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| 1 | A formal model for access control with supporting spatial context显示文摘There is an emerging recognition of the importance of utilizing contextual informa tion in authorization decisions. Controlling access to resources in the field of wireless and mobile networking require the definition of a formal model for access control with supporting spatial context. However, traditional RBAC model does not specify these spatial requirements. In this paper, we extend the existing RBAC model and propose the SC-RBAC model that utilizes spatial and location-based information in security policy definitions. The concept of spatial role is presented, and the role is assigned a logical location domain to specify the spatial boundary. Roles are activated based on the current physical position of the user which obtained from a specific mobile terminal. We then extend SC-RBAC to deal with hierarchies, modeling permission, user and activation inheritance, and prove that the hierarchical spatial roles are capable of constructing a lattice which is a means for articulate multi-level security policy and more suitable to control the information flow security for safety-critical location-aware information systems. Next, constrained SC-RBAC allows express various spatial separations of duty constraints, location-based cardinality and temporal constraints for specify fine-grained spatial semantics that are typical in location-aware systems. Finally, we introduce 9 invariants for the constrained SC-RBAC and its basic security theorem is proven. The constrained SC-RBAC provides the foundation for applications in need of the constrained spatial context aware access control. | ZHANG Hong HE YePing SHI ZhiGuo | 2007 | Science in China(Series F)2007，50，3： | 7 |
| 2 | The effect of 2,4-diamino-6-hydroxy-pyrimidine on PoStburn Staphylococcus aureus sepsis in rats显示文摘Objective;GTP-cyclohydrolase I (GTP-CHI) is the first and rate-limiting enzyme for the de novo bio-synthesis of biopterin.The present study was to observe the effect of 2,4-diamino-6-hydroxy-pyrimidine (DAHP),an inbibtor of GTP-CHI,on the development of postburn Staphylococcus aureus sepsis.Methods;56 male Wistarrats were randomly divided into four groups as follows;normal control group (n=10),scald control group(n=10),postburn sepsis group (n=20) and DAHP treatment group (n=16).In the scald control gro... | Li Hongyun Yao Yongming Shi ZhiGuo Dong Ning Yu Yan Lu Lianrong Sheng Zhiyong (C.Y.Sheng) Research Department of Burn Institute,304th Hospital of PLA,Beijing 100037 | 2002 | 感染.炎症.修复2002，3，1： | 6 |
| 3 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 4 | Contents of soil organic carbon and nitrogen in water-stable aggregates in abandoned agricultural lands in an arid ecosystem of Northwest China显示文摘Soil organic matter content in water-stable aggregates(WSA) in the arid ecosystems(abandoned agricultural lands especially) of China is poorly understood. In this study, we examined the WSA sizes and stability, and soil organic carbon(OC) and nitrogen(N) contents in agricultural lands with abandonment ages of 0, 3, 12, 20, 30 and 40 years, respectively, in the Minqin Oasis of Northwest China. The total soil OC and N contents at depths of 0–20, 20–40 and 40–60 cm in abandoned agricultural lands were compared to those in cultivated land(the control). Agricultural land abandonment significantly(P<0.05) influenced the distribution of MWD(mean weight diameter), and OC and N contents. There were significant increases in MWD and the proportion of macroaggregates(sizes >0.25 mm) as the age of agricultural land abandonment increased. The effect of abandonment ages of agricultural lands on MWD was determined by the changes of OC and N accumulation in WSA sizes >2 mm. The total OC and N contents presented a stratification phenomenon across soil depths in this arid ecosystem. That is, both of them decreased significantly at depths of 0–20 and 40–60 cm while increased at the depth of 20–40 cm. The WSA sizes <0.053 mm had the highest soil OC and N contents(accounting for 51.41%–55.59% and 42.61%–48.94% of their total, respectively). Soil OC and N contents in microaggregates(sizes 0.053–0.25 mm) were the dominant factors that influenced the variations of total OC and N contents in abandoned agricultural lands. The results of this study suggested that agricultural land abandonment may result in the recovery of WSA stability and the shifting of soil organic matter from the silt+clay(<0.053 mm) and microaggregate fractions to the macroaggregate fractions. However, agricultural land abandonment did not increase total soil OC and N contents in the short-term. | WANG Junqiang LIU Lichao QIU Xiaoqing WEI Yujie LI Yanrong SHI Zhiguo | 2016 | Journal of Arid Land2016，8，3： | 6 |
