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| 1 | Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein显示文摘Beclin 1 基因是 haplo 不够的肿瘤 suppressor 并且在 autophagy 起一个必要作用。然而, Beclin 1 由工作的分子的机制仍然保持大部分未知。这里,我们在 1.6 Å 报导 Beclin 1 的 evolutionarily 保存的领域(ECD ) 的水晶结构;分辨率。Beclin 1 ECD 展览一以前 unreported 褶层,与在中央轴附近相称性地安排的三次结构的重复。Beclin 1 ECD 定义膜绑定领域的一个新奇的类,与为与 cardiolipin 充实的类脂化合物膜的强壮的偏爱。在 Beclin 1 ECD 的一个表面环的尖端,包括三芳香的氨基酸,与类脂化合物膜充当一根恐水病的手指到伙伴,因而导致膜和 liposomes 的变丑。这些芳香的残余的变化使 Beclin 1 变为不能稳定地在 vitro 与类脂化合物膜联系并且不能充分在 vivo 在 Beclin 1-knockdown 房间救 autophagy。这些观察为译解形成一个重要框架 Beclin 1 的生物功能。 | Weljlao Huang Wooyoung Chol Wanqiu Hu Na Mi Qiang Guo Meisheng Ma Mei Liu Yuan Tian Peilong Lu Feng-Liang Wang Haiteng Deng Lei Liu Ning Gao Li Yu Yigong Shi | 2012 | Cell Research2012，22，3： | 21 |
| 2 | Downregulation of LINC01296 suppresses non-small-cell lung cancer via targeting miR-143-3p/ATG2B显示文摘The 5-year survival rate of lung cancer is one of the lowest among various malignant tumors.Long noncoding RNAs(lncRNAs),noncoding RNAs longer than 200 nucleotides,can function either as tumor suppressors or as oncogenes.The aim of this study is to investigate the function of lncRNA LINC01296 and its molecular mechanism in non-small-cell lung cancer(NSCLC).According to the Gene Expression Omnibus database,10 differentially expressed lncRNAs in NSCLC cells and patient tissues are upregulated.LINC01296 is the one with the most significant overexpression.Knockdown of LINC01296 inhibits the growth and migration,arrests the cell cycle,and promotes the apoptosis of NSCLC cells.Knocking down LINC01296 in vivo suppresses tumor growth and metastasis.LINC01296 also acts as the sponge of miR-143-3p.Lowering the expression of LINC01296 leads to decreased expression of autophagy-related 2B,ATG2B,a target gene of miR-143-3p.Moreover,downregulation of LINC01296 promotes paclitaxel sensitivity in NSCLC.These results demonstrated that the LINC01296/miR-143-3p/ATG2B axis is crucial in promoting the development of NSCLC and paclitaxel resistance.Our study may provide new ideas for the further research of clinical chemotherapy of NSCLC in the near future. | Yanli Li Hui Zhang Jing Guo Wanqiu Li Xianyi Wang Caiyan Zhang Qiangling Sun Zhongliang Ma | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 8 |
| 3 | A Self-Powered Fast-Response Ultraviolet Detector of p–n Homojunction Assembled from Two ZnO-Based Nanowires显示文摘Nowadays, fabrication of micro/nano-scale electronic devices with bottom-up approach is paid much research attention. Here, we provide a novel micro/nano-assembling method, which is accurate and efficient, especially suitable for the fabrication of micro/nano-scale electronic devices. Using this method, a self-powered ZnO/Sb-doped ZnO nanowire p–n homojunction ultraviolet detector(UVD) was fabricated, and the detailed photoelectric properties were tested. At a reverse bias of -0.1 V under UV light illumination, the photoresponse sensitivity of the UVD was 26.5 and the rise/decay time of the UVD was as short as 30 ms. The micro/nano-assembling method has wide potential applications in the fabrication of specific micro/nano-scale electronic devices. | Yumei Wang Ying Chen Wanqiu Zhao Longwei Ding Li Wen Haixia Li Fan Jiang Jun Su Luying Li Nishuang Liu Yihua Gao | 2017 | Nano-Micro Letters2017，9，1： | 2 |
| 4 | Sensitivity of Dynamical Intraseasonal Prediction Skills to Different Initial Conditions*显示文摘 | Fu Xiouhua Wang Bin Lee June-Yi Wang Wanqiu Gao Li | 2011 | Monthly Weather Review2011，，8： | 1 |
| 5 | Effect of Molyb- date Bath Service Life on Corrosion Resistance of Con- version Coating Deposited on Hot Dip Galvanized Steel 显示文摘 | Wanqiu Zhou Li Sheng Shigang Xin | 2013 | Advanced Materials Research2013，752，2： | 1 |
| 6 | High frequency AC electric glow discharge visualization technology and application in big diameter hypersonic low-density wind tunnel显示文摘In order to visualize the rarefied flow field in aΦ1m hypersonic low-density wind tunnel,an electric glow discharge technique based on high frequency excited power has been developed.Firstly,finite element simulation analysis has been carried out,and it is concluded that the breakdown voltage can be reduced by using high frequency power supply;then an electric glow discharge apparatus has been fabricated,and the discharge images were compared with simulations;besides,a clear flow field around HB-1 standard model has been observed using this technology;finally,the influence of glow discharge on the flow field,as well as the differences between direct current and high frequency electric glow discharges is discussed at the end of this paper. | Wanqiu Jiang Huacheng Qiu Yanguang Yang Yilei Shi Jie Wang Jie Li Zhengyi Long Chunman Mao | 2021 | Advances in Aerodynamics2021，3，1： | 1 |
