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| 1 | Chromosomal localization of the major ribosomal RNA genes in scallop Chlamys farreri显示文摘The chromosomes of Chlamys farreri were analyzed by means of silver staining and fluorescence in situ hybridization (FISH) with 18S—28S rDNA probe. Probe was made by PCR amplification of a DNA fragment containing internal transcribed spacers ITS1 between 18S and 5.8S ribosomal RNA gene, ITS2 between 5.8S and 28S ribosomal RNA gene and 5.8S rRNA gene, and labeled by PCR incorporation of bio-16-dUTP. FISH signals were located on the short arm of subtelocentric chromosome 10. After silver-staining, nucleolus organizer regions (NORs) could be observed on the telomere of the short arm of chromosome 10. However, one metaphase spread displayed an additional silver spot on the short arm of subtelocentric chromosome 12. | HUANG Xiaoting BAO Zhenmin BI Ke HU Jingjie ZHANG Can ZHANG Quanqi HU Xiaoli | 2006 | Acta Oceanologica Sinica2006，25，3： | 10 |
| 2 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 3 | Linking microbial carbon pump capacity and efficacy to soil organic carbon storage and stability under heavy metal pollution显示文摘Heavy metal pollution can lead to a great loss of soil organic carbon(SOC).However,the microbial mechanisms that link heavy metal pollution to SOC remain poorly understood.Here,we investigated five apple-orchard soils at different distances from a Pb-Zn smelter.After assessing the heavy metal pollution level based on Grade Ⅱ of the national soil environmental quality standard(China),we found SOC stocks and microbial carbon pump(MCP)capacity(i.e.,microbial residue carbon)under medium and heavy pollution levels were significantly lower than those under safe,cordon and light pollution levels.The structural equation model showed causality in the SOC variations linked to pollution level through MCP capacity,which could contribute 77.8% of the variance in SOC storage.This verified MCP capacity can serve as a key parameter for evaluation of SOC storage under heavy metal pollution.Soil MCP efficacy,i.e.,the proportion of microbial residue carbon to SOC,also decreased under medium and heavy pollution.This suggested that,with a heavier pollution level,there was a higher rate of reduction of microbial residue carbon in soil than the rate of reduction of SOC.As MCP efficacy can be a useful assessment of SOC stability,the significantly positive relationship between MCP efficacy and clay content in correlation analysis implied that lower MCP efficacy was correlated with SOC stability under the heavier pollution level.Our study provides valuable insights to identify the mechanisms of microbially mediated C transformation processes that are influenced by heavy metal pollution in agroecosystems. | Xiao Liu Xia Xu Tian Ma Shiwei Zhou Xiaoli Bi Hongbo He Xudong Zhang Weihuan Li | 2023 | Soil Ecology Letters2023，5，2： | 1 |
| 4 | Assembly of plant communities in coastal wetlands--the role of saltcedar Tamarix chinensis during early succession显示文摘Aims The mechanisms of plant community assembly are hypothesized to vary at different stages of succession.Here,we explore the local assemblage structure of a herbaceous plant community at its early stage of succession in a supratidal wetland.specifically,we assess the role of Chinese saltcedar(Tamarix chinensis),the lone dominant shrub species,in shaping the spatial structure and species composi-tion in the local plant community,after landscape alteration.Methods We used the multivariate trend-surface analysis for analyzing the spatial structure of the community composition.a null model was also used to detect potential biotic interactions between species.statistical significance was derived from a permutation test by randomizing the presence-absence matrix and functional traits independently.sensitivity analysis by randomly selecting 50 subplots and repeating the null model tests was also done.Finally,rank correlation analysis was used to study the relationship between effect sizes and distance to nearest T.chinensis individuals.Important Findings The herbaceous plant community was highly structured and shaped by the presence of T.chinensis.at local scale,two functional traits,plant height and leaf area,were found to be significantly convergent.Dispersal,environmental stress and interspecific competition played a trivial effect on the local community assembly.The facilitating effect of T.chinensis on the pioneering herbaceous plants,through acting as a wind shelter,was put forward as the dominant community assembly process. | Meng Gao Xinxiu Wang Cang Hui Huapeng Yi Chuanqi Zhang Xiaoqing Wu Xiaoli Bi Yong Wang Luxiang Xiao De Wang | 2015 | Journal of Plant Ecology2015，8，5： | 1 |
| 5 | Coastal use accelerated the regional sea-level rise 显示文摘 | BI Xiaoli LU Qingshui PAN Xubin | 2013 | Ocean & Coastal Management2013，82，3： | 1 |
| 6 | An amperometric penicillin biosensor with enhanced sensitivity based on co-immobilization of carbon nanotubes,hematein,and β-lactamase on glassy carbon electrode显示文摘 | CHEN Bi MA Ming SU Xiaoli | 2010 | Analytica Chimica Acta2010，674，1： | 1 |
