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| 1 | High salt primes a specific activation state of macrophages, M(Na)显示文摘 | Wu-Chang Zhang Xiao-Jun Zheng Lin-Juan Du Jian-Yong Sun Zhu-Xia Shen Chaoji Shi Shuyang Sun Zhiyuan Zhang Xiao-qing Chen Mu Qin Xu Liu Jun Tao Lijun Jia Heng-yu Fan Bin Zhou Ying Yu Hao Ying Lijian Hui Xiaolong Liu Xianghua Yi Xiaojing Liu Lanjing Zhang Sheng-Zhong Duan | 2015 | Cell Research2015，25，8： | 15 |
| 2 | An improved form of smoothed particle hydrodynamics method for crack propagation simulation applied in rock mechanics显示文摘The simulation of crack propagation processes in rock engineering has been not only a research hot spot among scholars but also a challenge.Based on this background,a new numerical method named improved kernel of smoothed particle hydrodynamics(IKSPH)has been put forward.By improving the kernel function in the traditional smoothed particle hydrodynamics(SPH)method,the brittle fracture characteristics of the base particles are realized.The particle domain searching method(PDSM)has also been put forward to generate the arbitrary complex fissure networks.Three numerical examples are analyzed to validate the efficiency of IKSPH and PDSM,which can correctly reveal the morphology of wing crack and the laws of crack coalescence compared with previous experimental and numerical studies.Finally,a rock slope model with complex joints is numerically simulated and the progressive failure processes are exhibited,which indicates that the IKSPH method can be well applied to rock mechanics engineering.The research results showed that IKSPH method reduces the programming difficulties and avoids the traditional grid distortion,which can provide some references for the application of IKSPH to rock mechanics engineering and the understanding of rock fracture mechanisms. | Shuyang Yu Xuhua Ren Jixun Zhang Haijun Wang Zhaohua Sun | 2021 | International Journal of Mining Science and Technology2021，31，3： | 6 |
| 3 | Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research and a new co-clinical model for treatment optimization显示文摘在下一代的定序和生物信息学的进展开始了在人的癌症染色体揭示复杂基因风景,包括口头的有鳞的房间癌(OSCC ) 。充分代表 intra-tumoral 和 inter-tumoral 异质的老于世故的现出症状之前的潜的模型被要求理解癌症的分子的差异并且达到个性化的治疗的目标。在最后十年,导出病人的异种皮移植(PDX ) 模型从能保留他们肿瘤被显示出与另外的传统的现出症状之前的潜的模型相比是在翻译癌症研究的比较喜欢的现出症状之前的潜的工具的施主的组织学、基因的特征的人的肿瘤样品产生了。明确地,遗传上明确的 PDX 模型能被使用加速指向的 antitumor 药开发和 biomarker 发现。最近,我们成功地为翻译癌症研究作为我们的肿瘤简历银行的部分建立了并且描绘一块 OSCC PDX 面板。在这篇论文,我们讨论 PDX 模型的建立,描述,和现出症状之前的潜的应用。特别地,我们基于验证注解集中于 PDX 模型的分类和应用,包括测试信息的 clinicopathological 特征, genomic 侧面,和药理学。我们在不久的将来也为耐心的层化和治疗优化在 co 临床的试用的开发探索这块注解得好的 PDX 面板的翻译的值。尽管各种各样的限制仍然存在,这条现出症状之前的潜的途径应该进一步被测试并且改善。 | Shuyang Sun Zhiyuan Zhang | 2016 | Frontiers of Medicine2016，10，1： | 5 |
| 4 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 5 | SRSF1 plays a critical role in invariant natural killer T cell development and function显示文摘Invariant natural killer T(iNKT)cells are highly conserved innate-like T lymphocytes that originate from CD4^(+)CD8^(+)double-positive(DP)thymocytes.Here,we report that serine/arginine splicing factor 1(SRSF1)intrinsically regulates iNKT cell development by directly targeting Myb and balancing the abundance of short and long isoforms.Conditional ablation of SRSF1 in DP cells led to a substantially diminished iNKT cell pool due to defects in proliferation,survival,and TCRαrearrangement.The transition from stage 0 to stage 1 of iNKT cells was substantially blocked,and the iNKT2 subset was notably diminished in SRSF1-deficient mice.SRSF1 deficiency resulted in aberrant expression of a series of regulators that are tightly correlated with iNKT cell development and iNKT2 differentiation,including