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| 1 | A natural variation in Ribonuclease H-like gene underlies Rht8 to confer“Green Revolution”trait in wheat显示文摘Dear Editor,Introduction of gibberellin(GA)-insensitive Reduced height(Rht)genes,Rht-B1b and Rht-D1b,has resulted in the“Green Revolution”in modern wheat cultivars(Triticum aestivum)that has skyrocketed wheat grain yields worldwide since the 1960s(Peng et al.,1999;Velde et al.,2021).However,Rht-B1b/D1b also reduce coleoptiles,which is undesired in dryland regions where deep planting is essential for seedling establishment(Rebetzke et al.,1999,Rebetzke et al.,2001;Ellis et al.,2004). | Lingling Chai Mingming Xin Chaoqun Dong Zhaoyan Chen Huijie Zhai Junhong Zhuang Xuejiao Cheng Naijiao Wang Jia Geng Xiaobo Wang Ruolin Bian Yingyin Yao Weilong Guo Zhaorong Hu Huiru Peng Guihua Bai Qixin Sun Zhenqi Su Jie Liu Zhongfu Ni | 2022 | Molecular Plant2022，15，3： | 8 |
| 2 | Vitality and wound-age estimation in forensic pathology:review and future prospects显示文摘Determining the age of a wound is challenging in forensic pathology,but it can contribute to the reconstruction of crime scenes and lead to arrest of suspects.Forensic scholars have tended to focus on evaluating wound vitality and determining the time elapsed since the wound was sustained.Recent progress in forensic techniques,particularly high-throughput analyses,has enabled evaluation of materials at the cellular and molecular levels,as well as simultaneous assessment of multiple markers.This paper provides an update on wound-age estimation in forensic pathology,summarizes the recent literature,and considers useful additional informa-tion provided by each marker.Finally,the future prospects for estimating wound age in foren-sic practise are discussed with the hope of providing something useful for further study. | Na Li Qiuxiang Du Rufeng Bai Junhong Sun | 2020 | Forensic Sciences Research2020，5，1： | 5 |
| 3 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 4 | Nonlocal vibration and buckling of two-dimensional layered quasicrystal nanoplates embedded in an elastic medium显示文摘A mathematical model for nonlocal vibration and buckling of embedded two-dimensional(2 D) decagonal quasicrystal(QC) layered nanoplates is proposed. The Pasternak-type foundation is used to simulate the interaction between the nanoplates and the elastic medium. The exact solutions of the nonlocal vibration frequency and buckling critical load of the 2 D decagonal QC layered nanoplates are obtained by solving the eigensystem and using the propagator matrix method. The present three-dimensional(3 D) exact solution can predict correctly the nature frequencies and critical loads of the nanoplates as compared with previous thin-plate and medium-thick-plate theories.Numerical examples are provided to display the effects of the quasiperiodic direction,length-to-width ratio, thickness of the nanoplates, nonlocal parameter, stacking sequence,and medium elasticity on the vibration frequency and critical buckling load of the 2 D decagonal QC nanoplates. The results show that the effects of the quasiperiodic direction on the vibration frequency and critical buckling load depend on the length-to-width ratio of the nanoplates. The thickness of the nanoplate and the elasticity of the surrounding medium can be adjusted for optimal frequency and critical buckling load of the nanoplate.This feature is useful since the frequency and critical buckling load of the 2 D decagonal QCs as coating materials of plate structures can now be tuned as one desire. | Tuoya SUN Junhong GUO E.PAN | 2021 | Applied Mathematics and Mechanics(English Edition)2021，42，8： | 3 |
