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| 1 | Targeting NF-κB pathway for the therapy of diseases:mechanism and clinical study显示文摘NF-κB pathway consists of canonical and non-canonical pathways.The canonical NF-κB is activated by various stimuli,transducing a quick but transient transcriptional activity,to regulate the expression of various proinflammatory genes and also serve as the critical mediator for inflammatory response.Meanwhile,the activation of the non-canonical NF-κB pathway occurs through a handful of TNF receptor superfamily members.Since the activation of this pathway involves protein synthesis,the kinetics of non-canonical NF-κB activation is slow but persistent,in concordance with its biological functions in the development of immune cell and lymphoid organ,immune homeostasis and immune response.The activation of the canonical and non-canonical NF-κB pathway is tightly controlled,highlighting the vital roles of ubiquitination in these pathways.Emerging studies indicate that dysregulated NF-κB activity causes inflammation-related diseases as well as cancers,and NF-κB has been long proposed as the potential target for therapy of diseases.This review attempts to summarize our current knowledge and updates on the mechanisms of NF-κB pathway regulation and the potential therapeutic application of inhibition of NF-κB signaling in cancer and inflammatory diseases. | Hui Yu Liangbin Lin Zhiqiang Zhang Huiyuan Zhang Hongbo Hu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 35 |
| 2 | Far-field coseismic displacements associated with the 2011 Tohoku-oki earthquake in Japan observed by Global Positioning System显示文摘Analysis of GEONET observations covering the entire territory of Japan shows that the great Tohoku-oki earthquake that occurred on March 11, 2011 off the east coast of Honshu in Japan caused an eastward movement of the northern part of the island by as much as 5.3 m. The GPS data from TEONET in China were used to derive far-field coseismic displacements and to assess the impact of the Tohoku-oki earthquake on crustal deformation in eastern China. The results reveal that the coseismic horizontal displacements induced by the earthquake are the level of millimeters to centimeters in North and Northeast China, with a maximum of 35 mm. Strain analysis also indicates that the earthquake resulted in an increase in the tensile strain on the north-northeast trending faults in North and Northeast China. The tensile strain imposed on the Yilan-Yitong and Dunhua-Mishan faults is more significant than that imposed on the faults in North China; the maximum normal strain reaches about 40 nano-strain. Considering that the static Coulomb stress loaded on the faults is limited, its effect on the regional seismic activity may not be significant. | WANG Min LI Qiang WANG Fan ZHANG Rui WANG YanZhao SHI HongBo ZHANG PeiZhen SHEN ZhengKang | 2011 | Chinese Science Bulletin2011，56，23： | 34 |
| 3 | Stenting for symptomatic intracranial arterial stenosis in China:1-year outcome of a multicentre registry study显示文摘background and purpose A multicentre prospective registry study of individually tailored stenting for a patient with symptomatic intracranial atherosclerotic stenosis(ICAS)combined with poor collaterals in China showed that the short-term safety and efficacy of stenting was acceptable.However,it remained uncertain whether the low event rate could be of a long term.We reported the 1-year outcome of this registry study to evaluate the long-term efficacy of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Methods Patients with symptomatic ICAS caused by 70%-99% stenosis located at the intracranial internal carotid,middle cerebral,intracranial vertebral or basilar arteries combined with poor collaterals were enrolled.Balloon-mounted stent or balloon plus self-expanding stent were selected based on the ease of vascular access and lesion morphology determined by the operators.The primary outcome was the rate of 30-day stroke,transient ischaemic attack and death,and 12-month ischaemic stroke within the same vascular territory,haemorrhagic stroke and vascular death after stenting.results From September 2013 to January 2015,300 patients(ages 58.3±9.78 years)were recruited.Among them,159 patients were treated with balloon-mounted stent and 141 with balloon plus self-expanding stent.During the 1-year follow-up,25 patients had a primary end point event.The probability of primary outcome at 1 year was 8.1%(95% CI 5.3% to 11.7%).In 76 patients with digital subtraction angiography follow-up,27.6%(21/76)had re-stenosis≥50% and 18.4%(14/76)had re-stenosis≥70%.No baseline characteristic was associated with the primary outcome.Conclusion The event rate remains low over 1 year of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Further randomised trial of comparing individually tailored stenting with best medical therapy is needed. | Ning Ma Yong Zhang Jie Shuai Changchun Jiang Qiyi Zhu Kangning Chen Li Liu Baomin Li Xiangqun Shi Lianbo Gao Yajie Liu Feng Wang Yongli Li Tieyan Liu Hongbo Zheng Dapeng Mo Feng Gao Yilong Wang Yongjun Wang Lei Feng Zhongrong Miao | 2018 | Stroke & Vascular Neurology2018，3，3： | 29 |