Myb,PLZF,Gata3,ICOS,and CD5.In particular,we found that SRSF1 directly binds and regulates pre-mRNA alternative splicing of Myb and that the expression of the short isoform of Myb is substantially reduced in SRSF1-deficient DP and iNKT cells.Strikingly,ectopic expression of the Myb short isoform partially rectified the defects caused by ablation of SRSF1.Furthermore,we confirmed that the SRSF1-deficient mice exhibited resistance to acute liver injury uponα-GalCer and Con A induction.Our findings thus uncovered a previously unknown role of SRSF1 as an essential post-transcriptional regulator in iNKT cell development and functional differentiation,providing new clinical insights into iNKT-correlated disease. | Jingjing Liu Menghao You Yingpeng Yao Ce Ji Zhao Wang Fang Wang Di Wang Zhihong Qi Guotao Yu Zhen Sun Wenhui Guo Juanjuan Liu Shumin Li Yipeng Jin Tianyan Zhao Hai-Hui Xue Yuanchao Xue Shuyang Yu | 2021 | Cellular & Molecular Immunology2021，18，11： | 3 |
| 6 | Profile of volatile compounds in 12 Chinese soy sauces produced by high-salt-diluted state fermentation显示文摘 | SUN Shuyang JIANG Wenguang ZHAO Yuping | 2010 | Journal of the Institute of Brewing2010，116，3： | 1 |
| 7 | Selected non-Saccharomyces wine yeasts in controlled multistarter fermentations with Saccharomyces cerevisiae on alcoholic fermentation behaviour and wine aroma of cherry wines显示文摘 | SUN Shuyang GONG Hansheng JIANG Xiaoman | 2014 | Food Microbiology2014，44，： | 1 |
| 8 | TCF-1 deficiency influences the composition of intestinal microbiota and enhances susceptibility to colonic inflammation显示文摘Dear Editor,The diversity and composition of gut microbiota play critical roles for maintaining the homeostasis of host commensal bacteria which are correlated with mammalian health(Ding and Schloss,2014).Disorder of microbial community is implicated in the pathogenesis of several human diseases,such as autoimmune disease,allergy,diabetes,obesity,and inflammatory bowel disease(IBD),which is clearly demonstrated to relate to gut dysbiosis in patients and mouse models(Saleh and Elson,2011). | Guotao Yu Fang Wang Menghao You Tiansong Xu Chunlei Shao Yuning Liu Ruiqi Liu Min Deng Zhihong Qi Zhao Wang Jingjing Liu Yingpeng Yao Jingjing Chen Zhen Sun Shanshan Hao Wenhui Guo Tianyan Zhao Zhengquan Yu Qian Zhang Yaofeng Zhao Feng Chen Shuyang Yu | 2020 | Protein & Cell2020，11，5： | 1 |
| 9 | Clinical utility of PDX cohorts to reveal biomarkers of intrinsic resistance and clonal architecture changes underlying acquired resistance to cetuximab in HNSCC显示文摘Cetuximab is a widely used drug for treating head and neck squamous cell carcinomas(HNSCCs);however,it provides restricted clinical benefits,and its response duration is limited by drug resistance.Here,we conducted randomized“Phase II-like clinical trials”of 49 HNSCC PDX models and reveal multiple informative biomarkers for intrinsic resistance to cetuximab(e.g.,amplification of ANKH,up-regulation of PARP3).After validating these intrinsic resistance biomarkers in another HNSCC PDX cohort(61 PDX models),we generated acquired cetuximab resistance PDX models and analyzed them to uncover resistance mechanisms.Whole exome sequencing and transcriptome sequencing revealed diverse patterns of clonal selection in acquired resistant PDXs,including the emergence of subclones with strongly activated RAS/MAPK.Extending these insights,we show that a combination of a RAC1/RAC3 dual-target inhibitor and cetuximab could overcome acquired cetuximab resistance in vitro and in vivo.Beyond revealing intrinsic resistance biomarkers,our PDX-based study shows how clonal architecture changes underlying acquired resistance can be targeted to expand the therapeutic utility of this important drug to more HNSCC patients. | Yanli Yao Yujue Wang Lan Chen Zhen Tian Guizhu Yang Rui Wang Chong Wang Qi Wu Yaping Wu Jiamin Gao Xindan Kang Shengzhong Duan Zhiyuan Zhang Shuyang Sun | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 1 |
