|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Analysis of the CDR3 Length Repertoire and the Diversity of TCRα Chain in Human Peripheral Blood T Lymphocytes显示文摘Analysis of complementarity determining region 3 (CDR3) length of T lymphocyte receptors (TCRs) by immunoscope spectratyping technique has been used successfully to investigate the diversity of TCR in autoimmune diseases and infection diseases. In this study, we investigated the patterns of CDR3 length distribution for all 32 TCR AV gene families in human peripheral blood lymphocytes of four normal volunteers by the immunoscope spectratyping technique. It was found that PCR products exhibited an obscure band on 1.5% agarose gel electrophoresis. Each TCR AV family exhibited more than 8 bands on 6% sequencing gel electrophoresis. The CDR3 spectratyping of all TCR AV families showed a standard Gaussian distribution with different CDR3 length, and the expression frequency of CDR3 was similar among the gene families. Most of CDR3 in TCR AV family recombine in frame. However, some of the CDR3 showed out-of frame gene rearrangement. Additionally, we found that in some of TCR AV families there were 18 amino acid discrepancies between the longest CDR3 and shortest CDR3. These results may be helpful to further study the recombination mechanism of human TCR genes, the TCR CDR3 gene repertoire, and the repertoire drift in health people and disease state. | Xinsheng Yao Ying Diao Wanbang Sun Junmin Luo Ming Qin Xianying Tang | 2007 | Cellular & Molecular Immunology2007，4，3： | 10 |
| 2 | A study of the spatial-temporal distribution and propagation characteristics of internal waves in the Andaman Sea using MODIS显示文摘This paper describes investigations of the internal waves in the Andaman Sea using Moderate Resolution Imaging Spectroradiometer(MODIS)imagery over the period of June 2010 to May 2016.Results of the spatial and temporal distribution,generation sources and propagation characteristics of internal waves are presented.The statistical analysis shows that internal waves can be observed in almost the entire area of the Andaman Sea.Most internal waves are observed in the northern,central and southern regions of the Andaman Sea.A significant number of internal waves between 7°N and 9°N in the East Indian Ocean are also observed.Internal waves can be observed year-round in the Andaman Sea,while most of internal waves are observed between February and April,with a maximum frequency of 15.03%in March.The seasonal distribution of the internal waves shows that the internal waves have mostly been observed in the dry season(February to April),and fewer internal waves are observed in the rainy season(May to October).The double peak distribution for the occurrence frequency of internal waves is found.With respect to the lunar influence,more internal waves are observed after the spring tide,which implies the spring tide may play an important role in internal wave generation in the Andaman Sea.Generation sources of internal waves are explored based on the propagation characteristics of internal waves.The results indicate that six sources are located between the Andaman Islands and the Nicobar Islands,and one is located in the northern Andaman Sea.Four regions with active internal wave phenomenon in the Andaman Sea were presented during the MODIS survey,and the propagation speed of internal waves calculated based on the semidiurnal generation period is smaller than the results acquired from pairs of the images with short time intervals. | Lina Sun Jie Zhang Junmin Meng | 2019 | Acta Oceanologica Sinica2019，38，7： | 10 |
| 3 | CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6显示文摘睫是毛一般的细胞器从房间表面延长与重要感觉并且活动性功能。睫的缺点能导致作为 ciliopathies 知道的大量人的疾病。然而,控制 ciliogenesis 的分子的机制仍然保持糟糕定义。这里,我们显示出那 cylindromatosis (CYLD ) ,怀有 deubiquitinase 活动的肿瘤 suppressor 蛋白质,在多重机关在主要、能动的睫的集会起一个关键作用。CYLD 猛烈老鼠 polydactyly 展出并且各种各样的睫的缺点,例如在基础身体抛锚和基础身体和 axenomes 的组织的破坏的失败。CYLD 的睫的功能部分从 70 kDa (Cep70 ) 的 centrosomal 蛋白质被归因于它 polyubiquitin 链的 deconjugation,为 Cep70 到的一个要求与 γ 交往;导管素并且在中心体本地化。另外, histone deacetylase 的调停 CYLD 的抑制 6 (HDAC6 ) ,它支持导管素 acetylation,为 CYLD 的睫的功能组成另一机制。HDAC6 的小分子的禁止者能部分在 CYLD 猛烈老鼠救睫的缺点。这些调查结果在 ciliogenesis 的调整强调蛋白质 ubiquitination 的重要性,作为这个过程的一个关键管理者识别 CYLD,并且建议在 ciliopathies 的 CYLD 缺乏的参与。 | Yunfan Yang Jie Ran Min Liu Dengwen Li Yuanyuan Li Xingjuan Shi Dan Meng Junmin Pan Guangshuo Ou Rim Aneja Sbao-Cong Sun Jun Zhou | 2014 | Cell Research2014，24，11： | 8 |