| 5 | Development and experimental validation of a novel hybrid powertrain with dual planetary gear sets for transit bus applications显示文摘Given that energy conservation and environmental protection are two important goals for the automotive industry, the application of a hybrid electric powertrain can improve vehicle energy efficiency while decreasing fuel consumption and engine emissions. Planetary gear-based power-split hybrid powertrains have become widely used in passenger vehicles, but remain rarely employed on transit buses. This study proposes a novel hybrid powertrain based on two planetary gear sets(CHS) and presents its operating principles along with development of a control strategy for the powertrain. The CHS hybrid powertrain operates in electric mode when the driving power demand is low, and changes to a hybrid electric mode according to the power-split principle of the planetary gear set. To validate the feasibility of the designed CHS hybrid powertrain, a prototype transit bus equipped with the designed hybrid powertrain system was built, and the operating characteristics of the system were analyzed through a performance test conducted on a chassis dynamometer. Compared with a conventional powertrain, the CHS hybrid powertrain can reduce fuel consumption by 39%. Thus, the CHS hybrid powertrain is a good solution for heavy-duty applications such as hybrid transit buses because of its simple structure and excellent fuel efficiency. | QIN KongJian WANG EnHua ZHAO Hang SHI GuangKui WANG RenGuang KONG ZhiGuo WANG Wei | 2015 | Science China(Technological Sciences)2015，58，12： | 5 |
| 6 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 7 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 8 | Fast cooperative trajectory optimization and test verification for close-range satellite formation using Finite Fourier Series method显示文摘The process of formation reconfiguration for close-range satellite formation should take into account the risk of collisions between satellites.To this end,this paper presents a method to rapidly generate low-thrust collision-avoidance trajectories in the formation reconfiguration using Finite Fourier Series(FFS).The FFS method can rapidly generate the collision-avoidance threedimensional trajectory.The results obtained by the FFS method are used as an initial guess in the Gauss Pseudospectral Method(GPM)solver to verify the applicability of the results.Compared with the GPM method,the FFS method needs very little computing time to obtain the results with very little difference in performance index.To verify the effectiveness,the proposed method is tested and validated by a formation control testbed.Three satellite simulators in the testbed are used to simulate two-dimensional satellite formation reconfiguration.The simulation and experimental results show that the FFS method can rapidly generate trajectories and effectively reduce the risk of collision between satellites.This fast trajectory generation method has great significance for on-line,constantly satellite formation reconfiguration. | Mingying HUO Zichen FAN Naiming QI Zhiguo SONG Xin SHI | 2020 | Chinese Journal of Aeronautics2020，33，8： | 3 |
| 9 | Mechanisms of chromatin-based epigenetic inheritance显示文摘Multi-cellular organisms such as humans contain hundreds of cell types that share the same genetic information(DNA sequences),and yet have different cellular traits and functions.While how genetic information is passed through generations has been extensively characterized,it remains largely obscure how epigenetic information encoded by chromatin regulates the passage of certain traits,gene expression states and cell identity during mitotic cell divisions,and even through meiosis.In this review,we will summarize the recent advances on molecular mechanisms of epigenetic inheritance,discuss the potential impacts of epigenetic inheritance during normal development and in some disease conditions,and outline future research directions for this challenging,but exciting field. | Wenlong Du Guojun Shi Chun-Min Shan Zhiming Li Bing Zhu Songtao Jia Qing Li Zhiguo Zhang | 2022 | Science China(Life Sciences)2022，65，11： | 2 |
| 10 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 11 | Irritable bowel syndrome in female patients is associated with alterations in structural brain networks显示文摘 | Jennifer S. Labus Ivo D. Dinov Zhiguo Jiang Cody Ashe-McNalley Alen Zamanyan Yonggang Shi Jui-Yang Hong Arpana Gupta Kirsten Tillisch Bahar Ebrat Sam Hobel Boris A. Gutman Shantanu Joshi Paul M. Thompson Arthur W. Toga Emeran A. Mayer | 2014 | Pain2014，，1： | 2 |
| 12 | Direct access to β-seleno sulfones at room temperature through selenosulfonylation of alkenes显示文摘A new protocol has been developed for the formation of C.Se and C.S bonds by the direct selenosulfonylation of alkenes.This protocol is operationally simplistic, has a wide substrate scope, uses readily available seleno and sulfonyl sources, and is amenable to gram-scale synthesis. This reaction represents a significant addition to the limited number of reactions available for the intermolecular selenide difunctionalization of alkenes and would be useful for the synthesis of sulfur-and selenium-containing molecules. | Kai Sun Yunhe Lv Zuodong Shi Fangfang Fu Chong Zhang Zhiguo Zhang | 2017 | Science China Chemistry2017，60，6： | 1 |
