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| 1 | Current status of severe fever with thrombocytopenia syndrome in China显示文摘Severe fever with thrombocytopenia syndrome(SFTS) is an emerging infectious disease caused by SFTS virus(SFTSV). SFTSV is associated with a high mortality rate and has been reported in China, South Korea and Japan. SFTSV undergoes rapid changes owing to evolution, gene mutations, and reassortment between different strains of SFTSV. In this review, we summarize the recent cases and general properties of SFTS, focusing on the epidemiology, genetic diversity,clinical features, and diagnostics of SFTSV in China. From 2010 to October 2016, SFTS cases were reported in 23 provinces of China, with increased numbers yearly. Infection and death cases are mainly found in central China, where the Haemaphysalis longicornis ticks are spread. The national average mortality rate of SFTS infection was 5.3%, with higher risk to elder people. The main epidemic period was from May to July, with a peak in May. Thus, SFTS reminds a significant public health problem, and development of prophylactic vaccines and effective antiviral drugs will be highly needed. | Jianbo Zhan Qin Wang Jing Cheng Bing Hu Jing Li Faxian Zhan Yi Song Deyin Guo | 2017 | Virologica Sinica2017，32，1： | 71 |
| 2 | 三种印尼油砂燃烧特性研究显示文摘采用热重分析方法研究油砂的燃烧特性。在升温速率分别为10,20,50℃/min条件下,得到了油砂燃烧失重(thermogravimetric,TG)、微商失重(differential thermogravimetric,DTG)曲线。基于TG-DTG曲线,求得了油砂燃烧特性参数,考查了加热速率、粒径对燃烧特性的影响。采用单个扫描速率法中常用的CR法和多重扫描速率法中FWO法以及DEAM法求解了油砂的燃烧动力学参数,研究结果表明:油砂具有着火容易、着火温度低、燃烧高温段反应比较强烈等燃烧特性。油砂燃烧分为3个阶段:燃烧低温段、过渡段、高温段。这3种模型的拟合度都很高,C-R法结果表明油砂燃烧不同反应阶段可用不同的反应级数来描述;DEAM和FWO法结果能更好地反映油砂燃烧的瞬时性,活化能在燃烧低温段和高温段逐渐增加,活化能在燃烧过渡段变化较为平缓。 | 王擎 王引 贾春霞 Deyin Wu | 2012 | 中国电机工程学报2012，32，26： | 16 |
| 3 | Molecular mechanisms of coronavirus RNA capping and methylation显示文摘The 5′-cap structures of eukaryotic m RNAs are important for RNA stability, pre-m RNA splicing,m RNA export, and protein translation. Many viruses have evolved mechanisms for generating their own cap structures with methylation at the N7 position of the capped guanine and the ribose 2′-Oposition of the first nucleotide, which help viral RNAs escape recognition by the host innate immune system. The RNA genomes of coronavirus were identified to have 5′-caps in the early1980 s. However, for decades the RNA capping mechanisms of coronaviruses remained unknown.Since 2003, the outbreak of severe acute respiratory syndrome coronavirus has drawn increased attention and stimulated numerous studies on the molecular virology of coronaviruses. Here, we review the current understanding of the mechanisms adopted by coronaviruses to produce the 5′-cap structure and methylation modification of viral genomic RNAs. | Yu Chen Deyin Guo | 2016 | Virologica Sinica2016，31，1： | 14 |
| 4 | The functions of tumor suppressor PTEN in innate and adaptive immunity显示文摘The tumor suppressor phosphatase and tensin homolog(PTEN)is a lipid and protein phosphatase that is able to antagonize the PI3K/AKT pathway and inhibit tumor growth.PTEN also possesses phosphatase-independent functions.Genetic alterations of PTEN may lead to the deregulation of cell proliferation,survival,differentiation,energy metabolism and cellular architecture and mobility.Although the role of PTEN in tumor suppression is extensively documented and well established,the evidence for its roles in immunity did not start to accumulate until recently.In this review,we will focus on the newly discovered functions of PTEN in the regulation of innate and adaptive immunity,including antiviral responses. | Lang Chen Deyin Guo | 2017 | Cellular & Molecular Immunology2017，14，7： | 12 |
| 5 | Distribution and deposition of polycyclic aromatic hydrocarbons in precipitation in Guangzhou, South China显示文摘Polycyclic aromatic hydrocarbons (PAHs) were measured in precipitation from March to August 2005 in Guangzhou, South China. Fourteen PAHs were studied, and their total concentrations varied from 616.6 to 3486.7 ng/L in dissolved phase and from 403.8 to 3125.5 ng/L in particulate phase. The estimated deposition loading of PAHs was 3568 μg/m2 during the monitoring period. The deposition of PAHs was a potential source for Pearl River comparing with the contents of surface water. In addition, the high concentration in precipitation here implied that PAHs pollution was a potential environmental problem in Guangzhou. Most precipitation concentrations of PAHs in March (the last month in winter in Guangzhou) were higher than in the other months (in rainy season). PAHs inclined to be adsorbed to particulate phase with the increase of molecular weight in rainwater. Combustion of fossil fuel and biomass might be the major source of PAHs, while the direct leakage or volatilization from petroleum products might be insignificant. | HUANG Deyin PENG Ping'an XU Yigang DENG Yunyun DENG Hongmei | 2009 | Journal of Environmental Sciences2009，21，5： | 9 |
