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| 1 | Chromosome-Level Reference Genome and Population Genomic Analysis Provide Insights into the Evolution and Improvement of Domesticated Mulberry (Morns alba)显示文摘Mulberry(Morns spp.)is the sole plant consumed by the domesticated silkworm.However,the genome of domesticated mulberry has not yet been sequenced,and the ploidy level of this species remains unclear.Here,we report a high-quality,chromosome-level domesticated mulberry(Morus alba)genome.Analysis of genomic data and karyotype analyses confirmed that M.alba is a diploid with 28 chromosomes(2/7=2x=28).Population genomic analysis based on resequencing of 134 mulberry accessions classified domesticated mulberry into three geographical groups,namely,Taihu Basin of southeastern China(Hu mulberry),northern and southwestern China,and Japan.Hu mulberry had the lowest nucleotide diversity among these accessions and demonstrated obvious signatures of selection associated with environmental adaptation.Further phylogenetic analysis supports a previous proposal that multiple domesticated mulberry accessions previously classified as different species actually belong to one species.This study expands our understanding of genome evolution of the genus Morus and population structure of domesticated mulberry,which would facilitate mulberry breeding and improvement. | Feng Jiao Rongsong Luo Xuelei Dai Hui Liu Gang Yu Shuhua Han Xin Lu Chao Su Qi Chen Qinxia Song Caiting Meng Fanghong Li Hongmei Sun Rui Zhang Tian Hui Yonghua Qian Aichun Zhao Yu Jiang | 2020 | Molecular Plant2020，13，7： | 10 |
| 2 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 3 | First-Principles Calculations of Electronic, Elastic and Thermal Properties of Magnesium Doped with Alloying Elements显示文摘First-principles calculations have been carried out to investigate the effects of alloying elements(Zn, Li, Y and Sc) on the electronic structure, elastic and thermal properties of Mg solid solution. The calculated cohesive energies show that Mg-Sc has the highest structural stability. The calculations of the densities of states(DOS) and electronic charge density difference indicate that Mg-Y(Sc) alloys have very strong covalent bonding due to a very strong Mg p-Y(Sc) d hybridization. The bulk modulus B, shear modulus G, Young's modulus E and Poisson ratio ν are derived using Voigt-Reuss-Hill(VRH) approximation. The results show that all the alloys can exhibit ductile properties at 2.77 at% R, and Mg-Zn(Li) alloys have the better ductility and plasticity. In the end, the Debye temperature and isochoric heat capacity are also calculated and discussed. | 杨晓敏 赵宇宏 HOU Hua ZHENG Shuhua HAN Peide | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，1： | 2 |
| 4 | Precision Medicine:What Challenges Are We Facing?显示文摘Following the publication of the US National Research Council(NRC)report‘‘Toward Precision Medicine:Building a Knowledge Network for Biomedical Research and a New Taxonomy of Diseases'in 2011[1],several nations have announced that their national research programs would definitely head toward this direction.Now,precision medicine(PM)became a banner for many large-scale | Yu Xue Eric-Wubbo Lameijer Kai Ye Kunlin Zhang Suhua Chang Xiaoyue Wang Jianmin Wu Ge Gao Fangqing Zhao Jian Li Chunsheng Han Shuhua Xu Jingfa Xiao Xuerui Yang Xiaomin Ying Xuegong Zhang Wei-Hua Chen Yun Liu Zhang Zhang Kun Huang Jun Yu | 2016 | Genomics, Proteomics & Bioinformatics2016，14，5： | 1 |
| 5 | Effect of pentanol on morphologies and pore structure of mesoporous silica 显示文摘 | Han Shuhua Hou Wanguo Yan Xin | 2003 | Langmuir2003，19，10： | 1 |
| 6 | Synthesis of rod-like mesoporous silica using mixed surfactants of cetyltrimethylammonium bromide and cetyltrimethylammonium chloride as templates显示文摘 | HAN Shuhua HOU Wanguo DANG Wenxiu | 2003 | Mater Lett2003，57，： | 1 |
