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| 1 | Structural Analyses of Short-Chain Prenyltransfemses Identify an Evolutionarily Conserved GFPPS Clade in Brassicaceae Plants显示文摘Terpenoids 是专业化植物的代谢物的最大、很多样的类,它在植物开发期间在多样的生理的进程工作。在植物 terpenoids 的生合成,短链的 prenyltransferases (SC 磅) 和萜烯 synthases (TPS ) ,在决定 terpenoid 的 playcritical 角色差异。有不同的链长度的 SC 磅 biosynthesize prenyl 焦磷酸盐,和这些混合物是 terpenoids 的直接先锋。Arabidopsis thaliana 拥有其功能清楚地不被知道的 SC 磅的亚群。在这研究,我们集中于 10 geranylgeranyl 焦磷酸盐象 synthase 一样[GGPPSL ] 蛋白质,它通常被认为生产 GGPP [C20 ] 。我们发现 Arabidopsis GGPPSL 基因家庭的成员的一个子集经历了 neo-functionalization:GGPPSL6, 7, 9,和 10 主要举办 geranylfarnesyl 焦磷酸盐 synthase 活动(C25;renamedAtGFPPS1, 2, 3,和 4 ) ,并且 GGPPSL8 生产甚至更长的链 prenyl 焦磷酸盐(≥C30;renamedpolyprenyl 焦磷酸盐 synthase 2, AtPPPS2 ) 。由解决 AtGFPPS2, AtPPPS2,和 AtGGPPS11 的水晶结构,我们揭示 SC 磅的产品链长度决心机制并且作为 “three floors” 解释它当模特儿。用这个模型,我们识别了在 Brassicaceae 植物散布并且发现 GFPPS 基因典型地与编码 TPS 的基因一起发生的新奇 GFPPS clade,形成 GFPPS-TPS 基因簇。 | ChengyuanWang Qingwen Chen Dongjie Fan Jianxu Li Guodong Wang Peng Zhang | 2016 | Molecular Plant2016，9，2： | 19 |
| 2 | Heteromeric Geranyl(geranyi) Diphosphate Synthase Is Involved in Monoterpene Biosynthesis in Arabidopsis Flowers显示文摘Dear Editor, Monoterpenes,together with sesquiterpenes,play varying roles in plant interactions with the environment depending on the organs in which they are produced;these compounds likely function to attract pollinators when they are present in flowers and can protect plants against herbivores or microbes when produced in leaves or in roots.It is well known that geranyl diphosphate (GPP),the common precursor of monoterpenes,is biosynthesized by geranyl diphosphate synthase (GPPS). | Qingwen Chen Dongjie Fan GuodongWang | 2015 | Molecular Plant2015，8，9： | 14 |
| 3 | A Resource for Inactivation of MicroRNAs Using Short Tandem Target Mimic Technology in Model and Crop Plants显示文摘microRNAs (miRNAs)are endogenous small non-coding RNAs that bind to mRNAs and target them for cleavage and/or translational repression,leading to gene silencing.We previously developed short tandem target mimic (STTM)technology to deactivate endogenous miRNAs in Arabidopsis.Here,we created hundreds of STTMs that target both conserved and species-specific miRNAs in Arabidopsis,tomato,rice,and maize,providing a resource for the functional interrogation of miRNAs.We not only revealed the functions of several miRNAs in plant development,but also demonstrated that tissue-specific inactivation of a few miRNAs in rice leads to an increase in grain size without adversely affecting overall plant growth and development.RNA-seq and small RNAseq analyses of STTM156/157 and STTM165/166 transgenic plants revealed the roles of these miRNAs in plant hormone biosynthesis and activation,secondary metabolism,and ion-channel activity-associated electrophysiology,demonstrating that STTM technology is an effective approach for studying miRNA functions.To facilitate the study and application of STTM transgenic plants and to provide a useful platform for storing and sharing of information about miRNA-regulated gene networks,we have established an online Genome Browser (http://gffzzc750bc0108fa4044svwnk9of9c5cb6ovk.ffgz.tsg.suse.edu.cn/designindex2.php) to display the transcriptomic and miRNAomic changes in STTMinduced miRNA knockdown plants. | Ting Peng Mengmeng Qiao Haiping Liu Sachin Teotia Zhanhui Zhang Yafan Zhao Bobo Wang Dongjie Zhao Lina Shi Cui Zhang Brandon Le Kestrel Rogers Chathura Gunasekara Haitang Duan Yiyou Gu Lei Tian Jinfu Nie Jian Qi Fanrong Meng Lan Huang Qinghui Chen Zhenlin Wang Jinshan Tang Xiaoqing Tang Ting Lan Xuemei Chen Hairong Wei Quanzhi Zhao Guiliang Tang | 2018 | Molecular Plant2018，11，11： | 7 |
