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| 1 | The HuangZaoSi Maize Genome Provides Insights into Genomic Variation and Improvement History of Maize显示文摘Maize is a globally important crop that was a classic model plant for genetic studies. Here, we report a 2.2 Gb draft genome sequence of an elite maize line, HuangZaoSi (HZS). Hybrids bred from HZS-improved lines (HILs) are planted in more than 60% of maize fields in China. Proteome clustering of six completed sequeneed maize genomes show that 638 proteins fall into 264 HZS-specific gene families with the majority of contributions from tandem duplication events. Resequencing and comparative analysis of 40 HZSrelated lines reveals the breeding history of HILs. More than 60% of identified selective sweeps were clustered in identity.by.descent conserved regions, and yield-related genes/QTLs were enriched in HZS characteristic selected regions. Furthermore, we dem on strated that HZS-specific family genes were not uniformly distributed in the genome but enriched in improvement/function.related genomic regions. This study provides an important and novel resource for maize genome research and expands our knowledge on the breadth of genomic variation and improvement history of maize. | Chunhui Li Wei Song Yingfeng Luo Shenghan Gao Ruyang Zhang Zi Shi Xiaqing Wang Ronghuan Wang Fengge Wang Jidong Wang Yanxin Zhao Aiguo Su Shuai Wang Xin Li Meijie Luo Shuaishuai Wang Yunxia Zhang Jianrong Ge Xinyu Tan Ye Yuan Xiaochun Bi Hang He Jianbing Yan Yuandong Wang Songnian Hu Jiuran Zhao | 2019 | Molecular Plant2019，12，3： | 15 |
| 2 | Progress of the key materials for organic solar cells显示文摘Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight,flexibility and roll-to-roll fabrication.Nowadays,18%power conversion efficiency has been achieved in the state-of-the-art organic solar cells.The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies,and the deep understanding on film morphology,molecular packing and device physics.Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance.The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors.In this review,we focus on those star materials and milestone work,and introduce the molecular structure evolution of key materials.These key materials include homopolymer donors,D-A copolymer donors,A-D-A small molecular donors,fullerene acceptors and nonfullerene acceptors.At last,we outlook the challenges and very important directions in key materials development. | Yang Tong Zuo Xiao Xiaoyan Du Chuantian Zuo Yuelong Li Menglan Lv Yongbo Yuan Chenyi Yi Feng Hao Yong Hua Ting Lei Qianqian Lin Kuan Sun Dewei Zhao Chunhui Duan Xiangfeng Shao Wei Li Hin-Lap Yip Zhengguo Xiaol Bin Zhang Qingzhen Bian Yuanhang Cheng Shengjian Liu Ming Cheng Zhiwen Jin Shangfeng Yang Liming Ding | 2020 | Science China Chemistry2020，63，6： | 15 |
| 3 | Analysis of risk factors affecting the prognosis of pancreatic neuroendocrine tumors显示文摘 | Tao Ming Yuan Chunhui Xiu Dianrong Shi Xueying Tao Liyuan Ma Zhaolai Jiang Bin Zhang Zhipeng Zhang Lingfu Wang Hangyan | 2014 | Chinese Medical Journal2014，，16： | 13 |
| 4 | Newly discovered hydrothermal fields along the ultraslow-spreading Southwest Indian Ridge around 63°E显示文摘The ultraslow-spreading Southwest Indian Ridge(SWIR) to the east of the Melville fracture zone is characterized by very low melt supply and intensive tectonic activity. Due to its weak thermal budget and extremely slow spreading rate, the easternmost SWIR was considered to be devoid of hydrothermal activity until the discovery of the inactive Mt. Jourdanne hydrothermal field(27°51′S, 63°56′E) in 1998. During the COMRA DY115-20 cruise in2009, two additional hydrothermal fields(i.e., the Tiancheng(27°51′S, 63°55′E) and Tianzuo(27°57′S, 63°32′E)fields) were discovered. Further detailed investigations of these two hydrothermal sites were conducted by Chinese manned submersible Jiaolong in 2014–2015. The Tiancheng filed can be characterized as a lowtemperature(up to 13.2°C) diffuse flow hydrothermal field, and is hosted by fractured basalts with hydrothermal fauna widespread on the seafloor. The Tianzuo hydrothermal field is an inactive sulfide field, which is hosted by ultramafic rocks and controlled by detachment fault. The discovery of the three hydrothermal fields around Segment #11 which receives more melt than the regional average, provided evidence for local enhanced magmatism providing heat source to drive hydrothermal circulation. We further imply that hydrothermal activity and sulfide deposits may be rather promising along the easternmost SWIR. | CHEN Jie TAO Chunhui LIANG Jin LIAO Shili DONG Chuanwan LI Huaiming LI Wei WANG Yuan YUE Xihe HE Yonghua | 2018 | Acta Oceanologica Sinica2018，37，11： | 5 |
