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| 1 | Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment显示文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified. | Jing Wang Yizhuo Zhao Qiming Wang Li Zhang Jianhua Shi Zhehai Wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo Xiuwen Wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li | 2018 | Cancer Biology & Medicine2018，15，4： | 46 |
| 2 | Two-Party Authenticated Key Agreement in Certificateless Public Key Cryptography显示文摘Certificateless public key cryptography was introduced to overcome the key escrow limitation of the identity-based cryp- tography. It combines the advantages of the identity-based cryp- tography and the traditional PKI. Many certificateless public key encryption and signature schemes have been proposed. However, the key agreement in CL-PKE is seldom discussed. In this paper, we present a new certificateless two party authentication key agreement protocol and prove its security attributes. Compared with the existing protocol, our protocol is more efficient. | SHI Yijuan LI Jianhua | 2007 | Wuhan University Journal of Natural Sciences2007，12，1： | 23 |
| 3 | The Yanshan orogeny and late Mesozoic multi-plate convergence in East Asia—Commemorating 90th years of the “Yanshan Orogeny”显示文摘The Yanshan movement/orogeny has been proposed for 90 years, which is of special significance in the history of geological research in China. This study conducted a review by synthesizing major achievements regarding episodic deformation features, sedimentary and magmatic records of the Yanshan orogeny in China, and clarified the episodic tectono-magmatism and its geodynamic origins. The tectonic implications of the Yanshan orogeny are discussed in the context of global plate tectonics and supercontinent reconstruction. Lines of evidence from structural, sedimentary and magmatic data suggest that the Yanshan orogeny represents a regional-scale tectonic event that affected the entire China continent in late Mesozoic period. Numerous age and structural constraints consistently indicate that the Yanshan orogeny was initiated in the Jurassic(at ~170±5 Ma). and was characterized by alternating stages of crustal shortening at ~170–136 Ma, crustal extension at ~135–90 Ma, and weak shortening at ~80 Ma. The 170–136 Ma crustal shortening was reflected in the generation of two regional stratigraphic unconformities(the Tiaojishan and Zhangjiakou unconformities), which were initially named the A and B episodes of 'the Yanshan Orogeny' by Mr.Wong Wenhao in 1928. Geodynamically, the Yanshan orogeny in East Asia was associated with nearly coeval oceanic subduction and continental convergence in the Paleo-Pacific, Neo-Tethys, and Mongol-Okhotsk tectonic domains. As a consequence, three giant accretionary-collisional tectonic systems were formed along the continental margins of East Asia, i.e., the Mongol-Okhotsk, Bangonghu-Nujiang, and SE China subduction-and collision-related accretionary systems. The Yanshan orogeny induced widespread crustal-scale folding and thrusting, tectonic reactivation of long-lived zones of crustal weakness,and extensive magmatism and mineralization in intraplate regions. Based on the time principle of supercontinent assembly and break-up, we propose that the mid-Late Jurassic multi-plate convergence in East Asia might represent the initiation of the assembly of the Amasia supercontinent, and the Yanshan orogeny might be the first 'stirrings' that is a prerequisite for the birth of the Amasia supercontinent. | Shuwen DONG Yueqiao ZHANG Hailong LI Wei SHI Huaimin XUE Jianhua LI Shiqi HUANG Yongchao WANG | 2018 | Science China Earth Sciences2018，61，12： | 21 |
| 4 | A Review of 3D Printing Technology for Medical Applications显示文摘 | Ojan Yan Hanhua Dong Jin Su Jianhua Han Bo Song Qingsong wei Yusheng Shi | 2018 | Engineering2018，4，5： | 20 |