| 4 | 新疆牧民定居后的社会整合与文化重构显示文摘新疆牧民定居看似一种迁移,牧民从一地迁往另一地,但是由于迁移,牧民从散居变成了聚居,相应地使其生产、生活系统发生了变化。定居的过程同时是一个社会整合的过程,是社会结构重构和发展的过程,也是民族文化发生变化需要重建的过程。本文拟就此过程中存在的问题进行探讨和研究,提出一些解决的意见和建议。 | 陈冬季 Chen Dongji | 2005 | 昌吉学院学报2005，，3： | 6 |
| 5 | Predictors of post coronary artery bypass grafting atrial fibrillation显示文摘Objective: To investigate the incidence and relative risk factors of post coronary artery bypass grafting(post-CABG) atrial fibrillation(AF). Methods: 312 patients with CABG were reviewed and divided into an AF group and a non-AF group. Statistical analysis was used to compare the data between the two groups and screen for risk factors of post-CABG AF. Results: 103/312 (33.01%) patients developed post-CABG AF. Univariate analysis showed that patients in AF group compared with those in non-AF group were more likely to have advanced age (≥70 years), early postoperative withdrawal of β-blockers, hypertension, left atrial enlargement (≥40 mm), a history of AF, prolonged p-wave duration (≥120 ms) and increased number of grafts (≥3). Multivariate logistic regression analysis showed that advanced age (≥70 years), early postoperative withdrawal of β-blockers, hypertension, left atrial enlargement (≥40 mm) and a history of AF were highly related to post-CABG AF. Conclusion: The incidence of AF in patients following CABG was 33.01% in this study. Advanced age, early postoperative withdrawal of β-blockers, hypertension, left atrial enlargement and a history of AF were independent risk factors of post-CABG AF. | Tongtong Shen Qijun Shan Biao Yuan Bing Yang Chun Chen Dongjie Xu Minglong Chen Jiangang Zou Kejiang Cao | 2007 | Journal of Nanjing Medical University2007，21，3： | 5 |
| 6 | Spatial correlation-based characterization of acoustic emission signal-cloud in a granite sample by a cube clustering approach显示文摘To extract more in-depth information of acoustic emission(AE)signal-cloud in rock failure under triaxial compression,the spatial correlation of scattering AE events in a granite sample is effectively described by the cube-cluster model.First,the complete connection of the fracture network is regarded as a critical state.Then,according to the Hoshen-Kopelman(HK)algorithm,the real-time estimation of fracture con-nection is effectively made and a dichotomy between cube size and pore fraction is suggested to solve such a challenge of the one-to-one match between complete connection and cluster size.After,the 3D cube clusters are decomposed into orthogonal layer clusters,which are then transformed into the ellip-soid models.Correspondingly,the anisotropy evolution of fracture network could be visualized by three orthogonal ellipsoids and quantitatively described by aspect ratio.Besides,the other three quantities of centroid axis length,porosity,and fracture angle are analyzed to evaluate the evolution of cube cluster.The result shows the sample dilatancy is strongly correlated to four quantities of aspect ratio,centroid axis length,and porosity as well as fracture angle.Besides,the cube cluster model shows a potential pos-sibility to predict the evolution of fracture angle.So,the cube cluster model provides an in-depth view of spatial correlation to describe the AE signal-cloud. | Dongjie Xue Zepeng Zhang Cheng Chen Jie Zhou Lan Lu Xiaotong Sun Yintong Liu | 2021 | International Journal of Mining Science and Technology2021，31，4： | 5 |
