regime and nitrogen(N) fertilizer are two important factors impacting greenhouse gases(GHG) emission from paddy field, whereas their effects have not been well studied in cold region. In this study, we conducted a two-year field experiment to study the impacts of water regime and N fertilizer on rice yields and GHG emissions in Harbin, China, a cold region located in high latitudes. Our results showed that intermittent irrigation significantly decreased methane(CH_4) emission compared with continuous flooding, however,the decrement was far lower than the global average level. The N_2O emissions were very small when flooded but peaked at the beginning of the disappearance of floodwater. The N fertilizer treatments increased CH_4 emissions at low level(75 kg N/ha). But both CH_4 and N_2O emissions were uninfluenced at the levels of 150 kg N/ha and 225 kg N/ha. Rice yields increased under intermittent irrigation and were highest at the level of 150 kg N/ha. From our results, we recommended that the intermittent irrigation and 150 kg N/ha as the ideal water regime-nitrogen fertilizer incorporation for this area to achieve low GHG emissions without impacting rice yields. | Wenjun Dong Jia Guo Lijun Xu Zhifeng Song Jun Zhang Ao Tang Xijuan Zhang Chunxu Leng Youhong Liu Lianmin Wang Lizhi Wang Yang Yu Zhongliang Yang Yilei Yu Ying Meng Yongcai Lai | 2018 | Journal of Environmental Sciences2018，30，2： | 12 |
| 3 | Downregulation of LINC01296 suppresses non-small-cell lung cancer via targeting miR-143-3p/ATG2B显示文摘The 5-year survival rate of lung cancer is one of the lowest among various malignant tumors.Long noncoding RNAs(lncRNAs),noncoding RNAs longer than 200 nucleotides,can function either as tumor suppressors or as oncogenes.The aim of this study is to investigate the function of lncRNA LINC01296 and its molecular mechanism in non-small-cell lung cancer(NSCLC).According to the Gene Expression Omnibus database,10 differentially expressed lncRNAs in NSCLC cells and patient tissues are upregulated.LINC01296 is the one with the most significant overexpression.Knockdown of LINC01296 inhibits the growth and migration,arrests the cell cycle,and promotes the apoptosis of NSCLC cells.Knocking down LINC01296 in vivo suppresses tumor growth and metastasis.LINC01296 also acts as the sponge of miR-143-3p.Lowering the expression of LINC01296 leads to decreased expression of autophagy-related 2B,ATG2B,a target gene of miR-143-3p.Moreover,downregulation of LINC01296 promotes paclitaxel sensitivity in NSCLC.These results demonstrated that the LINC01296/miR-143-3p/ATG2B axis is crucial in promoting the development of NSCLC and paclitaxel resistance.Our study may provide new ideas for the further research of clinical chemotherapy of NSCLC in the near future. | Yanli Li Hui Zhang Jing Guo Wanqiu Li Xianyi Wang Caiyan Zhang Qiangling Sun Zhongliang Ma | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 8 |
| 4 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 5 | Chimeric classical swine fever (CSF)-Japanese encephalitis (JE) viral replicon as a non-transmissible vaccine candidate against CSF and JE infections显示文摘 | Zhenhua Yang Rui Wu Robert W. Li Ling Li Zhongliang Xiong Haizhong Zhao Deyin Guo Zishu Pan | 2012 | Virus Research2012，，1： | 2 |
| 6 | Influencing factors on local reduction of graphene oxide with a heated AFM tip显示文摘In this paper,the factors influencing the local thermal reduction of graphene oxide (GO) sheets are investigated.The lateral force microscopy and scanning polarization force microscopy verify that the heated tips of atomic force microscope (AFM) can thermally reduce the GO into electrical conductive nanostructures.The tip temperature,heating time,and loading force applied by the AFM tip are found to have important effects on the thermal reduction of GO,while the environmental humidity is negligible. | WU Zhongliang SHEN Yue ZHOU Xingfei GUO Shouwu ZHANG Yi | 2011 | Nuclear Science and Techniques2011，22，4： | 1 |