| 4 | Study on the amplitude inversion of internal waves at Wenchang area of the South China Sea显示文摘The field experiment is conducted from April 16,2005 to July 20,2005 at Wenchang area east of Hainan Island(19°35'N,112°E) of China.Internal wave packets are observed frequently with thermistor chains during the experiment.Meanwhile,internal waves are also detected from a synthetic aperture radar(SAR) image on June 19,2005 and several other moderate-resolution imaging spectroradiometer(MODIS) images near a mooring position.The distance between the positive and negative peaks induced by the internal wave can be obtained from satellite images.Combined with remote sensing images and in situ data,a new method to inverse the amplitude of the internal wave is proposed based on a corrected nonlinear Schr?dinger(NLS) equation.Two relationships are given between the peak-to-peak distance and the characteristic wavelength of the internal wave for different nonlinear and dispersion coefficients.Based on the satellite images,the amplitude inversion of the internal waves are carried out with the NLS equation as well as the Kd V equation.The calculated amplitudes of the NLS equation are close to the observation amplitude which promise the NLS equation a reliable method. | ZHANG Xudong WANG Jing SUN Lina MENG Junmin | 2016 | Acta Oceanologica Sinica2016，35，7： | 8 |
| 5 | Selenium deficiency induces spleen pathological changes in pigs by decreasing selenoprotein expression,evoking oxidative stress,and activating inflammation and apoptosis显示文摘Background:The immune system is one aspect of health that is affected by dietary selenium(Se)levels and selenoprotein expression.Spleen is an important immune organ of the body,which is directly involved in cellular immunity.However,there are limited reports on Se levels and spleen health.Therefore,this study established a Se-deficient pig model to investigate the mechanism of Se deficiency-induced splenic pathogenesis.Methods:Twenty-four pure line castrated male Yorkshire pigs(45 days old,12.50±1.32 kg,12 full-sibling pairs)were divided into two equal groups and fed Se-deficient diet(0.007 mg Se/kg)or Se-adequate diet(0.3 mg Se/kg)for 16 weeks.At the end of the trial,blood and spleen were collected to assay for erythroid parameters,the osmotic fragility of erythrocytes,the spleen index,histology,terminal deoxynucleotidyl transferase nick-end labeling(TUNEL)staining,Se concentrations,the selenogenome,redox status,and signaling related inflammation and apoptosis.Results:Dietary Se deficiency decreased the erythroid parameters and increased the number of osmotically fragile erythrocytes(P<0.05).The spleen index did not change,but hematoxylin and eosin and TUNEL staining indicated that the white pulp decreased,the red pulp increased,and splenocyte apoptosis occurred in the Se deficient group.Se deficiency decreased the Se concentration and selenoprotein expression in the spleen(P<0.05),blocked the glutathione and thioredoxin antioxidant systems,and led to redox imbalance.Se deficiency activated the NF-κB and HIF-1αtranscription factors,thus increasing pro-inflammatory cytokines(IL-1β,IL-6,IL-8,IL-17,and TNF-α),decreasing anti-inflammatory cytokines(IL-10,IL-13,and TGF-β)and increasing expression of the downstream genes COX-2 and iNOS(P<0.05),which in turn induced inflammation.In addition,Se-deficiency induced apoptosis through the mitochondrial pathway,upregulated apoptotic genes(Caspase3,Caspase8,and Bak),and downregulated antiapoptotic genes(Bcl-2)(P<0.05)at the mRNA level,thus verifying the results of TUNEL staining.Conclusions:These results indicated that Se deficiency induces spleen injury through the regulation of selenoproteins,oxidative stress,inflammation and apoptosis. | Shuang Li Wenjuan Sun Kai Zhang Jiawei Zhu Xueting Jia Xiaoqing Guo Qingyu Zhao Chaohua Tang Jingdong Yin Junmin Zhang | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 4 |