| 6 | A study of electron-shuttle mechanism in Klebsiella pneumoniae based-microbial fuel cells显示文摘In microbial fuel cell (MFC), the rate of electron transfer to anode electrode is a key intrinsic limiting factor on the power output of MFCs. Using Klebsiella pneumoniae (K. pneumoniae) strain L17 as biocatalyst, we studied the mechanism of electron shuttle via self-producing mediator in a cubic air-chamber MFC. To eliminate the influence of biofilm mechanism, the anode electrode was coated with microfiltration membrane (0.22 μm). Data showed that the microfiltration membrane coated and uncoated MFCs achieved the maximum voltage outputs of 316.2 and 426.2 mV after 270 and 120 h, respectively. When the medium was replaced in MFCs that had the highest power generation, the power output dropped by 62.1% and 8.8%, and required 120 and 48 h to resume the original level in the coated and uncoated MFCs, respectively. The results suggested an electron-shuttle mechanism rather than biofilm mechanism was responsible for electricity generation in the membrane coated MFC. Cyclic voltammetric measurements demonstrated the presence of an electrochemical active compound produced by K. pneumoniae strain L17, which was identified to be 2,6-di-tert-butyl-p-benzoquinon (2,6-DTBBQ) by GC-MS. 2,6-DTBBQ, as a recyclable electron shuttle, could transfer electrons between K. pneumoniae L17 and the anode electrode. | DENG LiFang LI FangBai ZHOU ShunGui HUANG DeYin NI JinRen | 2010 | Chinese Science Bulletin2010，55，1： | 9 |
| 7 | Fabrication of asymmetric poly(m-phenylene isophthalamide)nanofiltration membrane for chromium(VI) removal显示文摘The feasibility of employing nanofiltration for the removal of chromium(VI) from wastewater was investigated. Poly (m-phenylene isophthalamide) (PMIA) was used to fabricate asymmetric nanofiltration membrane through the phase-inversion technique. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) were used to characterize the obtained membrane, and the both confirmed a much smoother surface which could reduce membrane fouling. The PMIA membrane showed different rejections to electrolytes in a sequence of Na2SO4 > MgSO4 > NaCl > MgCl2, which was similar to the sequence of the negatively charged nanofiltration membranes. Separation experiments on chromium(VI) solution were conducted at various operating conditions, such as feed concentration, applied pressure and pH. It is concluded that chromium(VI) could be effectively removed from chromiumcontaining wastewater by the PMIA nanofiltration membranes while maintaining their pollution resistance under alkaline condition. | Xiaojing Ren Changwei Zhao Songshan Du Tao Wang Zhaokun Luan Jun Wang Deyin Hou | 2010 | Journal of Environmental Sciences2010，22，9： | 9 |
| 8 | Fluoride removal from brackish groundwater by direct contact membrane distillation显示文摘The direct contact membrane distillation applied for fluoride removal from brackish groundwater was investigated.The self-prepared polyvinylidene fluoride membrane exhibited high rejection of inorganic salt solutes.The maximum permeate flux 35.6 kg/(m2 ·hr) was obtained with the feed solution at 80°C and the cold distillate water at 20°C.The feed concentration had no significant impact on the permeate flux and the rejection in fluoride.The precipitation of CaCO3 would clog the hollow fiber inlets and foul the membrane surface with increasing concentration factor when natural groundwater was used directly as the feed,which resulted in a rapid decline in the module efficiency.This phenomenon was diminished by acidification of the feed.The experimental results showed that the permeate flux and the quality of obtained distillate kept stable before concentration factor reached 5.0 with the acidified groundwater as feed.The membrane module efficiency began to decline gradually when the feed continued to be concentrated,which can be mainly attributed to the formation of CaF2 deposits on the membrane surface.In addition,a 300 hr continuous fluoride removal experiment of acidified groundwater was carried out with concentration factor at 4.0,the permeate flux kept stable and the permeate fluoride was not detected. | Deyin Hou Jun Wang Changwei Zhao Baoqiang Wang Zhaokun Luan Xiangcheng Sun | 2010 | Journal of Environmental Sciences2010，22，12： | 7 |
