|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Parishin C's prevention of Aβ_(1–42)-induced inhibition of long-term potentiation is related to NMDA receptors显示文摘The rhizome of Gastrodia elata(GE), a herb medicine, has been used for treatment of neuronal disorders in Eastern Asia for hundreds of years. Parishin C is a major ingredient of GE. In this study, the i.c.v. injection of soluble Aβ1–42oligomers model of LTP injury was used. We investigated the effects of parishin C on the improvement of LTP in soluble Aβ1–42oligomer–injected rats and the underlying electrophysiological mechanisms. Parishin C(i.p. or i.c.v.) significantly ameliorated LTP impairment induced by i.c.v. injection of soluble Aβ1–42oligomers. In cultured hippocampal neurons,soluble Aβ1–42oligomers significantly inhibited NMDAR currents while not affecting AMPAR currents and voltage-dependent currents. Pretreatment with parishin C protected NMDA receptor currents from the damage induced by Aβ. In summary, parishin C improved LTP deficits induced by soluble Aβ1–42oligomers. The protection by parishin C against Aβ-induced LTP damage might be related to NMDA receptors. | Zhihui Liu Weiping Wang Nan Feng Ling Wang Jiangong Shi Xiaoliang Wang | 2016 | Acta Pharmaceutica Sinica B2016，6，3： | 25 |
| 2 | Factors Affecting Sensory Quality of Cooked japonica Rice显示文摘The sensory quality of cooked rice is an important factor in determining its market price, as well as consumer acceptance and breeding efforts aimed at improvement of rice grain quality. In this study,the sensory quality and physicochemical properties of three japonica rice varieties harvested in two different growing locations(Xiangshui and Hangzhou of China) were compared to determine the most important factors affecting the sensory quality. All the three varieties had higher scores for overall sensory quality in Xiangshui than in Hangzhou, indicating that the growing location is a key factor in determining the sensory quality of cooked japonica rice. In addition to growing location, variety(genotype) also had an important effect. Longdao 18 scored the highest for overall sensory quality in the two locations, whereas Longdao 30 had the lowest score in Xiangshui, and both Longdao 20 and Longdao 30 had the lowest scores in Hangzhou. Many physicochemical properties, such as apparent amylose content, protein content, thermal properties and free amino acid contents, showed significant differences between the two locations. Correlation analysis showed that apparent amylose content and protein content had contrasting effects on all the sensory attributes. The overall sensory quality was negatively correlated with protein content(r =-0.89, P < 0.01) and positively correlated with gel hardness(r = 0.91, P < 0.01),indicating that the protein content and hardness are important physicochemical properties for predicting the sensory quality of japonica rice. These findings will provide guidance for selection from the diverse genotypes available to develop new varieties with the desired eating and cooking quality. | XU Yanjie YING Yining OUYANG Shuhong DUAN Xiaoliang SUN Hui JIANG Shukun SUN Shichen BAO Jinsong | 2018 | Rice science2018，25，6： | 23 |
| 3 | Medusoid Fossils from the Sinian Xingmincun Formation of Southern Liaoning Province显示文摘Abundant medusoid soft-bodied metazoan fossils have been found in the Sinian Xingmincun Formation(with an isotopic age of 650 Ma) at Qipanmo, Qidingshan and Yangtun of the Dalian-Jinzhou area, southern Liaoning Province; in addition, a number of macroscopic algal fossils have been discovered for the first time in the Getun Formation overlying the Xingmincun Formation. Medusoid fossils include 3 genera and 6 species(all of which are new). Judging from their biological characters, these medusoid fossils are considered to have an intimate affinity with the Ediacara fauna in the terminal Precambrian of Australia, as their characters are close to each other. The authors suggest that these medusoids and the Edicara fauna might be the products of the same period. The discovery of the medusoid fauna in the Xingmincun Formation marks an important event in the evolution of the terminal Precambrian organisms in China, and it is of major practical significance in the study of the Sinian System of China and the correlation of the Sinian strata of northern and southern China. | Hong Zuomin, Huang Zhenfu, Yang Xinde, Lan Jing, Xian Bingcai, Yang Yajun, Regional Geological Survey Party, Bureau of Geology and Mineral Resources of Liaoning Province, Jinzhou, Liaoning and Liu Xiaoliang Shenyang Institute of Geology and Resources, Chinese Academy of Geological Sciences, Shenyang, Liaoning Fang Xinzhong | 1989 | Acta Geologica Sinica(English Edition)1989，63，1： | 20 |