| 4 | Principles and methods for the validation of quantitative remote sensing products显示文摘We first discuss the relativity of 'true value and homogeneity' for quantitative remote sensing products (QRSPs), and then propose the definitions of 'eigenaccuracy' and 'eigenhomogeneity' under practical conditions. The eigenaccuracy and eigenhomogeneity for land surface crucial parameters such as albedo, leaf area index (LAI), and surface temperature are analyzed based on a series of experiments. Secondly, we point out the differences and similarities between the scale-free phenomena of the QRSPs and the measurements of the coastline length (1-dimensional) and the curved surface area (2-dimensional). An information fractal algorithm for the QRSPs is presented. In a case study for the LAI, when the fractal dimension is 2.16, the ratio of the LAI retrieval values obtained respectively from remote sensing data of 30 m and 6 km pixel resolution can actually reach as high as 2.86 for the same 6 km pixel using the same retrieval model. Finally, we propose an operational validation method 'one test and two matches' and multipoint observation when the real situation does not allow carrying out scanning measurement without gap and overlap on the ground surface. | RenHua Zhang Jing Tian ZhaoLiang Li HongBo Su ShaoHui Chen XinZhai Tang | 2010 | Science China Earth Sciences2010，53，5： | 27 |
| 5 | The mechanism and risk factors for immune checkpoint inhibitor pneumonitis in non-small cell lung cancer patients显示文摘Immune checkpoint inhibitors(ICIs)are new and promising therapeutic agents for non-small cell lung cancer(NSCLC).However,along with demonstrating remarkable efficacy,ICIs can also trigger immune-related adverse events.Checkpoint inhibitor pneumonitis(CIP)has been reported to have a morbidity rate of 3%to 5%and a mortality rate of 10%to 17%.Moreover,the incidence of CIP in NSCLC is higher than that in other tumor types,reaching 7%to 13%.With the increased use of ICIs in NSCLC,CIP has drawn extensive attention from oncologists and cancer researchers.Identifying high risk factors for CIP and the potential mechanism of CIP are key points in preventing and monitoring serious adverse events.In this review,the results of our analysis and summary of previous studies suggested that the risk factors for CIP may include previous lung disease,prior thoracic irradiation,and combinations with other drugs.Our review also explored potential mechanisms closely related toCIP,including increasedT cell activity against associated antigens in tumor and normal tissues,preexisting autoantibodies,and inflammatory cytokines. | Xiaoyang Zhai Jian Zhang Yaru Tian Ji Li Wang Jing Hongbo Guo Hui Zhu | 2020 | Cancer Biology & Medicine2020，17，3： | 25 |
| 6 | Observation and analysis of atmospheric volatile organic compounds in a typical petrochemical area in Yangtze River Delta, China显示文摘Volatile organic compounds(VOCs) are a kind of important precursors for ozone photochemical formation. In this study, VOCs were measured from November 5 th, 2013 to January 6 th, 2014 at the Second Jinshan Industrial Area, Shanghai, China. The results showed that the measured VOCs were dominated by alkanes(41.8%), followed by aromatics(20.1%), alkenes(17.9%), and halo-hydrocarbons(12.5%). The daily trend of the VOC concentration showed a bimodal feature due to the rush-hour traffic in the morning and at nightfall. Based on the VOC concentration, a receptor model of Positive Matrix Factorization(PMF) coupled with the information related to VOC sources was applied to identify the major VOC emissions. The result showed five major VOC sources: solvent use and industrial processes were responsible for about 30% of the ambient VOCs, followed by rubber chemical industrial emissions(23%), refinery and petrochemical industrial emissions(21%), fuel evaporations(13%) and vehicular emissions(13%). The contribution of generalized industrial emissions was about 74% and significantly higher than that made by vehicle exhaust. Using a propylene-equivalent method, alkenes displayed the highest concentration, followed by aromatics and alkanes. Based on a maximum incremental reactivity(MIR)method, the average hourly ozone formation potential(OFP) of VOCs is 220.49 ppbv. The most significant source for ozone chemical formation was identified to be rubber chemical industrial emissions, following one by vehicular emission. The data shown herein may provide useful information to develop effective VOC pollution control strategies in industrialized area. | Yunchen Zhang Rui Li Hongbo Fu Dong Zhou Jianmin Chen | 2018 | Journal of Environmental Sciences2018，30，9： | 21 |