| 9 | Generation and manipulation of chiral terahertz waves in the three-dimensional topological insulator Bi2Te3显示文摘Arbitrary manipulation of broadband terahertz waves with flexible polarization shaping at the source has great potential in expanding numerous applications,such as imaging,information encryption,and all-optical coherent control of terahertz nonlinear phenomena.Topological insulators featuring unique spinmomentum-locked surface state have already exhibited very promising prospects in terahertz emission,detection,and modulation,which may lay a foundation for future on-chip topological insulator-based terahertz systems.However,polarization-shaped terahertz emitters based on topological insulators with an arbitrarily manipulated temporal evolution of the amplitude and the electric-field vector direction have not yet been explored.We systematically investigated the terahertz radiation from topological insulator Bi2Te3 nanofilms driven by femtosecond laser pulses and successfully realized the generation of efficient chiral terahertz waves with controllable chirality,ellipticity,and principal axis.The convenient engineering of the chiral terahertz waves was interpreted by a photogalvanic effect(PGE)-induced photocurrent,while the linearly polarized terahertz waves originated from linear PGE-induced shift currents.Our work not only provides further understanding of femtosecond coherent control of ultrafast spin currents but also describes an effective way to generate spin-polarized terahertz waves at the source. | Haihui Zhao Xinhou Chen Chen Ouyang Hangtian Wang Deyin Kong Peidi Yang Baolong Zhang Chun Wang Gaoshuai Wei Tianxiao Nie Weisheng Zhao Jungang Miao Yutong Li Li Wang Xiaojun Wu | 2020 | Advanced Photonics2020，2，6： | 6 |
| 10 | A novel selective autophagy receptor,CCDC50,delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection显示文摘Autophagy is a con served process that delivers cytosolic substa nces to the lysosome for degradatio n,but its direct role in the regulation of antiviral inn ate immu nity remains poorly un derstood.Here,through high-throughput screeni ng,we discovered that CCDC50 functions as a previously unknown autophagy receptor that negatively regulates the type I interferon(IFN)signaling pathway initiated by RIG-I-like receptors(RLRs),the sensors for RNA viruses.The expression of CCDC50 is enhanced by viral infection,and CCDC50 specifically recognizes K63-polyubiquitinated RLRs,thus delivering the activated RIG-I/MDA5 for autophagic degradation.The associatio n of CCDC50 with phagophore membrane protei n LC3 is con firmed by crystal structure analysis.In contrast to other known autophagic cargo receptors that associate with either the LIR-docking site(LDS)or the UIMdocking site(UDS)of LC3,CCDC50 can bind to both LDS and UDS,representing a new type of cargo receptor.In mouse models with RNA virus infection,CCDC50 deficiency reduces the autophagic degradation of RIG-I/MDA5 and promotes type I IFN responses,resulting in enhaneed viral resistance and improved survival rates.These results reveal a new link between autophagy and antiviral innate immune resp on ses and provide additional in sights into the regulatory mecha nisms of RLR-mediated antiviral signaling. | Panpan Hou Kongxiang Yang Penghui Jia Lan Liu Yuxin Lin Zibo Li Jun Li Shuliang Chen Shuting Guo Ji'An Pan Junyu Wu Hong Peng Weijie Zeng Chunmei Li Yingfang Liu Deyin Guo | 2021 | Cell Research2021，31，1： | 5 |
