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| 1 | K-ras^G12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis显示文摘增加的氧气的 glycolysis 和氧化应力是癌症房间新陈代谢的重要特征,但是内在的生物化学、分子的机制留下逃犯。用四圜素可诱导的模型,我们显示出 K 地岬 G12V 原因 mitochondrial 机能障碍,导致反应的氧的减少的呼吸,提高的 glycolysis,和增加的产生种类。K 地岬蛋白质与线粒体被联系,并且导致呼吸的链建筑群的快速的抑制 -- 我和在由影响 cyclosporin 敏感的渗透的 mitochondrial transmembrane 潜力的减少转移毛孔。而且, K 地岬 在 vitro 的 G12V 表示提高转变房间的能力允许新陈代谢的改编到高 glycolytic 新陈代谢在 vivo 形成肿瘤。我们的学习建议 mitochondrial 机能障碍的那正式就职是由 K 地岬 G12V 在癌症房间引起新陈代谢的变化和 ROS 应力,并且支持肿瘤开发。 | Yumin Hu Weiqin Lu Gang Chen Peng Wang Zhao Chen Yan Zhou Marcia Ogasawara Dunyaporn Trachootham Li Feng Helene Pelicano Paul J Chiao Michael J Keating Guillermo Garcia-Manero Peng Huang | 2012 | Cell Research2012，22，2： | 6 |
| 2 | A rapid and accurate direct measurement method of underground coal seam gas content based on dynamic diffusion theory显示文摘Coal seam gas content is frequently measured in quantity during underground coal mining operation and coalbed methane(CBM)exploration as a significant basic parameter.Due to the calculation error of lost gas and residual gas in the direct method,the efficiency and accuracy of the current methods are not inadequate to the large area multi-point measurement of coal seam gas content.This paper firstly deduces a simplified theoretical dynamic model for calculating lost gas based on gas dynamic diffusion theory.Secondly,the effects of various factors on gas dynamic diffusion from coal particle are experimentally studied.And sampling procedure of representative coal particle is improved.Thirdly,a new estimation method of residual gas content based on excess adsorption and competitive adsorption theory is proposed.The results showed that the maximum error of calculating the losing gas content by using the new simplified model is only 4%.Considering the influence of particle size on gas diffusion law,the particle size of the collected coal sample is below 0.25 mm,which improves the measurement speed and reflects the safety representativeness of the sample.The determination time of gas content reduced from 36 to 3 h/piece.Moreover,the absolute error is 0.15–0.50 m^3/t,and the relative error is within 5%.A new engineering method for determining the coal seam gas content is developed according to the above research. | Yanwei Liu Yang Du Zhiqiang Li Fajun Zhao Weiqin Zuo Jianping Wei Hani Mitri | 2020 | International Journal of Mining Science and Technology2020，30，6： | 6 |
| 3 | Influence of carbon on the giant magnetocaloric effect of LaFe_11.7Si_1.3显示文摘The influences of carbon on phase formation, Curie temperature, and magnetic entropy change of the NaZn13-type LaFe11.7Si1.3 were investigated. Seven carbon-containing alloys, LaFe11.7Si1.3Cx with x = 0, 0.03, 0.06, 0.10, 0.20, 0.30, and 0.50, respectively, were prepared for this investigation. Experimental results show that addition of a small amount of carbon in LaFe11.7Si1.3 is favorable for the formation of the NaZn13-type structure of LaFe11.7Si1.3Cx. The lattice constant increases with C addition and x increases in the alloy because of the introduction of C as interstitial atoms. The Cu- rie temperature of LaFe11.7Si1.3Cx increases from 194 K to 225 K as x increases from 0 to 0.5. Large magnetic entropy changes were observed in these carbon-containing alloys LaFe11.7Si1.3Cx because of their first-order structural/magnetic transition. The maximum magnetic entropy change of 27.5 J?kg?1?K?1 at 202 K for the 0-1.56 T magnetic field change was observed in the alloy with x = 0.06. The large magnetic-entropy changes corresponding to low magnetic field change, and the low cost of the material of LaFe11.7Si1.3Cx makes it a promising candidate to be used as magnetic refrigerants in the cor- responding temperature range. | LI Junqin LIU Fusheng AO Weiqin ZHUANG Yinghong ZHOU Kaiwen | 2006 | Rare Metals2006，25，5： | 5 |
| 4 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 5 | Effect of Support on Catalytic Performance of Photothermal Fischer-Tropsch Synthesis to Produce Lower Olefins over FesC2-based Catalysts显示文摘Photothermal Fischer-Tropsch synthesis(FTS)has been extensively studied,but few reports were focused on systematically exploring the influence of support on catalytic performance.Herein,a series of Fe5C2-based catalysts with different supports was fabricated via a one-step wet-chemical method for photothermal conversion of syngas to lower olefins.Under light irradiation,the optimized FesC2/a-Al2O3 catalyst demonstrated remarkable photothermal FTS activity,delivering selectivity to lower olefins of 50.3%with a CO conversion rate of 52.5%.Characterization studies using X-ray diffraction and Mossbauer spectroscopy analysis revealed that the active catalyst mainly contained FesC2 nanoparticles on a-AbO3 support.It was found that the weak interaction between active phase and a-AhO3 could promote the formation of FesC2,which contributed to the high selectivity to lower olefins. | LI Yuan LI Ruizhe LI Zhenhua WEI Weiqin OUYANG Shuxin YUAN Hong ZHANG Tierui | 2020 | Chemical Research in Chinese Universities2020，36，6： | 3 |