| 5 | A FVCOM-Based Unstructured Grid Wave, Current,Sediment Transport Model,I.Model Description and Validation显示文摘An effort was made to couple FVCOM (a three-dimensional (3D),unstructured grid,Finite Volume Coastal Ocean Model) and FVCOM-SWAVE (an unstructured grid,finite-volume surface wave model) for the study of nearshore ocean processes such as tides,circulation,storm surge,waves,sediment transport,and morphological evolution.The coupling between FVCOM and FVCOM-SWAVE was achieved through incorporating 3D radiation stress,wave-current-sediment-related bottom boundary layer,sea surface stress parameterizations,and morphology process.FVCOM also includes a 3D sediment transport module.With accurate fitting of irregular coastlines,the model provides a unique tool to study sediment dynamics in coastal ocean,estuaries,and wetlands where local geometries are characterized by inlets,islands,and intertidal marsh zones.The model was validated by two standard benchmark tests: 1) spectral waves approaching a mild sloping beach and 2) morphological changes of seabed in an idealized tidal inlet.In Test 1,model results were compared with both analytical solutions and laboratory experiments.A further comparison was also made with the structured grid Regional Ocean Model System (ROMS),which provides an insight into the performance of the two models with the same open boundary forcing. | WU Lunyu CHEN Changsheng GUO Peifang SHI Maochong QI Jianhua GE Jianzhong | 2011 | Journal of Ocean University of China2011，10，1： | 15 |
| 6 | The impact of climate change and human activities on streamflow and sediment load in the Pearl River basin显示文摘This paper uses monthly streamflow, suspended sediment concentration, and meteorological data to examine the impact of human activity and climate change on streamflow and sediment load in the Pearl River basin from the 1950s to the 2000s. The influences of climate change and human activities on hydrological processes were quantitatively evaluated using the Mann–Kendall abrupt change test and power rating curves. The results showed that:(1) abrupt changes and turning points in streamflow occurred in 1963, 1983, and 1991 which were found to be consistent with global ENSO events and volcanic eruptions. However, abrupt changes in sediment load showed significant spatial differences across the Pearl River basin. For the Xijiang River, an abrupt change in sediment load occurred in 2002, and after 2007 the change becomes significant at the 95% confidence level. At Beijiang and Dongjiang, abrupt changes in sediment load occurred in 1998 and 1988, respectively.(2) The time series of sediment load data was divided into four periods according to abrupt changes. The contribution of climate change and human activities is different in the different rivers. For the Xijiang River, compared with the first period, climate change and human activities contributed 83% and 17%, respectively, to the increasing sediment load during the second period. In the third period, the variation of sediment load followed a decreasing trend. The contribution from climate change and human activities also changed to t236% and -136%, respectively. In the fourth period, climate change and human activities contributed -32% and t132%, respectively. Meanwhile, For the Beijiang River, climate change and human activities contributed 90% and 10% in the second period, the contribution of climate change increased to t115% and human activities decreased to -15% in the third period. In the fourth period, the value for climate change decreased to t36% and human activities increased to t64%. For the Dongjiang River, the contribution of human activities was from 74.5% to 90%, and the values for climate change were from 11% to 25%. Therefore, the effect of human activity showed both spatial and temporal differences, and it seems likely that the decreased sediment load will continue to be controlled mainly by human activities in the future. | Chuangshou Wu Changchen Ji Benwei Shi Yaping Wang Jianhua Gao Yang Yang Jinbin Mu | 2019 | International Journal of Sediment Research2019，34，4： | 12 |