| 11 | Mass transfer characteristics in a rotating packed bed with split packing显示文摘The rotating packed bed(RPB) with split packing is a novel gas–liquid contactor, which intensifies the mass transfer processes controlled by gas-side resistance. To assess its efficacy, the mass transfer characteristics with adjacent rings in counter-rotation and co-rotation modes in a split packing RPB were studied experimentally.The physical absorption system NH3–H2O was used for characterizing the gas volumetric mass transfer coefficient(kyae) and the effective interfacial area(ae) was determined by chemical absorption in the CO2–NaO H system. The variation in kyaeand aewith the operating conditions is also investigated. The experimental results indicated that kyaeand aefor counter-rotation of the adjacent packing rings in the split packing RPB were higher than those for co-rotation, and both counter-rotation and co-rotation of the split packing RPB were superior over conventional RPBs under the similar operating conditions. | Youzhi Liu Deyin Gu Chengcheng Xu Guisheng Qi Weizhou Jiao | 2015 | Chinese Journal of Chemical Engineering2015，23，5： | 4 |
| 12 | Hydroxyl carboxylate based non-phosphorus corrosion inhibition process for reclaimed water pipeline and downstream recirculating cooling water system显示文摘A combined process was developed to inhibit the corrosion both in the pipeline of reclaimed water supplies(PRWS) and in downstream recirculating cooling water systems(RCWS)using the reclaimed water as makeup. Hydroxyl carboxylate-based corrosion inhibitors(e.g.,gluconate, citrate, tartrate) and zinc sulfate heptahydrate, which provided Zn^(2+)as a synergistic corrosion inhibition additive, were added prior to the PRWS when the phosphate(which could be utilized as a corrosion inhibitor) content in the reclaimed water was below 1.7 mg/L, and no additional corrosion inhibitors were required for the downstream RCWS.Satisfactory corrosion inhibition was achieved even if the RCWS was operated under the condition of high numbers of concentration cycles. The corrosion inhibition requirement was also met by the appropriate combination of PO_4^(3-) and Zn^(2+) when the phosphate content in the reclaimed water was more than 1.7 mg/L. The process integrated not only water reclamation and reuse, and the operation of a highly concentrated RCWS, but also the comprehensive utilization of phosphate in reclaimed water and the application of non-phosphorus corrosion inhibitors. The proposed process reduced the operating cost of the PRWS and the RCWS, and lowered the environmental hazard caused by the excessive discharge of phosphate. Furthermore, larger amounts of water resources could be conserved as a result. | Jun Wang Dong Wang Deyin Hou | 2016 | Journal of Environmental Sciences2016，28，1： | 4 |
| 13 | Fabrication of PVDF nanofibrous hydrophobic composite membranes reinforced with fabric substrates via electrospinning for membrane distillation desalination显示文摘To improve the mechanical properties of the electrospun nanofibrous membrane, the nonwoven fabrics and spacer fabrics were employed as support substrates to fabricate polyvinylidene fluoride(PVDF) nanofibrous composite membranes. The influences of the substrate on membrane morphology, hydrophobicity, pore size and pore size distribution,porosity, mechanical strength and permeability were comprehensive evaluated. The electrospun composite membranes had a three dimension bead-fiber interconnected open structure and a rough membrane surface. The membrane surface presented a multilevel re-entrant structure and all the water contact angles were above 140°. In contrast with the pure PVDF nanofibrous membrane, the stress at break and the elastic modulus of the composite membranes increased by 4.5–16 times and 17.5–37 times, respectively. Since the spacer fabrics had less resistance to mass transfer, the membranes composited with spacer fabrics exhibited greater permeate fluxes compared with the composite membranes with the nonwoven fabrics as substrates.During the membrane distillation test, the highest permeate flux was up to 49.3 kg/m^2/hr at the feed temperature of 80°C. The long-time and repeat operation of membrane distillation desalination indicated the fabricated membrane with a good resistance to scaling and wetting.The results suggested the potential of the electrospun composite membrane for membrane distillation application. | Kuiling Li Deyin Hou Chaochen Fu Kai Wang Jun Wang | 2019 | Journal of Environmental Sciences2019，31，1： | 4 |
