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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma显示文摘Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer featured with high intra-tumoral heterogeneity and poor prognosis. To comprehensively delineate the PDAC intra-tumoral heterogeneity and the underlying mechanism for PDAC progression, we employed single-cell RNA-seq (scRNA-seq) to acquire the transcriptomic atlas of 57,530 individual pancreatic cells from primary PDAC tumors and control pancreases, and identified diverse malignant and stromal cell types, including two ductal subtypes with abnormal and malignant gene expression profiles respectively, in PDAC. We found that the heterogenous malignant subtype was composed of several subpopulations with differential proliferative and migratory potentials. Cell trajectory analysis revealed that components of multiple tumor-related pathways and transcription factors (TFs) were differentially expressed along PDAC progression. Furthermore, we found a subset of ductal cells with unique proliferative features were associated with an inactivation state in tumor-infiltrating T cells, providing novel markers for the prediction of antitumor immune response. Together, our findings provide a valuable resource for deciphering the intra-tumoral heterogeneity in PDAC and uncover a connection between tumor intrinsic transcriptional state and T cell activation, suggesting potential biomarkers for anticancer treatment such as targeted therapy and immunotherapy. | Junya Peng Bao-Fa Sun Chuan-Yuan Chen Jia-Yi Zhou Yu-Sheng Chen Hao Chen Lulu Liu Dan Huang Jialin Jiang Guan-Shen Cui Ying Yang Wenze Wang Dan Guo Menghua Dai Junchao Guo Taiping Zhang Quan Liao Yi Liu Yong-Liang Zhao Da-Li Han Yupei Zhao Yun-Gui Yang Wenming Wu | 2019 | Cell Research2019，29，9： | 24 |
| 3 | Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation显示文摘Pancreatic ductal adenocarcinoma(PDAC)has poor prognosis due to limited therapeutic options.This study examines the roles of genome-wide association study identified PDAC-associated genes as therapeutic targets.We have identified HNF4G gene whose silencing most effectively repressed PDAC cell invasiveness.HNF4G overexpression is induced by the deficiency of transcriptional factor and tumor suppressor SMAD4.Increased HNF4G are correlated with SMAD4 deficiency in PDAC tumor samples and associated with metastasis and poor survival time in xenograft animal model and in patients with PDAC(log-rank P=0.036;HR=1.60,95%CI=1.03–2.47).We have found that Metformin suppresses HNF4G activity via AMPK-mediated phosphorylation-coupled ubiquitination degradation and inhibits in vitro invasion and in vivo metastasis of PDAC cells with SMAD4 deficiency.Furthermore,Metformin treatment significantly improve clinical outcomes and survival in patients with SMAD4-deficient PDAC(log-rank P=0.022;HR=0.31,95%CI=0.14–0.68)but not in patients with SMAD4-normal PDAC.Pathway analysis shows that HNF4G may act in PDAC through the cell-cell junction pathway.These results indicate that SMAD4 deficiency-induced overexpression of HNF4G plays a critical oncogenic role in PDAC progression and metastasis but may form a druggable target for Metformin treatment. | Chengcheng Wang Taiping Zhang Quan Liao Menghua Dai Junchao Guo Xinyu Yang Wen Tan Dongxin Lin Chen Wu Yupei Zhao | 2021 | Protein & Cell2021，12，2： | 5 |
| 4 | Provenance and tectonic setting transition as recorded in the Neoproterozoic strata, western Jiangnan Orogen:Implications for South China within Rodinia显示文摘The Neoproterozoic Tonian strata (ca.870-725 Ma) in the western Jiangnan Orogen archive the records of sedimentary provenance and tectonic setting which can be used to understand the geological evolution of the South China Continent.These strata are separated into the basement and cover sequences by a regional angular unconformity.The basement sequence can be subdivided into the lower and the upper parts by the widespread interbedded ca.840 Ma basalt with pillow structure.In the present work,234 concordant detrital zircon analyses are obtained from three Tonian sandstone samples in the Fanjingshan district,Guizhou Province.Combined with previous results,a total of 1736 analyses of detrital zircon U-Pb ages derived from 12 formations of Tonian strata in the western Jiangnan Orogen are used to decipher the integrated sedimentary and tectonic histories.The zircons from the lowermost part of the basement sequence (the Yujiagou Formation) show oval morphology and display two Paleoproterozoic age peaks at 2325 Ma and 1845 Ma which are similar with the detrital zircon age peaks from the Late Paleoproterozoic to Early Mesoproterozoic Dongchuan/Dahongshan/Hekou groups,suggesting a