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| 1 | Optimization and control of a reactive distillation process for the synthesis of dimethyl carbonate显示文摘Dimethyl carbonate is an environmentally benign and biodegradable chemical.Based on integration of reactive distillation and pressure-swing distillation technologies,a novel process for synthesis of dimethyl carbonate through transesterification with propylene carbonate and methanol has been developed by Huang et al.In this work,the optimization of this process was performed by minimizing the total TAC.The results show that the optimal design flowsheet can save energy consumption by 18.6% with the propylene carbonate conversion of 99.9%.Then,an effective plant-wide control structure for the process was developed.Dynamic simulation results demonstrate that the temperature/flow rate cascade control plus with simple temperature control can keep not only product purity but also the conversion of the reactant at their desired values in the face of the disturbance in reactant feed flow rate and feed composition. | Zhixian Huang Yixiong Lin Xiaoda Wang Changshen Ye Ling Li | 2017 | Chinese Journal of Chemical Engineering2017，25，8： | 8 |
| 2 | Preparation and shaping of solid acid SO_4^(2-)/TiO_2 and its application for esterification of propylene glycol monomethyl ether and acetic acid显示文摘The solid acid SO_4^(2-)/TiO_2 was prepared by immersion method and applied for synthesis of propylene glycol methyl ether acetate(PMA) through esterification reaction of propylene glycol monomethyl ether(PM)and acetic acid(HAc). The optimal catalyst preparation condition was determined by orthogonal analysis of parameters in a five-factor and four-level test. The obtained solid acid catalysts were characterized in detail by means of X-ray powder diffraction, thermogravimetry, pyridine adsorbed IR analysis, scanning electron microscopy, and BET surface area method. Synthesis of PMA was studied in this paper through experimental investigation of reaction conditions such as temperature, molar ratio of reactants, catalyst dosage and agitation speed. Based on its possible reaction mechanism, a pseudo-homogeneous kinetic model was established and its activation energies E_a^+ and E_a^-,65.68 × 10~3J·mol^(-1) and 57.78 × 10~3J·mol^(-1), were estimated. To prepare shaped solid acid catalyst SO_4^(2-)/TiO_2, the shaping method of impregnation–shaping–impregnation was applied. The optimal molding formulation of solid acid catalyst, obtained from the orthogonal test, was found to be binder 7 wt%, reinforcing agent 20 wt%, pore forming material 2.5 wt%, and lubricant 4 wt%.The results of performance test of catalyst demonstrated that the shaped solid acid catalyst exhibited high activity and stability. | Zhixian Huang Yixiong Lin Ling Li Changshen Ye Ting Qiu | 2017 | Chinese Journal of Chemical Engineering2017，25，9： | 8 |
| 3 | Using in situ REE analysis to study the origin and diagenesis of dolomite of Lower Paleozoic,Tarim Basin显示文摘In situ REE concentrations of various dolomites from Tarim Basin were obtained by LA-ICP-MS analysis,and the data were normalized to standard seawater(Seawater Normalized=SWN).Most of the samples have a ΣREE range of less than 20 ppm.All samples show similar REESWN distributions with heavy REE depletion,and positive Ce anomaly,which indicates that they have the same dolomitization fluids(seawater).According to the origin and diagenetic process of dolomite,two types of dolomite are determined and described as follows:1) syndepositional dolomite,with the highest REE concentrations(more than 20 ppm),the cores of which are more enriched in REE compared with their cortexes,indicating that they underwent the dolomitization of calcareous sediments by hypersaline and subsequent diagenesis decreased the REE content of the cortex because of the low REE concentration of the diagenetic fluids;2) diagenetic dolomite,which can be subdivided into four groups.(1) burial dolomite which has higher REE concentrations than limestone,but lower than syndepositional dolomite.This shows that pore fluids with high salinity dolomitized the pre-existing limestone;(2) void filling dolomite which has the similar REE patterns with the matrix dolomite.In addition,the Eu anomaly is not obvious,suggesting that the dolomitization fluids originated from the diagenetic fluids;(3) recrystallized dolomite,whose REE concentration was obviously decreased,indicating that the REE concentration was decreased during the recrystallization processes;and(4) hydrothermal altered void-filling dolomite,which has the lowest REE concentration,but obvious positive Eu anomaly,reflecting its hydrothermal activity related origin.Thus,the diverse REE signatures,which were recorded in different dolomites,retain the information of their formation conditions and subsequent diagenetic processes.In situ REE analysis of dolomite is an effective probe into the origin and diagenetic process of dolomite. | WANG XiaoLin JIN ZhiJun HU WenXuan ZHANG JunTao QIAN YiXiong ZHU JingQuan LI Qing | 2009 | Science China Earth Sciences2009，52，5： | 7 |