| 5 | Static deformation of a multilayered one-dimensional hexagonal quasicrystal plate with piezoelectric effect显示文摘Quasicrystals(QCs) are sensitive to the piezoelectric(PE) effect. This paper studies static deformation of a multilayered one-dimensional(1 D) hexagonal QC plate with the PE effect. The exact closed-form solutions of the extended displacement and traction for a homogeneous piezoelectric quasicrystal(PQC) plate are derived from an eigensystem. The general solutions for multilayered PQC plates are then obtained using the propagator matrix method when mechanical and electrical loads are applied on the top surface of the plate. Numerical examples for several sandwich plates made up of PQC, PE, and QC materials are provided to show the effect of stacking sequence on phonon, phason, and electric fields under mechanical and electrical loads, which is useful in designing new composites for engineering structures. | Tuoya SUN Junhong GUO Xiaoyan ZHANG | 2018 | Applied Mathematics and Mechanics(English Edition)2018，39，3： | 3 |
| 6 | The chromosome-scale genome of Phoebe bournei reveals contrasting fates of terpene synthase (TPS)-a and TPS-b subfamilies显示文摘Terpenoids,including aromatic volatile monoterpenoids and sesquiterpenoids,function in defense against pathogens and herbivores.Phoebe trees are remarkable for their scented wood and decay resistance.Unlike other Lauraceae species investigated to date,Phoebe species predominantly accumulate sesquiterpenoids instead of monoterpenoids.Limited genomic data restrict the elucidation of terpenoid variation and functions.Here,we present a chromosome-scale genome assembly of a Lauraceae tree,Phoebe bournei,and identify 72 full-length terpene synthase(TPS)genes.Genome-level comparison shows pervasive lineage-specific duplication and contraction of TPS subfamilies,which have contributed to the extreme terpenoid variation within Lauraceae species.Although the TPS-a and TPS-b subfamilies were both expanded via tandem duplication in P.bournei,more TPS-a copies were retained and constitutively expressed,whereas more TPS-b copies were lost.The TPS-a genes on chromosome 8 functionally diverged to synthesize eight highly accumulated sesquiterpenes in P.bournei.The essential oil of P.bournei and its main component,b-caryophyllene,exhibited antifungal activities against the three most widespread canker pathogens of trees.The TPS-a and TPS-b subfamilies have experienced contrasting fates over the evolution of P.bournei.The abundant sesquiterpenoids produced by TPS-a proteins contribute to the excellent pathogen resistance of P.bournei trees.Overall,this study sheds light on the evolution and adaptation of terpenoids in Lauraceae and provides valuable resources for boosting plant immunity against pathogens in various trees and crops. | Xiao Han Junhong Zhang Shuang Han Sun Li Chong Guanliang Meng Minyan Song Yang Wang Shengcai Zhou Chengcheng Liu Luhuan Lou Xiongzhen Lou Longjun Cheng Erpei Lin Huahong Huang Qi Yang Zaikang Tong | 2022 | Plant Communications2022，3，6： | 3 |
| 7 | Analysis of sensitivity and specificity:precise recognition of neutrophils during regeneration of contused skeletal muscle in rats显示文摘In this report,we applied the TissueFAXS 200 digital pathological analysis system to rapidly and accurately identify neutrophils during regeneration of contused skeletal muscle,and to provide information for follow-up studies on neutrophils to estimate wound age.Rat injury model was established,and skeletal muscle samples were obtained from the control group and contusion groups at 1,1.5,2,3,4,and 6 h,as well as at 1,3,5,and 15 d post-injury(n紏5 per group).The expression of nuclei and neutrophils was detected by hematoxylin and eosin(HE)staining and immunohistochemical(IHC)staining.A total of 20 injury site areas of 0.25mm^(2)(0.5mm0.5mm)were then randomly selected at all time points.A TissueFAXS 200 digital pathological analysis system was used to identify the positive and negative numbers.Knowledge of five professional medical workers were considered the gold standard to measure the false positive rate(FPR),false negative rate(FNR),sensitivity,specificity,and area under the curve(AUC)of receiver