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194篇 您的检索式:作者名="Chunhui Liu"
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1Seafloor hydrothermal activity and polymetallic sulfide exploration on the southwest Indian ridge显示文摘Polymetallic sulfides have attracted more attentions,which are regarded as one of the potential seabed mineral resources for their high grade of precious metal elements such as Cu,Zn,Pb,Au,and Ag.Since2007,there are four China dayang cruises(CDCs)with eight legs totally,which have been carried out to investigate polymetallic sulfides on the southwest Indian ridge(SWIR),and eight hydrothermal vents have been found.In2011,the China Ocean Mineral Resources Research and Development Association(COMRA)and International Seabed Authority(ISA)signed a 15-year contract for exploration for polymetallic sulfides located on the SWIR between 46°S and 53°S.The area allocated to the COMRA is approximately 10,000 km2.In this paper,we review the recent research advances about hydrothermal activity of the SWIR by the CDCs.As for the sulfides exploration in the future,some aspects should be emphasized,such as the controlling factors of sulfide mineralization on the SWIR,prospecting methods of inactive and buried sulfide deposits,sulfides resources assessment method,and the nearbottom sulfides exploration technology systems.Chunhui Tao Huaiming Li Xiaobing Jin Jianping Zhou Tao Wu Yonghua He Xianming Deng Chunhua Gu Guoyin Zhang Weiyong Liu 2014Chinese Science Bulletin2014,59,19:25
2Substance P-modified human serum albumin nanoparticles loaded with paclitaxel for targeted therapy of glioma显示文摘The blood–brain barrier(BBB) and the poor ability of many drugs to cross that barrier greatly limits the efficacy of chemotherapies for glioblastoma multiforme(GBM). The present study exploits albumin as drug delivery vehicle to promote the chemotherapeutic efficacy of paclitaxel(PTX) by improving the stability and targeting efficiency of PTX/albumin nanoparticles(NPs). Here we characterize PTX-loaded human serum albumin(HSA) NPs stabilized with intramolecular disulfide bonds and modified with substance P(SP) peptide as the targeting ligand. The fabricated SP-HSA-PTX NPs exhibited satisfactory drug-loading content(7.89%) and entrapment efficiency(85.7%) with a spherical structure(about 150 nm) and zeta potential of -12.0 mV. The in vitro drug release from SP-HSA-PTX NPs occurred in a redox-responsive manner. Due to the targeting effect of the SP peptide, cellular uptake of SP-HSA-PTX NPs into brain capillary endothelial cells(BCECs) and U87 cells was greatly improved.The low IC_(50), prolonged survival period and the obvious pro-apoptotic effect shown by TUNEL analysis all demonstrated that the fabricated SP-HSA-PTX NPs showed a satisfactory anti-tumor effect and could serve as a novel strategy for GBM treatment.Chunhui Ruan Lisha Liu Yifei Lu Yu Zhang Xi He Xinli Chen Yujie Zhang Qinjun Chen Qin Guo Tao Sun Chen Jiang 2018Acta Pharmaceutica Sinica B2018,8,1:19
3A comprehensive review of integrative pharmacology-based investigation:A paradigm shift in traditional Chinese medicine显示文摘Over the past decade,traditional Chinese medicine(TCM) has widely embraced systems biology and its various data integration approaches to promote its modernization.Thus,integrative pharmacology-based traditional Chinese medicine(TCMIP) was proposed as a paradigm shift in TCM.This review focuses on the presentation of this novel concept and the main research contents,methodologies and applications of TCMIP.First,TCMIP is an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics-pharmacodynamics(PK-PD) correlations through the integration of knowledge from multiple disciplines and techniques and from different PK-PD processes in vivo.Then,the main research contents of TCMIP are introduced as follows:chemical and ADME/PK profiles of TCM formulas;confirming the three forms of active substances and the three action modes;establishing the qualitative PK-PD correlation;and building the quantitative PK-PD correlations,etc.After that,we summarize the existing data resources,computational models and experimental methods of TCMIP and highlight the urgent establishment of mathematical modeling and experimental methods.Finally,we further discuss the applications of TCMIP for the improvement of TCM quality control,clarification of the molecular mechanisms underlying the actions of TCMs and discovery of potential new drugs,especially TCM-related combination drug disco very.Haiyu Xu Yanqiong Zhang Ping Wang Junhong Zhang Hong Chen Luoqi Zhang Xia Du Chunhui Zhao Dan Wu Feng Liu Hongjun Yang Changxiao Liu 2021Acta Pharmaceutica Sinica B2021,11,6:18