| 10 | Characterization of the aroma-active compounds in five sweet cherry cultivars grown in Yantai (China)显示文摘 | SUN Shuyang JIANG Wenguang ZHAO Yuping | 2010 | Flvaour and Fragrance Journal2010，25，： | 1 |
| 11 | Incorporating mesopelagic fish into the evaluation of conservation areas for marine living resources under climate change scenarios显示文摘Mesopelagic fish(meso-fish)are central species within the Southern Ocean(SO).However,their ecosystem role and adaptive capacity to climate change are rarely integrated into protected areas assessments.This is a pity given their importance as crucial prey and predators in food webs,coupled with the impacts of climate change.Here,we estimate the habitat distribution of nine meso-fish using an ensemble model approach(MAXENT,random forest,and boosted regression tree).Four climate model simulations were used to project their distribution under two representative concentration pathways(RCP4.5 and RCP8.5)for short-term(2006–2055)and long-term(2050–2099)periods.In addition,we assess the ecological representativeness of protected areas under climate change scenarios using meso-fish as indicator species.Our models show that all species shift poleward in the future.Lanternfishes(family Myctophidae)are predicted to migrate poleward more than other families(Paralepididae,Nototheniidae,Bathylagidae,and Gonostomatidae).In comparison,lanternfishes were projected to increase habitat area in the eastern SO but lose area in the western SO;the opposite was projected for species in other families.Important areas(IAs)of meso-fish are mainly distributed near the Antarctic Peninsula and East Antarctica.Negotiated protected area cover 23% of IAs at present and 38%of IAs in the future(RCP8.5,long-term future).Many IAs of meso-fish still need to be included in protected areas,such as the Prydz Bay and the seas around the Antarctic Peninsula.Our results provide a framework for evaluating protected areas incorporating climate change adaptation strategies for protected areas management. | Shuhao Liu Yang Liu Katharina Teschke Mark AHindell Rachel Downey Briannyn Woods Bin Kang Shuyang Ma Chi Zhang Jianchao Li Zhenjiang Ye Peng Sun Jianfeng He Yongjun Tian | 2024 | Marine Life Science & Technology2024，6，1： | 0 |
| 12 | Developing a Comprehensive Regime for Personal Information Protection in Networked Chinese Public Sectors显示文摘 | Xiaomi An Shuyang Sun Wenlin Bai Bin Zhang Xiaoyu Huang Hepu Deng | 2015 | Management Studies2015，3，1： | 0 |
| 13 | A Pore-Forming Strategy Toward Porous Carbon-Based Substrates for High Performance Flexible Lithium Metal Full Batteries显示文摘Self-standing carbon-based substrates with satisfied structural stability and property adjustability have promising applications in flexible lithium(Li)metal batteries(FLMBs).Current strategies for modifying carbon materials are normally carried out on powder carbon,and very few of them are suitable for self-standing carbon substrates.Herein,a pore-forming strategy based on the redox chemistry of metallic oxide nanodots is developed to prepare two porous carbon substrates for anode and cathode.Starting with cotton cloth,the resulting hollow carbon fibers substrate with nanopores effectively prevents from Li dendrites formation and large volume change in lithium metal anode(LMA).Simulations indicate that the porous structure leads to homogeneous ion flux,Li-ion concentration,and electric field during Li