| 14 | Adaptive Attitude Control for Multi-MUAV Systems With Output Dead-Zone and Actuator Fault显示文摘Many mechanical parts of multi-rotor unmanned aerial vehicle(MUAV)can easily produce non-smooth phenomenon and the external disturbance that affects the stability of MUAV.For multi-MUAV attitude systems that experience output dead-zone,external disturbance and actuator fault,a leader-following consensus anti-disturbance and fault-tolerant control(FTC)scheme is proposed in this paper.In the design process,the effect of unknown nonlinearity in multi-MUAV systems is addressed using neural networks(NNs).In order to balance out the effects of external disturbance and actuator fault,a disturbance observer is designed to compensate for the aforementioned negative impacts.The Nussbaum function is used to address the problem of output dead-zone.The designed fault-tolerant controller guarantees that the output signals of all followers and leader are synchronized by the backstepping technique.Finally,the effectiveness of the control scheme is verified by simulation experiments. | Guowei Dong Liang Cao Deyin Yao Hongyi Li Renquan Lu | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，9： | 4 |
| 15 | PTEN-L promotes type I interferon responses and antiviral immunity显示文摘Phosphatase and tensin homolog deleted on chromosome ten(PTEN)is a well-known tumor suppressor that acts as a dual-specificity phosphatase and is frequently mutated in human cancer.Our previous work has demonstrated that PTEN also plays a vital role in type I interferon responses and antiviral innate immunity.Recently,a translational variant of PTEN with a long N-terminal extension(PTEN-L)has been discovered that is secreted into the extracellular environment and enters recipient cells,where it exerts a phosphatase function antagonistic to PI3K/Akt signaling and tumorigenesis.In this study,we demonstrate that PTEN-L promotes type I interferon responses and antiviral innate immunity during viral infection in a phosphatase activity-dependent manner.Compared with canonical PTEN,PTEN-L also exerts its antiviral function when it is applied exogenously in protein form.This finding was confirmed in cell cultures and mouse infection models.Furthermore,PTEN-L enhances the responses of both type I interferon and proinflammatory cytokines,thus suggesting that PTEN-L might possess additional functions compared with those of PTEN.Thus,the antiviral function of PTEN-L may open an avenue for the use of PTEN-L in antiviral therapy,particularly in patients with PTEN-deficient tumors. | Yuanyuan Cao Hongyun Wang Liu Yang Zhen Zhang Chenlin Li Xu Yuan Lang Bu Lang Chen Yu Chen Chun-Mei Li Deyin Guo | 2018 | Cellular & Molecular Immunology2018，15，1： | 3 |
| 16 | A Model for Loadout Analysis and Its Programming Implementation显示文摘- In this paper, the authors use the finite element method to conduct a special static analysis for the loadout procedure of offshore structures. By introducing a variable Xmove (the distance between the relative coordinate system fixed in the moving upper structure and the absolute coordinate system fixed on slideway), adopting substructure to treat the upper structure, and using the elastic foundation beam to model the slideway, the model for the analysis of the loadoul procedure is established. On the basis of this model, DASOS-J loadout program, a program system for the static analysis of loadout offshore structures, is also developed. | Zhong Wanxie , Yao Shizhong Wu Lianyuan and Xi Deyin Professor, Shanghai Jiao Tong University, 200030, Shanghai Engineer, Shanghai Jiao Tong University, 200030, Shanghai Lecturer, Shanghai Jiao Tong University. 200030, Shanghai | 1993 | China Ocean Engineering1993，8，4： | 3 |