| 6 | Detection of ocean internal waves based on Faster R-CNN in SAR images显示文摘Ocean internal waves appear as irregular bright and dark stripes on synthetic aperture radar(SAR)remote sensing images.Ocean internal waves detection in SAR images consequently constituted a difficult and popular research topic.In this paper,ocean internal waves are detected in SAR images by employing the faster regions with convolutional neural network features(Faster R-CNN)framework;for this purpose,888 internal wave samples are utilized to train the convolutional network and identify internal waves.The experimental results demonstrate a 94.78%recognition rate for internal waves,and the average detection speed is 0.22 s/image.In addition,the detection results of internal wave samples under different conditions are analyzed.This paper lays a foundation for detecting ocean internal waves using convolutional neural networks. | BAO Sude MENG Junmin SUN Lina LIU Yongxin | 2020 | Journal of Oceanology and Limnology2020，38，1： | 2 |
| 7 | A numerical study of the generation mechanism of internal solitary waves in the Luzon Strait显示文摘The South China Sea(SCS) is a hot spot for oceanic internal solitary waves due to many factors, such as the complexity of the terrain environment. The internal solitary waves in the northern SCS mainly originate in the Luzon Strait. The generation mechanism of the internal solitary waves in the Luzon Strait is discussed using a modulation instability. The energy gain of the modulation instability is derived based on the fully nonlinear Schr?dinger equation. The peak value of the gain is calculated under different conditions of stratification,wavelength and the initial amplitude of an internal tidal wave. The characteristics of the modulation instability in the Luzon Strait are investigated. The conditions that make the internal tidal wave evolve into an internal solitary wave in the Luzon strait are also obtained. The results show that the internal tide waves can generate the modulation instability in the Luzon Strait and that the maximum gain occur at the eastern sill of the Luzon Strait,where the internal tide waves start to break up into internal solitary trains. The magnitude and the scope of the peak gain are relevant to the stratification and the initial conditions of the internal tide waves. The numerical simulation results are consistent with the in-situ data. | WANG Jing SUN Meiling ZHANG Xudong SUN Lina MENG Junmin | 2015 | Acta Oceanologica Sinica2015，34，7： | 2 |
| 8 | Undulated 2D Covalent Organic Frameworks Based on Bowl-Shaped Cyclotricatechylene显示文摘Two 2D wavy hexagonal hexahydroxyl cyclotricatechylene (CTC) based COFs, CTC-COF-2 and CTC-COF-3were synthesized through solvothermal reaction. The bowl-shaped conformation caused CTC skeletons packed in acolumnar manner with the same oriented units, thus forming an undulated structure. The gas adsorption propertiesof CTC-COFs were investigated, which show the potential application abilities in hydrogen storage of CTC-COFs.The introduction of pyrene into CTC-COF-3 makes it a potential semiconducting π-conjugated material. | Jingru Zhen Sanyuan Ding Wei Wang Junmin Liu Junliang Sun Zhitang Huang Qiyu Zheng | 2016 | Chinese Journal of Chemistry2016，34，8： | 2 |
| 9 | Effects and mechanism research of the desilication pretreatment for high-aluminum fly ash 显示文摘 | ZHU Guorui TAN Wei SUN Junmin | 2013 | Energy & Fuels2013，27，11： | 1 |
| 10 | Mineralogy, chemical combustion, and microstruture of ferrospheres in fly ashes from coal combustion显示文摘 | Zhao Yongchun Zhang Junying Sun Junmin | 2006 | Energy & Fuels2006，20，： | 1 |
| 11 | Study on the propagation velocity of internal solitary waves in the Andaman Sea using Terra/Aqua-MODIS remote sensing images显示文摘The Andaman Sea has been a classic study region for internal solitary waves(ISWs)for several decades,and extraordinarily large ISWs are characteristic of the Andaman Sea in the Indian Ocean.This paper presents results on the estimation of the propagation velocity of ISWs in the Andaman Sea that were tracked using 195 image pairs acquired by MODIS National Aeronautics and Space Administration(NASA)Terra/Aqua satellites between January 2014 and December 2018.A total of 562 ISWs were identified during the period,and the results of the propagation velocity distribution of ISWs in the Andaman Sea are presented.The estimated propagation velocity of ISWs agrees well with the theoretical results derived from the Korteweg-de Vries(KdV)equation using monthly climatology stratification data and local bathymetry.The ISW propagation