4Progress of the key materials for organic solar cells显示文摘Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight,flexibility and roll-to-roll fabrication.Nowadays,18%power conversion efficiency has been achieved in the state-of-the-art organic solar cells.The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies,and the deep understanding on film morphology,molecular packing and device physics.Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance.The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors.In this review,we focus on those star materials and milestone work,and introduce the molecular structure evolution of key materials.These key materials include homopolymer donors,D-A copolymer donors,A-D-A small molecular donors,fullerene acceptors and nonfullerene acceptors.At last,we outlook the challenges and very important directions in key materials development.Yang Tong Zuo Xiao Xiaoyan Du Chuantian Zuo Yuelong Li Menglan Lv Yongbo Yuan Chenyi Yi Feng Hao Yong Hua Ting Lei Qianqian Lin Kuan Sun Dewei Zhao Chunhui Duan Xiangfeng Shao Wei Li Hin-Lap Yip Zhengguo Xiaol Bin Zhang Qingzhen Bian Yuanhang Cheng Shengjian Liu Ming Cheng Zhiwen Jin Shangfeng Yang Liming Ding 2020Science China Chemistry2020,63,6:15
5MCP-1-induced ERK/GSK-3β/Snail signaling facilitates the epithelial-mesenchymal transition and promotes the migration of MCF-7 human breast carcinoma cells显示文摘Monocyte chemoattractant protein-1(MCP-1)is a chemotactic cytokine that can bind to its receptor cysteine-cysteine chemokine receptor 2(CCR2)and plays an important role in breast cancer cell metastasis.However,the molecular mechanisms underlying MCP-1-induced alterations in cellular functions during tumor progression are poorly understood.Here,we showed that MCP-1 stimulated the epithelial-mesenchymal transition(EMT)and induced the tumorigenesis of breast cancer cells by downregulating E-cadherin,upregulating vimentin and fibronectin,activating matrix metallopeptidase-2(MMP-2),and promoting migration and invasion.Moreover,MCP-1 treatment reduced glycogen synthase kinase-3β(GSK-3β)activity via the MEK/ERK-mediated phosphorylation of serine-9 in MCF-7 cells.The inhibition of MEK/ERK by U0126 attenuated the MCP-1-induced phosphorylation of GSK-3βand decreased the expression of Snail,an EMT-related transcription factor,leading to the inhibition of MCF-7 cell migration and invasion.Inactivation of GSK-3βby LiCl(lithium chloride)treatment notably increased MMP-2 activity,vascular endothelial growth factor expression and EMT of MCF-7 cells.These findings revealed that MCP-1-induced EMT and migration are mediated by the ERK/GSK-3β/Snail pathway,and identified a potential novel target for therapeutic intervention in breast cancer.Shun Li Juan Lu Yu Chen Niya Xiong Li Li Jing Zhang Hong Yang Chunhui Wu Hongjuan Zeng Yiyao Liu 2017Cellular & Molecular Immunology2017,14,7:14
6The Genesis Mechanism of the Mantle Fluid Action and Evolution in the Ore-Forming Process: A Case Study of the Laowangzhai Gold Deposit in Yunnan, China显示文摘Based on petrological studies of the wall rocks, mineralizing rocks, ores and veins from the Laowangzhai gold deposit, it is discovered that along with the development of silication, carbonation and sulfidation, a kind of black opaque ultra-microlite material runs through the spaces between grains, fissures and cleavages. Under observations of the electron microprobe, scanning electronic microscopy and energy spectrum, this kind of ultra-microlite material is confirmed to consist of ultra microcrystalline quartz, silicate, sulfides and carbonates, as well as rutile, scheelite and specularite (magnetite), showing characters of liquation by the analyses of SEM and energy spectrum. The coexistence of immiscibility and precipitating