passive margin basin in which the sediments were mainly sourced from the southwestern Yangtze Block.However,the zircon age population of the lower part of the basement sequence (the Xiaojiahe,Huixiangping formations and their equivalents) indicates the sedimentary derivation from bidirectional sources (the ca.870 Ma arc materials in the south and the old detritus from the southwestern Yangtze Block) which is consistent with a back arc setting for the deposition of the sediments.Zircons from the upper part of the basement sequence (the Duyantang Formation and its equivalent) show euhedral and subangular morphology and display a unimodal age peak at ca.835 Ma.This sequence was possibly deposited in a convergent setting and the detritus were came from the locally distributed syn-collisional igneous rocks.The lower part of the cover sequence (the Xinzhai and Wuye formations and their equivalents) shows a distinct zircon age peak at 815-809 Ma and two subordinate peaks at 2485 Ma and 2018 Ma,suggesting that the basin had gradually transformed into a continental rift basin and received the detritus from the ca.815 Ma post-collisional magmatic rocks as well as from different Paleoproterozoic source rocks in the northern Yangtze Block.We propose a tectonic evolution model that envisages eruption of ca.840 Ma basalt in a back arc basin that existed during ca.870-835 Ma,an angular unconformity was formed during amalgamation of the Yangtze Block and the Cathaysia Block at ca.835-820 Ma and the rifting of the South China Continent was initiated at ca.800 Ma.Our study concludes that the South China Continent was formed on the periphery of the Rodinia supercontinent. | Jiawei Zhang Taiping Ye Yaran Dai Jianshu Chen Hui Zhang Chuangu Dai Guohua Yuan Kaiyuan Jiang | 2019 | Geoscience Frontiers2019，10，5： | 4 |
| 5 | Pancreatic head cancer: Open or minimally invasive pancreaticoduodenectomy?显示文摘Pancreatic head cancer still represents an insurmountable barrier for patients and pancreatic surgeons.Pancreaticoduodenectomy(PD)continues to be the operative standard of care and potentially curative procedure for pancreatic head cancer.Despite the rapid development of minimally invasive techniques,whether the efficacy of minimally invasive pancreaticoduodenectomy(MIPD)is noninferior or superior to open pancreaticoduodenectomy(OPD)remains unclear.In this review,we summarized the history of OPD and MIPD and the latest staging and classification information for pancreatic head cancer as well as the proposed recommendations for MIPD indications for patients with pancreatic head cancer.By reviewing the MIPD-vs.OPD-related literature,we found that MIPD shows noninferiority or superiority to OPD in terms of safety,feasibility,enhanced recovery after surgery(ERAS)and several short-term and long-term outcomes.In addition,we analyzed and summarized the different MIPD outcomes in the USA,Europe and China.Certain debates over MIPD have continued,however,selection bias,the large number of low-volume centers,the steep MIPD learning curve,high conversion rate and administration of neoadjuvant therapy may limit the application of MIPD for pancreatic head cancer. | Mengyu Feng Zhe Cao Zhiwei Sun Taiping Zhang Yupei Zhao | 2019 | Chinese Journal of Cancer Research2019，31，6： | 4 |
| 6 | MiR-135a biogenesis and regulation in malignancy:a new hope for cancer research and therapy显示文摘MicroRNAs(miRNAs)are evolutionarily conserved small non-coding RNAs that affect posttranscriptional regulation by binding to the 3′-untranslated region of target messenger RNAs.MiR-135a is a critical miRNA that regulates gene expression,and many studies have focused on its function in cancer research.MiR-135a is dysregulated in various cancers and regulates cancer cell proliferation and invasionvia several signaling pathways,such as the MAPK and JAK2/STAT3 pathways.MiR-135a has also been found to promote or inhibit the epithelial-mesenchymal transition and chemoresistance in different cancers.Several studies have discovered the value of miR-135a as a novel biomarker for cancer diagnosis and prognosis.These studies have suggested the potential of therapeutically manipulating miR-135a to improve the outcome of cancer patients.Although these findings have demonstrated the role of miR-135a in cancer progression and clinical applications,a number of questions remain to be answered,such as the dual functional roles of miR-135a in cancer.In this review,we summarize the available studies regarding miR-135a and cancer,including background on the biogenesis and expression of miR-135a in cancer and relevant signaling pathways involved in miR-135a-mediated tumor progression.We also focus on the clinical application of miR-135a as a biomarker in diagnosis and as a therapeutic agent or target in cancer treatment,which will provide a greater level of insight into the translational value of miR-135a. | Zhe Cao Jiangdong Qiu Gang Yang Yueze Liu Wenhao Luo Lei You Lianfang Zheng Taiping Zhang | 2020 | Cancer Biology & Medicine2020，17，3： | 4 |