| 7 | Natural Variation in CCD4 Promoter Underpins Species-Specific Evolution of Red Coloration in Citrus Peel显示文摘Carotenoids and apocarotenoids act as phytohormones and volatile precursors that influence plant development and confer aesthetic and nutritional value critical to consumer preference.Citrus fruits display considerable natural variation in carotenoid and apocarotenoid pigments.In this study,using an integrated genetic approach we revealed that a 5;c/s-regulatory change at CCD4b encoding CAROTENOID CLEAVAGE DIOXYGENASE 4b is a major genetic determinant of natural variation in C3 0 apocarotenoids responsible for red coloration of citrus peel.Functional analyses demonstrated that in addition the known role in synthesizing 3-citraurin,CCD4b is also responsible for the production of another important C3 0 apocarotenoid pigment,p-citraurinene.Furthermore,analyses of the CCD4b promoter and transcripts from various citrus germplasm accessions established a tight correlation between the presence of a putative 5'c/s-regulatory enhancer within an MITE transposon and the enhanced allelic expression of CCD4b in C3 0 apocarotenoid-rich red-peeled accessions.Phylogenetic analysis provided further evidence that functional diversification of CCD4b and naturally occurring variation of the CCD4b promoter resulted in the stepwise evolution of red peels in mandarins and their hybrids.Taken together,our findings provide new insights into the genetic and evolutionary basis of apocarotenoid diversity in plants,and would facilitate breeding efforts that aim to improve the nutritional and aesthetic value of citrus and perhaps other fruit crops. | Xiongjie Zheng Kaijie Zhu Quan Sun Weiyi Zhang Xia Wang Hongbo Cao Meilian Tan Zongzhou Xie Yunliu Zeng Junli Ye Lijun Chai Qiang Xu Zhiyong Pan Shunyuan Xiao Paul D.Fraser Xiuxin Deng | 2019 | Molecular Plant2019，12，9： | 18 |
| 8 | High speed interpolation for micro-line trajectory and adaptive real-time look-ahead scheme in CNC machining显示文摘CNC machining plays an important role in mechanical manufacturing.A key issue is to improve the machining feedrate while keeping the machining precision and satisfying the acceleration constraints of the CNC machine.For the consecutive micro-line segments interpolation,the velocities at the junction of two segments are the bottlenecks for the machining efficiency.This paper proposes a multi-period turning method to improve the feedrate at the junctions using the linear acceleration and deceleration mode,which utilizes the maximal acceleration capabilities of the NC machine while satisfying the machining precision.A new and more efficient look-ahead method and a feedrate override method are also proposed to boast the global machining speed.The proposed algorithm has been implemented on Blue Sky NC System,and experimented in real material manufacturing.Compared with several existing algorithms,the current algorithm can improve the manufacturing time ranging from 50% to 180%,depending on the machining parameters,and also results in better machining quality.In addition,the algorithm also satisfies the need of real-time interpolation. | ZHANG LiXian SUN RuiYong GAO XiaoShan LI HongBo | 2011 | Science China(Technological Sciences)2011，54，6： | 17 |
| 9 | Influence of Gd_2O_3 and Yb_2O_3 Co-doping on Phase Stability,Thermo-physical Properties and Sintering of 8YSZ显示文摘The role of multicomponent rare earth oxides in phase stability, thermophysical properties and sintering for ZrO2-based thermal barrier coatings (TBCs) materials is investigated. 8YSZ codoped with 3 mol% Gd2O3 and 3 mol% Yb2O3 (GYb-YSZ) powders are synthesized by solid state reaction for 24 h at various temperatures. As temperature increases, stabilizers are dissolved into zirconia matrix gradually. Synthesized at 1 500 °C, GYb-YSZ is basically composed of cubic phase. GYb-YSZ exhibits excellent phase stability and sinters lower than 8YSZ by nearly three times. The thermal conductivity of GYb-YSZ is much lower than that of 8YSZ, and the thermal expansion coefficient of GYb-YSZ is comparable to that of 8YSZ. The influence of Gd2O3 and Yb2O3 co-doping on phase stability, thermal conductivity and sintering of 8YSZ is discussed. | ZHANG Yanli GUO Lei YANG Yongping GUO Hongbo ZHANG Hongju GONG Shengkai | 2012 | Chinese Journal of Aeronautics2012，25，6： | 17 |