velocity decreases as they propagate from deep to shallow water;the maximum propagation velocity of 3.27 m/s was estimated on the western side of the Nicobar Islands and minimum speed of 0.54 m/s occurred in the shallow water region of the southeastern Andaman Sea.The results show that the ISW propagation characteristics differ in the northern,central,and southern regions of the Andaman Sea.In the northern Andaman Sea,the velocity of ISWs propagating westward was greater than that of ISWs propagating eastward at the same water depth.In the central Andaman Sea,the propagation velocity of the ISWs differed over a small area at a depth of 2500 m,and the velocity of ISWs in the deep mixing layer in winter was higher than that in the shallow mixing layer in spring.Monthly variations in ISW propagation velocity were analyzed in the southern Andaman Sea,and the velocity of ISWs differed greatly in shallow water and was not significantly different in deep water.Water depth and monthly stratification play vital roles in controlling the phase speed of ISWs in the Andaman Sea.This study will provide a basis for the propagation and prediction of ISWs in the Andaman Sea. | Lina SUN Jie ZHANG Junmin MENG | 2021 | Journal of Oceanology and Limnology2021，39，6： | 1 |
| 12 | A new global gridded sea surface temperature product constructed from infrared and microwave radiometer data using the optimum interpolation method显示文摘A new 0.1° gridded daily sea surface temperature(SST) data product is presented covering the years 2003–2015. It is created by fusing satellite SST data retrievals from four microwave(Wind Sat, AMSR-E, ASMR2 and HY-2 A RM)and two infrared(MODIS and AVHRR) radiometers(RMs) based on the optimum interpolation(OI) method. The effect of including HY-2 A RM SST data in the fusion product is studied, and the accuracy of the new SST product is determined by various comparisons with moored and drifting buoy measurements. An evaluation using global tropical moored buoy measurements shows that the root mean square error(RMSE) of the new gridded SST product is generally less than 0.5℃. A comparison with US National Data Buoy Center meteorological and oceanographic moored buoy observations shows that the RMSE of the new product is generally less than 0.8℃. A comparison with measurements from drifting buoys shows an RMSE of 0.52–0.69℃. Furthermore, the consistency of the new gridded SST dataset and the Remote Sensing Systems microwave-infrared SST dataset is evaluated, and the result shows that no significant inconsistency exists between these two products. | SUN Weifu WANG Jin ZHANG Jie MA Yi MENG Junmin YANG Lei MIAO Junwei | 2018 | Acta Oceanologica Sinica2018，37，9： | 1 |
| 13 | A novel CyclinE/CyclinA-CDK Inhibitor targets p27 Kip1 degradation, cell cycle progression and cell survival: Implications in cancer therapy显示文摘 | Lu Dai Yuqing Liu Junyang Liu Xiaoming Wen ZhengShuang Xu Zhuo Wang Hong Sun Shoubin Tang Anita R. Maguire Junmin Quan Hui Zhang Tao Ye | 2013 | Cancer Letters2013，，1： | 1 |
| 14 | Guidelines for the diagnosis and treatment of acute pancreatitis in China (2021)显示文摘Acute pancreatitis(AP)is a common acute abdominal condition of the digestive system.In recent years,treatment concepts,methods,and strategies for the diagnosis of AP have advanced,and this has played an important role in promoting the standardization of AP diagnosis and treatment and improving the treatment quality of AP patients.On the basis of previous guidelines and expert consensus,this guideline adopts an evidence-based,problem-based expression;synthesizes important clinical research data at home and abroad in the most recent 5 years;and forms 29 recommendations through multidisciplinary expert discussion,including diagnosis,treatment,and follow-up.It is expected to provide evidence support for the treatment of AP in the clinical setting in China. | Fei Li Shouwang Cai Feng Cao Rufu Chen Deliang Fu Chunlin Ge Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Ang Li Haimin Li Shengping Li Weiqin Li Yixiong Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Changqing Yan Yinmo Yang Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 1 |
