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| 1 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 2 | Phase transformation and structural evolution in a Ti-5at.%Al alloy induced by cold-rolling显示文摘The phase transformation,deformation mechanism and their correlation in a cold-rolled Ti-5 at.%Al alloy were investigated.Two types of phase transformations from a hexagonal close-packed(HCP)structure to a face-centered cubic(FCC)structure were observed:the basal-type(B-type)with an orientation relation-ship of<1210HCP//<110FCC and{0001}HCP//{111}FCC,and the prismatic-type(P-type)with an orientation-relationship of<1210HCP//<110FCC and 1010HCP//110FCC.The two types of transformations both accommodate the strain along theaxis of the HCP matrix.With the proceeding of deformation,different deformation mechanisms were activated in the FCC and the HCP structures,respectively,which led to a faster grain refinement rate in the FCC structure than in the HCP matrix.Deformation twins with zero macroscopic strain were prevalent in the FCC domains produced by the B-type transformation,while deformation twins with macroscopic strain were normally observed in the FCC domains produced by the P-type transformation.This is in accordance with the lattice mismatches produced during phase transformation.The easy occurrence of deformation twinning in the FCC structure contributed significantly to the grain refinement process.In addition,the interaction between neighboring FCC domains produced by the two types of phase transformations also accelerated the grain refinement process. | Bingqiang Wei Song Ni Yong Liu Xiaozhou Liao Min Song | 2020 | Journal of Materials Science & Technology2020，47，14： | 1 |
| 3 | Enhancing {1012} twin boundary migration capability in Ti-Al solid solution alloys with increasing Al content显示文摘1.Introduction Titanium(Ti)and its alloys have been widely used in the aerospace,biomedical and chemical industries due to their high specific strength,low Young’s modulus,superior biocompatibility and strong corrosion resistance[1–5].While Ti alloys have high strength,they usually present relatively poor ductility and formability at room temperature[5].Therefore,their deformation behaviors and corresponding mechanisms have been the focus of attention in order to obtain better formability and mechanical properties.Forα-Ti and its alloys with hexagonal close-packed(HCP)structure,the most common slip system is prismatic a slip at room temperature[6–9].Pyramidal c+a slip can coordinate c-axis strain,but it is general difficult to activate c+a slip in polycrystalline Ti alloys[6,9]although reducing grain size can increase the propensity of c+a slip[9].Due to the limited slip systems for accommodating c-axis strain,deformation twinning plays an important role to coordinate strain along the c-axis of the HCP structure during plastic deformation. | Hao Zhang Bingqiang Wei Xiaoqin Ou Song Ni Xiaozhou Liao Min Song | 2023 | Journal of Materials Science & Technology2023，，16： | 0 |
| 4 | Structural characterization of the{1122}twin boundary and the corresponding stress accommodation mechanisms in pure titanium显示文摘{11-22}compression twin plays an important role in accommodating deformation along the c axis of HCP metals.However,the studies on the interface structure of{11-22}twin boundary(TB),especially the twin tip,and the corresponding local stress release mechanism are still limited.This work studied the interface characters of{11-22}TB of a deformed pure titanium by transmission electron microscope.The{11-22}TB presented serrated character,consisting of coherent twin boundary(CTB)and(0002)_(T)//(11-2-2)_(M) or(11-2-2)_(T)//(0002)_(M) steps,and the twin tip was fully composed of the basal-pyramidal(BPy)and pyramidal-basal(PyB)steps.The twin tip presents asymmetric morphology and the step height at the twin tip is much larger than that away from the twin tip.Two types of local stress accommodation mechanisms were observed:zonal dislocation emission and hexagonal close packed structure to facecentered cubic structure transformation.The zonal dislocation was produced by the dissociation of the1/3<11-2-3>dislocation that was nucleated at the twin tip and the phase transformation was introduced by emission of Shockley partial dislocations from the{11-22}twin boundary. | Bingqiang Wei Song Ni Yong Liu Min Song | 2021 | Journal of Materials Science & Technology2021，，13： | 0 |
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