| 10 | Effects of applying lactic acid bacteria to the fermentation on a mixture of corn steep liquor and air-dried rice straw显示文摘This study was to determine the fermentation quality of a mixture of corn steep liquor(CSL)(178 g/kg wet basis) and air-dried rice straw(356 g/kg wet basis) after being treated with inoculants of different types of lactic acid bacteria(LAB). The treatments included the addition of no LAB additive(control),which was deionized water; homo-fermentative LAB alone(^(ho)LAB), which was Lactobacillus plantarum alone), and a mixture of homo-fermentative and hetero-fermentative LAB(^(he+ho)LAB), which were L. plantarum, Lactobacillus casei, and Lactobacillus buchneri. The results showed that the inoculation of the mixture of CSL and air-dried rice straw with ^(he+ho)LAB significantly increased the concentration of acetic acid and lactic acid compared with the control(P < 0.05). The addition of ^(he+ho)LAB effectively inhibited the growth of yeast in the silage. The concentration of total lactic acid bacteria in the ^(he+ho)LAB-treated silage was significant higher than those obtained in other groups(P < 0.05). The duration of the aerobic stability of the silages increased from 56 h to >372 h. The control group was the first to spoil, whereas the silage treated with ^(he+ho)LAB remained stable throughout the 372 h period of monitoring. The results demonstrated that the ^(he+ho)LAB could effectively improve the fermentation quality and aerobic stability of the silage. | Xinxin Li Wenbin Xu Jinshan Yang Hongbo Zhao Chunfang Pan Xue Ding Yonggen Zhang | 2016 | Animal Nutrition2016，，3： | 17 |
| 11 | High-speed femtosecond laser plasmonic lithography and reduction of graphene oxide for anisotropic photoresponse显示文摘Micro/nanoprocessing of graphene surfaces has attracted significant interest for both science and applications due to its effective modulation of material properties,which,however,is usually restricted by the disadvantages of the current fabrication methods.Here,by exploiting cylindrical focusing of a femtosecond laser on graphene oxide(GO)films,we successfully produce uniform subwavelength grating structures at high speed along with a simultaneous in situ photoreduction process.Strikingly,the well-defined structures feature orientations parallel to the laser polarization and significant robustness against distinct perturbations.The proposed model and simulations reveal that the structure formation is based on the transverse electric(TE)surface plasmons triggered by the gradient reduction of the GO film from its surface to the interior,which eventually results in interference intensity fringes and spatially periodic interactions.Further experiments prove that such a regular structured surface can cause enhanced optical absorption(>20%)and an anisotropic photoresponse(~0.46 ratio)for the reduced GO film.Our work not only provides new insights into understanding the laser-GO interaction but also lays a solid foundation for practical usage of femtosecond laser plasmonic lithography,with the prospect of expansion to other two-dimensional materials for novel device applications. | Tingting Zou Bo Zhao Wei Xin Ye Wang Bin Wang Xin Zheng Hongbo Xie Zhiyu Zhang Jianjun Yang Chunlei Guo | 2020 | Light(Science & Applications)2020，9，1： | 17 |
| 12 | A study on key technologies of unmanned driving显示文摘 | Xinyu Zhang Hongbo Gao Mu Guo Guopeng Li Yuchao Liu Deyi Li | 2016 | CAAI Transactions on Intelligence Technology2016，1，1： | 14 |
| 13 | Earthquake-related Tectonic Deformation of Soft-sediments and Its Constraints on Basin Tectonic Evolution显示文摘The authors introduced two kinds of newly found soft-sediment deformation-syn-sedimentary extension structure and syn-sedimentary compression structure,and discuss their origins and constraints on basin tectonic evolution.One representative of the syn-sedimentary extension structure is syn-sedimentary boudinage structure,while the typical example of the syn-sedimentary compression structure is compression sand pillows or compression wrinkles.The former shows NW-SE-trending contemporaneous extension events related to earthquakes in the rift basin near a famous Fe-Nb-REE deposit in northern China during the Early Paleozoic(or Mesoproterozoic as proposed by some researches),while