| 7 | Tectonic evolution of the Dabashan orocline, central China: Insights from the superposed folds in the eastern Dabashan foreland显示文摘The Dabashan orocline is situated in the northwestern margin of the central Yangtze block,central China.Previous studies have defned the orthogonal superposed folds growing in its central-western segment thereby confrming its two-stage tectonic evolution history.Geological mapping has revealed that more types of superposed folds have developed in the eastern segment of the orocline,which probably provides more clues for probing the structure and tectonic history of the Dabashan orocline.In this paper,based on geological mapping,structural measurements and analyses of deformation,we have identifed three groups of folds with different trends(e.g.NW-,NE-and nearly E-trending folds)and three types of structural patterns of superposed folds in the eastern Dabashan foreland(e.g.syn-axial,oblique,and conjunctional superposed folds).In combination with geochronological data,we propose that the synaxial superposed folds are due to two stages of wNeS shortening in the west and north of the Shennongjia massif,and that oblique superposed folds have been resulted from the superposition of the NW-and NE-trending folds onto the early ~E-W folds in the east of the Shennongjia massif in the late Jurassic to early Cretaceous.The conjunctional folds are composed of the NW-and NE-trending folds,corresponding to the regional-scale dual-orocline in the eastern Sichuan as a result of the southwestward expansion of the Dabashan foreland during late Jurassic to early Cretaceous,coeval with the northwestward propagation of the Xuefengshan foreland.Integration of the structure and geochronology of the belt shows that the Dabashan orocline is a combined deformation belt primarily experiencing a twostage tectonic evolution history in Mesozoic,initiation of the Dabashan orocline as a foreland basin along the front of the Qinling orogen in late Triassic to early Jurassic due to collisional orogeny,and the fnal formation of the Dabashan orocline owing to the southwestward propagation of the Qinling orogen during late Jurassic to early Cretaceous intra-continental orogeny.Our studies provide some evidences for understanding the structure and deformation of the Dabashan orocline. | Wei Shi Jianhua Li Mi Tian Guoli Wu | 2013 | Geoscience Frontiers2013，4，6： | 12 |
| 8 | Total mesopancreas excision for pancreatic head cancer: analysis of 120 cases显示文摘Objective: To evaluate the feasibility and safety of total mesopancreas excision(TMpE) in the treatment of pancreatic head cancer. Methods: The clinical and pathological data of 120 patients with pancreatic head cancer who had undergone TMpE in our center from May 2010 to January 2014 were retrospectively analyzed. Results: The mean operative time was(275.0±50.2) min and the average intra-operative blood loss was(390.0±160.5) mL. Post-operative complications were reported in 45 patients, while no peri-operative death was noted. The specimen margins were measured in three dimensions, and 86 patients(71.6%) achieved R0 resection. Conclusions: TMpE is safe and feasible for pancreatic head cancer and is particularly helpful to increase the R0 resection rate. | Wenguang Wu Xu'an Wang Xiangsong Wu Maolan Li Hao Weng Yang Cao Ruifa Bao Sijun Su Jianhua Lu Wei Gong Weibin Shi Jun Gu Xuefeng Wang Yingbin Liu Zhiwei Quan Shuyou Peng | 2016 | Chinese Journal of Cancer Research2016，28，4： | 10 |
| 9 | OsDMI3 Is a Novel Component of Abscisic Acid Signaling in the Induction of Antioxidant Defense in Leaves of Rice显示文摘Ca2+ 和 calmodulin (凸轮) 被看了抗氧化剂防卫到在 abscisic 酸(骆驼毛的织物) 的一个重要角色导致了的玩。然而, Ca2+/CaM-dependent 蛋白质 kinase (CCaMK ) 是否涉及这个过程,是未知的。在现在的学习,米饭 CCaMK 的角色, OsDMI3,在导致骆驼毛的织物的抗氧化剂,防卫在米饭(Oryza sativa ) 的叶子被调查植物。有骆驼毛的织物, H2O2,和聚乙烯乙二醇(木钉) 的处理导致了 OsDMI3 和 OsDMI3 的活动的表示,并且 H2O2 在水应力下面为表示和 OsDMI3 的活动的导致骆驼毛的织物的增加被要求。Subcellular 本地化分析证明 OsDMI3 位于原子核,细胞质,和血浆膜。在米饭原物和在米饭原物的 OsDMI3 的 silencing 显示出的 RNA 干扰(RNAi ) 的 OsDMI3 的短暂表示的分析那 OsDMI3 为表示和 superoxide dismutase (草皮) 和过氧化氢酶(猫) 的活动的导致骆驼毛的织物的增加被要求。进一步,氧化损坏由木钉的更高的集中导致了, H2O2 在 OsDMI3 的异种被加重。而且,在原物和 OsDMI3 的异种的 OsDMI3 的 RNAi silencing 的分析证明 H2O2 累积的高水平要求在骆驼毛的织物发信号的 OsDMI3 激活,而是起始的 H2O2 生产导致了由骆驼毛的织物不依赖于在米饭植物的叶子的 OsDMI3 的激活。我们的数据表明 OsDMI3 是在在米饭的导致骆驼毛的织物的抗氧化剂防卫的一个重要部件。 | Ben Shi Lan Ni Aying Zhang Jianmei Cao Hong Zhang Tingting Qin Mingpu Tan Jianhua Zhang Mingyi-Jiang | 2012 | Molecular Plant2012，5，6： | 10 |