| 7 | 3D printing CO_(2)-activated carbon nanotubes host to promote sulfur loading for high areal capacity lithium-sulfur batteries显示文摘Lithium-sulfur batteries(LSBs)have emerged as a promising high energy density system in miniaturized energy storage devices.However,serious issues rooted in large volume change(80%),poor intrinsic conductivity,“shuttle effect”of S cathode,and limited mass loading of traditional electrode still make it a big challenge to achieve high energy density LSBs in a limited footprint.Herein,an innovative carbon dioxide(CO_(2))assisted three-dimensional(3D)printing strategy is proposed to fabricate threedimensional lattice structured CO_(2)activated single-walled carbon nanotubes/S composite thick electrode(3DP S@CNTs-CO_(2))for high areal capacity LSBs.The 3D lattice structure formed by interwoven CNTs and printed regular macropores can not only act as fast electron transfer networks,ensuring good electronic conductivity of thick electrode,but is beneficial to electrolyte infiltration,effectively boosting ion diffusion kinetics even under a high-mass loading.In addition,the subsequent hightemperature CO_(2)in-situ etching can induce abundant nanopores on the wall of CNTs,which significantly promotes the sulfur loading as well as its full utilization as a result of shortened ion diffusion paths.Owing to these merits,the 3DP S@CNTs-CO_(2)electrode delivers an impressive mass loading of 10 mg·cm^(−2).More importantly,a desired attribute of linearly scale up in areal capacitance with increased layers is observed,up to an outstanding value of 5.74 mAh·cm^(−2),outperforming most reported LSBs that adopt strategies that physically inhibit polysulfides.This work provides a thrilling drive that stimulates the application of LSBs in new generation miniaturized electronic devices. | Haiyan Chen Jingfeng Liu Wanqiu Cao Hanna He Xiaolong Li Chuhong Zhang | 2023 | Nano Research2023，16，6： | 0 |
| 8 | Cell-free synthetic biology for in vitro biosynthesis of pharmaceutical natural products显示文摘Natural products with significant biological activities continuously act as rich sources for drug discovery and development.To harness the potential of these valuable compounds,robust methods need to be developed for their rapid and sustainable production.Cell-free biosynthesis of pharmaceutical natural products by in vitro reconstruction of the entire biosynthetic pathways represents one such solution.In this review,we focus on in vitro biosynthesis of two important classes of natural products,polyketides(PKs)and nonribosomal peptides(NRPs).First,we summarize purified enzyme-based systems for the biosynthesis of PKs,NRPs,and PK/NRP hybrids.Then,we introduce the cell-free protein synthesis(CFPS)-based technology for natural product production.With that,we discuss challenges and opportunities of cell-free synthetic biology for in vitro biosynthesis of natural products. | Jian Li Lingkai Zhang Wanqiu Liu | 2018 | Synthetic and Systems Biotechnology2018，3，2： | 0 |
| 9 | Linearized Transformed L1 Galerkin FEMs with Unconditional Convergence for Nonlinear Time Fractional Schr¨odinger Equations显示文摘A linearized transformed L1 Galerkin finite element method(FEM)is presented for numerically solving the multi-dimensional time fractional Schr¨odinger equations.Unconditionally optimal error estimates of the fully-discrete scheme are proved.Such error estimates are obtained by combining a new discrete fractional Gr¨onwall inequality,the corresponding Sobolev embedding theorems and some inverse inequalities.While the previous unconditional convergence results are usually obtained by using the temporal-spatial error spitting approaches.Numerical examples are presented to confirm the theoretical results. | Wanqiu Yuan Dongfang Li Chengjian Zhang | 2023 | Numerical Mathematics(Theory,Methods and Applications)2023，16，2： | 0 |