the latter indicates NE-SW-trending contemporaneous compression activities related to earthquakes in the Middle Triassic in the Nanpanjiang remnant basin covering south Guizhou,northwestern Guangxi and eastern Yunnan in southwestern China.The syn-sedimentary boudinage structure was found in an earthquake slump block in the lower part of the Early Paleozoic Sailinhudong Group,20 km to the southeast of Bayan Obo,Inner Mongolia,north of China.The slump block is composed of two kinds of very thin layers—pale-gray micrite(microcrystalline limestone)of 1?2 cm thick interbedded with gray muddy micrite layers with the similar thickness.Almost every thin muddy micrite layer was cut into imbricate blocks or boudins by abundant tiny contemporaneous faults,while the interbedded micrite remain in continuity.Boudins form as a response to layer-parallel extension(and/or layer-perpendicular flattening)of stiff layers enveloped top and bottom by mechanically soft layers.In this case,the imbricate blocks cut by the tiny contemporaneous faults are the result of abrupt horizontal extension of the crust in the SE-NW direction accompanied with earthquakes.Thus,the rock block is,in fact,a kind of seismites.The syn-sedimentary boudins indicate that there was at least a strong earthquake belt on the southeast side of the basin during the early stage of the Sailinhudong Group.This may be a good constraint on the tectonic evolution of the Bayan Obo area during the Early Paleozoic time.The syn-sedimentary compression structure was found in the Middle Triassic flysch in the Nanpanjiang Basin.The typical structures are compression sand pillows and compression wrinkles.Both of them were found on the bottoms of sand units and the top surface of the underlying mud units.In other words,the structures were found only in the interfaces between the graded sand layer and the underlying mud layer of the flysch.A deformation experiment with dough was conducted,showing that the tectonic deformation must have been instantaneous one accompanied by earthquakes.The compression sand pillows or wrinkles showed uniform directions along the bottoms of the sand layer in the flysch,revealing contemporaneous horizontal compression during the time between deposition and diagenesis of the related beds.The Nanpanjiang Basin was affected,in general,with SSW-NNE compression during the Middle Triassic,according to the syn-sedimentary compression structure.The two kinds of syn-sedimentary tectonic deformation also indicate that the related basins belong to a rift basin and a remnant basin,respectively,in the model of Wilson Cycle. | LU Hongbo ZHANG Yuxu ZHANG Qiling XIAO Jiafei | 2006 | Acta Geologica Sinica(English Edition)2006，80，5： | 13 |
| 14 | Kinematics and Dynamics Analysis of a Quadruped Walking Robot with Parallel Leg Mechanism显示文摘It is desired to require a walking robot for the elderly and the disabled to have large capacity,high stiffness,stability,etc.However,the existing walking robots cannot achieve these requirements because of the weight-payload ratio and simple function.Therefore,Improvement of enhancing capacity and functions of the walking robot is an important research issue.According to walking requirements and combining modularization and reconfigurable ideas,a quadruped/biped reconfigurable walking robot with parallel leg mechanism is proposed.The proposed robot can be used for both a biped and a quadruped walking robot.The kinematics and performance analysis of a 3-UPU parallel mechanism which is the basic leg mechanism of a quadruped walking robot are conducted and the structural parameters are optimized.The results show that performance of the walking robot is optimal when the circumradius R,r of the upper and lower platform of leg mechanism are 161.7 mm,57.7 mm,respectively.Based on the optimal results,the kinematics and dynamics of the quadruped walking robot in the static walking mode are derived with the application of parallel mechanism and influence coefficient theory,and the optimal coordination distribution of the dynamic load for the quadruped walking robot with over-determinate inputs is analyzed,which solves dynamic load coupling caused by the branches' constraint of the robot in the walk process.Besides laying a theoretical foundation for development of the prototype,the kinematics and dynamics studies on the quadruped walking robot also boost the theoretical research of the quadruped walking and the practical applications of parallel mechanism. | WANG Hongbo SANG Lingfeng HU Xing ZHANG Dianfan YU Hongnian | 2013 | Chinese Journal of Mechanical Engineering2013，26，5： | 12 |