| 10 | Formation of the Moping Dome in the Xuefengshan Orocline, Central China and its Tectonic Significance显示文摘Many equiaxial dome-like structures developed in the north segment of the Xuefengshan orocline, Central China are obviously inconcordant with the NE-trending linear structures in this area, which contain important records for understanding the structural framework and evolution of this belt. In this paper, taking one of the typical dome-like structures in the Xuefengshan orcline (e.g. Moping dome-like structure) as an example, based on its structural framework interpratatoin, superposed deformation analysis and paleo-stress fields reconstruction, we propose the Moping dome-like structure is composed of two populations of different-striking thrust-fold structures, ~E-trending and NE-striking structures, indicative of two-stages shortening, ~N- and NW-striking, respectively. Together with the geochronological analysis, we suggest the first stage of shortening occurred in Late Triassic to Early Jurassic, due to the Indosinian intercollisional orogeny of the Yangtze Block and the North China Block. The second occurred during Late Jurassic Early Cretaceous owing to Yanshanian intracontinental orogeny, leading to the intensive superposition of the NE-trending structures onto the ~E-trending structures, and the final ocurrence of the Moping dome. Thus, our study indicates the Xuefengshan arc-shape belt also experienced two-phase deformation, and resulted from the superposition of NE SW structures onto ~E-W structures in Late Jurassic Early Cretaceous, which could provide new structural evidence for probing the Mesozoic tectonic framework and evolution of the Xuefengshan orocline. | SHI Wei DONG Shuwen LI Jianhua TIAN Mi WU Guoli | 2013 | Acta Geologica Sinica(English Edition)2013，87，3： | 9 |
| 11 | Proanthocyanidins Inhibit Seed Germination by Maintaining a High Level of Abscisic Acid in Arabidopsis thaliana显示文摘Proanthocyanidins (PAs) are the main products of the flavonoid biosynthetic pathway in seeds, but their biological function during seed germination is still unclear. We observed that seed germination is delayed with the increase of exogenous PA concentration in Arabidopsis. A similar inhibitory effect occurred in peeled Brassica napus seeds, which was observed by measuring radicle elongation. Using abscisic acid (ABA), a biosynthetic and metabolic inhibitor, and gene expression analysis by real-time polymerase chain reaction, we found that the inhibitory effect of PAs on seed germination is due to their promotion of ABA via de novo biogenesis, rather than by any inhibition of its degradation. Consistent with the relationship between PA content and ABA accumulation in seeds, PA-deficient mutants maintain a lower level of ABA compared with wild-types during germination. Our data suggest that PA distribution in the seed coat can act as a doorkeeper to seed germination. PA regulation of seed germination is mediated by the ABA signaling pathway. | Liguo Jia Qiuyu Wu Nenghui Ye Rui Liu Lu Shi Weifeng Xu Hui Zhi A. N. M. Rubaiyath Bin Rahman Yiji Xia Jianhua Zhang | 2012 | Journal of Integrative Plant Biology2012，54，9： | 9 |
| 12 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 13 | Monotone rank estimation of transformation models with length-biased and right-censored data显示文摘This paper considers the monotonic transformation model with an unspecified transformation function and an unknown error function, and gives its monotone rank estimation with length-biased and rightcensored data. The estimator is shown to be√n-consistent and asymptotically normal. Numerical simulation studies reveal good finite sample performance and the estimator is illustrated with the Oscar data set. The variance can be estimated by a resampling method via perturbing the U-statistics objective function repeatedly. | CHEN XiaoPing SHI JianHua ZHOU Yong | 2015 | Science China Mathematics2015，58，10： | 8 |