operating characteristic(ROC)curves.As a result,with a staining area of neutrophils from 8 μm^(2) to 15 μm^(2),the FPR was 4.28%–12.14%,the FNR was 12.42%–64.08%,the sensitivity was 35.92%–87.58%,the specificity was 87.86%–95.72%,the Youden index was 0.316–0.754,the accuracy was 82.80%–88.30%,and the AUC was 0.771–0.826.The AUC was largest when the cut-off value of the staining area was 12 mm^(2).Our results show that this software-based method is more accurate than the human eye in evaluating neutrophil infiltration.Based on the sensitivity and specificity,neutrophils can be accurately identified during regeneration of contused skeletal muscle.The TissueFAXS 200 digital pathological analysis system can also be used to optimize conditions for different cell types under various injury conditions to determine the optimal cut-off value of the staining area and provide optimal conditions for further study.Furthermore,it will provide evidence for forensic pathology cases. | Jiajia Niu Guoshuai An Zhen Gu Peng Li Qiqing Liu Rufeng Bai Junhong Sun Qiuxiang Du | 2022 | Forensic Sciences Research2022，7，2： | 2 |
| 8 | Bending Deformation of Multilayered One-Dimensional Quasicrystal Nanoplates Based on the Modified Couple Stress Theory显示文摘The modified couple stress theory has been applied in many nanomaterials except for nano-quasicrystals.In this paper,the modified couple stress theory is firstly adopted to analyze the static bending deformation of multilayered one-dimensional(ID)hexagonal quasicrystal(QC)nanoplates under surface loadings.The general solutions for the extended displacement and traction vectors in a simply supported and homogeneous QC nanoplate are derived by solving an eigenvalue problem reduced from the governing equations.Utilizing the propagator matrix method,the analytical solutions of multilayered ID QC nanoplates are then obtained by assuming that the layer interfaces are continuous.Numerical examples for some kinds of nanoplates made up of QC and crystal(BaTiOa)are provided to illustrate the effects of the material length parameter,the number of layers and the stacking sequence of nanoplates on the phonon and phason fields,which is helpful for the application of QCs to surface coating and solar energy selective absorber. | Xiaofei Li Junhong Guo Tuoya Sun | 2019 | Acta Mechanica Solida Sinica2019，32，6： | 2 |
| 9 | Mathematical modeling on hot air drying of thin layer apple pomace显示文摘 | Zhengfu Wang Junhong Sun Xiaojun Liao Fang Chen Guanghua Zhao Jihong Wu Xiaosong Hu | 2006 | Food Research International2006，，1： | 2 |
| 10 | Synthesis of hercynite by reaction sintering显示文摘 | Junhong Chen Lingyan Yu Jialin Sun Yong Li Wendong Xue | 2010 | Journal of the European Ceramic Society2010，，3： | 2 |
| 11 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 12 | Mathematical modeling on hot air drying of thin layer apple pomace显示文摘 | Zhengfu Wang Junhong Sun Xiaojun Liao | 2007 | Food Research International2007，40，1： | 1 |
| 13 | En- vironmental contamination by phthalates in China 显示文摘 | Hu Xiaoyu Zhang Kerong Sun Junhong | 2003 | Chin J Heal Lab Technol2003，13，1： | 1 |
| 14 | Mathematical modeling on hot air drying of thin layer apple pomace显示文摘 | WANG Zhengfu SUN Junhong LIAO Xiaojun | 2007 | Food Research International2007，40，： | 1 |
| 15 | A novel Hough transform method for line detection by enhancing accumulator array 显示文摘 | JI Junhong CHEN Guodong SUN Lining | 2011 | Pattern Recognition Letters2011，32，11： | 1 |
| 16 | Evaluation of MTS, XTT, MTT and 3HTdR incorpora- tion for assessing hepatocyte density 显示文摘 | WANG LISHENG SUN JUNHONG MARGRET HOR- VAT | 1996 | Methods in Cell Science1996，18，3： | 1 |