| 10 | Somatic embryogenesis and plant regeneration in Betula platyphalla显示文摘Betula platyphylla is a native tree species in northern China that has high economic and medicinal value.We developed an efficient protocol for the induction of somatic embryogenesis in B.platyphalla from immature zygotic embryos and assessed the effects of explant type,genotype,and plant growth regulators(PGRs)on embryogenic callus induction.Among the various explants evaluated,embryogenic callus was only produced from mature and immature zygotic embryos on medium with added 2,4-dichlorophenoxyacetic acid(2,4-D).Supplementation of 2,4-D-containing medium with cytokinins increased the frequency of embryogenic callus induction.On the 20 days after pollination,immature zygotic embryos that had been collected in mid-May yielded embryogenic tissue at the highest frequency(16.8%)when cultured on half-strength MS medium supplemented with 2.0 mg L^(-1)2,4-D and 0.2 mg L^(-1)6-benzylaminopurine(6-BA).The process of proliferation of embryogenic callus,somatic embryo formation,and subsequent plantlet conversion occurred under optimal culture conditions.When regenerated plants weretransplanted to soil,95%of them developed normally and grew vigorously.This somatic embryogenesis system required 3–4 months for the regeneration of B.platyphalla plantlets from immature zygotic embryos. | Jingli Yang Da Yang Wanqiu Lü Xin Zhang Miaomiao Ma Guifeng Liu Jing Jiang Chenghao Li | 2021 | Journal of Forestry Research2021，32，3： | 0 |
| 11 | Main Measures and Achievements in the Development of Organic Agriculture in Nanchong City显示文摘In order to improve the quality and efficiency of agriculture,increase farmers'income steadily and rapidly,and improve the ecological environment of agriculture,a strong city of organic agriculture should be constructed in Nanchong City.Based on ecological agriculture,Nanchong makes great efforts to build a strong city of organic agriculture,takes environmental protection supervision as an opportunity to promote sustainable agricultural development feasibly,takes regional brands as the starting point,and promotes the development of agricultural brand.The main measures and achievements of the development of organic agriculture in Nanchong City are analyzed and discussed starting with the next work plan. | Ying GAO Changjia PENG Fengyuan LI Jiawei DU Jun LUO Ning LU Wanqiu WANG | 2019 | Asian Agricultural Research2019，11，10： | 0 |
| 12 | Cultivating New Agricultural Operators to Promote the Transformation and Upgrading of Traditional Agriculture——A Case Study of Nanchong City显示文摘In order to provide reference for cultivating new agricultural operators to promote the transformation and upgrading of traditional agriculture,the main practices,achievements and problems of cultivating new agricultural operators to promote the transformation and upgrading of traditional agriculture in Nanchong City,Sichuan Province were analyzed firstly,and then some measures were proposed. | Hui LI Wanqiu WANG Changjia PENG Shipei LI Yong DU Fengrong ZHOU Jielin ZHANG Honghuan XIAO Ya ZHOU Xiangyou CHENG | 2019 | Asian Agricultural Research2019，11，2： | 0 |
| 13 | A novel N^(6)-Deoxyadenine methyltransferase METL-9 modulates C.elegans immunity via dichotomous mechanisms显示文摘N_(6)-Methyldeoxyadenine(6mA)has been rediscovered as a DNA modification with potential biological function in metazoans.However,the physiological function and regulatory mechanisms regarding the establishment,maintenance and removal of 6mA in eukaryotes are still poorly understood.Here we show that genomic 6mA levels change in response to pathogenic infection in Caenorhabditis elegans(C.elegans).We further identify METL-9 as the methyltransferase that catalyzes DNA 6mA modifications upon pathogen infection.Deficiency of METL-9 impairs the induction of innate immune response genes and renders the animals more susceptible to pathogen infection.Interestingly,METL-9 functions through both 6mA-dependent and-independent mechanisms to transcriptionally regulate innate immunity.Our findings reveal that 6mA is a functional DNA modification in immunomodulation in C.elegans. | Chengchuan Ma Tingling Xue Qi Peng Jie Zhang Jialiang Guan Wanqiu Ding Yi Li Peixue Xia Liankui Zhou Tianyu Zhao Sheng Wang Li Quan Chuan-Yun Li Ying Liu | 2023 | Cell Research2023，33，8： | 0 |
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