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| 1 | Prediction of H7N9 epidemic in China显示文摘 | Zhang Zhaojie Xia Yao Lu Yi Yang Jingchao Zhang Luwen Su Hui Lin Lili Wang Guoling Wang Tongmei Lin Shao Guo Zhongmin Lu Jiahai | 2014 | Chinese Medical Journal2014，，2： | 8 |
| 2 | Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation显示文摘在房间期间,分割要求忠诚有丝分裂的锭子汇编和染色体分离的基因信息的稳定的传播。运用了 GTPase 戏在有丝分裂的锭子汇编的一个关键角色。然而,在锭子的 Ran-GTP 的一个化学坡度的产生怎么被联合到有丝分裂的 translational 以后修正,从来没被描绘过。这里,我们解决了复杂结构与核苷酸版本因素 Mog1 跑了并且描出一个新奇有丝分裂特定的调整 acetylation 的 Ran-Mog1 相互作用在染色体分离期间。我们的指导结构的功能的分析表明那 Mog1 与 RCC1 竞争为以一种 GTP/GDP-dependent 方式变有约束力。生物化学的描述表明了那 Mog1 固定跑阻止 RCC1 有约束力、随后的 GTP 装载。令人惊讶地,跑了是 TIP60 的真正的底层,并且由 TIP60 的 Lys134 的 acetylation 解放 Mog1 从在有丝分裂期间变有约束力。重要地,这个得到 acetylation 的开关对 RCC1 变有约束力支持 Ran-GTP 的高水平,它为染色体排列是必要的。这些结果建立一以前 TIP60 由调节在提供 Ran-GTP 水平的 homeostatic 控制的规章的机制运用了的 uncharacterized 为在有丝分裂的染色体分离的受动器绑定。 | Xiaoling Bao Heng Liu Xing Liu Ke Ruan Yonshui Zhang Zhiyong Zhang Qi Hu Ying Liu Saima Akram Jiahai Zhang Qingguo Gong Wenwen wang Xiao Yuan Jian-Li Lingli Zhao Zhen Dou Ruijun Tian Xuebiao Yao Jihui Wu Yunyu Shi | 2018 | Journal of Molecular Cell Biology2018，10，1： | 8 |
| 3 | ARCHITECTURE OF MANUFACTURING EXECUTION SYSTEM IN THE EXTENDED ENTERPRISE显示文摘The extended enterprise is formed according to the philosophy of dispersed networked manufacturing. Manufacturing execution system (MES) can close the information gap which exists between device control system and production information management system. The functions and the web-based architecture of the MES in the extended enterprise are introduced. Using the cooperating system models of object-oriented and distributed agents and CORBA, all objects keep to uniform interface standards and are easily inserted to object request broker. The utilization of distributed MES in extended enterprise can adapt fast change of manufacturing environment and resource. It also can improve the independent management capability of manufacturing cell and the enterprise response capability to global economic competition. | Song Haisheng College of Electronic and Mechanical Engineering, Hebei University of Science and Technology,Shijiazhuang 050054,China Wang Jiahai Zhang Shu Tongji University | 2002 | Chinese Journal of Mechanical Engineering2002，15，1： | 6 |
| 4 | Subtyping of type A influenza by sequencing the variable regions of HA gene specifically amplified with RT-PCR显示文摘The outbreak of a novel influenza A(H1N1) virus across the globe poses a threat to human health.It is of paramount importance to develop a rapid,reliable and inexpensive diagnostic procedure.Based on the bioinformatic information from public database,primers specific for influenza A virus surface protein haemagglutinin(HA) of several subtypes(including H1,H2,H3,H5,H7 and H9) were designed.Primer-specific PCR products were subjected to sequencing for accurately distinguishing H1 and H3 subtypes from others.This sequencing-based detection method will not only be applied to rapid detection and simultaneous subtype identification of new influenza A virus H1N1,but also provide the strategies to monitor other new types ofinfluenza virus with explosive potential. | YAN An DING GuoHui ZHOU ZhenFeng DONG Hui ZHANG YaKun ZHU Lei HE YunGang ZHANG GuoQing LI YiXue SUN Bing HUANG Zhong LAN Ke JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenGan ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN WeiRong XIONG Hui | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 5 | The mutation network for the hemagglutinin gene from the novel influenza A (H1N1) virus显示文摘A mutation network for the hemagglutinin gene(HA) of the novel type A(H1N1) influenza virus was constructed.Sequence homology analysis indicated that one HA sequence type from the viruses mainly isolated from Mexico was likely the original type in this epidemic.Based on the 658A and 1408T mutations in HA,the viruses evolving into this epidemic were divided into three categories,the Mexico,the transitional and the New York type.The three groups of viruses presented distinctive clustering features in their geographic distributions. | HE YunGang DING GuoHui BIAN Chao HUANG Zhong LAN Ke SUN Bing WANG XueCai LI YiXue WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang JIN WeiRong XIONG Hui DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenAn ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN Li | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 6 | Efficacy of Cytidine-5'-diphosp-bocholine Combined with Compound Anisodine in the Treatment of Early Optic Nerve Contusion显示文摘Purpose:To