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| 1 | 500μm field-of-view probe-based confocal microendoscope for large-area visualization in the gastrointestinal tract显示文摘Rapid large-area tissue imaging at the cellular resolution is important for clinical diagnosis.We present a probe-based confocal microendoscope(p CM)with a field-of-view(FOV)diameter over 500μm,lateral resolution of 1.95μm,and outer diameter of 2.6 mm,compatible with the biopsy channel of conventional gastroscopes.Compared to a conventional p CM,our system's FOV increased by a factor of 4 while maintaining the probe size and cellular resolution—comparable to the FOV of Zeiss Axio Observer's 20×=0.8 numerical aperture objective lens.Ex vivo imaging of wide areas in healthy and diseased rat gastrointestinal tract tissues demonstrates the system's practicality. | HUA LI ZHENGYI HAO JIANGFENG HUANG TINGTING LU QIAN LIU LING FU | 2021 | Photonics Research2021，9，9： | 1 |
| 2 | Myosin 1D and the branched actin network control the condensation of p62 bodies显示文摘Biomolecular condensation driven by liquid-liquid phase separation(LLPS)is key to assembly of membraneless organelles in numerous crucial pathways.It is largely unknown how cellular structures or components spatiotemporally regulate LLPS and condensate formation.Here we reveal that cytoskeletal dynamics can control the condensation of p62 bodies comprising the autophagic adaptor p62/SQSTM1 and poly-ubiquitinated cargos.Branched actin networks are associated with p62 bodies and are required for their conden satio n.Myosi n 1D,a bran ched acti n-associated motor protein,drives coalesce nee of small nano scale p62 bodies into large micron-scale condensates along the branched actin network.Impairment of actin cytoskeletal networks compromises the condensation of p62 bodies and retards substrate degradation by autophagy in both cellular models and Myosin ID knockout mice.Coupling of LLPS scaffold to cytoskeleton systems may represent a general mechanism by which cells exert spatiotemporal control over phase condensation processes. | Xuezhao Feng Wanqing Du Mingrui Ding Wenkang Zhao Xirenayi Xirefu Meisheng Ma Yuhui Zhuang Xiaoyu Fu Jiangfeng Shen Jinpei Zhang Xiuying Lei Daxiao Sun Qing Xi Yiliyasi Aisa Qian Chenr Ying Li Wenjuan Wang Shanjin Huang Li Yu Pilong Li Na Mi | 2022 | Cell Research2022，32，7： | 1 |
| 3 | Research Progress on Serum Porphyrin and Chronic Liver Disease显示文摘Liver cirrhosis is an important cause of chronic liver cancer.At present,a breakthrough has been achieved in the development of chronic hepatitis C treatment,but there is no effective measure to completely cure chronic hepatitis B.Porphyrins are a class of macromolecular heterocyclic compounds formed by interconnecting the a-carbon atoms of four pyrrole-like substituents through hypomethyl bonds.Porphyrins and their derivatives widely exist in organelles related to energy transfer in organisms.They are mainly involved in the synthesis of heme in human body.Heme is an iron-containing porphyrin compound,15-20% of which is synthesized and utilized in the liver.Studies have found that porphyrin metabolism disorder can occur in patients with chronic liver disease.The early stage of viral hepatitis is accompanied by increased production of porphyrins and their compounds,increased levels of peripheral circulating porphyrins,porphyrin cholestasis,and biochemical changes of free porphyrins which precede the histological changes.The accumulation of serum and liver protoporphyrins and the oxidative stress can cause liver and extrahepatic damage.On the one hand,porphyrin metabolism disorder can aggravate chronic liver disease,and even progress to liver cirrhosis and liver cancer.On the other hand,chronic liver disease can also aggravate porphyrin metabolism disorder,recurrent attacks,and damage to liver and extrahepatic tissues and organs. | Xia Wang Yu Cai Weiqin Li Yuanyuan Jia Jiangfeng Fu Yaping Ni Kaige Liu | 2022 | Journal of Clinical and Nursing Research2022，6，3： | 0 |
| 4 | The clinical effectiveness and safety of using epidermal growth factor,fibroblast growth factor and granulocyte-macrophage colony stimulating factor as therapeutics in acute skin wound healing:a systematic review and meta-analysis显示文摘Background:Promoting wound healing is crucial to restore the vital barrier function of injured skin.Growth factor products including epidermal growth factor(EGF),fibroblast growth factor(FGF)and granulocyte-macrophage colony stimulating factor(GM-CSF)have been used for decades although no systematic evaluation exists regarding their effectiveness and safety issues in treating acute skin wounds.This has resulted in a lack of guidelines and standards for proper application regimes.Therefore,this systematic review and meta-analysis was performed to critically evaluate the effectiveness and safety of these growth factors on skin acute