| 7 | Effects of experimental nitrogen and/or phosphorus additions on soil nematode communities in a secondary tropical forest显示文摘 | Jie Zhao Faming Wang Jian Li Bi Zou Xiaoli Wang Zhian Li Shenglei Fu | 2014 | Soil Biology and Biochemistry2014，，： | 1 |
| 8 | PPAR-γactivation promotes xenogenic bioroot regeneration by attenuating the xenograft induced-oxidative stress显示文摘Xenogenic organ transplantation has been considered the most promising strategy in providing possible substitutes with the physiological function of the failing organs as well as solving the problem of insufficient donor sources.However,the xenograft,suffered from immune rejection and ischemia-reperfusion injury(IRI),causes massive reactive oxygen species(ROS)expression and the subsequent cell apoptosis,leading to the xenograft failure.Our previous study found a positive role of PPAR-γ in antiinflammation through its immunomodulation effects,which inspires us to apply PPAR-γ agonist rosiglitazone(RSG)to address survival issue of xenograft with the potential to eliminate the excessive ROS.In this study,xenogenic bioroot was constructed by wrapping the dental follicle cells(DFC)with porcine extracellular matrix(p ECM).The hydrogen peroxide(H_(2)O_(2))-induced DFC was pretreated with RSG to observe its protection on the damaged biological function.Immunoflourescence staining and transmission electron microscope were used to detect the intracellular ROS level.SD rat orthotopic transplantation model and superoxide dismutase 1(SOD1)knockout mice subcutaneous transplantation model were applied to explore the regenerative outcome of the xenograft.It showed that RSG pretreatment significantly reduced the adverse effects of H2O2on DFC with decreased intracellular ROS expression and alleviated mitochondrial damage.In vivo results confirmed RSG administration substantially enhanced the host’s antioxidant capacity with reduced osteoclasts formation and increased periodontal ligament-like tissue regeneration efficiency,maximumly maintaining the xenograft function.We considered that RSG preconditioning could preserve the biological properties of the transplanted stem cells under oxidative stress(OS)microenvironment and promote organ regeneration by attenuating the inflammatory reaction and OS injury. | Tingting Lan Fei Bi Yuchan Xu Xiaoli Yin Jie Chen Xue Han Weihua Guo | 2023 | International Journal of Oral Science2023，15，1： | 1 |
| 9 | Distribution of mercury species in water and sediments in Caohai Lake, Guizhou Province显示文摘 | Xiaoli QIAN Xinbin FENG Xiangyang BI | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 10 | Direct infection of SARS-CoV-2 in human iPSC-derived 3D cardiac organoids recapitulates COVID-19 myocarditis显示文摘Dear editor,The pandemic of coronavirus disease-19(COVID-19)has lasted for more than three years,causing lots of extra death and posing a serious threat to public health.This pandemic swept the last global safety island in a matter of months,coinciding with the switch of zero-COVID policy of China.The causative agent,SARS-CoV-2,spreads globally and then lurks in the population with sporadic outbreaks in local areas.Meanwhile,the sequelae of convalescent COVID-19 patients receded slowly.The pantissue tropism of SARS-CoV-2 results in a wide range of symptoms in patients,including cardiovascular disorders.Cardiac complications occur in 20%–44%of hospitalized patients,which is an independent risk factor for COVID-19 mortality(Ma et al.,2022;Patone et al.,2022).Survivors of acute COVID-19 also have a substantial risk of cardiovascular disease burden lasting up to one year(Xie et al.,2022). | Weijie Wang Jinxuan Yang Pinfang Kang Jinsong Bai Xiaoli Feng Liuqi Huang Yiming Zhang Yuechun Wu Bi Tang Hongju Wang JianJie Jiang Minghua Li Bing Zhao Xinglou Yang | 2023 | Virologica Sinica2023，38，6： | 0 |
| 11 | Analysis of Channeling-Path Phenomena in a Complex Fault-Block Reservoir with Low Recovery Factor and High Water-Cut Ratio显示文摘Current methods for the analysis of channeling-path phenomena in reservoirs cannot account for the influence of time and space on the actual seepage behavior.In the present study,this problem is addressed considering actual production data and dynamic characteristic parameters quantitatively determined in the near wellbore area by fitting the water-cut curve of the well.Starting from the dynamic relationship between injection and production data,the average permeability is determined and used to obtain a real-time quantitative characterization of the seepage behavior of the channeling-path in the far wellbore area.For the considered case study(Jidong oilfield),it is found that the seepage capacity of the channeling-path in the far wellbore area is far less(10 times smaller)than that of the channeling-path in the near wellbore area.The present study and the proposed model(combining near wellbore area and far wellbore area real-time data)have been implemented to support the definition of relevant adjustment measures to ultimately improve oil recovery. | Qunyi Wang Xiaoli Ma Yongbin Bi Haiyan He Xiao Gu Tongjing Liu Lekun Zhao | 2023 | Fluid Dynamics & Materials Processing2023，19，2： | 0 |