| 4 | Late Mesoarchean crust growth event: evidence from the ca. 2.8 Ga granodioritic gneisses of the Xiaoqinling area, southern North China Craton显示文摘Recently, more attention has been paid to Precambrian magma events and crustal growth of the North China Craton(NCC), accompanying with controversy in activity stages and dynamic mechanism. In this study, we report the Archean(2802 ± 13 Ma) granodioritic gneisses in the Taihua Complex from the Xiaoqinling area, located in the southern margin of the NCC. The zircon Lu–Hf isotope analysis of the rocks showed ^(176)Hf/^(177)Hf ratios of0.280977–0.281228, corresponding to ε_(Hf)(t) values ranging from-3.5 to +6.6, and two–stage Hf model ages varying from 2836 to 3409 Ma. It was confirmed that late Mesoarchean(2.9–2.8 Ga) juvenile crust made contribution to the source material of these ca. 2.8 Ga granodioritic gneisses in the Xiaoqinling area. The whole rock geochemical data indicate that the granodioritic gneisses are high-K calc-alkaline series, probably generated at relatively high pressure and temperature, and formed under the continental arc setting. Statistically, we conclude that the magmatic activities during 2.9–2.7 Ga may represent the most intense crustal growth events in the NCC and these Archean rocks at different locations in southern NCC underwent a similar crustal evolution history. | Xiaoliang Jia Xiyan Zhu Mingguo Zhai Yan Zhao Hong Zhang Jialin Wu Tao Liu | 2016 | Science Bulletin2016，61，12： | 16 |
| 5 | Hollow-in-hollow carbon spheres with hollow foam-like cores for lithium-sulfur batteries显示文摘 | Jun Zang Taihua An Yajie Dong Xiaoliang Fang Mingsen Zheng Quanfeng Dong Nanfeng Zheng | 2015 | Nano Research2015，8，8： | 15 |
| 6 | Catalytic fast pyrolysis of Kraft lignin with HZSM-5 zeolite for producing aromatic hydrocarbons显示文摘 | Xiangyu LI Lu SU Yujue WANG Yanqing YU Chengwen WANG Xiaoliang LI Zhihua WANG | 2012 | Frontiers of Environmental Science & Engineering2012，6，3： | 14 |
| 7 | Robust adaptive fault-tolerant control of a tandem coaxial ducted fan aircraft with actuator saturation显示文摘This paper is concerned with the robust adaptive fault-tolerant control of a tandem coaxial ducted fan aircraft under system uncertainty, mismatched disturbance, and actuator saturation.For the proposed aircraft, comprehensive controllability analysis is performed to evaluate the controllability of each state as well as the margin to reject mismatched disturbance without any knowledge of the controller. Mismatched disturbance attenuation is ensured through a structured Hinfinity controller tuned by a non-smooth optimization algorithm. Embedded with the H-infinity controller, an adaptive control law is proposed in order to mitigate matched system uncertainty and actuator fault. Input saturation is also considered by the modified reference model. Numerical simulation of the novel ducted fan aircraft is provided to illustrate the effectiveness of the proposed method. The simulation results reveal that the proposed adaptive controller achieves better transient response and more robust performance than classic Model Reference Adaptive Control(MRAC) method, even with serious actuator saturation. | Xiaoliang WANG Changle XIANG Homayoun NAJJARAN Bin XU | 2018 | Chinese Journal of Aeronautics2018，31，6： | 14 |
| 8 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 9 | Three pairs of alkaloid enantiomers from the root of Isatis indigotica显示文摘Three pairs of enantiomerically pure alkaloids with diverse structure features, named isatindigoticoic acid A and epiisatindigoticoic acid A [(—)-1 and(+)-1], phaitanthrin A and epiphaitanthrin A [(—)-2 and(+)-2], and isatindopyrromizol A and epiisatindopyrromizol A [(—)-3and(+)-3], respectively, were isolated from an aqueous extract of the roots of Isatis indigotica. Racemic and scalemic mixtures of these enantiomers were separated by HPLC on a chiral semi-preparative column.Their structures including absolute configurations were determined by extensive spectroscopic analysis in conjunction with the calculation of electronic circular dichroism(ECD) spectra. The enantiomer pairs possess parent structures of 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid, indolo[2,1-b]quinazolinone, and 3-thioxohexahydro-1H-pyrrolo[1,2-c]imidazol-1-one, respectively. Except for phaitanthrin A[(—)-2] which the configuration was previously undetermined, these compounds are new enantiomeric natural products. | Yufeng Liu Xiaoliang Wang Minghua Chen Sheng Lin Li Li Jiangong Shi | 2016 | Acta Pharmaceutica Sinica B2016，6，2： | 12 |