| 4 | MicroRNA-140 regulates cell growth and invasion in pancreatic duct adenocarcinoma by targeting iASPP显示文摘MicroRNAs 是从在经由绑定调整蛋白质表示水平到 mRNA 起重要作用的 RNA 发卡结构处理的 22 核苷酸 RNA,也压制它的翻译或加快它的降级。在人,他们调整很编码蛋白质的基因,包括在癌症和另外的疾病重要的基因。在这研究, microRNA-140 (miR-140 ) 的表示被表明显著地在胰腺的管腺癌标本和房间线被压制,与他们的邻近的正常纸巾相比。在生物信息学分析的帮助下, p53 (iASPP ) 的刺激 apoptosis 蛋白质的禁止者被识别是 miR-140 的一个直接目标,并且酶记者实验证实了这发现。miR-140 的 Overexpression 减少 iASPP, Np63, MMP2,和 MMP9 的蛋白质表情。PANC-1 房间的生长和侵略被 miR-140 的 overexpression 在 vitro 稀释。PANC-1 房间线上的 miR-140 的镇压效果能被 iASPP 的用手的 overexpression 部分外面平衡。首先,这些调查结果提供了卓见进 miR-140 的功能的机制,建议 miR-140/iASPP 轴可以防碍 proliferative 和胰腺的管腺癌房间的侵略性质,并且显示 miR-140 能是为胰腺的管腺癌的一个潜在的治疗学的目标。 | Shuai Liang Xuejun Gong Gewen Zhang Gengwen Huang Yebin Lu Yixiong Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，2： | 4 |
| 5 | Standard pancreatoduodenectomy versus extended pancreatoduodenectomy with modified retroperitoneal nerve resection in patients with pancreatic head cancer:a multicenter randomized controlled trial显示文摘Background:The extent of pancreatoduodenectomy for pancreatic head cancer remains controversial,and more high-level clinical evidence is needed.This study aimed to evaluate the outcome of extended pancreatoduodenectomy(EPD)with retroperitoneal nerve resection in pancreatic head cancer.Methods:This multicenter randomized trial was performed at 6 Chinese highvolume hospitals that enrolled patients between October 3,2012,and September 21,2017.Four hundred patients with stage I or II pancreatic head cancer and without specific pancreatic cancer treatments(preoperative chemotherapy or chemoradiation)within three months were randomly assigned to undergo standard pancreatoduodenectomy(SPD)or EPD,with the latter followed by dissection of additional lymph nodes(LNs),nerves and soft tissues 270◦on the right side surrounding the superior mesenteric artery and celiac axis.The primary endpoint was overall survival(OS)by intention-to-treat(ITT).The secondary endpoints were disease-free survival(DFS),mortality,morbidity,and postoperative pain intensity.Results:TheR1 ratewas slightly lower with EPD(8.46%)thanwith SPD(12.56%).The morbidity and mortality rates were similar between the two groups.The median OS was similar in the EPD and SPD groups by ITT in the whole study cohort(23.0 vs.20.2 months,P=0.100),while the median DFS was superior in the EPD group(16.1 vs.13.2 months,P=0.031).Patients with preoperative CA19–9<200.0 U/mL had significantly improved OS and DFS with EPD(EPD vs.SPD,30.8 vs.20.9 months,P=0.009;23.4 vs.13.5 months,P<0.001).The EPD group exhibited significantly lower locoregional(16.48%vs.35.20%,P<0.001)andmesenteric LNrecurrence rates(3.98%vs.10.06%,P=0.022).The EPD group exhibited less back pain 6 months postoperation than the SPD group.Conclusions:EPD for pancreatic head cancer did not significantly improve OS,but patients with EPD treatment had significantly improved DFS.In the subgroup analysis,improvements in bothOS and DFS in the EPD armwere observed in patients with preoperative CA19–9<200.0 U/mL.EPD could be used as an effective surgical procedure for patients with pancreatic head cancer,especially those with preoperative CA19–9<200.0 U/mL. | Qing Lin Shangyou Zheng Xianjun Yu Meifu Chen Yu Zhou Quanbo Zhou Chonghui Hu Jing Gu Zhongdong Xu LinWang Yimin Liu Qingyu Liu MinWang Guolin Li He Cheng Dongkai Zhou Guodong Liu Zhiqiang Fu Yu Long Yixiong Li Weilin Wang Renyi Qin Zhihua Li Rufu Chen | 2023 | Cancer Communications2023，43，2： | 3 |
| 6 | Investigation on High Power Diode Laser Cladding of Ni-Fe-Cr Based Alloy Coatings显示文摘Appropriate laser cladding processing parameters for a Ni-Fe-Cr based alloy coating with good quality were studied using 3.5 kW diode laser.The characterization of the coating was investigated,and the influence of each parameter was analyzed.The mechanical properties and wear resistance of the coating were compared with the corresponding chemical composition wrought and cast materials.The results showed that a coating with aspect ratio about 3,dilution ratio 8%-10%and wetting angle 35o-50°could be formed with the laser power 1200-1500 W,travelling speed 8-10 mm/s,powder feed rate 16-18 g/min and shield gas flow 15 l/min.The tensile strength of the coating reached 953 MPa which was higher than that of wrought material 918 MPa and cast material 830 MPa.The microhardness of multi-layer coating was higher than that of single layer coating.The wear resistance of the coating was at the same level with the wrought and cast materials. | Zhang Yaocheng Jian, Huang Nie Pulin Liu Honggang Li Zhuguo Wu Yixiong | 2012 | 稀有金属材料与工程2012，41，S1： | 2 |