| 7 | Current epidemiology of pancreatic cancer: Challenges and opportunities显示文摘Pancreatic cancer(PC) is an increasingly common disease worldwide. Having a better understanding of worldwide and regional epidemiologic features and risk factors of PC is essential to identify new approaches for prevention,early diagnosis, surveillance, and treatment. In this article, we review the epidemiologic features and risk factors for PC and discuss opportunities and challenges of PC future treatment. | Wenhao Luo Jinxin Tao Lianfang Zheng Taiping Zhang | 2020 | Chinese Journal of Cancer Research2020，32，6： | 3 |
| 8 | Wavelength-tunable infrared light emitting diode based on ordered ZnO nanowire/Si1-xGex alloy heterojunction显示文摘 | Taiping Zhang Renrong Liang Lin Dong Jing Wang Jun Xu Caofeng Pan | 2015 | Nano Research2015，8，8： | 2 |
| 9 | Advantage of dual wavelength light-emitting diodes with dip-shaped quantum wells显示文摘Dual-wavelength light-emitting diodes (DW-LEDs) with dip-shaped quantum wells have been studied by numerical simulation.The emission spectra,light output power,carrier concentration in the quantum wells and internal quantum efficiency are investigated.The simulation results indicate that the DW-LEDs with dip-shaped quantum wells perform better than conventional LEDs with rectangular quantum wells in terms of light output power,leakage current and efficiency droop.These improvements in the electrical and optical characteristics are mainly attributed to the alleviation of the electrostatic field in the dip-shaped quantum wells. | XU YiQin FAN GuangHan ZHOU DeTao LI Xin LU TaiPing ZHAO Fang ZHANG YunYan ZHENG ShuWen GONG ChangChun | 2012 | Chinese Science Bulletin2012，57，20： | 2 |
| 10 | Reconsideration of the sediment characteristics of the second member of the Triassic Xujiahe Formation in Sanhuiba,Huaying Mountain显示文摘The second member of the Triassic Xujiahe Formation in the Sanhuiba area in Huaying Mountain is an important section of sedimentary delta facies in the Chongqing Tianfu Geological Survey and Training Base. In spite of some initial efforts on its lithology and lithofacies, the existing research is yet to be completed and suffers from contradictory conclusions and inadequate evidence. Starting from the sedimentary microfacies types and cyclic features, we analyzed the vertical sequence of a sedimentary delta model and discovered that this section is a constructional delta deposit. Eight incomplete and asymmetric regressive cycles are marked off, given that frequent erosion surfaces appeared in the section. Based on the analysis of structural characteristics of every monocycle, we summarized the system of cycles, tracts and sequence characteristics of the overall section. In view of this systematic series of cycles, we discussed the features of the syndepositional tectonic movements in the area and conclude that, due to frequent erosion, migration and diversion of a sub-channel branch was brought about by oscillating movements of the crust. In a comparison with neighboring sections, we explored the cause of erosion and the relations between erosion and cycles. This study greatly strengthens existing research and theories, makes an important and comprehensive contribution to geological surveys and training in the area and provides essential suggestions for coal exploration, oil and gas evaluation and in general to exploration and development in the target stratum. | LIAO Taiping HU Jingjing ZHANG Furong LIU Lijing | 2010 | Mining Science and Technology2010，20，4： | 2 |
| 11 | Sr speciation in producing SrCO_3 with celestite显示文摘Strontium speciation transferring in strontium residue and mixing strontium ore are investigated with extracting experiment, X-ray powder diffraction(XRD), X-ray fluorescence spectrometer(XRF) and Atomic Absorption Spectroscopy(AAS). The results show that there are strontium carbonate, strontium sulfate, strontium sulfide, and a little amount of strontium silicate and strontium ferrite in strontium residue. Impurities in strontium residue mainly contain carbonate and oxide of calcium, iron, magnesium and aluminum etc. The amount of strontium sulfide in strontium residue is larger than that in strontium ore. And a little strontium silicate and strontium ferrite are found in strontium ore. It is concluded that acid soluble method is used firstly in the process of producing strontium carbonate from mixing strontium ore. In addition, mechanical smash method and surface active treatment to strontium samples are beneficial to the ratio-leaching increase of strontium. The research achievement helps to save energy and decrease pollutants emission in strontium processing industry. | LIU Chenglun ZHANG Li XU Longjun SU Zhimin XIE Taiping WANG Yuan | 2014 | Chinese Journal Of Geochemistry2014，33，3： | 2 |