| 14 | A semiempirical algorithm for SAR wave height retrieval and its validation using Envisat ASAR wave mode data显示文摘Many synthetic aperture radar(SAR) wave height retrieval algorithms have been developed.However,the wave height retrievals from most existing methods either depend on other input as the first guess or are restricted to the long wave regime.A semiempirical algorithm is presented,which has the objective to estimate the wave height from SAR imagery without any prior knowledge.The proposed novel algorithm was developed based on the theoretical SAR ocean wave imaging mechanism and the empirical relation between two types of wave period.The dependency of the proposed model on radar incident and wave direction was analyzed.For Envisat advanced synthetic aperture radar(ASAR) wave mode data,the model can be reduced to the simple form with two input parameters,i.e.,the cutoff wavelength and peak wavelength of ocean wave,which can be retrieved from SAR imagery without any prior knowledge of wind or wave.Using Envisat ASAR wave mode data and the collocated buoy measurements from NDBC,the semiempirical algorithm is validated and compared with the Envisat ASAR level 2 products.The root-mean-square-error(RMSE) and scatter index(SI) in respect to the in situ measurements are 0.52 m and 19% respectively.Validation results indicate that,for Envisat ASAR wave mode data,the proposed method works well. | WANG He ZHU Jianhua YANG Jingsong SHI Chaoying | 2012 | Acta Oceanologica Sinica2012，31，3： | 6 |
| 15 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 16 | Retinal nerve fiber layer (RNFL) integrity and its relations to retinal microvasculature and microcirculation in myopic eyes显示文摘Background:The aim was to determine retinal nerve fiber layer function and its relations to retinal microvasculature and microcirculation in patients with myopia.Method:Polarization-sensitive optical coherence tomography(PS-OCT)was used to measure phase retardation per unit depth(PR/UD,proportional to the birefringence)of the retinal nerve fiber layer(RNFL).Optical coherence tomography angiography(OCTA)was used to measure macular vessel density analyzed using fractal analysis.In addition,a retinal function imager(RFI)was used to measure macular blood flow velocities in arterioles and venules.Twenty-two patients with moderate myopia(MM,refraction>3 and<6 diopters),seventeen patients with high myopia(HM,≥6 D)and 29 healthy control subjects(HC,≤3.00 D)were recruited.One eye of each patient was imaged.Results:Although the average PR/UD of the RNFL in the HM group did not reach a significant level,the birefringence of the inferior quadrant was significantly lower(P<0.05)in the HM group compared to the HC group.Significant thinning of the average RNFL and focal thinning of RFNL in temporal,superior and inferior quadrants in the HM group were found,compared to the HC group(P<0.05).There were no significant differences of retinal blood flow velocities in arterioles and venules among groups(P>0.05).The macular vessel density in both superficial and deep vascular plexuses was significantly lower in the HM group than in the other two groups(P<0.05)as well as in the MM group than in the HC group(P<0.05).The average PR/UD and PR/UD in the inferior quadrant were not related to refraction,axial length,blood flow velocities and macular vessel densities(r ranged from−0.09 to 0.19,P>0.05).Conclusions:The impairment of the retinal nerve fiber birefringence in the HM group may be one of the independent features in high myopic eyes,which appeared not to relate to macular microvascular density and blood flow velocity. | Dongyi Qu Ying Lin Hong Jiang Yi Shao Yingying Shi Shriya Airen Giovanni Gregori Jianhua Wang | 2018 | Eye and Vision2018，5，1： | 5 |