| 5 | Classification of four distinct osteoarthritis subtypes with a knee joint tissue transcriptome atlas显示文摘The limited molecular classifications and disease signatures of osteoarthritis(OA)impede the development of prediagnosis and targeted therapeutics for OA patients.To classify and understand the subtypes of OA,we collected three types of tissue including cartilage,subchondral bone,and synovium from multiple clinical centers and constructed an extensive transcriptome atlas of OA patients.By applying unsupervised clustering analysis to the cartilage transcriptome,OA patients were classified into four subtypes with distinct molecular signatures:a glycosaminoglycan metabolic disorder subtype(C1),a collagen metabolic disorder subtype(C2),an activated sensory neuron subtype(C3),and an inflammation subtype(C4).Through ligand-receptor crosstalk analysis of the three knee tissue types,we linked molecular functions with the clinical symptoms of different OA subtypes.For example,the Gene Ontology functional term of vasculature development was enriched in the subchondral bone-cartilage crosstalk of C2 and the cartilage-subchondral bone crosstalk of C4,which might lead to severe osteophytes in C2 patients and apparent joint space narrowing in C4 patients.Based on the marker genes of the four OA subtypes identified in this study,we modeled OA subtypes with two independent published RNA-seq datasets through random forest classification.The findings of this work contradicted traditional OA diagnosis by medical imaging and revealed distinct molecular subtypes in knee OA patients,which may allow for precise diagnosis and treatment of OA. | Chunhui Yuan Zongyou Pan Kun Zhao Jun Li Zixuan Sheng Xudong Yao Hua Liu Xiaolei Zhang Yang Yang Dongsheng Yu Yu Zhang Yuzi Xu Zhi-Yong Zhang Tianlong Huang Wanlu Liu Hongwei Ouyang | 2020 | Bone Research2020，8，4： | 4 |
| 6 | Titanium-Containing Mesoporous Materials: Synthesis and Application in Selective Catalytic Oxidation显示文摘包含钛我酣睡的分子筛具有在有笨重分子的选择催化氧化法的大意义。关于设计和 Ti-contaming 的合成的最近的研究和开发我酣睡的材料被考察了。为包含 Ti 的准备的各种各样的策略我酣睡的材料,例如直接合成并且合成以后,被描述。包含 Ti 的修正我由表面接枝的酣睡的材料并且种原子也被讨论。所有途径主要瞄准了改善稳定性, hydrophobicity,并且主要催化活。各种各样的合成系统的结构、机械学的特征被讨论。包含 Ti 我在液相的酣睡的材料有氧化剂简短被总结的 H2O2 的有机化合物的催化氧化,由催化氧化反应为精细化学药品的绿合成显示出他们的宽广实用程序。给词调音:我酣睡的材料;钛;分子筛;沸石;描述; | Jie Li Chunhui Zhou Huali Xie Zhonghua Ge Liangcai Yuan Xiaonian Li | 2006 | Journal of Natural Gas Chemistry2006，15，3： | 2 |
| 7 | Squeeze flow of interstitial Herschel-Bulkley fluid between two rigid spheres显示文摘Interaction between two spheres with an interstitial fluid is crucial in discrete element modeling for simulating the behaviors of 'wet' particulate materials.The normal viscous force of squeeze flow between two arbitrary rigid spheres with an interstitial Herschel-Bulkley fluid was studied on the basis of Reynolds' lubrication theory,resulting in analytical integral expressions of pressure distribution and the viscous force between the two spheres.According to the variation of shear stress,the fluid was divided into yielding and unyielding regions,followed by a discussion on the thickness of the two regions.The result of this paper could be reduced to either the power-law fluid or the Bingham fluid case. | Chunhui Xu Li Yuan Yong Xu Wenbin Hang | 2010 | Particuology2010，8，4： | 2 |
| 8 | Data analysis of 36 cases with intraductal papillary mucinous neoplasm of the pancreas for their clinicopathological features, diagnosis, and treatment显示文摘 | Yuan Chunhui Xiu Dianrong Tao Ming Ma Zhaolai Jiang Bin Li Zhifei Li Lei Wang Liang Wang Hangyan Zhang Tonglin | 2014 | Chinese Medical Journal2014，，23： | 2 |