| 7 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 8 | Molten hydroxide for detoxification of chlorine-containing waste: Unraveling chlorine retention efficiency and chlorine salt enrichment显示文摘Hazardous waste dechlorination reduces the potential of creating dioxins during the incineration process. To investigate the salt effect on waste dechlorination, molten hydroxides with a low melting temperature were utilized for the pre-dechlorination and decomposition of chlorine-containing organic wastes(COWs) including trichlorobenzene(TCB),perchloroethylene, hexachlorobenzene and chlordane. The results showed that a eutectic mixture of caustic sodium and potassium hydroxides(41 wt.% NaOH and 59 wt.% KOH) led to a low melting point below 300°C and a relatively high chlorine retention efficiency(CRE) with TCB as a representative COWs. The amounts of hydroxides, reaction time, and temperature all had notable influence on CRE. When the mass ratio of hydroxides to TCB reached 30:1,approximately 98.1% of the TCB was destroyed within 2.5 hr at 300°C with CRE of 71.6%.According to the residue analysis, the shapes of reaction residues were irregular with particles becoming swollen and porous. The benzene ring and C–Cl bonds disappeared, while carboxyl groups formed in the residues. The stripped chlorine was retained and condensed to form chloride salts, and the relative abundance of the chloride ions associated with the mass of TCB in residues increased from 0 to 75.0% within the 2.5 hr reaction time. The observed concentration of dioxins in residues was 5.6 ngTEQ/kg. A reaction pathway and possible additional reactions that occur in this dechlorination system were proposed. Oxidizing agents may attack TCB and facilitate hydrogenation/dechlorination reactions, making this process a promising and environmentally friendly approach for chlorine-containing organic waste treatment. | Shijin Dai Yilin Zheng Youcai Zhao Yu Chen Dongjie Niu | 2019 | Journal of Environmental Sciences2019，31，8： | 3 |
| 9 | DNA methylation status of H19 and Xist genes in lungs of somatic cell nuclear transfer bovines显示文摘In somatic cell nuclear transfer (SCNT) technologies,the donor cell’s nuclei need to be epigenetically reprogrammed for embryonic development. The incomplete reprogramming of donor cell nuclei has been implicated as a primary reason for the low efficiency of SCNT. DNA methylation is a major epige-netic modification of the genome that regulates crucial aspects of genome function,including estab-lishment of genomic imprinting. In order to make sure whether the DNA methylation reprogramming is efficient in SCNT animals,we analyzed the DNA methylation status of two imprinting genes,H19 and Xist,in lungs of deceased SCNT bovines that died within 48 h of birth using bisulfite sequencing analysis. Our findings demonstrated that cloned bovines showed significantly lower DNA methylation of H19 than controls (P<0.05),and three tested CpGs sites (1,2,3) exhibited unmethylation in one cloned bovine (9C3); however,Xist showed similar DNA methylation levels between clones and con-trols,and both showed hypermethylation (96.11% and 86.67%). | CHEN Jie LI DongJie LIU YanQin ZHANG Cui DAI YunPing LI ShiJie LI Ning | 2008 | Chinese Science Bulletin2008，53，13： | 3 |
| 10 | Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation显示文摘Dear Editor,Herpesviridae is a large family of double-stranded DNA(dsDNA)viruses that cause a variety of human diseases ranging from cold sores and chicken pox to congenital defects,blindness and cancer(Chayavichitsilp et al.,2009;Wang et al.,2018).In the past 70 years,substantial advances in our knowledge of the molecular biology of herpesviruses have led to insights into disease pathogenesis and management.However,the mechanism for capsid assembly that requires the ordered packing of about 4,000 protein subunits into the hexons,pentons and triplexes remains elusive.It is still a puzzle how initially identical subunits adopt both hexameric