| 17 | Physicochemistry and Mineralogy of Storm Dust and Dust Sediment in Northern China显示文摘Dust sediments collected from 1995 to 1998 in Beijing, Dunhuang, Inner Mongolia, Kashi, the Kunlun Mountains, Lanzhou, Ningxia, the Taklimakan Desert, and Xi’an, China, were characterized in terms of their physical, chemical, and mineralogical properties. Most aerosols and dust analysed ranged in texture from silty clay to clay loam. Their median particle diameters (Mds) generally ranged between 5 to 63 μm, coinciding with those of loess from central China and the ?nest sand from northwestern China. The dust sediments were characterized by a predominance of SiO2 and Al2O3, followed by K2O. Their SiO2/Al2O3 and K2O/SiO2 molar ratios ranged from 5.17 to 8.43 and from 0.009 to 0.0368, respectively. The mass concentration spectrum during a dust storm showed a single peak, rather than the triple peak generally observed under clear sky conditions. The dominant minerals were chlorite, illite, calcite, and dolomite. These physical, chemical, and mineralogical properties were consistent with those of aeolian soils and loess in western and central China. The results suggest that aerosols and ?ne-grained fractions of dust sediments collected in northern China are mainly composed of soil material transported from the arid and semiarid regions of China and Mongolia by prevailing winds. The rate of deposition and properties of dust falling on eastern China were strongly in?uenced by meteorological conditions, season, latitude, longitude, and altitude of the sampling sites. | LIU Wei(刘蔚) FENG Qi(冯起) WANG Tao(王涛) ZHANG Yanwu(张艳武) SHI Jianhua(施建华) | 2004 | Advances in Atmospheric Sciences2004，21，5： | 5 |
| 18 | Anlotinib as third- or further-line therapy for short-term relapsed small-cell lung cancer: subgroup analysis of a randomized phase 2 study (ALTER1202)显示文摘Patients with small-cell lung cancer (SCLC) relapse within months after completing previous therapies. This study aimed to investigate the efficacy and safety of anlotinib as third- or further-line therapy in patients with short-term relapsed SCLC from ALTER1202. Patients with short-term relapsed SCLC (disease progression within 3 months after completing ≥ two lines of chemotherapy) in the anlotinib (n = 67) and placebo (n = 34) groups were analyzed. The primary endpoint was progression-free survival (PFS). The secondary endpoints included overall survival, objective response rate (ORR), disease control rate, and safety. Anlotinib significantly improved median PFS/OS (4.0 vs. 0.7 months, P < 0.0001)/(7.3 vs. 4.4 months, P = 0.006) compared with placebo. The ORR was 4.5%/2.9% in the anlotinib/placebo group (P = 1.000). The DCR in the anlotinib group was higher than that in the placebo group (73.1% vs. 11.8%, P < 0.001). The most common adverse events (AEs) were hypertension (38.8%), loss of appetite (28.4%), and fatigue (22.4%) in the anlotinib group and gamma-glutamyl transpeptidase elevation (20.6%) in the placebo group. No grade 5 AEs occurred. For patients with short-term relapsed SCLC, third- or further-line anlotinib treatment was associated with improved survival benefit. Further studies are warranted in this regard. | Jianhua Shi Ying Cheng Qiming Wang Kai Li Lin Wu Baohui Han Gongyan Chen Jianxing He Jie Wang Haifeng Qin Xiaoling Li | 2022 | Frontiers of Medicine2022，16，5： | 5 |
| 19 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 20 | ^(234)Th/^(238)U disequilibrium and particulate organic carbon export in the northwestern South China Sea显示文摘234 Th was utilized as a tracer of particulate organic carbon (POC) export in the northwestern South China Sea (SCS) on the basis of the data collected at four stations during a spring cruise.Depth profiles of dissolved and particulate 234 Th activities were measured in the upper 60 m,showing a significant deficit relative to 238 U over the investigated stations.A stratified structure of 234 Th-238 U disequilibrium was in general observed in the upper 60 m water column,indicating that the euphotic zone of the northwestern SCS in this reason can be divided into two layers,an upper and lower layer,with different export rates.POC export fluxes were estimated from a one-dimensional steady state model of 234 Th fluxes in combination with the measurement of POC/ 234 Th ratios on suspended particles.The POC export in this region ranged from 8.2 to 20.0 mmol/(m 2 · d),with an average of 16.0 mmol/(m 2 · d),and was slightly higher than those previously reported in the southern SCS. | MA Hao ZENG Zhi YU Wen HE Jianhua CHEN Liqi CHENG Jianping YIN Mingduan ZENG Shi | 2011 | Acta Oceanologica Sinica2011，30，3： | 5 |
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