| 15 | Characteristics of the lunar samples returned by the Chang'E-5 mission显示文摘Forty-five years after the Apollo and Luna missions returned lunar samples,China's Chang’E-5(CE-5)mission collected new samples from the mid-latitude region in the northeastern Oceanus Procellarum of the Moon.Our study shows that 95%of CE-5 lunar soil sizes are found to be within the range of 1.40-9.35μm,while 95%of the soils by mass are within the size range of 4.84-432.27μm.The bulk density,true density and specific surface area of CE-5 soils are 1.2387 g/cm^(3),3.1952 g/cm^(3) and 0.56 m^(2)/g,respectively.Fragments from the CE-5 regolith are classified into igneous clasts(mostly basalt),agglutinate and glass.A few breccias were also found.The minerals and compositions of CE-5 soils are consistent with mare basalts and can be classified as low-Ti/low-Al/low-K type with lower rare-earth-element contents than materials rich in potassium,rare earth element and phosphorus.CE-5 soils have high FeO and low Mg index,which could represent a new class of basalt. | Chunlai Li Hao Hu Meng-Fei Yang Zhao-Yu Pei Qin Zhou Xin Ren Bin Liu Dawei Liu Xingguo Zeng Guangliang Zhang Hongbo Zhang Jianjun Liu Qiong Wang Xiangjin Deng Caijin Xiao Yonggang Yao Dingshuai Xue Wei Zuo Yan Su Weibin Wen Ziyuan Ouyang | 2022 | National Science Review2022，9，2： | 12 |
| 16 | Chang'E-1 Lunar Mission:An Overview and Primary Science Results显示文摘Chang'E-1 is the first lunar mission in China,which was successfully launched on Oct.24th,2007.It was guided to crash on the Moon on March 1,2009,at 52.36°E,1.50°S,in the north of Mare Fecunditatis.The total mission lasted 495 days,exceeding the designed life-span about four months.1.37Terabytes raw data was received from Chang'E-1.It was then processed into 4Terabytes science data at different levels.A series of science results have been achieved by analyzing and applicating these data,especially 'global image of the Moon of China's first lunar exploration mission'.Four scientific goals of Chang'E-1 have been achieved.It provides abundant materials for the research of lunar sciences and cosmochemistry.Meanwhile these results will serve for China's future lunar missions. | Ouyang Ziyuan Li Chunlai Lu Chang Liu Jianzhong Zou Yongliao Zhang Hongbo Jianjun Zuo Wei Su Yah Wen Weibin Bian Wei Zhao Baochang Wang Jianyu Yang Jianfeng Chang Jin Wang Huanyu Zhang Xiaohui Wang Shijin Wang Min Ren Xin Mu Lingli Kong Deqing Wang Xiaoqian Wang Fang Geng Liang Zhang Zhoubin Zheng Lei Zhu Xinying Zheng Yongchun Li Junduo Zou Xiaoduan Xu Chun Shi Shuobiao Gao Yifei Gao Guannan | 2010 | 空间科学学报2010，30，5： | 11 |
| 17 | Molecular geochemical characteristics of gas source rocks from the Upper Triassic Xujiahe Formation indicate transgression events in the Sichuan Basin显示文摘The geochemical characteristics of saturated and aromatic hydrocarbons from different formations and lithologies provide ob-vious evidence for transgressions that occurred during Upper Triassic Xujiahe stage in Sichuan Basin with a great impact on the source input and depositional environment.A clear dual peak distribution for normal alkanes and obvious abundant com-pounds sourced from bacteria and algae in whole oil gas chromatogram indicates the abundance of lower organisms input.The ratio of Pr/Ph is low,ranging from 0.33 to 0.86 with an average of 0.60,quite different from Pr/Ph >2.0 for coal measures in swamp environment,representing source rocks from saline lake or marine facies.In the gas source rocks extracts,abundant β-carotane,-carotane,and their degradated series were detected in the whole oil chromatogram,indicating a reducing envi-ronment.The concentrations of methyl steranes and dinosteranes are high.The content of polycyclic aromatic sulfur heterocy-cles(PASH) is relatively higher in aromatic fraction and the assemblage of fluorene,dibenzofuran,and dibenzothiophene is different from the typical saline lake and the regular swamp facies source rocks,manifesting the transgression effects on gas source rocks. | ZHANG Min HUANG GuangHui LI HongBo HU GuoYi ZHANG ShuiChang | 2012 | Science China Earth Sciences2012，55，8： | 10 |