| 17 | Research on the Fe-silicon nitride material self-producing N_2 at high temperature显示文摘The Fe-silicon nitride synthesized by flashing combustion process was studied to determine the reaction temperature between Fe and silicon nitride, the account of N_2 given out in the course of the reaction, and the change of the microstructure during calcination. The results showed that at 1127.2℃ the Fe-silicon nitride self-reacts and releases N_2 and under 101.3 kPa the volume of N_2 given out in the course of the reaction is 20 times more than that of the starting material. N_2 is produced quickly, and completes in several decade seconds. With the producing of N_2, the structure of Silicon Nitride around Fe becomes loose and porous, or cracks are formed by the reaction between Fe and silicon nitride. So if it is made use of that Fe-silicon nitride self-producing N_2 at the high temperature, the performance of the material on a base of Fe-silicon nitride could be greatly improved. | Junhong Chen Xueda Wang Jialin Sun Huasheng Zhan Wen Song | 2006 | Journal of University of Science and Technology Beijing2006，13，1： | 1 |
| 18 | Cancer-associated histone mutation H2BG53D disrupts DNA–histone octamer interaction and promotes oncogenic phenotypes显示文摘Dear Editor,Recent studies from us and others have deciphered the clinical relevance of a variety of oncohistones1 in different diseases.The H3K27M and H3K36M mutant histones exert dominant-negative effects on methylation levels of histone H3K27 and H3K36 on wildtype histone protein in pediatric brain cancers2–4 and chondroblastoma,5,6 respectively.In contrast to H3K27M and H3K36M that act in trans to cause global reduction of methylation at the respective residues,the H3G34 mutations,including H3G34V/R and H3G34W/L found in pediatric high-grade glioma and giant cell tumor of the bone,affect the H3K36 methylation in cis and alter the H3K36 methylation on the nucleosome containing the H3G34 mutation(s). | Yi Ching Esther Wan Tsz Chui Sophia Leung Dongbo Ding Xulun Sun Jiaxian Liu Lina Zhu Tze Zhen Evangeline Kang Du Yang Yuchen Zhang Jitian Zhang Chengmin Qian Michael Shing Yan Huen Qing Li Maggie Zi Ying Chow Zongli Zheng Junhong Han Ajay Goel Xin Wang Toyotaka Ishibashi Kui Ming Chan | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 19 | Expression pattern of asialoglycoprotein receptor in human testis显示文摘 | Pingnan Sun Junhong Zheng Guizhou She Xiujing Wei Xiaoyu Zhang Haijun Shi Xiaoling Zhou | 2013 | Cell and Tissue Research2013，，3： | 1 |
| 20 | African swine fever virus MGF505-3R inhibits cGAS-STING-mediated IFN-βpathway activation by degrading TBK1显示文摘African swine fever virus(ASFV)is an important pathogen causing acute infectious disease in domestic pigs and wild boars that seriously endangers the global swine industry.As ASFV is structurally complex and encodes a large number of functional proteins,no effective vaccine has been developed to date.Thus,dissecting the mechanisms of immune escape induced by ASFV proteins is crucial.A previous study showed that the ASFV-encoded protein is an important factor in host immunity.In this study,we identified a negative regulator,MGF505-3R,that significantly downregulated cGAS/STING-and poly(dG:dC)-mediated IFN-βand interferon stimulation response element(ISRE)reporter activity and suppressed IFNB1 and IFIT2 mRNA levels.In addition,TBK1,IRF3 and IκBαphosphorylation levels were also inhibited.Mechanistically,MGF505-3R interacted with cGAS/TBK1/IRF3 and targeted TBK1 for degradation,thereby disrupting the cGAS-STING-mediated IFN-βsignaling pathway,which appears to be highly correlated with autophagy.Knockdown MGF505-3R expression enhanced IFN-βand IL-1βproduction.Taken together,our study revealed a negative regulatory mechanism involving the MGF505-3R-cGAS-STING axis and provided insights into an evasion strategy employed by ASFV that involves autophagy and innate signaling pathways. | Mingyang Cheng Jiawei Luo Yuetong Duan Yu Yang Chunwei Shi Yu Sun Yiyuan Lu Junhong Wang Xiaoxu Li Jianzhong Wang Nan Wang Wentao Yang Yanlong Jiang Guilian Yang Yan Zeng Chunfeng Wang Xin Cao | 2022 | Animal Diseases2022，2，3： | 1 |
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