co-crystallization strongly suggests that the mineralizing fluid changed from the melt to the hydrothermal fluid. Combined with the element geochemical researches, it is realized that the ultra-microlite aggregate is the direct relics of the mantle fluid behaving like a melt and supercritical fluid, which goes along with the mantle-derived magma and will escape from the magma body at a proper time. During the alteration process, the nature of the mantle fluid changed and it is mixed with the crustal fluid, which are favorable for mineralization in the Loawangzhai gold deposit.LIU Xianfan LI Chunhui LU Qiuxia DENG Biping SONG Xiangfeng ZHAO Fufeng CHU Yating XIAO Jixiong YI Liwen HUANG Yupeng 2012Acta Geologica Sinica(English Edition)2012,86,3:13
7γ-secretase inhibitor DAPT prevents neuronal death and memory impairment in sepsis associated encephalopathy in septic rats显示文摘Huang Man Liu chunhui Hu Yueyu Wang Pengfei Ding Meiping 2014Chinese Medical Journal2014,,5:12
8A comparative study on source apportionment of polycyclic aromatic hydrocarbons in sediments of the Daliao River,China:Positive matrix factorization and factor analysis with non-negative constraints显示文摘Two receptor models,positive matrix factorization (PMF) and factor analysis with non-negative constraints (FA-NNC),were applied for source apportionment of polycyclic aromatic hydrocarbons (PAHs) in sediments of the Daliao River,China.The source profiles and source contributions derived from the two receptor models were comparable.For PMF,PAHs mainly came from coal combustion (43.3%),followed by biomass burning (24.3%),traffic emissions (16.7%) and coke oven (15.7%).As for FA-NNC,coal combustion (50.4%) was dominant,followed by biomass burning (21.9%),traffic emission (15.7%) and coke oven (12.0%).The source apportionment results are consistent with the results from the specific PAH diagnostic ratios and emission inventory analysis.In addition,the source apportionment results are consistent with the structure of energy material usage in Liaoning Province of China.LIU ChunHui TIAN FuLin CHEN JingWen LI XueHua QIAO XianLiang 2010Chinese Science Bulletin2010,55,10:10
9Mild moxibustion at Tianshu (ST 25) decreases expression of prokineticin-1 and prokineticin receptor-1 in colon tissue of rats with chronic visceral hyperalgesia显示文摘Prokineticin-1 and prokineticin receptor-1 play important roles in visceral hypersensitivity and in-flammatory pain. Visceral hypersensitivity is closely associated with irritable bowel syndrome. Mild moxibustion can relieve chronic visceral hyperalgesia in rats with irritable bowel syndrome. We hypothesized that prokineticin-1 and prokineticin receptor-1 is the key target in the mechanism. This study established chronic visceral hyperalgesia rat models by colorectal distention. Protein and mRNA expression of prokineticin-1 and prokineticin receptor-1 were determined by immunohisto-chemical method and fluorescence quantitative-PCR, respectively, and were found to be signifi-cantly increased in visceral hyperalgesic rats. Mild moxibustion at Tianshu (ST 25) decreased prokineticin-1 and prokineticin receptor-1 expression in chronic visceral hyperalgesia rats and lessen the chronic visceral hyperalgesia in rats with irritable bowel syndrome at different levels of colorectal distention pressure.Luyi Wu Chunhui Bao Linbao Ge Cili Zhou Huirong Liu Li Qi Tao Yi Huangan Wu Xiaomei Wang 2011Neural Regeneration Research2011,6,33:9
10Advances in luminescent lanthanide complexes and applications显示文摘Luminescent lanthanide complexes have been widely investigated as light emitting materials in bio-imaging and sensing, solid state lighting and display, anti-fake tags and light conversion films, due to their characterized photophysical properties including large Stokes shift, long lifetime, and sharp emission spectrum, arising from the sensitized f-f transitions. In this review, we summarize the most recent advances in luminescent lanthanide complexes and their applications from 2015 to August 2017 concerning of general concepts to potential applications. We first introduce the basic concept of sensitized luminescence of lanthanide complexes and the strategies used for highly luminescent complexes. Then recent varieties of luminescent lanthanide complexes and their hybrid materials are presented. Finally, applications are discussed in detail.WEI Chen MA Li WEI HuiBo LIU ZhiWei BIAN ZuQiang HUANG ChunHui 2018Science China(Technological Sciences)2018,61,9:8