and pentameric conformations in the capsid and select the correct locations needed to form closed shells of the proper size.Biochemical and genetic studies have shown that the portal is involved in initiation of capsid assembly(Newcomb et al.,2005)and functions akin to a DNA-sensor coupling genome-packaging achieved by a genome-packaging machinery-“terminase complex”(Chen et al.,2020;Yunxiang Yang,2020)with icosahedral capsid maturation(Lokareddy et al.,2017).Structural investigations of the herpesvirus portal have proven challenging due to the small size of this dodecamer,which accounts for less than 1%of the total mass of the capsid protein layer and the technical difficulties involved in resolving non-icosahedral components of such large icosahedral viruses(diameter is∼1,250Å).Efforts of many investigators over two decades have made to reconstruct the cryo-electron microscopy(cryo-EM)structure of herpesvirus portal vertex and more recently near-atomic structures of two herpesvirus(herpes simplex virus type 1(HSV-1)and Kaposi’s sarcoma-associated herpesvirus(KSHV))portal vertices were reported(McElwee et al.,2018;Gong et al.,2019;Liu et al.,2019). | Nan Wang Wenyuan Chen Ling Zhu Dongjie Zhu Rui Feng Jialing Wang Bin Zhu Xinzheng Zhang Xiaoqing Chen Xianjie Liu Runbin Yan Dongyao Ni Grace Guoying Zhou Hongrong Liu Zihe Rao Xiangxi Wang | 2020 | Protein & Cell2020，11，5： | 2 |
| 11 | Tpeak-Tend interval as a new risk factor for arrhythmic event in pa-tient with Brugada syndrome显示文摘Objective: To evaluate Tpeak- Tend ( Tp- e) interval in surface standard ECG as a new risk factor for arrhythmic event inpatient with Brugada syndrome. Methods: 23 male patients with Brugada syndrome and 20 male patients with paroxysmalsupraventricular tachycardia ( PSVT) as the control group were investigated in this study. Tp- e interval in surface standardECG was compared between BrS and PSVT patients. Results: Tp- e interval in BrS patients was significantly longer thanthat in PSVT patients ( 109.57±22.86 ms vs. 88.50±13.08ms, P<0.05) . There was significant difference in Tp- e interval be-tween 16 BrS patients with arrhythmic events ( including syncope, clinical ventricular fibrillation [ VF] and programmed elec-trical stimulation [ PES] - induced VF) and 7 BrS patients without arrhythmic events and PSVT patients ( 118.12±20.40ms vs.90.00±15.27ms, P<0.05; 118.12±20.40ms vs. 88.50±13.08ms, P<0.05). However, Tp- e interval was similar in BrS patients with-out arrhythmic events and PSVT patients (90.00±15.27ms vs 88.50±13.08ms, P>0.05). Conclusion: The prolongation of Tp- einterval could serve as a new noninvasive event predictor for arrhythmic events in patients with Brugada syndrome. | Jinfeng Wang Qijun Shan Bing Yang Minglong Chen Jiangang Zou Dongjie Xu Chun Chen Kejiang Cao | 2007 | Journal of Nanjing Medical University2007，21，4： | 2 |
| 12 | Enhanced electrical properties in bilayered ferroelectric thin films显示文摘Sr2Bi4Ti5O18(SBTi) single layered and Sr2Bi4Ti5O18 /Pb(Zr0.53Ti0.47)O3(SBTi/PZT) bilayered thin films have been prepared on Pt/TiO2/SiO2/Si substrates by pulsed-laser deposition(PLD).The related structural characterizations and electrical properties have been comparatively investigated.X-ray diffraction reveals that both films have crystallized into perovskite phases and scanning electron microscopy shows the sharp interfaces.Both films show well-saturated ferroelectric hysteresis loops,however,compared with the single layered SBTi films,the SBTi/PZT bilayered films have significantly increased remnant polarization(Pr) and decreased coercive field(Ec),with the applied field of 260 kV/cm.The measured Pr and Ec of SBTi and SBTi/PZT films were 7.9 C/cm 2,88.1 kV/cm and 13.0 C/cm 2,51.2 kV/cm,respectively.In addition,both films showed good fatigue-free characteristics,the switchable polarization decreased by 9% and 11% of the initial values after 2.2 10 9 switching cycles for the SBTi single layered films and the SBTi/PZT bilayered films,respectively.Our results may provide some guidelines for further optimization of multilayered ferroelectric thin films. | ZHANG Hao LONG WeiJie CHEN YaQing GUO DongJie | 2013 | Science China Chemistry2013，56，3： | 2 |
