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| 1 | Middle segmental pancreatectomy: A safe and organ-preserving option for benign and low-grade malignant lesions显示文摘AIM: To study the feasibility and safety of middle segmental pancreatectomy (MSP) compared with pancreaticoduodenectomy (PD) and extended distal pancreatectomy (EDP). METHODS: We studied retrospectively 36 cases that underwent MSP, 44 patients who underwent PD, and 26 who underwent EDP with benign or low-grade malignant lesions in the mid-portion of the pancreas, between April 2003 and December 2009 in Ruijin Hospital. The perioperative outcomes and long-term outcomes of MSP were compared with those of EDP and PD. Periop-erative outcomes included operative time, intraoperative hemorrhage, transfusion, pancreatic fistula, intraabdominal abscess/infection, postoperative bleeding, reoperation, mortality, and postoperative hospital time. Long-term outcomes, including tumor recurrence, newonset diabetes mellitus (DM), and pancreatic exocrine insufficiency, were evaluated. RESULTS: Intraoperative hemorrhage was 316.1 ± 309.6, 852.2 ± 877.8 and 526.9 ± 414.5 mL for the MSP, PD and EDP groups, respectively (P < 0.05). The mean postoperative daily fasting blood glucose level was significantly lower in the MSP group than in the EDP group (6.3 ± 1.5 mmol/L vs 7.3 ± 1.5 mmol/L, P < 0.05). The rate of pancreatic fistula was higher in the MSP group than in the PD group (42% vs 20.5%, P = 0.039), all of the fistulas after MSP corresponded to grade A (9/15) or B (6/15) and were sealed following conservative treatment. There was no significant difference in the mean postoperative hospital stay between the MSP group and the other two groups. After a mean follow-up of 44 mo, no tumor recurrences were found, only one patient (2.8%) in the MSP group vs five (21.7%) in the EDP group developed new-onset insulin-dependent DM postoperatively (P = 0.029). Moreover, significantly fewer patients in the MSP group than in the PD (0% vs 33.3%, P < 0.001) and EDP (0% vs 21.7%, P = 0.007) required enzyme substitution. CONCLUSION: MSP is a safe and organ-preserving option for benign or low-grade malignant lesions in the neck and proximal body of the pancreas. | Zhi-Yong Du Shi Chen Bao-San Han Bai-Yong Shen Ying-Bing Liu ChengHong Peng | 2013 | World Journal of Gastroenterology2013，19，9： | 18 |
| 2 | Robotic-assisted versus open total pancreatectomy: a propensity score-matched study显示文摘Background:Total pancreatectomy(TP)is a complex surgical procedure with significant postoperative morbidity.Despite the narrowed range of indications for TP,the introduction of neoadjuvant chemotherapy and the increasing complexity of surgical resections performed in high-volume centers has increased the number of annually performed TPs,especially regarding malignant disease.The introduction of robotic-assisted pancreatic surgery has provided a novel and minimally invasive approach for TP,yet the feasibility of this technique is still unknown.This study assessed the safety and efficacy of robotic-assisted total pancreatectomy(RTP)compared to conventional open total pancreatectomy(OTP).Methods:All patients who underwent TP between March 2015 and July 2019 in a high-volume institution for pancreatic surgery were included in this retrospective study.Clinical data and perioperative outcomes were derived from the prospectively maintained institutional database.A 1:1 propensity score matching(PSM)method was utilized to compare the RTP and OTP cohorts to minimize bias.Results:A standardized surgical protocol was utilized for RTP following a learning curve of RPD and RDP.The median operative time for patients who underwent RTP was significantly decreased compared to those who underwent OTP[300(IQR,250-360)vs.360 min(IQR,300-525),P=0.031].Additionally,en bloc resection and spleen-preserving rates were also higher in the RTP cohort.Major 30-day morbidity(Clavien-Dindo>IIIa)and 90-day mortality were similar between the two cohorts.After a median follow-up time of 15(IQR,8-24)months,both the RTP and OTP cohorts had a comparable quality of life regarding exocrine and endocrine insufficiency.Conclusions:RTP appears to be safe and feasible when utilized in high-volume centers for the indicated management of benign and highly selected malignant pancreatic disease.However,further prospective randomized studies are needed to assess the feasibility of this approach. | Yuanchi Weng Mengmin Chen Georgios Gemenetzis Yusheng Shi Xiayang Ying Xiaxing Deng Chenghong Peng Jiabin Jin Baiyong Shen | 2020 | Hepatobiliary Surgery and Nutrition2020，9，6： | 3 |