| 18 | Placement Optimization of Caching UAV-Assisted Mobile Relay Maritime Communication显示文摘Recently, due to the deployment flexibility of unmanned aerial vehicles(UAVs), UAV-assisted mobile relay communication system has been widely used in the maritime communication. However, the performance of UAV-assisted mobile relay communication system is limited by the capacity of wireless backhaul link between base station and UAV. In this paper, we consider a caching UAV-assisted decode-and-forward relay communication system in a downlink maritime communication. For the general case with multiple users, the optimal placement of UAV is obtained by solving the average achievable rate maximization problem through the one-dimensional linear search. For a special case with single user, we derive a semi closedform expression of the optimal placement of UAV. Simulation results confirm the accuracy of analytical results and show that the optimal placement of UAV and the average achievable rate significantly depend on the cache capacity at UAV. We also show the difference between the performances of the air-to-ground model and the air-to-sea model. | Jun Zhang Fengzhu Liang Bin Li Zheng Yang Yi Wu Hongbo Zhu | 2020 | China Communications2020，17，8： | 10 |
| 19 | Observations of atmospheric pollutants at Lhasa during 2014-2015:Pollution status and the influence of meteorological factors显示文摘Atmospheric pollutants including SO_2, NO_2, CO, O_3 and inhalable particulate matter(PM2.5 and PM10) were monitored continuously from March 2014 to February 2015 to investigate characteristics of air pollution at Lhasa, Tibetan Plateau. Species exhibited similar seasonal variations except O_3, with the peaks in winter but low valleys in summer. The maximum O_3 concentration was observed in spring, followed by summer, autumn, and winter. The positive correlation between O_3 and PM10 in spring indicated similar sources of them, and was assumed to be turbulent transport. Temperature was the dominant meteorological factor for most species in spring. High temperature accelerates O_3 photochemistry, and favors air disturbance which is conductive to dust resuspension in spring. Relative humidity(RH) and atmospheric pressure were the main meteorological factors in summer. RH showed negative correlations with species, while atmospheric pressure posed opposite situation. Wind speed(WS) was the dominant meteorological factor in autumn, the negative correlations between WS and species indicated diffusion by wind. Most species showed non-significant correlations with meteorological factors in winter, indicating the dependence of pollution on source emission rather than restriction by meteorology. Pollution weather character indicated that emissions were from biomass burning and dust suspension, and meteorological factors also played an important role. Air stream injection from the stratosphere was observed during O_3 pollution period. Air parcels from Southwest Asia were observed during air pollution period in winter. An enhancement in air pollutants such as O_3 would be expected in the future, more attention should be given to countermeasures for prevention of air pollution in the future. | Bu Duo Lulu Cui Zhenzhen Wang Rui Li Liwu Zhang Hongbo Fu Jianmin Chen Huifang Zhang A.Qiong | 2018 | Journal of Environmental Sciences2018，30，1： | 9 |
| 20 | KIF2C:a novel link between Wnt/β-catenin and mTORCI signaling in the pathogenesis of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and is the fourth-leading cause of cancer-related deaths worldwide.HCC is refractory to many standard cancer treatments and the prognosis is often poor,highlighting a pressing need to identify biomarkers of aggressiveness and potential targets for future treatments.Kinesin family member 2C(KIF2C)is reported to be highly expressed in several human tumors.Nevertheless,the molecular mechanisms underlying the role of KIF2C in tumor development and progression have not been investigated.In this study,we found that KIF2C expression was significantly upregulated in HCC,and that KIF2C up-regulation was associated with a poor prognosis.Utilizing both gain and loss of function assays,we showed that KIF2C promoted HCC cell proliferation,migration,invasion,and metastasis both in vitro and in vivo.Mechanistically,we identified TBC1D7 as a binding partner of KIF2C,and this interaction disrupts the formation of the TSC complex,resulting in the enhancement of mammalian target of rapamycin complexl(mTORCI)signal transduction.Additionally,we found that KIF2C is a direct target of the Wnt/β-catenin pathway,and acts as a key factor in mediating the crosstalk between Wnt/β-catenin and mTORCI signaling.Thus,the results of our study establish a link between Wnt/β-catenin and mTORCI signaling,which highlights the potential of KIF2C as a therapeutic target for the treatment of HCC. | Shi Wei Miaomiao Dai Chi Zhang Kai Teng Fengwei Wang Hongbo Li Weipeng Sun Zihao Feng Tiebang Kang Xinyuan Guan Ruihua Xu Muyan Cai Dan Xie | 2021 | Protein & Cell2021，12，10： | 8 |
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