| 13 | Identification and Functional Characterization of a NovelΔ12 Fatty Acid Desaturase Gene from Haematococcus pluvialis显示文摘The freshwater microalga Haematococcus pluvialis accumulates large amounts of fatty acids in response to adverse conditions.However,the key fatty acid desaturase genes in H.pluvialis remain unknown.In this study,we cloned and functionally characterized aΔ12 fatty acid desaturase gene,and designated it as HpFAD2.The open reading frame of HpFAD2 consisted of 1137 base pairs and encoded 378 amino acids.The deduced polypeptide showed 70%identity to other endoplasmic reticulumΔ12 fatty acid desaturases,whereas it had only 44%identity to plastidΔ12 fatty acid desaturases.The PSORT algorithm and phylogenetic analysis further confirmed its affiliation to the endoplasmic reticulumΔ12 fatty acid desaturases.Heterologous expression was performed in Saccharomyces cerevisiae cells transformed with the recombinant plasmid pYES2-HpFAD2.Two additional fatty acids(C16:2 and C18:2)were detected in the yeast transformants.The results indicatedΔ12 desaturation activity and substrate preference for C18:1 over C16:1.The transcriptional levels of H.pluvialis HpFAD2 at different growth stages were measured by quantitative polymerase chain reaction(PCR),indicating that the HpFAD2 transcriptional levels were significantly higher in red cells than those in green cells.Our study brings more insight into the fatty acid biosynthetic pathway of H.pluvialis. | ZHANG Lin CHEN Wenbi YANG Shuping ZHANG Yuanbo XU Jilin YANG Dongjie WU Zuyao LIU Tong CAO Jiayi | 2020 | Journal of Ocean University of China2020，19，6： | 2 |
| 14 | Performance Analysis and Evaluation of a Supercritical CO2 Rankine Cycle Coupled with an Absorption Refrigeration Cycle显示文摘The utilization of sensible waste heat such as flue gas and industrial surplus heat is essential for energy saving. Supercritical CO2 power generation cycle is a promising way to be used in this field. In this paper, a new supercritical CO2 Rankine cycle coupled with an absorption refrigeration cycle is proposed, which consists of a reheating supercritical CO2 cycle, a mixed-effect Li Br-H2O absorption refrigeration cycle and solar subsystem including evacuated-tube collector and a hot water storage tank. The system has four variants according to the presence or absence of solar subsystem and net cooling energy output. The thermodynamic model of the proposed system was established and its performance was evaluated. The proposed system is able to realize cascade utilization of flue gas waste heat and efficient conversion of solar energy. It has much higher thermodynamic efficiency than the reference system(i.e., the conventional supercritical CO2 Brayton cycle). Taking combined power and cooling system driven by flue gas waste heat and solar energy as an example, its thermal efficiency and exergy efficiency are 20.37% and 54.18% respectively, compared with the 14.74% and 35.96% of the reference system. Energy Utilization Diagrams(EUD) are implemented to investigate the irreversible losses and variation of the exergy destruction in the energy conversion process. Parametric analysis in two key parameters is conducted to provide guidance for the system optimal design. | CHEN Yi XU Dongjie CHEN Zheng GAO Xiang REN Fukang HAN Wei | 2020 | Journal of Thermal Science2020，29，4： | 2 |
