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| 1 | Terrestrial carbon sinks in China and around the world and their contribution to carbon neutrality显示文摘Enhancing the terrestrial ecosystem carbon sink(referred to as terrestrial C sink) is an important way to slow down the continuous increase in atmospheric carbon dioxide(CO_(2)) concentration and to achieve carbon neutrality target.To better understand the characteristics of terrestrial C sinks and their contribution to carbon neutrality,this review summarizes major progress in terrestrial C budget researches during the past decades,clarifies spatial patterns and drivers of terrestrial C sources and sinks in China and around the world,and examines the role of terrestrial C sinks in achieving carbon neutrality target.According to recent studies,the global terrestrial C sink has been increasing from a source of (-0.2±0.9) Pg C yr^(-1)(1 Pg=1015g)in the 1960s to a sink of (1.9±1.1) Pg C yr^(-1) in the 2010s.By synthesizing the published data,we estimate terrestrial C sink of 0.20–0.25 Pg C yr^(-1) in China during the past decades,and predict it to be 0.15–0.52 Pg C yr^(-1) by 2060.The terrestrial C sinks are mainly located in the mid-and high latitudes of the Northern Hemisphere,while tropical regions act as a weak C sink or source.The C balance differs much among ecosystem types:forest is the major C sink;shrubland,wetland and farmland soil act as C sinks;and whether the grassland functions as C sink or source remains unclear.Desert might be a C sink,but the magnitude and the associated mechanisms are still controversial.Elevated atmospheric CO_(2) concentration,nitrogen deposition,climate change,and land cover change are the main drivers of terrestrial C sinks,while other factors such as fires and aerosols would also affect ecosystem C balance.The driving factors of terrestrial C sink differ among regions.Elevated CO_(2) concentration and climate change are major drivers of the C sinks in North America and Europe,while afforestation and ecological restoration are additionally important forcing factors of terrestrial C sinks in China.For future studies,we recommend the necessity for intensive and long-term ecosystem C monitoring over broad geographic scale to improve terrestrial biosphere models for accurately evaluating terrestrial C budget and its dynamics under various climate change and policy scenarios. | Yuanhe Yang Yue Shi Wenjuan Sun Jinfeng Chang Jianxiao Zhu Leiyi Chen Xin Wang Yanpei Guo Hongtu Zhang Lingfei Yu Shuqing Zhao Kang Xu Jiangling Zhu Haihua Shen Yuanyuan Wang Yunfeng Peng Xia Zhao Xiangping Wang Huifeng Hu Shiping Chen Mei Huang Xuefa Wen Shaopeng Wang Biao Zhu Shuli Niu Zhiyao Tang Lingli Liu Jingyun Fang | 2022 | Science China(Life Sciences)2022，65，5： | 32 |
| 2 | Preliminary Scientific Results of Chang'E-1 Lunar Orbiter:Based on Payloads Detection Data in the First Phase显示文摘Chang'E-1 lunar Orbiter was launched by Long March 3A rocket from Xichang Satel-lite Launch Center at 18:05BT(Beijing Time) Oct.24,2007.It is the first step of its ambitious three-stage moon program,a new milestone in the Chinese space exploration history.The primary science objectives of Chang'E-1 lunar orbiter are to obtain three-Dimension(3D) stereo images of the lunar surface,to analyze the distribution and abundance of elements on the surface,to investigate the thickness of lunar soil,evaluate helium-3 resources and other characteristics,and to detect the space environment around the moon.To achieve the above four mission objectives,eight sets of scientific instruments are chosen as the payloads of the lunar orbiter,including a CCD stereo camera(CCD),a Sagnac-based interferometer spectrometer(ⅡM),a Laser Altimeter(LAM),a Microwave Radiometer(MRM),a Gamma-Ray Spectrometer(GRS),an X-ray spectrometer(XRS),a High-Energy Particle Detector(HPD),and two Solar Wind Ion Detectors(SWID).The detected data of the payloads show that all payloads work well.This paper introduces the status of payloads in the first phase and preliminary scientific results. | OUYANG Ziyuan JIANG Jingshan LI Chunlai SUN Huixian ZOU Yongliao LIU Jianzhong LIU Jianjun ZHAO Baochang REN Xin YANG Jianfeng ZHANG Wenxi WANG Jianyu MOU Lingli CHANG Jin ZHANG Liyan WANG Huanyu LI Yongquan ZHANG Xiaohui ZHENG Yongchun WANG Shijin BIAN Wei | 2008 | 空间科学学报2008，28，5： | 24 |