deposition.Li symmetrical cell based on this substrate remains stable for 8300 h with an ultralow voltage hysteresis of 9 mV.Via a similar route,porous carbon cloth substrate is obtained for subsequently seeding V_(2)O_(5)nanowires to prepare the cathode.The assembled FLMBs pouch cell delivers a capacity of 8.2 mAh with a high capacity retention of~100%even under dramatic deformation.The demonstrated strategy has far-reaching potential in preparing free-standing porous carbon-based materials for flexible energy storage devices. | Yanfei Li Shuyang Ye Jian Lin Yihan Song Xinglong Wu Jingping Zhang Changlu Shao Zhongmin Su Haizhu Sun Dwight S.Seferos | 2023 | Energy & Environmental Materials2023，6，3： | 0 |
| 14 | A biomimetic nanoplatform for customized photothermal therapy of HNSCC evaluated on patient-derived xenograft models显示文摘Cancer cell membrane(CCM)derived nanotechnology functionalizes nanoparticles(NPs)to recognize homologous cells,exhibiting translational potential in accurate tumor therapy.However,these nanoplatforms are majorly generated from fixed cell lines and are typically evaluated in cell line-derived subcutaneous-xenografts(CDX),ignoring the tumor heterogeneity and differentiation from inter-and intra-individuals and microenvironments between heterotopic-and orthotopic-tumors,limiting the therapeutic efficiency of such nanoplatforms.Herein,various biomimetic nanoplatforms(CCM-modified gold@Carbon,i.e.,Au@C-CCM)were fabricated by coating CCMs of head and neck squamous cell carcinoma(HNSCC)cell lines and patient-derived cells on the surface of Au@C NP.The generated Au@C-CCMs were evaluated on corresponding CDX,tongue orthotopic xenograft(TOX),immunecompetent primary and distant tumor models,and patient-derived xenograft(PDX)models.The Au@C-CCM generates a photothermal conversion efficiency up to 44.2% for primary HNSCC therapy and induced immunotherapy to inhibit metastasis via photothermal therapy-induced immunogenic cell death.The homologous CCM endowed the nanoplatforms with optimal targeting properties for the highest therapeutic efficiency,far above those with mismatched CCMs,resulting in distinct tumor ablation and tumor growth inhibition in all four models.This work reinforces the feasibility of biomimetic NPs combining modular designed CMs and functional cores for customized treatment of HNSCC,can be further extended to other malignant tumors therapy. | Qi Wu Lan Chen Xiaojuan Huang Jiayi Lin Jiamin Gao Guizhu Yang Yaping Wu Chong Wang Xindan Kang Yanli Yao Yujue Wang Mengzhu Xue Xin Luan Xin Chen Zhiyuan Zhang Shuyang Sun | 2023 | International Journal of Oral Science2023，15，1： | 0 |
| 15 | Hierarchical Absorbing Interface Conditions for Wave Propagation on Non-Uniform Meshes显示文摘In this paper,we propose hierarchical absorbing interface conditions to solve the problem of wave propagation in domains with a non-uniform space discretization or grid size inhomogeneity using Pad´e Via Lanczos(PVL)method.The proposed interface conditions add an auxiliary variable in the wave system to eliminate the spurious reflection at the interface between regions with different mesh sizes.The auxiliary variable with proper boundary condition can suppress the spurious reflection by cancelling the boundary source term produced by the space inhomogeneity in variational perspective.The new hierarchical interface conditions with the help of PVL implementation can effectively reduce the degree of freedom in solving the wave propagation problem. | Shuyang Dai Zhiyuan Sun Fengru Wang Jerry Zhijian Yang Cheng Yuan | 2022 | Numerical Mathematics(Theory,Methods and Applications)2022，15，1： | 0 |
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