| 10 | Disease profile and plasma neutralizing activity of postvaccination Omicron BA.1 infection in Tianjin,China:a retrospective study显示文摘Dear Editor,SARS-CoV-2 Omicron variant BA.1 first emerged on the Chinese mainland on January 8,2022,in Tianjin and caused a large wave of infections.1 Four rounds of mass testing of its~14 million residents were launched on January 9,12,15,and 20,respectively.As of February 7,2022,a total of 430 individuals were tested positive for Omicron BA.1,with no new infections detected for the following 16 days.In the Chinese mainland,the most delivered vaccines are inactivated vaccines.As of January 8,2022,up to 93.2%of Tianjin’s residents had been vaccinated with at least one dose.2 We investigated the protection conferred by vaccination against Omicron BA.1 by examining the breakthrough infections among vaccinees as compared with unvaccinated cases.Our study population comprised all 430 cases during the outbreak of Omicron BA.1 in Tianjin. | Hong Zheng Yunlong Cao Xiaosu Chen Fengmei Wang Ye Hu Weiliang Song Yangyang Chai Qingqing Gu Yansong Shi Yingmei Feng Shuxun Liu Yan Xie Xiaoliang Sunney Xie Wentao Jiang Zhongyang Shen | 2022 | Cell Research2022，32，8： | 12 |
| 11 | GSDME as an executioner of chemotherapy-induced cell death显示文摘Cell death is a crucial process required for development,tissue homeostasis,and pathological cell loss in multicellular organisms.Cell death mainly occurs in two alternative modes:apoptosis or necrosis.Apoptosis is a form of programmed cell death with typical morphological features,including cell shrinkage,chromatin condensation,and DNA fragmentation(Degterev and Yuan,2008).The dying cell is eventually fragmented into membrane-bound | Xiaoliang Yu Sudan He | 2017 | Science China(Life Sciences)2017，60，11： | 12 |
| 12 | Adsorption separation of carbon dioxide, methane and nitrogen on monoethanol amine modified β-zeolite显示文摘A new type of composite adsorbents was synthesized by incorporating monoethanol amine (MEA) into β-zeolite. The parent and MEA- functionalized β-zeolites were characterized by X-ray diffraction (XRD), N2 adsorption, and thermogravimetric analysis (TGA). The adsorption behavior of carbon dioxide (CO2), methane (CH4), and nitrogen (N2) on these adsorbents was investigated at 303 K. The results show that the structure of zeolite was well preserved after MEA modification. In comparison with CH4 and N2, CO2 was preferentially adsorbed on the adsorbents investigated. The introduction of MEA significantly improved the selectivity of both CO2/CH4 and CO2/N2, the optimal selectivity of CO2/CH4 can reach 7.70 on 40 wt% of MEA-functionalized β-zeolite (MEA(40)-β) at 1 atm. It is worth noticing that a very high selectivity of CO2/N2 of 25.67 was obtained on MEA(40)-β. Steric effect and chemical adsorbate-adsorbent interaction were responsible for such high adsorption selectivity of CO2. The present MEA-functionalized β-zeolite adsorbents may be a good candidate for applications in flue gas separation, as well as natural gas and landfill gas purifications. | Xiaoliang Xu Xingxiang Zhao Linbing Sun Xiaoqin Liu | 2009 | Journal of Natural Gas Chemistry2009，18，2： | 11 |
| 13 | Adsorption separation of carbon dioxide,methane,and nitrogen on Hβand Na-exchangedβ-zeolite显示文摘二氧化碳的吸附等温线(公司 2), 甲烷(CH 4), 和氮(Hβ 和钠上的 N 2) 交换了 β-zeolite (Naβ) 容量的联盟者在 273 和 303 K 被测量。结果证明所有等温线具有 Brunauer 类型我和井与 Langmuir-Freundlich 相关模型。在钠离子交换以后,吸附增加的三种被吸附物质总计,当公司 2 吸附能力的增加大小比 CH 4 和 N 2 的高得多时。在 CH 4 上的公司 2 和在在钠交换以后提高的 N 2 上的公司 2 的选择。另外,吸附数据的起始的热在 Naβ 与 Na + 离子暗示了公司 2 分子的一个更强壮的相互作用。这些结果能在沸石被归因于和额外的框架阳离子的公司 2 的更大的静电的相互作用。然而, Naβ 在能被归功于到与 Naβ 的 N 2 的中等亲密关系的 N 2, 上在 CH 4 的选择显示出减少。装载的功能显示在 Naβ 的公司 2 的吸附介绍精力充沛地异构的侧面的吸附的 isosteric 热的变化。相反, CH 4 的吸附被发现实质上同类,它建议在 CH 4 和格子氧原子之间的分散相互作用,并且如此的相互作用不取决于沸石的可交换的阳离子。 | Xiaoliang Xu Xingxiang Zhao Linbing Sun Xiaoqin Liu | 2008 | Journal of Natural Gas Chemistry2008，17，4： | 11 |