investigate the efficacy of anisodine combined with cytidine-5'-diphosp-bocholine (citicoline) in the treatment of early optic nerve contusion.Methods:A total of 33 subjects eligible for inclusion were selected from 105 patients clinically diagnosed with optic nerve contusion.These patients were subsequently divided into the control group (n =16) and the intervention group (n =17).In the control group,the participants received therapy consisting of glucocorticoids,mannitol,vasodilators and vitamin B.The patients in the intervention group additionally received anisodine in combination with citicoline.The visual acuity was graded on a scale from 0 to 8.Results:Prior to treatment,.the 25th,50th and 75th percentiles of visual acuity grade were 3,4 and 6.75 for the controls,and 3,4 and 6.5 for the patients in the intervention group (P=0.97).After treatment,the 25th,50th and 75th percentiles of visual acuity grade were 4,6 and 7.75 in the control group,and 7,7 and 8 in the intervention group (P=0.046).A significant difference was observed in both control (P=0.005) and intervention groups(P=0.001) when comparing presenting visual acuity before and after treatment.Conclusion:The combination of anisodine and citicoline with standard steroid and mannitol therapy appears to be effective in the treatment of early optic nerve contusion. | Wenhua Wang Yan Huang Jianli Zhang Jiahai Jiang Jinxiu Huang | 2012 | Eye Science2012，27，1： | 3 |
| 7 | Clinical Study on Interferon Treatment of Early Scarring in Filtering Bleb显示文摘Purpose:To investigate the effectiveness of needle revision combined with subconjuctival injection of interferon α-2b in reversing early scarring of filtering blebs following trabeculectomy surgery.Methods:Twenty-five glaucoma patients (31 eyes) who presented with scarred or encapsulated filtering bleb after glaucoma surgery underwent needle revision in combination with subconjuctival injection of interferon α-2b,and were followed for 12 months.Intraocular pressure (IOP) and filtering bleb morphology were observed post treatment.Results:.The mean time until scarring occurred was 21.0±7.4 days..The average time between recognition of bleb scarring and completion of needle revision was 2.2±0.8 days.The time interval between surgery and needle revision was inversely correlated with the time until needle revision (r=-0.694,P < 0.001).The mean IOPs before and after needle revision were 24.2±2.7 mmHg and 19.6±3.8 mmHg,respectively (t=5.916,P < 0.001)..At the 12-month follow-up visit,.18 eyes (58.1%).achieved complete success in IOP control,.and 6 eyes (19.4%) had conditional success..The overall success rate for needling was thus 77.4%.Subconjunctival hemorrhage was observed in 4 eyes during the needle revision procedure.Punctate staining was found in the corneal epithelium of 2 eyes.Shallow anterior chamber (Grade I or II) was identified in 5 eyes.Conclusion:Slit-lamp needle revision combined with subconjunctival injection of interferon α-2b may be efficacious in the treatment of early scarring of filtering blebs,easy and safe to perform,.and may be considered for more widespread application. | Wenhua Wang Jianli Zhang Yan Huang Jinxiu Huang Jiahai Jiang | 2011 | Eye Science2011，26，4： | 2 |
| 8 | Solving Multitrip Pickup and Delivery Problem With Time Windows and Manpower Planning Using Multiobjective Algorithms显示文摘The multitrip pickup and delivery problem with time windows and manpower planning(MTPDPTW-MP)determines a set of ambulance routes and finds staff assignment for a hospital. It involves different stakeholders with diverse interests and objectives. This study firstly introduces a multiobjective MTPDPTW-MP(MO-MTPDPTWMP) with three objectives to better describe the real-world scenario. A multiobjective iterated local search algorithm with adaptive neighborhood selection(MOILS-ANS) is proposed to solve the problem. MOILS-ANS can generate a diverse set of alternative solutions for decision makers to meet their requirements. To better explore the search space, problem-specific neighborhood structures and an adaptive neighborhood selection strategy are carefully designed in MOILS-ANS. Experimental results show that the proposed MOILS-ANS significantly outperforms the other two multiobjective algorithms. Besides, the nature of objective functions and the properties of the problem are analyzed. Finally, the proposed MOILS-ANS is compared with the previous single-objective algorithm and the benefits of multiobjective optimization are discussed. | Jiahai Wang Yuyan Sun Zizhen Zhang Shangce Gao | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，4： | 2 |
