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| 1 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 2 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 3 | Balancing selection and wild gene pool contribute to resistance in global rice germplasm against planthopper显示文摘Interactions and co-evolution between plants and herbivorous insects are critically important in agriculture.Brown planthopper(BPH)is the most severe insect of rice,and the biotypes adapt to feed on different rice genotypes.Here,we present genomics analyses on 1,520 global rice germplasms for resistance to three BPH biotypes.Genome-wide association studies identified 3,502 single nucleotide polymorphisms(SNPs)and 59 loci associated with BPH resistance in rice.We cloned a previously unidentified gene Bph37 that confers resistance to BPH.The associated loci showed high nucleotide diversity.Genome-wide scans for trans-species polymorphisms revealed ancient balancing selection at the loci.The secondarily evolved insect biotypes II and III exhibited significantly higher virulence and overcame more rice varieties than the primary biotype I.In response,more SNPs and loci evolved in rice for resistance to biotypes II and III.Notably,three exceptional large regions with high SNP density and resistance-associated loci on chromosomes 4 and 6 appear distinct between the resistant and susceptible rice varieties.Surprisingly,these regions in resistant rice might have been retained from wild species Oryza nivara.Our findings expand the understanding of long-term interactions between rice and BPH and provide resistance genes and germplasm resources for breeding durable BPH-resistant rice varieties. | Cong Zhou Qian Zhang Yu Chen Jin Huang Qin Guo Yi Li Wensheng Wang Yongfu Qiu Wei Guan Jing Zhang Jianping Guo Shaojie Shi Di Wu Xiaohong Zheng Lingyun Nie Jiaoyan Tan Chaomei Huang Yinhua Ma Fang Yang Xiqin Fu Bo Du Lili Zhu Rongzhi Chen Zhikang Li Longping Yuan Guangcun He | 2021 | Journal of Integrative Plant Biology2021，63，10： | 2 |
| 4 | CRM1 is a novel independent prognostic factor for the poor prognosis of gastric carcinomas显示文摘 | Fang Zhou Wensheng Qiu Ruyong Yao Jinyu Xiang Xiaoxiao Sun Shihai Liu Jing Lv Lu Yue | 2013 | Medical Oncology2013，，4： | 1 |
| 5 | A citric acid method to prepare LiMn2O4 for lithium-ion batteries显示文摘 | Yang Wensheng Liu Qingguo Qiu Weihua | 1999 | Solid State Ionics1999，121，： | 1 |
| 6 | FOXM 1 mediates resistance to docetaxel in gastric cancer via up‐regulating Stathmin显示文摘 | Xiaoxiao Li Ruyong Yao Lu Yue Wensheng Qiu Weiwei Qi Shihai Liu Yasai Yao Jun Liang | 2014 | J. Cell. Mol. Med2014，，5： | 1 |
| 7 | Effects of different carbon sources on the electrochemical properties of Li 4 Ti 5 O 12 /C composites显示文摘 | Ruying Wang Juan Wang Tian Qiu Lipeng Chen Haimei Liu Wensheng Yang | 2012 | Electrochimica Acta2012，，： | 1 |
| 8 | Prognostic significance of the co?expression of nucleophosmin and trefoilfactor 3 in postoperative gastric cancer patients显示文摘 | Yong Li Zhenqing Sun Kewei Liu Wensheng Qiu Ruyong Yao Tongtong Feng Chao Xin Lu Yue | 2014 | Molecular and Clinical Oncology2014，，6： | 1 |
| 9 | Repurposing FBP1:dephosphorylating IκBα to suppress NFκB显示文摘Metabolic enzymes can function as protein kinases and protein phosphatases to govern the phosphorylation status of protein substrates,thereby regulating pivotal cellular activities.A new study published in Cell Research demonstrated that fructose 1,6-bisphosphatase 1 directly dephosphorylates IκBαto suppress NFκB activation and modulate the tumor immune microenvironment.As a critical protein post-translational modification that plays an important role in the regulation of fundamental cellular activities,protein phosphorylation is controlled by two groups of enzymes with opposite activities:protein kinases and protein phosphatases.1 The human genome possesses>500 protein kinases for protein phosphorylation and<200 identified protein phosphatases for dephosphorylation,2 suggesting that protein dephosphorylation is less specifically regulated by protein phosphatases and that cells may use unknown and classic protein phosphatase-irrelevant mechanisms to dephosphorylate proteins.In the human genome,1653 of∼2700 human enzymes are metabolic enzymes。 | Gang Zhang Jingjing Tao Liming Lin Wensheng Qiu Zhimin Lu | 2023 | Cell Research2023，33，6： | 0 |
| 10 | X-ray Photoelectron Spectroscopy on Superconducting T_(12)CaBa_(2)Cu_(2)O_(8) Thin Film显示文摘We have prepared single-phase superconducting T_(12)CaBa_(2)Cu_(2)O_(8) thin film by dc magnetron sputtering process and measured X-ray photoelectron spectra of the film at room and liquid nitrogen temperatures.From the relative intensities of the Ba3d,Tl4f.O1 s and Cu2p spectra taken at different take-off angles,we have concluded that there is an adventitious contamination(nonsupercon-ducting phase)surface layer.After excluding contributions from these spurious phases,we have tentatively assigned which core-level shifts should be caused by the superconducting phase transition. | ZENG Wensheng QIU ping YAN Shaolin LI Zengfa ZHANG Guangyin | 1991 | Chinese Physics Letters1991，8，6： | 0 |
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