| 17 | Preparation of high concentration polyaluminum chloride by chemical synthesis-membrane distillation method with self-made hollow fiber membrane显示文摘A method of direct contact membrane distillation (DCMD) with a self-made hollow polyvinylidene fluoride membrane was applied to prepare high concentration polyaluminum chloride (PACl) with high Alb content based on chemical synthesis. The permeate flux and Al species distribution were investigated. The experimental results showed that the permeate flux decreased from 14 to 6 kg/(m2·hr) at the end of the DCMD process, which can be mainly attributed to the formation of NaCl deposits on the membrane surface. The Alb content decreased slightly, only from 86.3% to 84.4%, when the DCMD experiment finished, correspondingly the Alc content increased slightly from 7.2% to 8.5%, and the Ala content remained at 7% during the whole DCMD process. A PACl with Alb content of 84% at total aluminum concentration 2.2 mol/L was successfully prepared by the chemical synthesis-DCMD method. | Changwei Zhao Yong Yan Deyin Hou Zhaokun Luan Zhiping Jia | 2012 | Journal of Environmental Sciences2012，24，5： | 3 |
| 18 | Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases显示文摘DNA sensing and timely activation of interferon(IFN)-mediated innate immunity are crucial for the defense against DNA virus infections and the clearance of abnormal cells.However,overactivation of immune responses may lead to tissue damage and autoimmune diseases;therefore,these processes must be intricately regulated.STING is the key adaptor protein,which is activated by cyclic GMP-AMP,the second messenger derived from cGAS-mediated DNA sensing.Here,we report that CCDC50,a newly identified autophagy receptor,tunes STING-directed type I IFN signaling activity by delivering K63-polyubiquitinated STING to autolysosomes for degradation.Knockout of CCDC50 significantly increases herpes simplex virus 1(HSV-1)-or DNA ligand-induced production of type I IFN and proinflammatory cytokines.Ccdc50-deficient mice show increased production of IFN,decreased viral replication,reduced cell infiltration,and improved survival rates compared with their wild-type littermates when challenged with HSV-1.Remarkably,the expression of CCDC50 is downregulated in systemic lupus erythematosus(SLE),a chronic autoimmune disease.CCDC50 levels are negatively correlated with IFN signaling pathway activation and disease severity in human SLE patients.CCDC50 deficiency potentiates the cGAS-STING-mediated immune response triggered by SLE serum.Thus,our findings reveal the critical role of CCDC50 in the immune regulation of viral infections and autoimmune diseases and provide insights into the therapeutic implications of CCDC50 manipulation. | Panpan Hou Yuxin Lin Zibo Li Ruiqing Lu Yicheng Wang Tian Tian Penghui Jia Xi Zhang Liu Cao Zhongwei Zhou Chunmei Li Jieruo Gu Deyin Guo | 2021 | Cellular & Molecular Immunology2021，18，10： | 3 |
| 19 | Coronavirus: epidemiology, genome replication and the interactions with their hosts显示文摘This special issue of the journal is dedicated to the recent progress on coronaviruses and covers the topics of viral epidemiology,virus replication and the interactions between the coronaviruses and their hosts.Members of the family Coronaviridae infect a wide range of vertebrates and humans.They usually | Zheng-Li Shi Deyin Guo Peter J.M.Rottier | 2016 | Virologica Sinica2016，31，1： | 3 |
| 20 | Nanoscale zero-valent iron supported on biochar for the highly efficient removal of nitrobenzene显示文摘The application of nanoscale zero-valent iron (nZVI) in the remediation of contaminated groundwater or wastewater is limited due to its lack of stability, easy aggregation and iron leaching. To address this issue, nZVI was distributed on oak sawdust-derived biochar (BC) to obtain the nZVI/BC composite for the highly efficient reduction of nitrobenzene (NB). nZVI, BC and nZVI/BC were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). For nZVI/BC, nZVI particles were uniformly dispersed on BC. nZVI/BC exhibited higher removal efficiency for NB than the simple summation of bare nZVI and BC. The removal mechanism was investigated through the analyses of UV-Visible spectra, mass balance and XPS. NB was quickly adsorbed on the surface of nZVI/BC, and then gradually reduced to aniline (AN), accompanied by the oxidation of nZVI to magnetite. The effects of several reaction parameters, e.g., NB concentration, reaction pH and nZVI/BC aging time, on the removal of NB were also studied. In addition to high reactivity, the loading of nZVI on biochar significantly alleviated Fe leaching and enhanced the durability of nZVI. | Gaoling Wei Jinhua Zhang Jinqiu Luo Huajian Xue Deyin Huang Zhiyang Cheng Xinbai Jiang | 2019 | Frontiers of Environmental Science & Engineering2019，13，4： | 3 |
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