| 9 | The effect of particle size gradation of conductive fillers on the conductivity and the flexural strength of composite bipolar plate显示文摘 | Shen Chunhui Pan Mu Yuan Runzhang | 2008 | International Journal of Hydrogen Energy2008，33，： | 1 |
| 10 | Effect of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV 6) for the treatment of diarrhea-dominant irritable bowel syndrome: a patient-blinded pilot trial with orthogonal design显示文摘OBJECTIVE: To investigate the effects of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV6) in patients with diarrhea-dominant irritable bowel syndrome(D-IBS) by assessing predominant factors, and determining the best factor combinations and their interactions. To identify the optimal quantity of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV 6) to achieve optimal efficacy.METHODS: An L9(3~4) orthogonal design was applied to 233 confirmed subjects based on the three most influential factors and the three most frequently used levels. Nine programs were designed.Subjects were assigned to four subgroups according to age and gender; each subject underwent one of the nine programs randomly. We selected Tianshu(ST 25, bilateral) and Qihai(CV 6). The scores of symptoms and the IBS Quality of Life(IBS-QOL) were evaluated after the final treatment.RESULTS: After treatment, clinical symptoms of all patients were significantly improved(P = 0.001).Quality of life also improved significantly(P < 0.05).For all the participants, frequency was the dominating factor regarding symptoms(P = 0.01). Duration was the dominating factor for quality of life(P =0.0001). The best combination for improving symptoms in 30-40-year-old male and female patients was two courses of 10 min each once a day, and for41-50-year-old male and female patients it was three courses of 10 min(males) or 30 min(females)twice a day. The best combination for quality of life was three courses of 20 min once a day. No interaction was found between frequency and course, or frequency and duration.CONCLUSION: Warming moxibustion Tianshu(ST25, bilateral) and Qihai(CV 6) is a promising therapy for D-IBS. To acquire optimal efficacy, the three main factors(duration, frequency and treatment course) of the warming moxibustion should reach a specific quantity and be combined appropriately. | Yang Ling Lu Yuan Zhang Haifeng Ma Xiaopeng Bao Chunhui Wu Huangan Zhao Chen Ding Guanghong Qi Li Zhou Shuang | 2017 | Journal of Traditional Chinese Medicine2017，37，4： | 1 |
| 11 | Statistical analysis and online monitoring for mu|fimode processes with between mode transitions显示文摘 | Chunhui Zhao Yuan Yao Furong Gao | 2010 | Chemical Engineering Science2010，65，22： | 1 |
| 12 | Lack of association between microRNA-137 SNP rs1625579 and schizophrenia in a replication study of Han Chinese显示文摘 | Jianmin Yuan Zaohuo Cheng Fuquan Zhang Zhenhe Zhou Shui Yu Chunhui Jin | 2015 | Molecular Genetics and Genomics2015，，1： | 1 |
| 13 | Statistical analysis and online monitoring for multimode processes with between mode transitions显示文摘 | ZHAO Chunhui YAO Yuan GAO Furong | 2010 | Chemical Engineering Science2010，65，22： | 1 |
| 14 | Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport显示文摘 | Yun Jin Yupin Song Xi Zhu Dan Zhou Chunhui Chen Zhirong Zhang Yuan Huang | 2011 | Biomaterials2011，，5： | 1 |
| 15 | Highly stereoselective construction of polycyclic benzofused tropane scaffolds and their latent bioactivities: bifunctional phosphonium salt-enabled cyclodearomatization process显示文摘Structurally fused heterocycles encompassing a centerpiece of benzotropane are significant scaffolds with a plethora of promising biological activities,but such molecular architectures pose a long-standing daunting synthetic challenge.Herein,we reported a highly efficient asymmetric cyclodearomatization of 2-nitrobenzofurans with cyclic azomethine ylides by employing bifunctional phosphonium salts as phase-transfer catalysts.Under optimized reaction conditions,a diverse array of polycyclic benzofused tropane derivatives with four contiguous 4°/3°stereocenters were readily synthesized in both high yields and diastereoselectivities with up to>99%ee.The practicality and utility of this protocol were further demonstrated by the scaled-up reaction and facile elaborations.Moreover,preliminary investigations into their antitumor activities were also presented. | Jian-Ping Tan Xiaojie Li Yuan Chen Xianle Rong Lixiang Zhu Chunhui Jiang Kai Xiao Tianli Wang | 2020 | Science China Chemistry2020，63，8： | 1 |