| 3 | Chang'E-1 Lunar Mission:An Overview and Primary Science Results显示文摘Chang'E-1 is the first lunar mission in China,which was successfully launched on Oct.24th,2007.It was guided to crash on the Moon on March 1,2009,at 52.36°E,1.50°S,in the north of Mare Fecunditatis.The total mission lasted 495 days,exceeding the designed life-span about four months.1.37Terabytes raw data was received from Chang'E-1.It was then processed into 4Terabytes science data at different levels.A series of science results have been achieved by analyzing and applicating these data,especially 'global image of the Moon of China's first lunar exploration mission'.Four scientific goals of Chang'E-1 have been achieved.It provides abundant materials for the research of lunar sciences and cosmochemistry.Meanwhile these results will serve for China's future lunar missions. | Ouyang Ziyuan Li Chunlai Lu Chang Liu Jianzhong Zou Yongliao Zhang Hongbo Jianjun Zuo Wei Su Yah Wen Weibin Bian Wei Zhao Baochang Wang Jianyu Yang Jianfeng Chang Jin Wang Huanyu Zhang Xiaohui Wang Shijin Wang Min Ren Xin Mu Lingli Kong Deqing Wang Xiaoqian Wang Fang Geng Liang Zhang Zhoubin Zheng Lei Zhu Xinying Zheng Yongchun Li Junduo Zou Xiaoduan Xu Chun Shi Shuobiao Gao Yifei Gao Guannan | 2010 | 空间科学学报2010，30，5： | 11 |
| 4 | Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation显示文摘在房间期间,分割要求忠诚有丝分裂的锭子汇编和染色体分离的基因信息的稳定的传播。运用了 GTPase 戏在有丝分裂的锭子汇编的一个关键角色。然而,在锭子的 Ran-GTP 的一个化学坡度的产生怎么被联合到有丝分裂的 translational 以后修正,从来没被描绘过。这里,我们解决了复杂结构与核苷酸版本因素 Mog1 跑了并且描出一个新奇有丝分裂特定的调整 acetylation 的 Ran-Mog1 相互作用在染色体分离期间。我们的指导结构的功能的分析表明那 Mog1 与 RCC1 竞争为以一种 GTP/GDP-dependent 方式变有约束力。生物化学的描述表明了那 Mog1 固定跑阻止 RCC1 有约束力、随后的 GTP 装载。令人惊讶地,跑了是 TIP60 的真正的底层,并且由 TIP60 的 Lys134 的 acetylation 解放 Mog1 从在有丝分裂期间变有约束力。重要地,这个得到 acetylation 的开关对 RCC1 变有约束力支持 Ran-GTP 的高水平,它为染色体排列是必要的。这些结果建立一以前 TIP60 由调节在提供 Ran-GTP 水平的 homeostatic 控制的规章的机制运用了的 uncharacterized 为在有丝分裂的染色体分离的受动器绑定。 | Xiaoling Bao Heng Liu Xing Liu Ke Ruan Yonshui Zhang Zhiyong Zhang Qi Hu Ying Liu Saima Akram Jiahai Zhang Qingguo Gong Wenwen wang Xiao Yuan Jian-Li Lingli Zhao Zhen Dou Ruijun Tian Xuebiao Yao Jihui Wu Yunyu Shi | 2018 | Journal of Molecular Cell Biology2018，10，1： | 8 |
| 5 | Physicochemical Control of the Early Permian Xiangshan Fe-Ti Oxide Deposit in Eastern Tianshan(Xinjiang),NW China显示文摘The Xiangshan mafic-ultramafic complex is one of the major Early Permian mafic-ultramafic intrusions in eastern Tianshan(Xinjiang, NW China), and consists of two major intrusive phases. The first intrusive phase is mainly gabbroic rocks hosting ilmenite mineralization, while the second intrusive phase is mainly lherzoilite associated with Ni-Cu sulfide mineralization. The Xiangshan ilmenite orebodies hosted in the Fe-Ti oxide-bearing gabbro occur along the contact between hornblende gabbros and leucogabbros. The hornblende gabbros and Fe-Ti oxide rich gabbros at Xiangshan are newly dated to be Early Permian(280.1 and 279.2 Ma, respectively). Major and trace element compositions of zircons and whole rocks from Xiangshan hornblende gabbro and Fe-Ti oxide gabbro have been measured by in situ excimer laser ablation ICP-MS. Zircon Ce^(4+)/Ce^(3+) ratios based on lattice-strain model and Ti-in-zircon temperatures of hornblende gabbro and Fe-Ti oxide gabbro of the Xiangshan complex are calculated to evaluate the physicochemical variations during the ilmenite mineralization. Whole-rock geochemistry and zircon trace element geochemistry suggest that Fe-Ti oxide gabbros were formed from a basaltic parent magma which had undergone a transfromation from being H_2O-rich to H_2O-poor. During the magmatic evolution, primitive, H_2O-poor basaltic melts may have been replenished into the system, increasing its solidus temperature and decreasing its oxygen fugacity and H_2O contents. This may have supperessed the Ti-rich poikilitic hornblende fractionation and promoted the plagioclase fractionation, which consequently concentrated the ore-forming components in the residual melts and generated the ilmenite mineralization. | Yu Shi Yuwang Wang Jingbin Wang Lutong Zhao Hongjing Xie Lingli Long Tao Zou Dedong Li Guochao Zhou | 2018 | Journal of Earth Science2018，29，3： | 6 |