11Adaptive optimization of agile organization of command and control resource显示文摘Adaptive optimization is one of the means that agile organization of command and control resource (AOC2R)adapts for the dynamic battlefield environment.A math model of the adaptive optimization of AOC2R is put forward by analyzing the interrelating concept and research.The model takes the adaptive process as a multi-stage decision making problem.The 2-phases method is presented to calculate the model,which obtains the related parameters by running the colored Petri net(CPN)model of AOC2R and then searches for the result by ant colony optimization(ACO)algorithm integrated with genetic optimization techniques.The simulation results demonstrate that the proposed algorithm greatly improves the performance of AOC2R.Yang Chunhui Liu Junxian Chen Honghui Luo Xueshan 2009Journal of Systems Engineering and Electronics2009,20,3:8
12Increasing open circuit voltage by adjusting work function of hole-transporting materials in perovskite solar cells显示文摘一系列传导性的聚合物,即, poly (3-methylthiophene )(PMT ) , poly (thiophene )( 磅) , poly (3-bromothiophene )(PBT ) 并且 poly (3-chlorothiophene )(%) ,经由电气化学的聚合过程被准备。随后,他们是的申请在 CH 3 NH 3 PbI 3 perovskite 太阳能电池被探索。讲道理地增加 HTM 的工作功能在改进开的电路电压证明有益,这被发现(V 有 ITO/conductive-polymer/CH 3)> NH 3 PbI 3/C60/BCP/Ag 结构。另外, higher-V 有 higher-work-function HTM 的 oc 设备展出了更高的再结合电阻。1.04 V 的最高开的电路电压与 % 从设备被获得,与工作功能 of-5.4 eV,作为搬运洞的层。它的功率变换效率达到了约16.5%的价值,与高度充满 0.764 的因素, 1.01 V 的可估计的开的电压和 21.4 mAmedian 的短路电流密度为 Zn 的大约 5 ility 的轨道的集体估计, Cu , Se , Mn ,我, Fe ,瞬间和 Br 。mea 覈 ? 覈??Weibo Yan Yu Li Senyun Ye Yunlong Li Haixia Rao Zhiwei Liu Shufeng Wang Zuqiang Bian Chunhui Huang 2016Nano Research2016,9,6:7
13Spatial-temporal Evolution and Determinants of the Belt and Road Initiative: A Maximum Entropy Gravity Model Approach显示文摘The spatial interaction model is an effective way to explore the geographical disparities inherent in the Belt and Road Initiative(BRI) by simulating spatial flows. The traditional gravity model implies the hypothesis of equilibrium points without any reference to when or how to achieve it. In this paper, a dynamic gravity model was established based on the Maximum Entropy(MaxEnt) theory to estimate and monitor the interconnection intensity and dynamic characters of bilateral relations. In order to detect the determinants of interconnection intensity, a Geodetector method was applied to identify and evaluate the determinants of spatial networks in five dimensions. The empirical study clearly demonstrates a heterogeneous and non-circular spatial structure. The main driving forces of spatial-temporal evolution are foreign direct investment, tourism and railway infrastructure construction, while determinants in different sub-regions show obvious spatial differentiation. Southeast Asian countries are typically multi-island area where aviation infrastructure plays a more important role. North and Central Asian countries regard oil as a pillar industry where power and port facilities have a greater impact on the interconnection. While Western Asian countries are mostly influenced by the railway infrastructure, Eastern European countries already have relatively robust infrastructure where tariff policies provide a greater impetus.HUANG Qinshi ZHU Xigang LIU Chunhui WU Wei LIU Fengbao ZHANG Xinyi 2020Chinese Geographical Science2020,30,5:7