| 16 | The key technologies of a new semi-automatic chemiluminescence immunoassay analyzer based on the photomultiplier tube 显示文摘 | Luo Gangyin Wang Bidou Yuan Chunhui | 2010 | IEEE Advanced Computer Theory and Engineering2010，，： | 1 |
| 17 | Guidelines for the diagnosis and treatment of acute pancreatitis in China (2021)显示文摘Acute pancreatitis(AP)is a common acute abdominal condition of the digestive system.In recent years,treatment concepts,methods,and strategies for the diagnosis of AP have advanced,and this has played an important role in promoting the standardization of AP diagnosis and treatment and improving the treatment quality of AP patients.On the basis of previous guidelines and expert consensus,this guideline adopts an evidence-based,problem-based expression;synthesizes important clinical research data at home and abroad in the most recent 5 years;and forms 29 recommendations through multidisciplinary expert discussion,including diagnosis,treatment,and follow-up.It is expected to provide evidence support for the treatment of AP in the clinical setting in China. | Fei Li Shouwang Cai Feng Cao Rufu Chen Deliang Fu Chunlin Ge Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Ang Li Haimin Li Shengping Li Weiqin Li Yixiong Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Changqing Yan Yinmo Yang Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 1 |
| 18 | Advanced duodenal carcinoma:Chemotherapy efficacy and analysis of prognostic factors显示文摘Objective This study aimed to determine the efficacy of chemotherapy and to identify potential chemotherapy agents to treat advanced primary duodenal carcinoma(PDC). Methods Seventy-three patients with advanced PDC were included in the study. Response rate(RR), disease control rate(DCR), progression-free survival(PFS), overall survival(OS) and prognosis were compared among patients using the Cox proportional hazards model. Results The overall RR and DCR of 52 patients were 21.15% and 69.23%, respectively. The median PFS and OS times were 4.51 and 11.47 months, respectively. Palliative chemotherapy improved the OS of patients with advanced PDC compared with patients who did not receive chemotherapy(14.28 months vs. 5.20 months, HR = 0.205, 95% CI: 0.077 to 0.547, P = 0.0016). Multivariate analysis indicated mucinous histology and liver metastasis as factors predictive of poor prognosis in patients with advanced PDC. Conclusion Palliative chemotherapy may improve the OS of patients with advanced PDC. Mucinous histology and liver metastasis were the main prognostic factors in patients with advanced PDC. | Junbao Liu Chengxu Cui Lifang Yuan Jinwan Wang Shuping Shi Zhujun Shao Haijian Tang Tingting Yang Chunhui Gao Nan Wang Wei Liu | 2016 | Oncology and Translational Medicine2016，2，1： | 1 |
| 19 | The effect of particle size gradation of conductive fillers on the conductivity and the flexural strength of composite bipolar plate显示文摘 | Shen Chunhui Pan Mu Yuan Runzhang | 2008 | International Journal of Hydrogen Energy2008，33，： | 1 |
| 20 | Functional Ionic Liquids Promoted Double Michael Reaction of Benzofuran-3-one or 1-1ndone and Symmetric Dienones: Construction of Spiro[benzofuran-2,1′-cyclohexane]-3-one or Spiro[cyclohexane-1,2′-indene]-1′,4(3′H)-dione Derivatives显示文摘在 benzofuran-3-one 或 1-indone 和对称的 dienones 之间的双迈克尔反应成功地面对催化离子的液体被开发并且 spiro [ benzofuran-2,1-cyclohexane ] -3-one 或 spiro [ cyclohexane-1,2-indene ]包含 spiro 的 -1,4(3H)-dione 衍生物第四级的 stereogenic 中心,广泛地在器官的合成在生物学上活跃的产品和积木存在,在优秀收益(多达99%)被获得。这个催化系统也被扩大到不太反应的 1-indone 的双迈克尔反应,需要的产品也在 31%-62% 收益被获得。催化系统为在温和条件下面的底层的一个女人高度活跃、有效。 | Chunhui Liu Yalun Xu Songyang Niu Liquan Wei Yong Liu Yanbo Wang Junyan Zhu Jiya Fu Jinfang Yuan | 2017 | Chinese Journal of Chemistry2017，35，8： | 1 |
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