| 9 | Structure modeling and spatial epitope analysis for HA protein of the novel H1N1 influenza virus显示文摘In recent months,a novel influenza virus H1N1 broke out around the world.With bioinformatics technology,the 3D structure of HA protein was obtained,and the epitope residues were predicted with the method developed in our group for this novel flu virus.58 amino acids were identified as potential epitope residues,the majority of which clustered at the surface of the globular head of HA protein.Although it is located at the similar position,the epitope of HA protein for the novel H1N1 flu virus has obvious differences in the electrostatic potential compared to that of HA proteins from previous flu viruses. | WU Di XU TianLei SUN Jing DAI JianXin DING GuoHui HE YunGang ZHOU ZhengFeng XIONG Hui DONG Hui JIN WeiRong BIAN Chao JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang WANG Hao CHE XiaoYan HUANG Zhong LAN Ke SUN Bing WU Fan YUAN ZhenAn ZHANG Xi ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi GUO YaJun ZHAO GuoPing LI YiXue CAO ZhiWei | 2009 | Chinese Science Bulletin2009，54，13： | 2 |
| 10 | Investigation of self-assembled protein dimers through an artificial ion channel for DNA sensing显示文摘Artificial nanopores have become promising tools for sensing DNA.Here,we report a new technique for sensing DNA through a conical-shaped nanopore embedded in track-etched polyethylene terephthalate(PET)membrane.Two different streptavidin-conjugated monovalent DNA probes were prepared that can bind to two distinct segments(at either end) of the target DNA.The size of target DNA-linked to the two streptavidin-conjugated monovalent DNA probes is double that of the individual probes.By precisely controlling the tip diameter of the conical nanopore embedded in the PET polymer,events due to the translocation of the streptavidin-conjugated monovalent DNA probes through the nanopore can be filtered and purposely undetected,whereas the current pulses due to the translocation of the target DNA-induced selfassembled complexes can be detected.The two streptavidin-conjugated DNA probes cannot be linked by multimismatched DNA.Therefore,multi-mismatched(nonspecific) DNA will not induce any current pulse signatures.The current pulse signatures for the self-assembled complex can be used to confirm the presence of the target DNA.The size-dependent detection of self-assembled complexes on the molecular level shows strong promise forthe detection of biomolecules without interference from the probes. | Siqi Zhang Ting Sun Erkang Wang Jiahai Wang | 2014 | Chinese Science Bulletin2014，59，35： | 2 |
| 11 | The Economy of distributed PV in China显示文摘 | YUAN Jiahai SUN Shenghui ZHANG Wenhua | 2014 | Energy2014，78，： | 1 |
| 12 | Protective effect of fluvastatin on influenza virus infection显示文摘 | Jing Peng Dingmei Zhang Yu Ma Guoling Wang Zhongmin Guo Jiahai Lu | 2014 | Molecular Medicine Reports2014，，6： | 1 |
| 13 | Interesting structural and dynamical behaviors exhibited by the AF-6 PDZ domain upon Bcr peptide binding 显示文摘 | Niu Xiaogang Chen Quan Zhang Jiahai | 2007 | Biochemistry2007，46，15： | 1 |
| 14 | Conformational change upon ligand binding and dynamics of the PDZ domain from leukemia-associated Rho guanine nucleotide exchange factor显示文摘 | Liu Jiangxin Zhang Jiahai Yang Yinshan | 2008 | Protein Sci2008，17，6： | 1 |
| 15 | Decision support for choice optimal power generation projects: Fuzzy comprehensive evaluation model based on the electricity market显示文摘 | ZHIHONG LIANG KUN YANG YAOWEI SUN JIAHAI YUAN HONGWEI ZHANG ZHIZHENG ZHANG | 2006 | Energy Policy2006，17，34： | 1 |
| 16 | Compact molten globule-like state of hUBF HMG Box1 at extremely low pH显示文摘 | Zhang Xuecheng Zhang Jiahai Li Xuan | 2005 | Biochim Biophys Acta2005，1748，1： | 1 |
| 17 | Structural and dynamic properties of the acid-unfolded state of hUBF HMG Box 1 provide clues for the early events in protein folding显示文摘 | Zhang Xuecheng Xu Yingqi Zhang Jiahai | 2005 | Biochemistry2005，44，： | 1 |
| 18 | Solution structure of the second bromodomain of Brd2 and its specific interaction with acetylated histone tails 显示文摘 | Huang Hongda Zhang Jiahai Shen Weiqun | 2007 | BMC Struct Biol2007，7，1： | 1 |
| 19 | Structural basis and binding properties of the second bromodomain of Brd4 with acetylated histone tails显示文摘 | Liu Ying Wang Xiqing Zhang Jiahai | 2008 | Biochemistry2008，47，24： | 1 |
| 20 | Investigation of the Structural Stability of hUBF HMG Box 5 by native-state hydrogen exchange 显示文摘 | Wang Dandan Zhang Jiahai Jin Xianju | 2007 | Biochemistry2007，46，5： | 1 |
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