14Influence of lactic acid bacteria on physicochemical indexes,sensory and flavor characteristics of fermented sea buckthorn juice显示文摘Sea buckthorn has been proved to be a good substrate for lactic acid bacteria(LAB),but the research on the fermentation of sea buckthorn juice(SBJ)by LAB is still rare.This study was designed to determine the performance of fermented SBJ(FSBJ)in four LAB and investigate the sensory aspects of FSBJ.The results showed that the utilization rates of reducing sugar,titratable acid,and malic acid of SBJ fermented by Lactobacillus casei(SBJLc)were the highest and that lactic acid content was the greatest.The organic acid compositions of the four kinds of FSBJs were also different.The viable counts of all FSBJs was greater than 7 log CFU/mL,and that the viable count of SBJ fermented by SBJLc was the highest.In this study,the Electronic tongue combined with Electronic nose was used for the first time to study SBJ.Results showed that compared with the control,the response value of Sourness was significantly increased,while Bitterness and Astringency were significantly decreased.There was a significant difference in four FSBJs.The results of the electronic nose showed that SBJ fermented by Lactobacillus plantarum LP56(SBJLp)could be well identified by sensors sensitive to aromatic substances.The volatile compound contents before and after fermentation were significantly different,the highest being SBJLp.Finally,the results of sensory evaluation experiments showed that SBJLp was the most acceptable to consumers in terms of sensory evaluation.Yuanye Liu Jie Sheng Jingjing Li Panling Zhang Fengxian Tang Chunhui Shan 2022Food Bioscience2022,46,2:6
15Characteristics and factors that influenced damage to dams in the M_s 8.0 Wenchuan earthquake显示文摘Based on raw data from dams damaged in the Wenchuan earthquake, including many that were severely damaged, characteristics and factors that influenced the damage are discussed in this paper. Findings from this study include: severely damaged dams were densely distributed along the seismologic fault; small dams, especially small earth-rock dams, had the most serious damage that was caused by a variety of factors; the most serious damage was caused by seismic waves; damage was aggregated by aftershocks; and the extent of the damage patterns increased with the seismic intensity. Damage patterns varied in different intensity zones and cracking was the most common type of damage. Most of the dams had a good base with relatively high bearing capacity, and the walls of the earth-rock dams were mostly of clay soil. This type of base and body material mitigated some of the damage to dams. Reservoir maintenance and other factors also have a significant impact on the seismic safety of the dam. Finally, some recommendations to reduce seismic damage to dams are proposed.Jing Liping Liang Haian Li Yongqiang Liu Chunhui 2011Earthquake Engineering and Engineering Vibration2011,10,3:6
16Stable high-performance hybrid perovskite solar cells with ultrathin polythiophene as hole-transporting layer显示文摘经由电气化学的聚合准备的 Ultrathin polythiophene 电影成功地被用作搬运洞的材料,代替常规 HTM-PEDOT : PSS,在平面 p-i-n CH 3 NH 3 PbI 3基于 perovskite 的太阳能电池,负担得起一系列 ITO/polythiophene/CH 3 NH 3 PbI 3/C60/BCP/Ag 设备。ultrathin polythiophene 电影拥有好发射度,高传导性,光滑的表面,高 wettability,与 PbI 2 DMF 答案的相容性,和匹配 CH 3 NH 3 PbI 3 perovskite 材料。大约 15.4% 的 A 答应功率变换效率,展示高度充满 0.774 的因素, 0.99 V 的开的电压,和电线走火 20.3 mAve 的当前的密度可逆纠纷。在我们的分析使用的一个不可缺少的工具是 Gnerating 潜力的一张有条件的表格。分析??Weibo Yan Yunlong Li Yu Li Senyun Ye Zhiwei Liu Shufeng Wang Zuqiang Bian Chunhui Huang 2015Nano Research2015,8,8:6
17A Tuberculosis Outbreak at a School-Xinjiang Uygur Autonomous Region, China, 2019显示文摘Summary What is already known about this topic?Worldwide,tuberculosis(TB)continues to be the most important cause of death from a single infectious agent,and China has a high TB burden.Although the reported incidence of TB in students is lower than that in general population,TB outbreaks in schools have continuously been reported in the past years,suggesting that schools are a high-risk setting for TB transmission.Senlu Wang Yan Cui Nianqiang Liu Xijiang Wang Xinqi Wang Weidong Wu Canyou Zhang Maiwulan Parehati Zhi Li Chunhui Yu Lijie Zhang Jun Cheng 2020China CDC weekly2020,2,46:5