| 3 | Outcomes of robotic surgery for pancreatic ductal adenocarcinoma显示文摘Background:To explore the effectiveness,safety,and efficacy of the robot-assisted surgery in the radical resection of pancreatic ductal adenocarcinoma(PDAC).Methods:The clinical data of 72 patients with PDAC who underwent radical resection using the da Vinci Surgical System from April 2010 to December 2014 were retrospectively analyzed.Results:Among these 72 patients,three were converted to conventional laparotomy due to the vascular invasion or due to the difficulties in tissue isolation from the surrounding organs.Among 39 patients who underwent the pancreatoduodenectomy,the average operative time was 395.3±118.8 min,and the mean intra-operative blood loss was 447.3±269.9 m L.Among 31 patients who underwent the distal pancreatectomy(DP),the average operative time was 185.5±74.1 min,and the mean intra-operative blood loss was 267.1±305.3 m L.In two patients who received the middle pancreatectomy(MP),the average operative time was 225 min and mean intra-operative blood loss was 100 m L.Among all the 72 patients,an average of 4.2±2.6 lymph nodes were dissected,with an average hospital stay of 22.6±10.7 days.Complications were observed in 18 patients,which included pancreatic fistula(n=11),bile leak(n=5),anastomotic bleeding(n=2),pancreatic fistula complicated with portal vein thrombosis(n=1),and anastomotic bleeding complicated with acute renal failure(n=1).Except that one patient died due to post-operative bleeding and acute renal failure,all the other patients were cured after conservative treatment.These 72 patients were followed for 1-45(15.6±5.8) months,during which 10 patients died.Eleven patients suffered from recurrence or metastasis,among which 6 had local recurrence,4 had liver metastasis,and 1 had ascites accompnaied with incision site tumor metastasis.Conclusions:Radical resection of PDAC by robotic surgical system is safe and feasible.It has less surgical trauma and enables faster post-operative recovery,and therefore can achieve the lymph node dissection scope and tumor resection margin required by the standards of radical resection for pancreatic cancer.Nevertheless,its long-term efficacy requires further validation. | Qian Zhan Xiaxing Deng Yuanchi Weng Jiabin Jin Zhichong Wu Hongwei Li Baiyong Shen Chenghong Peng | 2015 | Chinese Journal of Cancer Research2015，27，6： | 3 |
| 4 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hvwnk9of9c5cb6ovk.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 5 | Downregulation of gas5 increases pancreatic cancer cell proliferation by regulating CDK6显示文摘 | Xiongxiong Lu Yuan Fang Zhengting Wang Junjie Xie Qian Zhan Xiaxing Deng Hao Chen Jiabin Jin Chenghong Peng Hongwei Li Baiyong Shen | 2013 | Cell and Tissue Research2013，，： | 2 |
| 6 | Hollow chitosan-alginate multilayer microcapsules as drug delivery vehicle: doxorubicin loading and in vitro and in vivo studies显示文摘 | Qinghe Zhao Baosan Han Zhaohai Wang Changyou Gao Chenghong Peng Jiacong Shen | 2007 | Nanomedicine: Nanotechnology, Biology, and Medicine2007，，： | 1 |
| 7 | The ABCC4 gene is a promising target for pancreatic cancer therapy显示文摘 | Zhuo Zhang Jiancheng Wang Baiyong Shen Chenghong Peng Minhua Zheng | 2011 | Gene2011，，2： | 1 |
| 8 | Guidelines for the diagnosis and treatment of acute pancreatitis in China (2021)显示文摘Acute pancreatitis(AP)is a common acute abdominal condition of the digestive system.In recent years,treatment concepts,methods,and strategies for the diagnosis of AP have advanced,and this has played an important role in promoting the standardization of AP diagnosis and treatment and improving the treatment quality of AP patients.On the basis of previous guidelines and expert consensus,this guideline adopts an evidence-based,problem-based expression;synthesizes important clinical research data at home and abroad in the most recent 5 years;and forms 29 recommendations through multidisciplinary expert discussion,including diagnosis,treatment,and follow-up.It is expected to provide evidence support for the treatment of AP in the clinical setting in China. | Fei Li Shouwang Cai Feng Cao Rufu Chen Deliang Fu Chunlin Ge Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Ang Li Haimin Li Shengping Li Weiqin Li Yixiong Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Changqing Yan Yinmo Yang Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 1 |
| 9 | Consensus of clinical diagnosis and treatment for non-functional pancreatic neuroendocrine neoplasms with diameter<2 cm显示文摘In clinical practice,pancreatic neuroendocrine neoplasms(pNENs)with a diameter smaller than 2 cm are commonly referred to as small pNENs.Due to their generally favorable biological characteristics,the diagnosis and treatment of small pNENs differ from other pNENs and are somewhat controversial.In response to this,the Chinese Pancreatic Surgery Association,Chinese Society of Surgery,Chinese Medical Association have developed a consensus on the diagnosis and treatment of small pNENs,which is based on evidence-based medicine and expert opinions.This consensus covers various topics,including concepts,disease assessment,treatment selection,follow-up,and other relevant aspects. | Wu Wenming Cai Shouwang Chen Rufu Fu Deliang Ge Chunlin Hao Chunyi Hao Jihui Huang Heguang Jian Zhixiang Jin Gang Li Fei Li Haimin Li Shengping Li Weiqin LiYixiong Liang Tingbo Liu Xubao Lou Wenhui Miao Yi Mou Yiping Peng Chenghong Qin Renyi Shao Chenghao Sun Bei Tan Guang Wang Huaizhi Wang Lei Wang Wei Wang Weilin Wei Junmin Wu Heshui Wu Zheng Yan Changqing Yang Yinmo Yin Xiaoyu Yu Xianjun Yuan Chunhui Zhao Yupei | 2023 | Journal of Pancreatology2023，6，3： | 0 |