| 14 | Physical modeling and spectrum spread analysis of surface clutter in forward scattering radar显示文摘In this paper, based on the processing results of measured clutter data in forward scattering radar, a special phenomenon that the clutter spectrum spread is insensitive to the wind speed and carrier frequency is observed. The pendulum model is first time introduced into the physical modeling and formation mechanism analysis of surface clutter, and the quantitative expression of clutter spectrum spread is analytically obtained. Under the assumption of pendulum model, the processing results of measured clutter data agree well with the results of theoretical analysis, which fully verifies the correctness of pendulum model and reveals the formation mechanism of surface clutter spectrum in forward scattering radar. Furthermore, according to the stability of clutter spectrum spread with respect to carrier frequencies and wind speed, the optimal cutofrequencies of clutter filter can be obtained, which establishes the basis for moving target detection and accurate parameters estimation. | LONG Teng, HU Cheng, ZENG Tao & LI XiaoLiang Radar Research Laboratory, Department of Electronic Engineering, Beijing Institute of Technology, Beijing 100081, China | 2010 | Science China(Information Sciences)2010，53，11： | 11 |
| 15 | Identification and primary genetic analysis of Arabidopsis stomatal mutants in response to multiple stresses显示文摘In response to variable environmental conditions, guard cells located in the leaf epidermis can integrate and cope with a multitude of complicated stimuli, thereby making stomata in an appro- priate state. However, many signaling components in guard cell signaling remain elusive. In our laboratory, a tool for non-invasive remote infrared thermal images was used to screen an ethyl methane sulfonate-mutagenized population for Arabidopsis stomatal response mutants under multiple stresses (ABA, H2O2, CO2, etc.). More than forty 'hot' or 'cold' mutants were isolated (above or below 0.5℃ in con- trast to normal plantlets). Identification and primary genetic analysis of these mutants show that they are monogenic recessive mutations and there exist distinct difference in stomata apertures compared to wild type. These mutants in response to various environmental stresses and hormones were comprehen- sively investigated, which enables us to further un- derstand the cross-talk in different signal transduction pathways. | SONG Yuwei KANG Yanli LIU Hao ZHAO Xiaoliang WANG Pengtao AN Guoyong ZHOU Yun MIAO Chen SONG Chunpeng | 2006 | Chinese Science Bulletin2006，51，21： | 11 |
| 16 | Nonlinear optical properties of graphene-based materials显示文摘Graphene,a two-dimensional carbon atom sheet,has attracted tremendous attention and research interest because of its exceptional physical properties.Graphene has high mobility and optical transparency,in addition to flexibility,robustness and environmental stability.The main focus so far has been on fundamental physics and electronic devices.However,because the linear dispersion of the Dirac electrons enables ultrawideband tunability,we believe its true potential lies in photonics and optoelectronics.In this review,we introduce recent advances in the nonlinear optical properties of graphene-based materials.The rise of graphene in nonlinear optics is shown by several recent results,ranging from saturable absorbers and the four-wave mixing effect to giant two-photon absorption,reverse saturable absorption and optical limiting.The relevant forms of the graphene-based materials include pure graphene,graphene oxide and graphene hybrids. | LIU ZhiBo ZHANG XiaoLiang YAN XiaoQing CHEN YongSheng TIAN JianGuo | 2012 | Chinese Science Bulletin2012，57，23： | 10 |