18Alkali metal salts doped pluronic block polymers as electron injection/transport layers for high performance polymer light-emitting diodes显示文摘A series of alkali metal salts doped pluronic block copolymer F127 were used as electron injection/transport layers (ETLs) for polymer light-emitting diodes with poly[2-(4-(3′,7′-dimethyloctyloxy)-phenyl)-p-phenylenevinylene] (P-PPV) as the emission layer. It was found that the electron transport capability of F127 can be effectively enhanced by doping with alkali metal salts. By using Li2CO3 (15%) doped F127 as ETL, the resulting device exhibited improved performance with a maximum luminous efficiency (LE) of 13.59 cd/A and a maximum brightness of 5529 cd/m2, while the device with undoped F127 as ETL only showed a maximum LE of 8.78 cd/A and a maximum brightness of 2952 cd/m2. The effects of the doping concentration, cations and anions of the alkali metal salts on the performance of the resulting devices were investigated. It was found that most of the alkali metal salt dopants can dramatically enhance the electron transport capability of F127 ETL and the performance of the resulting devices was greatly improved.ZHANG Kai LIU ShengJian GUAN Xing DUAN ChunHui ZHANG Jie ZHONG ChengMei WANG Lei HUANG Fei CAO Yong 2012Science China Chemistry2012,55,5:5
19Time correction of the ocean bottom seismometers deployed at the southwest Indian ridge using ambient noise cross-correlation显示文摘Seismic monitoring using ocean bottom seismometers(OBS) is an efficient method for investigating earthquakes in mid-ocean ridge far away from land. Clock synchronization among the OBSs is difficult without direct communication because electromagnetic signals cannot propagate efficiently in water. Time correction can be estimated through global positioning system(GPS) synchronization if clock drift is linear before and after the deployment. However, some OBSs in the experiments at the southwest Indian ridge(SWIR) on the Chinese DY125-34 cruise had not been re-synchronized from GPS after recovery. So we attempted to estimate clock drift between each station pairs using time symmetry analysis(TSA) based on ambient noise cross-correlation. We tested the feasibility of the TSA method by analyzing daily noise cross-correlation functions(NCFs) that extract from the data of another OBS experiment on the Chinese DY125-40 cruise with known clock drift and the same deployment site. The results suggest that the NCFs' travel time of surface wave between any two stations are symmetrical and have an opposite growing direction with the date. The influence of different band-pass filters,different components and different normalized methods was discussed. The TSA method appeared to be optimal for the hydrophone data within the period band of 2–5 s in dozens of km-scale interstation distances. A significant clock drift of ~2 s was estimated between OBSs sets through linear regression during a 108-d deployment on the Chinese cruise DY125-34. Time correction of the OBS by the ambient noise cross-correlation was demonstrated as a practical approach with the appropriate parameters in case of no GPS re-synchronization.LIU Yunlong LIU Cai TAO Chunhui YAO Huajian QIU Lei WANG Ao RUAN Aiguo WANG Hanchuang ZHOU Jianping LI Huaiming DONG Chuanwan 2018Acta Oceanologica Sinica2018,37,5:5
20Two-dimensional like conjugated copolymers for high efficiency bulk-heterojunction solar cell application:Band gap and energy level engineering显示文摘Three two-dimensional like conjugated copolymers PFSDCN,PFSDTA and PFSDCNIO,which consist of alternating fluorene and triphenylamine main chain,and different pendant acceptor groups (malononitrile,1,3-diethtyl-2-thiobarbituric acid and 2-(1,2-dihydro-1-oxoinden-3-ylidene)malononitrile) with thiophene as π-bridge,have been designed,synthesized and characterized.The structure-property relationships of the two-dimensional like conjugated copolymers were systematically investigated.The absorption spectra,band gaps,and energy levels of the polymers were effectively tuned by simply attaching different acceptor groups.As the electron-withdrawing ability of the acceptors increased,the band gaps of the polymers were narrowed from 2.05 to 1.61 eV;meanwhile,the LUMO energy levels of the polymers decreased from -3.27 to -3.75 eV,whereas their relatively deep HOMO energy levels of ~-5.35 eV were preserved.BHJ solar cells were fabricated and characterized by using the three polymers as donor materials and the highest power conversion efficiency of 2.87% was achieved for the device based on PFSDTA:(6,6)-phenyl-C71-butyric acid methyl ester blend.DUAN ChunHui WANG ChuanDao LIU ShengJian HUANG Fei CHOY C.H.Wallace CAO Yong 2011Science China Chemistry2011,54,4:5
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