| 15 | Fast-Track Surgery Improves Postoperative Clinical Recovery and Immunity After Elective Surgery for Colorectal Carcinoma: Randomized Controlled Clinical Trial显示文摘 | Dongjie Yang Weiling He Sheng Zhang Huayun Chen Changhua Zhang Yulong He | 2012 | World Journal of Surgery2012，，8： | 2 |
| 16 | Preparation and Characterization of the System SiO_2-CaO-P_2O_5 Bioactive Glasses by Microemulsion Approach显示文摘The system of SiO2-CaO-P2O5 bioactive glasses(BG) were successfully synthesized by microemulsion approach.X-ray diffraction(XRD),scanning electron micro scopy(SEM) and energy dispersive X-ray(EDX) analyses,transmission electron microscopy(TEM),Fourier transform infrared spectroscopy(FTIR),BET N2 gas adsorption analysis techniques were utilized in order to evaluate the phase composition,dimension,morphology,interconnectivity of pores and particle size of the synthesized BG respectiveely.The biocompatibility of BG was assessed by using dimethylthiazol diphenyl tetrazolium bromide(MTT).The BG scaffolds were implanted in rabbit mandibles and studied histologically.The results showed that the BG with a particle size less than 100 nm was prepared successfully.The measured BET specific surface area and pore volume was 113.9 m2/g and 0.28 cm3/g respectively.Cell cultures revealed that BG has been shown to have good biocompatibility and is also beneficial to the survival of Schwann cells,which can promote cell proliferation in vivo assay indicating that the BG can promote osteoconductivity. | 王洪新 CHEN Xiaoming WANG Youfa CHENG Dongji | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，5： | 1 |
| 17 | Percutaneous local tumor ablation vs. stereotactic body radiotherapy for early-stage non-small cell lung cancer: a systematic review and meta-analysis显示文摘Background:Percutaneous local tumor ablation(LTA)and stereotactic body radiotherapy(SBRT)have been regarded as viable treatments for early-stage lung cancer patients.The purpose of this study was to compare the efficacy and safety of LTA with SBRT for early-stage non-small cell lung cancer(NSCLC).Methods:PubMed,Embase,Cochrane library,Ovid,Google scholar,CNKI,and CBMdisc were searched to identify potential eligible studies comparing the efficacy and safety of LTA with SBRT for early-stage NSCLC published between January 1,1991,and May 31,2021.Hazard ratios(HRs)or odds ratios(ORs)with 95%confidence intervals(CIs)were applied to estimate the effect size for overall survival(OS),progression-free survival(PFS),locoregional progression(LP),and adverse events.Results:Five studies with 22,231 patients were enrolled,including 1443 patients in the LTA group and 20,788 patients in the SBRT group.The results showed that SBRT was not superior to LTA for OS(HR=1.03,95%CI:0.87-1.22,P=0.71).Similar results were observed for PFS(HR=1.09,95%CI:0.71-1.67,P=0.71)and LP(HR=0.66,95%CI:0.25-1.77,P=0.70).Subgroup analysis showed that the pooled HR for OS favored SBRT in patients with tumors sized>2 cm(HR=1.32,95%CI:1.14-1.53,P=0.0003),whereas there was no significant difference in patients with tumors sized≤2 cm(HR=0.93,95%CI:0.64-1.35,P=0.70).Moreover,no significant differences were observed for the incidence of severe adverse events(≥grade 3)(OR=1.95,95%CI:0.63-6.07,P=0.25)between the LTA group and SBRT group.Conclusions:Compared with SBRT,LTA appears to have similar OS,PFS,and LP.However,for tumors>2 cm,SBRT is superior to LTA in OS.Prospective randomized controlled trials are required to determine such findings. | Dongjie Chen Man Zhao Xiaoyong Xiang Jun Liang | 2022 | Chinese Medical Journal2022，，13： | 1 |