| 17 | Longitudinal non-vascular transport pathways originating from acupuncture points in extremities visualised in human body显示文摘A subcutaneous transport pathway in humans has been previously visualised by injection of a paramagnetic tracer into the specific region of skin.In the current study,we further investigated the behaviours of imaging tracers in the transport pathways using imaging techniques.Three types of imaging tracers,including Gd-DTPA,iodised oil,and fluorescein sodium,were hypodermically injected into different acupuncture points of healthy volunteers to visualise the transport pathways by magnetic resonance imaging(MRI),X-ray,CT,and a digital fluorescein camera.Several longitudinal transport pathways in the arms and feet,which represent venous vessels and subcutaneous transport pathways(STPs) without well-defined boundaries,were visualised by MRI.Among the visualised veins,the partial walls of a few veins were enhanced by Gd-DTPA.The fluorescent images further indicated that STPs likely represent boundless pathways.The findings in this study suggested that specific anatomical structures within the subcutaneous tissues or the partial walls of certain veins werenot vascular conduits but rather represented unique transport pathways in humans that warrant extensive future studies. | Hongyi Li Jiabin Tong Weiguo Cao Min Chen Hua Li Hong Dai Liang Xu Xiaoliang Chen | 2014 | Chinese Science Bulletin2014，59，35： | 10 |
| 18 | Characterization and Fine Mapping of a Novel Rice Albino Mutant low temperature albino 1显示文摘白化体异种是为学习叶绿素生合成和叶绿体开发并且克隆在植物涉及这些过程的基因的有用基因资源。这里,我们报导新奇米饭异种低温度白化体 1 (lta1 ) 当在比 20 楢潮低的温度下面成长时,那显示出的白化体在 4 | Yu Peng Yi Zhang Jun Lv Jianhui Zhang Ping Li Xiaoliang Shi Yufeng Wang Honglei Zhang Zuhua He Sheng Teng | 2012 | Journal of Genetics and Genomics2012，39，8： | 9 |
| 19 | Potassium 2-(l-hydroxypentyl)-benzoate attenuates neuroinflammatory responses and upregulates heme oxygenase-1 in systemic lipopolysaccharide-induced inflammation in mice显示文摘A neuroinflammatory response is commonly involved in the progression of many neurodegenerative diseases. Potassium 2-(1-hydroxypentyl)-benzoate(PHPB), a novel neuroprotective compound, has shown promising effects in the treatment of ischemic stroke and Alzheimer's disease(AD). In the present study, the anti-inflammatory effects of PHPB were investigated in the plasma and brain of C57BL/6 mice administered a single intraperitoneal(i.p.) injection of lipopolysaccharide(LPS). Levels of i NOS and the cytokines TNFα, IL-1β and IL-10 were elevated in plasma, cerebral cortex and hippocampus after LPS injection and the number of microglia and astrocytes in cortex and hippocampus were increased. LPS also upregulated the expression of heme oxygenase-1(HO-1) in the cortex and hippocampus. PHPB reduced the levels of i NOS and cytokines in the plasma and brain, decreased the number of microglia and astrocytes and further enhanced the upregulation of HO-1. In addition, PHPB inhibited the LPS-induced phosphorylation of ERK, P38 and JNK. These results suggest that PHPB is a potential candidate in the treatment of neurodegenerative diseases through inhibiting neuroinflammation. | Chunyang Zhao Weizhen Hou Hui Lei Longjian Huang Shan Wang Dandan Cui Changhong Xing Xiaoliang Wang Ying Peng | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 9 |
| 20 | A Method for Spatial Heterogeneity Evaluation on Landscape Pattern of Farmland Shelterbelt Networks:A Case Study in Midwest of Jilin Province,China显示文摘On the basis of landscape ecology, combining the Spot 5 high resolution satellite imagery with GIS, a method evaluating the spatial heterogeneity of shelterbelts distribution at landscape scale is put forward in this paper. The distance coefficients of reasonable and existing landscape indexes of farmland shelterbelt networks were com-puted, and then through the classification of the distance coefficients, and the establishment of evaluation rules, the spatial heterogeneity of farmland shelterbelts was evaluated. The method can improve the evaluating system of previ-ous studies on shelterbelts distribution, resolve the disadvantages of lacking spatiality of overall evaluation, and make the evaluation results have more directive significance for shelterbelt management. Based on this method, spatial het-erogeneity of shelterbelt networks was evaluated in the midwest of Jilin Province, China. The results show that the re-gions with fewer shelterbelts and no closed network account for 34.7% of the total area, but only 4.9% of the area has relative reasonable pattern of shelterbelt networks. Many problems exist in the distribution pattern of shelterbelts, therefore, much attention should be paid to construct farmland shelterbelts in the study area. | SHI Xiaoliang LI Ying DENG Rongxin | 2011 | Chinese Geographical Science2011，21，1： | 9 |
您所在的机构暂未开通此部分的功能，请联系管理员