| 6 | Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver显示文摘Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of obesity.Although cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains obscure.Using high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor immunosurveillance.Transcriptome analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD patients.Notably,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC development.Moreover,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell depletion.Mechanistically,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and NAFLD-HCC.This study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic. | Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng | 2022 | Cellular & Molecular Immunology2022，19，7： | 3 |
| 7 | Restricted peri-operative fluid administration adjusted by serum lactate level improved outcome after major elective surgery for gastrointestinal malignancy显示文摘 | Yu WenKui Li Ning Gong JianFeng Li WeiQin Tang ShaoQiu Tong Zhihui Gao Tao Zhang JuanJuan Xi FengChan Shi Hui Zhu WeiMing Li Jie-Shou | 2010 | Surgery2010，，4： | 2 |
| 8 | Simulation of magnesium alloy AZ31 sheet during cylindrical cup drawing with rate independent crystal plasticity finite element method显示文摘 | Weiqin Tang Shaorui Zhang Yinghong Peng Dayong Li | 2009 | Computational Materials Science2009，，2： | 1 |
| 9 | Ultra-stable aqueous foam stabilized by water-soluble alkyl acrylate crosspoly- mer显示文摘 | LV Weiqin LI Ying LI Yaping | 2014 | Colloids and Surfaces A:Physicochemical and Engineering Aspects2014，457，： | 1 |
| 10 | Mechanical anisotropy and deep drawing be- haviors of AZ31 magnesium alloy sheets produced by unidirectional and cross rolling显示文摘 | TANGA Weiqin HUANGB Shiyao LI Dayong PENG Yinghong | 2015 | Journal of Materials Processing Technology2015，215，2015： | 1 |
| 11 | Dehydroepiandrosterone (DHEA) and its sulfated derivative (DHEAS) regulate apoptosis during neurogenesis by triggering the Akt signaling pathway in opposing ways显示文摘 | Lei Zhang Bing shen Li Wu Ma Jeffery L Barker Yoong H Chang Weiqin Zhao David R Rubinow | 2002 | Molecular Brain Research2002，，1： | 1 |
| 12 | Thymosin Alpha 1 is Associated with Improved Cellular Immunity and Reduced Infection Rate in Severe Acute Pancreatitis Patients in a Double-Blind Random- ized Control Study 显示文摘 | Xinying Wang Weiqin Li Chenglin Niu | 2011 | Inflammation2011，34，3： | 1 |
| 13 | Crystal plasticity finite element modelling of the extrusion texture of a magnesium alloy显示文摘 | Yichuan Shao Tao Tang Dayong Li Weiqin Tang Yinghong Peng | 2015 | Modelling and Simulation in Materials Science and Engineering2015，，： | 1 |
| 14 | A meta-analysis of the association between induced abortion and breast cancer risk among Chinese females显示文摘 | Yubei Huang Xiaoliang Zhang Weiqin Li Fengju Song Hongji Dai Jing Wang Ying Gao Xueou Liu Chuan Chen Ye Yan Yaogang Wang Kexin Chen | 2014 | Cancer Causes & Control2014，，2： | 1 |
| 15 | -3Fatty Acids-Supplemented Paren-teral Nutrition Decreases Hyperinflammatory Response and Attenuates Sys-temic Disease Sequelae in Severe Acute Pancreatitis : A Randomized andControlled Study 显示文摘 | Xinying Wang Weiqin Li Ning Li | 2008 | Journal of Parenteral & Enteral Nutrition2008，32，： | 1 |
| 16 | Guidelines for the diagnosis and treatment of acute pancreatitis in China (2021)显示文摘Acute pancreatitis(AP)is a common acute abdominal condition of the digestive system.In recent years,treatment concepts,methods,and strategies for the diagnosis of AP have advanced,and this has played an important role in promoting the standardization of AP diagnosis and treatment and improving the treatment quality of AP patients.On the basis of previous guidelines and expert consensus,this guideline adopts an evidence-based,problem-based expression;synthesizes important clinical research data at home and abroad in the most recent 5 years;and forms 29 recommendations through multidisciplinary expert discussion,including diagnosis,treatment,and follow-up.It is expected to provide evidence support for the treatment of AP in the clinical setting in China. | Fei Li Shouwang Cai Feng Cao Rufu Chen Deliang Fu Chunlin Ge Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Ang Li Haimin Li Shengping Li Weiqin Li Yixiong Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Changqing Yan Yinmo Yang Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 1 |