| 12 | Sub-nanometer Pt_(2)In_(3) intermetallics as ultra-stable catalyst for propane dehydrogenation显示文摘Pt-based catalysts are the typical industrial catalysts for propane dehydrogenation(PDH),which still suffer from insufficient lo ng-term durability due to the structu ral instability and coke deposition.A commercial γ-Al_(2)O_(3) supported thermally robust sub-nanometer Pt2In3intermetallic catalyst with atomically ordered structure and rigorously separated Pt single atoms was fabricated,which showed outstanding robustness in 240 h long-term operation at 600℃ with the deactivation rate constant kdas low as0.00078 h^(-1), ranking among the lowest reported values.Based on various in situ characterizations and theoretical calculations,it was proved that the catalyst stability not only resulted from the separated Pt single-atom sites but also significantly affected by the distance of adjacent Pt atoms.An increasing distance to 3.25 A in the Pt_(2)In_(3)could induce a weak π-adsorption configuration of propylene on Pt sites,which facilitated the desorption of propylene and restrained the side reactions like coking. | Yanan Xing Guiyue Bi Xiaoli Pan Qike Jiang Yuanlong Tan Yang Su Leilei Kang Bonan Li Lin Li Aiqin Wang Jingyuan Ma Xiaofeng Yang Xiao Yan Liu Tao Zhang | 2023 | Journal of Energy Chemistry2023，，8： | 0 |
| 13 | Predicting the effect of dissolved humic acid on sorption of benzotriazole to biochar显示文摘Dissolved organic matter plays a critical role in affecting sorption properties of biochar for organic contaminants.In this study,dissolved humic acid(DHA)as a representative of dissolved organic matter and oak sawdust-derived biochar as a sorbent were prepared and characterized.Roles of DHA in sorption of benzotriazole(BTA),an emerging organic contaminant,to biochar in different electrolyte solutions were investigated.The results revealed the dual roles of DHA in BTA sorption to biochar.On the one hand,DHA can compete for sites and/or block pores available for BTA to inhibit the adsorption of BTA to biochar.On the other hand,the sorbed DHA on biochar can serve as additional partitioning phase to promote the partition of BTA.The finding was in accordance with the site energy distribution analysis of BTA sorption that the site energy of the highest occurring frequency in the DHA-BTA system was lower than that in the DHA-free system(3.41-10.4 versus 13.1-20.1 kJ mol^(−1)).The variation in apparent BTA sorption to biochar affected by DHA was thus a combination of changes in both its partition and adsorption properties.A modified Dual-mode model including the aqueous concentration of DHA was proposed to predict the effect of DHA on BTA sorption to biochar in different electrolyte solutions,which showed good prediction performance with most BTA sorption coefficient(K_(d),L g^(−1))deviations within 0.1 log unit. | Lin Wu Xiaoli Zhao Erping Bi | 2022 | Biochar2022，4，1： | 0 |
| 14 | Metal records in lake/reservoir sediments adjacent to different pollution sources from Guizhou, southwestern China显示文摘 | Xiangyang BI Xinbin FENG Yuangen YANG Guangle QIU Xiaoli QIAN Weiyang BAI Zhongqing WEI Taoze LIU | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 15 | Phylogenetic analysis of Pectinidae (Bivalvia) based on the ribosomal DNA internal transcribed spacer region显示文摘The ribosomal DNA internal transcribed spacer (ITS) region is a useful genomic region for understanding evolutionary and genetic relationships. In the current study, the molecular phylogenetic analysis of Pectinidae (Mollusca: Bivalvia) was performed using the nucleotide sequences of the nuclear ITS region in nine species of this family. The sequences were obtained from the scallop species Argopecten irradians, Mizuhopecten yessoensis, Amusium pleuronectes and Mimachlamys nobilis, and compared with the published sequences of Aequipecten opercularis, Chlamys farreri, C. distorta, M. varia, Pecten maximus, and an outgroup species Perna viridis. The molecular phylogenetic tree was constructed by the neighbor-joining and maximum parsimony methods. Phylogenetic analysis based on ITS1, ITS2, or their combination always yielded trees of similar topology. The results support the morphological classifications of bivalve and are nearly consistent with classification of two subfamilies (Chlamydinae and Pectininae) formulated by Waller. However, A. irradians, together with A. opercularis made up of genera Amusium, evidences that they may belong to the subfamily Pectinidae. The data are incompatible with the conclusion of Waller who placed them in Chlamydinae by morphological characteristics. These results provide new insights into the evolutionary relationships among scallop species and contribute to the improvement of existing classification systems. | HUANG Xiaoting BI Ke HU Jingjie HU Xiaoli BAO Zhenmin | 2007 | Acta Oceanologica Sinica2007，26，6： | 0 |
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