| 13 | Solid-state reaction preparation and photoluminescence properties of Na,2 Ba6 ( Si2 07 ) ( SiO4 ) 2 : Eu2 + phosphors显示文摘 | Shi Pinglu Xia Zhiguo | 2014 | Mater Res Bu112014，49，1： | 1 |
| 14 | A simple sam- ple preparation approach based on hydrophilic solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry for determination of endogenous cyto- kinins显示文摘 | Cai Baodong Zhu Jiuxia Shi Zhiguo | 2013 | Journal of Chromatography B2013，94，： | 1 |
| 15 | Adaptive Regularized Particle Filter for Synchronization of Chaotic Colpitts Circuits in an AWGN Channel 显示文摘 | Hong Shaohua Shi Zhiguo Wang Lin | 2013 | Circuits Systems and Signal Processing2013，32，2： | 1 |
| 16 | Magnetic retrieval of graphene: extraction of sulfonamide antibiotics from environmental water samples显示文摘 | LUO Yanbo SHI Zhiguo GAO Qiang | 2011 | J Chromatogr A2011，1218，10： | 1 |
| 17 | A Fixed-pointAlgorithm for Blind Source Separation with NonlinearAutocorrelation显示文摘 | SHI Zhenwei JIANG Zhiguo ZHOU Fugen | 2009 | Journal of Computatianal andApplied Mathematics2009，223，02： | 1 |
| 18 | Nanocatalytic bacteria disintegration reverses immunosuppression of colorectal cancer显示文摘Tumor-associated bacteria(TAB)play a critically important role in regulating the microenvironment of a tumor,which consequently greatly deteriorates the therapeutic effects by chemo-and radiotherapy deactivation and,more considerably,leads to substantial immunosuppression.On the contrary,herein we propose a nanocatalytic tumor-immunotherapeutic modality based on the bacteria disintegration by bacteria-specific oxidative damage under magnetic hyperthermia for highly effective immune response activation-promoted tumor regression.A monodispersed and superparamagnetic nanocatalytic medicine modified by arginyl-glycyl-aspartic acid(RGD)and(3-carboxypropyl)triphenylphosphonium bromide(TPP),named as MNP-RGD-TPP herein,has been synthesized,which features selective accumulation at the TAB by the electrostatic affinity,enabling effective TAB disintegration by the nanocatalytic Fenton reaction producing abundant cytotoxic hydroxyl radicals in situ under alternating magnetic field-induced hyperthermia.More importantly,the lipopolysaccharide has been metabolically secreted from the destructed TAB as pathogen-associated molecular patterns(PAMPs)to M1-polarize tumor-associated macrophages(TAMs)and promote the maturation of dendritic cells(DCs)for innate immuno-response activation of TAMs,followed by cytotoxic T lymphocytes awakening under the PAMPs presentation by the mature DCs against tumor cells.The integrated innate and adaptive immunity activations based on this TAB-promoted nanocatalytic immunomedicine,instead of magnetic heating-induced hyperthermia or the released Fe2+/Fe3+Fenton agent,has been found to achieve excellent therapeutic efficacy in an orthotopic colorectal cancer model,demonstrating the great potential of such an integrated immunity strategy in clinical tumor immunotherapy. | Han Jiang Yuedong Guo Zhiguo Yu Ping Hu Jianlin Shi | 2022 | National Science Review2022，9，11： | 1 |
| 19 | Preparation of porous carbon-silica composite monoliths显示文摘 | Shi ZhiGuo Feng YuQi Xu Li | 2003 | Carbon2003，41，13： | 1 |
| 20 | Lake-level records support a mid-Holocene maximum precipitation in northern China显示文摘Lake level and its inferred East Asian summer monsoon(EASM)evolution in northern boundary of EASM during the Holocene are highly debated.Here,we present a 15-ka record of glycerol dialkyl glycerol tetraethers(GDGTs)in a closed lake in northern China to address this issue.Surface and downcore sediment data demonstrate sedimentary GDGT-0 and branched GDGTs(brGDGTs)are of aquatic production.Contents of GDGT-0 and brGDGTs increase but brGDGT-based paleo-temperature proxy decreases with water depth in surface sediments along a nearshore to offshore transect.This trend is likely due to an increasingly hypoxic condition,favored by anaerobic microbes producing these GDGT-0 and brGDGTs,in bottom water.Accordingly,brGDGT-derived water temperature and pH would reflect bottom water conditions that are largely regulated by water depth of the lake.Downcore GDGT data and their derived temperature and pH consistently reveal a gradually increasing lake level from the late Pleistocene to the early Holocene,a high level during 9.5-5 ka BP and a decreasing trend afterward.The lake-level records from independent and robust proxies in this study largely agree with pollen records in the region,supporting a mid-Holocene maximum EASM precipitation. | Jiantao CAO Zhiguo RAO Fuxi SHI Ergang LIAN Guodong JIA | 2021 | Science China Earth Sciences2021，64，12： | 1 |
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