wounds and provide guidelines for application regimes.Methods:We searched PubMed/Medline(1980-2020),Cochrane Library(1980-2020),Cochrane CENTRAL(from establishment to 2020),ClinicalTrials.gov(from establishment to 2020),Chinese Journal Full-text Database(CNKI,1994-2020),China Biology Medicine disc(CBM,1978-2019),Chinese Scientific Journal Database(VIP,1989-2020)andWanfang Database(WFDATA,1980-2019).Randomized controlled trials(RCTs),quasi-RCTs and controlled clinical trials treating patients with acute skin wounds from various causes and with those available growth factors were included.Results:A total of 7573 papers were identified through database searching;229 papers including 281 studies were kept after final screening.Administering growth factors significantly short-ened the healing time of acute skin wounds,including superficial burn injuries[mean differ-ence(MD)=−3.02;95%confidence interval(CI):−3.31∼−2.74;p<0.00001],deep burn injuries(MD=−5.63;95%CI:−7.10∼−4.17;p<0.00001),traumata and surgical wounds(MD=−4.50;95%CI:−5.55∼−3.44;p<0.00001).Growth factors increased the healing rate of acute skin wounds and decreased scar scores.The incidence of adverse reactions was lower in the growth factor treatment group than in the non-growth factor group.Conclusions:The studied growth factors not only are effective and safe for managing acute skin wounds,but also accelerate their healing with no severe adverse reactions. | Yating Wei Jiangfeng Li Yao Huang Xun Lei Lijun Zhang Meifang Yin Jiawen Deng Xiaoyan Wang Xiaobing Fu Jun Wu | 2022 | Burns & Trauma2022，10，1： | 0 |
| 5 | Using data-limited approaches to assess data-rich Indian Ocean bigeye tuna:Data quantity evaluation and critical information for management implications显示文摘The majority of fishery stocks in the world are data limited,which limits formal stock assessments.Identifying the impacts of input data on stock assessment is critical for improving stock assessment and developing precautionary management strategies.We compare catch advice obtained from applications of various datalimited methods(DLMs)with forecasted catch advice from existing data-rich stock assessment models for the Indian Ocean bigeye tuna(Thunnus obesus).Our goal was to evaluate the consistency of catch advice derived from data-rich methods and data-limited approaches when only a subset of data is available.The Stock Synthesis(SS)results were treated as benchmarks for comparison because they reflect the most comprehensive and best possible scientific information of the stock.This study indicated that although the DLMs examined appeared robust for the Indian Ocean bigeye tuna,the implied catch advice differed between data-limited approaches and the current assessment,due to different data inputs and model assumptions.Most DLMs tended to provide more optimistic catch advice compared with the SS,which was mostly influenced by historical catches,current abundance and depletion estimates,and natural mortality,but was less sensitive to life-history parameters(particularly those related to growth).This study highlights the utility of DLMs and their implications on catch advice for the management of tuna stocks. | Ya'nan Li Jiangfeng Zhu Xiaojie Dai Dan Fu Yong Chen | 2022 | Acta Oceanologica Sinica2022，41，3： | 0 |
| 6 | Thermodynamic Modeling and Simulation of Air System Control Device显示文摘This paper aims to obtain the thermodynamic characteristics of the air system control device sealing part in different compressor bleed air and ambient temperature.On the basis of considering the main factors affecting the heat exchange process and simplifying the physical model of the air system control device,the thermodynamic model of air system control device is established based on the basic theory of laminar flow heat transfer and heat conduction theory.Then the piston motion characteristics and the thermodynamic characteristics of the air system control device seal are simulated.The simulation results show that the valve actuation dynamic time of piston is about 0.13 s in the actual working conditions,and the temperature effect on the dynamic response of the piston rod is only 5 ms when the inlet air temperature at 300 ℃ and 370 ℃.The maximum temperature of the air system control device sealing part is not more than 290 ℃ under long time working condition of compressor air entraining.The highest temperature of the sealing part can reach up to 340 ℃ when the air flow temperature reaches the limit temperature of 370 ℃,and the longest duration working temperature limit is not more than 14 s.Therefore,the selection of control device sealing material should consider the work characteristic of instantaneous temperature limit. | FU Jiangfeng LI Huacong LIU Xianwei HONG Linxiong | 2019 | Transactions of Nanjing University of Aeronautics and Astronautics2019，36，3： | 0 |
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