| 12 | Multiseale fa- cial structure representation for face recognition under varying illumination 显示文摘 | Zhang Taiping Tang Yuanyan Fang Bin | 2009 | Pattern Reeagnition2009，42，2： | 1 |
| 13 | Analysis of clinical characteristics and treatment of pancreatic cystic tumors显示文摘Objective: To summarize experience in the diagnosis and treatment of pancreatic cystic neoplasms.Methods: This is a retrospective study of 207 patients who were diagnosed with pancreatic cystic tumors at Peking Union Medical College Hospital between Jan 2009 and Mar 2014.Clinical data, such as clinical manifestations, radiological and pathological images and surgical recordings, were collected.Results: Of the 207 included patients, females accounted for 76.81%, and the mean patient age was 52.04 years.Malignancy was more common in older patients who presented with marasmus and jaundice.Other risk factors included solid components in the tumor, a large tumor size, and elevated levels of tumor markers.Surgical treatment was required when a malignant tumor was suspected.The operation approach was selected based on the location, size and characteristics of the tumor.The position of the tumor relative to the pancreatic duct also played a significant role.Conclusions: No specific symptoms were observed for the patients with pancreatic cystic tumors.Imaging played an important role in making a differential diagnosis.Furthermore, surgical treatment should be proposed for patients with significant symptoms and potentially malignant tumors.The tumor resection rate is high, suggestive of good prognosis. | Lei You Jianchun Xiao Zhe Cao Wanying Zhang Quan Liao Menghua Dai Taiping Zhang Yupei Zhao | 2016 | Chinese Journal of Cancer Research2016，28，5： | 1 |
| 14 | Topology Preserving Non-negative Matrix Factorization for Face Recognition显示文摘 | Zhang Taiping Fang Bin Tang Yuanyan | 2008 | IEEE Trans on Image Processing2008，17，4： | 1 |
| 15 | HTS filter and front-end subsystem for GSM1800 wireless base station显示文摘 | Yusheng He Hong Li Aisheng He Shunzhou Li Chunguang Li Xueqiang Zhang Taiping Zhang Lingwen Yan Wenxiu Zhu Yuan Zhou Jingtao Liang Jiasheng Hong Lancaster M. J | 2002 | Science in China Series E: Technological Science2002，，6： | 1 |
| 16 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 17 | The Chinese guidelines for neoadjuvant therapy of pancreatic cancer(2020)显示文摘Aiming to keep pace with the renewal of international guidelines and refine the domestic treatment system of pancreatic cancer,the Chinese Pancreatic Surgery Association,Chinese Medical Association and Pancreatic Disease Committee of China Research Hospital Association launched this Chinese guidelines for neoadjuvant therapy of pancreatic cancer(2020 edition).Based on the Grading of Recommendations Assessment,Development,and Evaluation system,the guidelines have conducted a discussion on the indication,regimen selection,therapeutic effect evaluation,pathological diagnosis,surgery strategy,etc.The guidelines have quantified the evidence level of the current clinical researches and provided recommendations for the clinical practice in neoadjuvant therapy of pancreatic cancer.The guidelines have highlighted the role of multiple disciplinary team and represented the conversion of treatment concepts in pancreatic cancer.Neoadjuvant therapy has prolonged the survival of part of pancreatic cancer patients.However,more high-quality clinical researches are in urgent need to improve the level of evidence,optimize the clinical practice,and improve the survival of patients. | Taiping Zhang Wenming Wu Yinmo Yang Yupei Zhao on behalf of Chinese Pancreatic Surgery Association Chinese Medical Association and Pancreatic Disease Committee of China Research Hospital Association | 2021 | Journal of Pancreatology2021，4，4： | 1 |
| 18 | Muhiscale facial structure representation for face recognition under va- rying illumination 显示文摘 | Zhang Taiping Fang Bin Yuan Yuan | 2009 | Pattern Recognition2009，42，2： | 1 |
| 19 | Study of solid-solid phase change of (n-CnH2n+1NH3) 2MCl4 for thermal energy storage显示文摘 | Li Weiping Zhang Daosheng Zhang Taiping | 1999 | Thermochimica Acta1999，326，12： | 1 |
| 20 | Face recognition under varying illumination using gradient faces显示文摘 | Zhang Taiping Tang Yuanyan Fang Bin | 2009 | IEEE Transactions on Image Processing2009，18，11： | 1 |
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