| 7 | Effects of the spacer length of gemini surfactants on the ordered pore of silica 显示文摘 | WANG SHASHA HAN SHUHUA CUI XIAOYAN | 2012 | Journal of Porous Materials2012，19，： | 1 |
| 8 | Coupling a glacier melt model to the Variable Infiltration Capacity (VIC) model for hydrological modeling in north-western China显示文摘 | Qiudong Zhao Baisheng Ye Yongjian Ding Shiqiang Zhang Shuhua Yi Jian Wang Donghui Shangguan Chuancheng Zhao Haidong Han | 2013 | Environmental Earth Sciences2013，，1： | 1 |
| 9 | Overexpression of astrocyte-elevated gene-1 is closely correlated with poor prognosis in human non–small cell lung cancer and mediates its metastasis through up-regulation of matrix metalloproteinase-9 expression显示文摘 | Shijun Sun Zunfu Ke Fen Wang Shuhua Li Wenfang Chen Anjia Han Zuo Wang Huijuan Shi Lian-tang Wang Xiaodong Chen | 2012 | Human Pathology2012，，7： | 1 |
| 10 | Asymptotic expansion of iterative galerkin methods for eigenvalue problem of fredholm integral equations显示文摘 | Shuhua Zhang Xiuqin Han | 2000 | Journal of Tianjin University of Commerce2000，20，3： | 1 |
| 11 | Distributions of surficial sediments and its response to dynamic actions in the Xiamen Bay sea area, China显示文摘Sediment distribution is important for morphodynamic evolution and shoreline changes in coastal zones and estuaries. In the study, the data of 230 surface sediment samples collected from the Xiamen Bay sea area in September 2008 are used to investigate the spatial distribution and sediment transport pathway. The grain size distribution of surficial sediments in the Xiamen Bay area is shown distinctly in this study. In addition, the Grain Size Transport Analysis model is used for conveying trend analysis of the sediment in this area, particularly for determining the sediment movement trend. The results indicate that eight sediment types are present for samples, with clayey silt comprising the highest percentage in the study area at 65.22%. Moreover, in the different subareas, the characteristics of grain size parameters are obviously different owing to different sediment sources and hydrodynamic conditions. Furthermore, runoff, tides, and waves are the main forces dominating sediment dynamics on the seabed and tidal flats, and the sediment movement trend is closely related to hydrodynamic conditions. | ZUO Shuhua HAN Zhiyuan HUANG Yunxin HAN Jie XIE Mingxiao | 2016 | Acta Oceanologica Sinica2016，35，4： | 1 |
| 12 | Synthesis of high-quality MCM-48 mesoporous silica using cationic Gemini surfactant C12-2-12显示文摘 | Han Shuhua Hou Wanguo | 2004 | Colloids and Surfaces A:Physicochem Eng Aspects2004，248，123： | 1 |
| 13 | An Investigation into Typical English Language Use Tasks across Jobs by International Talents显示文摘Along with the progress of economic globalization and the Belt and Road Initiative,there is a great need for international talents with global vision,knowledge of international rules and regulations,English language proficiency,and the ability to participate in international affairs and competitions.Through text analysis and interviews,this study collects typical English language use tasks in the workplace,and uses questionnaires to investigate the importance and difficulty of different tasks for English language users in different industries,positions and ranks,hence providing references for the design of English training and assessment tasks for international talents. | Shuhua Wang Miao Hu Chengli Zheng Ziyue Han | 2020 | 教育研究前沿(中英文版)2020，10，1： | 0 |
| 14 | Several Problems in the Development of Basic Disciplines | CHEN Shijun, HAN Wenxiu, LIU Shuhua, XU Xuejun Tianjin University, Tianjin, China | 1993 | Systems Science and Systems Engineering1993，3，1： | 0 |
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