| 15 | A novel CyclinE/CyclinA-CDK Inhibitor targets p27 Kip1 degradation, cell cycle progression and cell survival: Implications in cancer therapy显示文摘 | Lu Dai Yuqing Liu Junyang Liu Xiaoming Wen ZhengShuang Xu Zhuo Wang Hong Sun Shoubin Tang Anita R. Maguire Junmin Quan Hui Zhang Tao Ye | 2013 | Cancer Letters2013，，1： | 1 |
| 16 | Isolation and characterization of collagen from the cartilage of Amur sturgeon ( Acipenser schrenckii )显示文摘 | Qiufang Liang Lin Wang Weihong Sun Zhenbin Wang Junmin Xu Haile Ma | 2013 | Process Biochemistry2013，，： | 1 |
| 17 | A novel CyclinE/CyclinA-CDK Inhibitor targets p27 Kip1 degradation, cell cycle progression and cell survival: Implications in cancer therapy显示文摘 | Lu Dai Yuqing Liu Junyang Liu Xiaoming Wen ZhengShuang Xu Zhuo Wang Hong Sun Shoubin Tang Anita R. Maguire Junmin Quan Hui Zhang Tao Ye | 2013 | Cancer Letters2013，，1： | 1 |
| 18 | A review of the etched terminal structure of a 4H-SiC PiN diode显示文摘The comparison of domestic and foreign studies has been utilized to extensively employ junction termination extension(JTE)structures for power devices.However,achieving a gradual doping concentration change in the lateral direction is difficult for SiC devices since the diffusion constants of the implanted aluminum ions in SiC are much less than silicon.Many previously reported studies adopted many new structures to solve this problem.Additionally,the JTE structure is strongly sensitive to the ion implantation dose.Thus,GA-JTE,double-zone etched JTE structures,and SM-JTE with modulation spacing were reported to overcome the above shortcomings of the JTE structure and effectively increase the breakdown voltage.They provided a theoretical basis for fabricating terminal structures of 4H-SiC PiN diodes.This paper summarized the effects of different terminal structures on the electrical properties of SiC devices at home and abroad.Presently,the continuous development and breakthrough of terminal technology have significantly improved the breakdown voltage and terminal efficiency of 4H-SiC PiN power diodes. | Hang Zhou Jingrong Yan Jialin Li Huan Ge Tao Zhu Bingke Zhang Shucheng Chang Junmin Sun Xue Bai Xiaoguang Wei Fei Yang | 2023 | Journal of Semiconductors2023，44，11： | 0 |
| 19 | Surveillance of Multidrug-Resistant Bacterial Infections in Non-Adult Patients-Zhejiang Province,China,2014-2019显示文摘ABSTRACT Introduction:Antimicrobial resistance has become a major public health threat globally.The prevalence of multidrug-resistant(MDR)bacterial infections increased substantially among inpatients under 18 years of age in recent years.In Zhejiang Province,China,the trends of drug-resistance in non-adult patients from 2014 to 2019 were monitored,aiming to determine the variation patterns and epidemiological features of MDR strains. | Yuchen Wu Shi Chen Jiaping Li Chang Cai Hanyu Wang Mingming Zhou Junmin Cao Qiang Wang Shenghai Wu Shibiao Ding Xiaofei Zhao Long Sun Qingfeng Hu Hongwei Zhou Xiang Qian Qing Yang Sheng Chen Rong Zhang | 2021 | China CDC weekly2021，3，47： | 0 |
| 20 | Catalytic hydrotreatment of humins into cyclic hydrocarbons over solid acid supported metal catalysts in cyclohexane显示文摘Humins are common undesirable sideproducts during many acid-catalyzed reactions in renewable biomass platform conversion. However, few studies have been reported to the efficient utilization of humins.For the first time, the selective catalytic conversion of biomass-derived humins into cyclic hydrocarbons with high conversion rate and selectivity is presented using a home-made Ru/W-P-Si-O bifunctional catalyst. The multistage polymerization structure of humins was studied through controlled experiments.Results show that the CAC bond network can be efficiently depolymerized at a mild reaction temperature of 340–380 °C, catalyzed by the cooperative catalysis of nano-Ru particles and porous strong Lewis solid acid. Particularly, 95.4% conversion of humins was achieved under the optimal condition with up to 88.3%yield of cyclic hydrocarbons. The detailed composition after liquefaction was also analyzed. This study paves the way for the efficient production of cyclic and aromatic hydrocarbons from furan-derived humin polymer through Lewis acid-catalyzed Diels–Alder reactions between furan rings. | Junmin Sun Hai Cheng Yao Zhang Yinmin Zhang Xunfeng Lan Yongfeng Zhang Qineng Xia Daqian Ding | 2021 | Journal of Energy Chemistry2021，30，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员