| 7 | The Philosophical Basis of Social Turning of Embodied Cognition From the Perspective of Symbolic Interactionism显示文摘Since the 1990s,embodied cognition has become the research trend of cognitive science.Due to excessive attention to embodiment and the physical environment,embodied cognition does not pay more attention to the social characteristics of cognition,especially the role of others and symbolic activities,making cognitive science research unable to get rid of solipsism.So,it is difficult for the embodied cognition to explain the uniformity and multiplicity of cognition,and the problem of“other”mind.To solve these problems,the paper expounds the relations between symbolic interactionism and embodied cognition and the necessity of social turning in embodied cognition.Through analyzing the thoughts of George H.Mead about cognition and the influence of his symbolic interactionism on embodied cognition,as well as discussing Mark Johnson’s view on social interactional aspects of embodied cognition,we emphasize that the social and symbolic interactions are indispensable factors of embodied cognition.The paper argues that higher-order cognition comes out of symbolic interactions;cognition generates from posture dialogue interaction and manifests itself through attitude;intersubjectivity is closely associated with symbolic interactionism.Therefore,studying the relations between symbolic interactionism and embodied cognition helps overcome the solipsism or individualism of embodied cognition,and accordingly contributes to the social turning of embodied cognition. | Xin Chang Huili Wang Dan Guo Zhongliang Cui | 2018 | Journal of Philosophy Study2018，8，7： | 0 |
| 8 | The role of noncoding RNAs in the tumor microenvironment of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the leading fatal malignancy worldwide.The tumor microenvironment(TME)can affect the survival,proliferation,migration,and even dormancy of cancer cells.Hypoxia is an important component of the TME,and hypoxia-inducible factor-1α(HIF-1α)is the most important transcriptional regulator.Noncoding RNAs(ncRNAs),including microRNAs(miRNAs),long noncoding RNAs(lncRNAs),and circular RNAs(circRNAs),comprise a large part of the human transcriptome and play an important role in regulating the tumorigenesis of HCC.This review discusses the role of ncRNAs in hepatocarcinogenesis,epithelial-mesenchymal transition(EMT),and angiogenesis in a hypoxic microenvironment,as well as the interactions between ncRNAs and key components of the TME.It further discusses their use as biomarkers and the potential clinical value of drugs,as well as the challenges faced in the future. | Qianqian Yang Hui Tian Ziyi Guo Zhongliang Ma Guangzhi Wang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，11： | 0 |
| 9 | Function approximation reinforcement learning of energy management with the fuzzy REINFORCE for fuel cell hybrid electric vehicles显示文摘In the paper,a novel self-learning energy management strategy(EMS)is proposed for fuel cell hybrid electric vehicles(FCHEV)to achieve the hydrogen saving and maintain the battery operation.In the EMS,it is proposed to approximate the EMS policy function with fuzzy inference system(FIS)and learn the policy parameters through policy gradient reinforcement learning(PGRL).Thus,a so-called Fuzzy REINFORCE algorithm is first proposed and studied for EMS problem in the paper.Fuzzy REINFORCE is a model-free method that the EMS agent can learn itself through interactions with environment,which makes it independent of model accuracy,prior knowledge,and expert experience.Meanwhile,to stabilize the training process,a fuzzy baseline function is adopted to approximate the value function based on FIS without affecting the policy gradient direction.More-over,the drawbacks of traditional reinforcement learning such as high computation burden,long convergence time,can also be overcome.The effectiveness of the proposed methods were verified by Hardware-in-Loop ex-periments.The adaptability of the proposed method to the changes of driving conditions and system states is also verified. | Liang Guo Zhongliang Li Rachid Outbib Fei Gao | 2023 | Energy and AI2023，13，3： | 0 |
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