| 7 | Uncorrelated linear discriminant analysis based on weighted pairwise Fisher criterion显示文摘 | Liang Yixiong Li Chengrong Gong Weigno | 2007 | Pattern Recognitinn2007，40，12： | 1 |
| 8 | An in- tegrated method for flexible platform modular architecture de- sign显示文摘 | LI Zhongkai CHENG Zhihong FENG Yixiong | 2013 | Journal of Engineering Design2013，24，1： | 1 |
| 9 | Uncorrelated linear discriminant analysis based on weighted pairwise Fisher criterion显示文摘 | LIANG Yixiong LI Chengrong GONG Weiguo | | 0，，12： | 1 |
| 10 | Formation of saddle dolomites in Upper Cambrian carbonates, western Tarim Basin (northwest China): Implications for fault-related fluid flow显示文摘 | Juntao Zhang Wenxuan Hu Yixiong Qian Xiaolin Wang Jian Cao Jingquan Zhu Qing Li Xiaomin Xie | 2009 | Marine and Petroleum Geology2009，，8： | 1 |
| 11 | Uncorre-lated linear discriminant analysis based on weighted pairwiseFisher criterion显示文摘 | Yixiong Liang Chengrong Li Weiguo Gong | 2007 | Pattern Recognition2007，，40： | 1 |
| 12 | Stability information in plasma image of high-power CO2 laser welding显示文摘 | Guohua Li Yan Cai Yixiong Wu | 2009 | Optics and Lasers in En- gineering2009，，47： | 1 |
| 13 | Stability information in plasma image of high-power CO2 laser welding显示文摘 | Guohua Li Yan Cai Yixiong Wu | | 0，，： | 1 |
| 14 | Mutation characteristic of STK11 gene in Chinese with Peutz-Jeghers syndrome显示文摘 | Li Yixiong Lu Xingsheng Xia Jiahui | 2001 | Chin J Med Genet2001，1，18： | 1 |
| 15 | Stability information in plasma image of high-power CO2 laser welding显示文摘 | Guohua Li Yan Cai Yixiong Wu | 2009 | Optics and Lasers in Engineering2009，47，： | 1 |
| 16 | Stability information in plasma image of high-power CO2 laser welding显示文摘 | Li Guohua Cai Yan Wu Yixiong | 2009 | Optics and Lasers in Engineering2009，47，： | 1 |
| 17 | 3D Printed Multi-material Medical Phantoms for Needle-tissue Interaction Modelling of Heterogeneous Structures显示文摘The fabrication of multi-material medical phantoms with both patient-specificity and realistic mechanical properties is of great importance for the development of surgical planning and medical training.In this work,a 3D multi-material printing system for medical phantom manufacturing was developed.Rigid and elastomeric materials are firstly combined in such application for an accurate tactile feedback.The phantom is designed with multiple layers,where silicone ink,Thermoplastic Polyurethane(TPU),and Acrylonitrile Butadiene Styrene(ABS)were chosen as printing materials for skin,soft tissue,and bone,respectively.Then,the printed phantoms were utilized for the investigation of needle-phantom interaction by needle insertion experiments.The mechanical needle-phantom interaction was characterized by skin-soft tissue interfacial puncture force,puncture depth,and number of insertion force peaks.The experiments demonstrated that the manufacturing conditions,i.e.the silicone grease ratio,interfacial thickness and the infill rate,played effective roles in regulating mechanical needle-phantom interaction.Moreover,the influences of material properties,including interfacial thickness and ultimate stress,on needle-phantom interaction were studied by finite element simulation.Also,a patient-specific forearm phantom was printed,where the anatomical features were acquired from Computed Tomography(CT)data.This study provided a potential manufacturing method for multi-material medical phantoms with tunable mechanical properties and offered guidelines for better phantom design. | Jun Yin Manqi Li Guangli Dai Hongzhao Zhou Liang Ma Yixiong Zheng | 2021 | Journal of Bionic Engineering2021，18，2： | 1 |
| 18 | Feature Selection Based on KPCA, SVM and GSFS for Face Recognition 显示文摘 | Li Weihong Gong Weiguo Liang Yixiong | 2005 | Lecture Notes in Control and Information Sciences2005，3687，1： | 1 |
| 19 | Uncorrelated linear discriminant analysis based on weighted pairwise Fisher criterion显示文摘 | Liang Yixiong Li Chengrong Gong Weiguo | 2007 | Pattern Recognition2007，40，12： | 1 |
| 20 | Feature selection based on KPCA, SVM and GSFS for face recognition显示文摘 | Weihong Li Weiguo Gong Yixiong Liang | 2005 | Lecture Notes in Control and Information Sciences2005，3687，1： | 1 |
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