| 10 | Intra-abdominal hypertension is an independent cause of acute renal failure after orthotopic liver transplantation显示文摘An independent association between acute renal failure(ARF)and intra-abdominal hypertension(IAH)after liver transplantation has not been established previously.The aim of this retrospective study was to understand the role of IAH as an independent risk factor for ARF in the early postoperative period.This study involved 62 subjects who underwent liver transplantation.Intra-abdominal pressure(IAP)was measured in the first three days after surgery by using the urinary bladder technique.An IAP of at least 20 mmHg per day was defined as IAH.Clinical parameters between group IAH and group NO-IAH were compared in terms of the incidence of ARF,blood creatinine levels,blood urea nitrogen(BUN)levels,urine volume per hour and glomerular filtration gradient(GFG).Hemodynamic variations were recorded in the first three postoperative days between group ARF and group NO-ARF.The perioperative suspected risk factors of ARF were determined for statistical evaluation using correlation coefficients and logistic regression analysis.In group IAH,45.8%patients developed ARF as against 7.9%in group NO-IAH;GFG was significantly lower at 0–72 h after surgery;and blood creatinine levels,BUN levels,urine volume per hour were significantly different at 24–72 h after surgery compared with group NO-IAH.The patients with ARF were not significantly different from those without ARF in terms of central venous pressure,pulmonary artery pressure and mean arterial pressure(MAP)in the first three postoperative days despite a significant increase in heart rate at 24–72h after operation.Postoperative IAH,intraoperative MAP and intraoperative blood transfusion volume of more than 15 U were found to be independent risk factors for ARF.IAH impaired renal function and was an independent risk factor for ARF after liver transplantation.Routine measurement should be taken to monitor IAP every eight hours postoperatively. | SHU Ming PENG Chenghong CHEN Hao SHEN Boyong ZHOU Guangwen SHEN Chuan LI Hongwei | 2007 | Frontiers of Medicine2007，1，2： | 0 |
| 11 | The application of the robotic surgical system in pancreaticoduodenectomy显示文摘Owing to the operative complexity, the application of minimally invasive surgery to pancreatic procedures has been delayed. However, with advances in technique, and since the introduction of robotic systems in particular, pancreatic minimally invasive surgery has made much progress. Laparoscopic and robotic technology has been widely adopted. The safety and feasibility of minimally invasive procedures for pancreaticoduodenectomy have been confirmed in many reports. However, even with these advantages, laparoscopic and robotic surgery cannot completely replace laparotomy. Pancreatic surgeons need to master these three operative methods to be able to handle complicated clinical situations. | Chenghong Peng Hua Li | 2016 | Oncology and Translational Medicine2016，2，6： | 0 |
| 12 | Guidelines for the diagnosis and treatment of pancreatic cancer in China (2021)显示文摘The incidence of pancreatic cancer has been rising worldwide,and its clinical diagnosis and treatment remain a great challenge.To present the update and improvements in the clinical diagnosis and treatment of pancreatic cancer in recent years,Chinese Pancreatic Association,the Chinese Society of Surgery,Chinese Medical Association revised the Guidelines for the Diagnosis and Treatment of Pancreatic Cancer in China(2014)after reviewing evidence-based and problem-oriented literature published during 2015-2021,mainly focusing on highlight issues regarding diagnosis and surgical treatment of pancreatic cancer,conversion strategies for locally advanced pancreatic cancer,treatment of pancreatic cancer with oligo metastasis,adjuvant and neoadjuvant therapy,standardized processing of surgical specimens and evaluation of surgical margin status,systemic treatment for unresectable pancreatic cancer,genetic testing,as well as postoperative follow up of patients with pancreatic cancer.Forty recommendation items were finally proposed based on the above issues,and the quality of evidence and strength of recommendations were graded using the Grades of Recommendation,Assessment,Development,and Evaluation system.This guideline aims to standardize the clinical diagnosis and therapy,especially surgical treatment of pancreatic cancer in China,and further improve the prognosis of patients with pancreatic cancer. | Yinmo Yang Xueli Bai Dapeng Bian Shouwang Cai Rufu Chen Feng Cao Menghua Dai Chihua Fang Deliang Fu Chunlin Ge Xiaochao Guo Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Fei Li Haimin Li Shengping Li Weiqin Li Yixiong Li Hongzhen Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Jingyong Xu Changqing Yan Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Jixin Zhang Jun Zhou Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 0 |
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