| 18 | Fast-Track Surgery Improves Postoperative Clinical Recovery and Immunity After Elective Surgery for Colorectal Carcinoma:Randomized Controlled Clinical Trial显示文摘 | Dongjie Yang Weiling He Sheng Zhang Huayun Chen Changhua Zhang Yulong He | 2012 | World Journal of Surgery2012，，8： | 1 |
| 19 | Analysis of Anomalous Enhancement in TEC and Electron Density in the China Region Prior to the 17 March 2015 Geomagnetic Storm Based on Ground and Space Observations显示文摘Total Electron Content(TEC)and electron density enhancement were observed on the day before 17 March 2015 great storm in the China Region.Observations from ground-and space-based instruments are used to investigate the temporal and spatial evolution of the pre-storm enhancement.TEC enhancement was observed from 24°N to 30°N after 10:00 UT at 105°E,110°E and 115°E longitudes on March 16.The maximum magnitude of TEC enhancement was more than 10 TECU and the maximal relative TEC enhancement exceeded 30%.Compared with geomagnetic quiet days,the electron density of Equatorial Ionization Anomaly(EIA)northern peak from Swarm A/C satellites on March 16 was larger and at higher latitudes.NmF2 enhanced during 11:30—21:00 UT at Shaoyang Station and increased by 200%at~16:00 UT.However,TEC and electron density enhancement were not accompanied by a significant change of hmF2.Most research has excluded some potential mechanisms as the main driving factors for storm-time density enhancements by establishing observational constraints.In this paper,we observed pre-storm enhancement in electron density at different altitudes and Equatorial Electrojet(EEJ)strength results derived from ground magnetometers observations suggest an enhanced eastward electric field from the E region probably played a significant role in this event. | Xiaoyun CHENG Dongjie YUE Changzhi ZHAI Yutian CHEN Xunzhe YIN | 2023 | Journal of Geodesy and Geoinformation Science2023，6，2： | 1 |
| 20 | A novel PI3K inhibitor XH30 suppresses orthotopic glioblastoma and brain metastasis in mice models显示文摘Glioblastoma is carcinogenesis of glial cells in central nervous system and has the highest incidence among primary brain tumors.Brain metastasis,such as breast cancer and lung cancer,also leads to high mortality.The available medicines are limited due to blood-brain barrier.Abnormal activation of phosphatidylinositol 3-kinases(PI3 K)signaling pathway is prevalent in glioblastoma and metastatic tumors.Here,we characterized a 2-amino-4-methylquinazoline derivative XH30 as a potent PI3 K inhibitor with excellent anti-tumor activity against human glioblastoma.XH30 significantly repressed the proliferation of various brain cancer cells and decreased the phosphorylation of key proteins of PI3 K signaling pathway,induced cell cycle arrest in G1 phase as well.Additionally,XH30 inhibited the migration of glioma cells and blocked the activation of PI3 K pathway by interleukin-17 A(IL-17 A),which increased the migration of U87 MG.Oral administration of XH30 significantly suppressed the tumor growth in both subcutaneous and orthotopic tumor models.XH30 also repressed tumor growth in brain metastasis models of lung cancers.Moreover,XH30 reduced IL-17 A and its receptor IL-17 RA in vivo.These results indicate that XH30 might be a potential therapeutic drug candidate for glioblastoma migration and brain metastasis. | Ming Ji Dongjie Wang Songwen Lin Chunyang Wang Ling Li Zhihui Zhang Jing Jin Deyu Wu Yi Dong Heng Xu Duo Lu Xiaoguang Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 1 |
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