| 17 | Unloading behaviors of the rare-earth magnesium alloy ZE10 sheet显示文摘Due to their low symmetry in crystal structure,low elastic modulus(~45 GPa)and low yielding stress,magnesium(Mg)alloys exhibit strong inelastic behaviors during unloading.As more and more Mg alloys are developed,their unloading behaviors were less investigated,especially for rare-earth(RE)Mg alloys.In the current work,the unloading behaviors of the RE Mg alloy ZE10 sheet is carefully studied by both mechanical tests and crystal plasticity modeling.In terms of the stress-strain curves,the inelastic strain,the chord modulus,and the active deformation mechanisms,the substantial anisotropy and the loading path dependency of the unloading behaviors of ZE10 sheets are characterized.The inelastic strains are generally larger under compressive Loading-Un Loading(L-UL)than under tensile L-UL,along the transverse direction(TD)than along the rolling direction(RD)under tensile L-UL,and along RD than along TD under compressive L-UL.The basal slip,twinning and de-twinning are found to be responsible for the unloading behaviors of ZE10 sheets. | Weiqin Tang Jeong Yeon Lee Huamiao Wang Dirk Steglich Dayong Li Yinghong Peng Peidong Wu | 2021 | Journal of Magnesium and Alloys2021，9，3： | 1 |
| 18 | Huge and ruptured amoebic liver abscess diagnosed by mNGS:A case report显示文摘Background Amoebic liver abscess(ALA)is caused by the protozoan parasite,Entamoeba histolytica,which is the most common extraintestinal presentation of infection with the protozoan.[1]Areas of high incidence of infection worldwide include India,Africa,Mexico,and parts of Central and South America.Although the prognosis of simple abscess is favorable,complex and large abscesses may rupture and be associated with high mortality.[2]The diagnosis of ALA is made through a combination of characteristic findings on imaging and serologic testing(antigen or antibody testing). | Weiqin Wang Daijun Song Xin Li Hui Xie | 2022 | Journal of Intensive Medicine2022，2，2： | 0 |
| 19 | Consensus of clinical diagnosis and treatment for non-functional pancreatic neuroendocrine neoplasms with diameter<2 cm显示文摘In clinical practice,pancreatic neuroendocrine neoplasms(pNENs)with a diameter smaller than 2 cm are commonly referred to as small pNENs.Due to their generally favorable biological characteristics,the diagnosis and treatment of small pNENs differ from other pNENs and are somewhat controversial.In response to this,the Chinese Pancreatic Surgery Association,Chinese Society of Surgery,Chinese Medical Association have developed a consensus on the diagnosis and treatment of small pNENs,which is based on evidence-based medicine and expert opinions.This consensus covers various topics,including concepts,disease assessment,treatment selection,follow-up,and other relevant aspects. | Wu Wenming Cai Shouwang Chen Rufu Fu Deliang Ge Chunlin Hao Chunyi Hao Jihui Huang Heguang Jian Zhixiang Jin Gang Li Fei Li Haimin Li Shengping Li Weiqin LiYixiong Liang Tingbo Liu Xubao Lou Wenhui Miao Yi Mou Yiping Peng Chenghong Qin Renyi Shao Chenghao Sun Bei Tan Guang Wang Huaizhi Wang Lei Wang Wei Wang Weilin Wei Junmin Wu Heshui Wu Zheng Yan Changqing Yang Yinmo Yin Xiaoyu Yu Xianjun Yuan Chunhui Zhao Yupei | 2023 | Journal of Pancreatology2023，6，3： | 0 |
| 20 | Research Progress on Serum Porphyrin and Chronic Liver Disease显示文摘Liver cirrhosis is an important cause of chronic liver cancer.At present,a breakthrough has been achieved in the development of chronic hepatitis C treatment,but there is no effective measure to completely cure chronic hepatitis B.Porphyrins are a class of macromolecular heterocyclic compounds formed by interconnecting the a-carbon atoms of four pyrrole-like substituents through hypomethyl bonds.Porphyrins and their derivatives widely exist in organelles related to energy transfer in organisms.They are mainly involved in the synthesis of heme in human body.Heme is an iron-containing porphyrin compound,15-20% of which is synthesized and utilized in the liver.Studies have found that porphyrin metabolism disorder can occur in patients with chronic liver disease.The early stage of viral hepatitis is accompanied by increased production of porphyrins and their compounds,increased levels of peripheral circulating porphyrins,porphyrin cholestasis,and biochemical changes of free porphyrins which precede the histological changes.The accumulation of serum and liver protoporphyrins and the oxidative stress can cause liver and extrahepatic damage.On the one hand,porphyrin metabolism disorder can aggravate chronic liver disease,and even progress to liver cirrhosis and liver cancer.On the other hand,chronic liver disease can also aggravate porphyrin metabolism disorder,recurrent attacks,and damage to liver and extrahepatic tissues and organs. | Xia Wang Yu Cai Weiqin Li Yuanyuan Jia Jiangfeng Fu Yaping Ni Kaige Liu | 2022 | Journal of Clinical and Nursing Research2022，6，3： | 0 |
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