| 6 | A novel mosquito-borne reassortant orbivirus isolated from Xishuangbanna,China显示文摘Dear Editor,The genus Orbivirus,within the family Reoviridae,includes 22 virus species(King et al.,2011).They are distributed globally,but are particularly prevalent in Europe,Asia,and Africa.In addition,they can be transmitted by ticks or other hematophagous insect vectors,including Culicoides,mosquitoes,and sandflies(Belaga- | Shaozhen Xing Xiaofang Guo Xianglilan Zhang Qiumin Zhao Lingli Li Shuqing Zuo Xiaoping An Guangqian Pei Qiang Sun Shi Cheng Yunfei Wang Hang Fan Zhiqiang Mi Yong Huang Zhiyi Zhang Hongning Zhou Jiusong Zhang Yigang Tong | 2017 | Virologica Sinica2017，32，2： | 4 |
| 7 | Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling显示文摘Dear Editor,At present,the world is suffering from an ongoing pandemic of 2019 novel coronavirus(COVID-19)which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2/2019-nCoV).To date,>20 million cases were confirmed with a death toll at>700,000.Although there are no clinically specific and effective antiviral treatments toward SARS-CoV-2 infection so far,the pathological study of SARS-CoV-2 infection and the development of SARS-CoV-2-specific vaccines are progressing rapidly within these several months.1 However,few reports mentioned the mechanism employed by SARS-CoV-2 for evading from surveillance of immune system. | Yaoxing Wu Ling Ma Zhen Zhuang Sihui Cai Zhiyao Zhao Lingli Zhou Jing Zhang Pei-Hui Wang Jincun Zhao Jun Cui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 8 | Petrogenesis and Metallogenesis of the Niumaoquan Gabbroic Intrusion Associated with Fe-Ti Oxide Ores in the Eastern Tianshan, NW China显示文摘The Niumaoquan layered gabbroic intrusion is in the southern margin of the Central Asian Orogenic Belt in North Xinjiang, China, and hosts a Fe-Ti oxide deposit in its evolved gabbroic phases. In this paper, we report zircon U-Pb age, Sr-Nd-Hf isotopes, plagioclase chemistry, and whole-rock geochemistry of the Niumaoquan layered gabbroic intrusion. Zircon grains separated from an anorthosite sample analyzed by laser ablation inductively coupled plasma mass spectrometry yielded a concordia age of 314.7±0.74 Ma, indicating that the Niumaoquan ore-bearing gabbroic intrusion was emplaced during the Late Carboniferous. The olivine gabbro texture and plagioclase chemistry suggest that plagioclase was an early crystallized silicate phase that crystallized prior to olivine. Fractional crystallization and accumulation of plagioclase significantly controlled the evolution of the Niumaoquan gabbroic intrusion and contributed to the formation of anorthosite layers, causing metallogenic elements to become enriched in the residual melt. The Niumaoquan gabbroic intrusion is characterized by the enrichment of large ion lithophile elements and depletion of high field strength elements, positive zircon εHf(t) values(+2.1 to +12.2), positive εNd(t) values(+3.3 to +5.2), and low initial ^(87)Sr/^(86)Sr ratios(0.7039 to 0.7047), suggesting that the parental magma was produced by interactions between metasomatized lithospheric mantle and depleted asthenospheric melts at an early post-collision stage. The Fe-Ti oxide mineralization of the Niumaoquan intrusion benefited from interactions between depleted asthenospheric melts and lithospheric mantle, and fractional crystallization of abundant plagioclase and magnesian minerals. | SHI Yu WANG Yuwang WANG Jingbin XIE Hongjing MAO Qigui ZHAO Lutong LONG Lingli LI Dedong ZHOU Guochao | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 3 |
| 9 | Discovery of a high-altitude ecotype and ancient lineage of Arabidopsis thaliana from Tibet显示文摘Arabidopsis thaliana(A.thaliana)has long been a model species for dicotyledon study,and was the first flowering plant to get its genome completed sequenced[1].Although most wild A.thaliana are collected in Europe,several studies have found a rapid A.thaliana west-east expansion from Central Asia[2].The Qinghai-Tibet Plateau(QTP)is close to Central Asia and known for its high alti- | Liyan Zeng Zhuoya Gu Min Xu Ning Zhao Weidong Zhu Takahiro Yonezawa Tianmeng Liu Lha Qiong Tashi Tersing Lingli Xu Yang Zhang Rongyan Xu Ningyu Sun Yanyan Huang Jiankun Lei Liang Zhang Feng Xie Fang Zhang Hongya Gu Yupeng Geng Masami Hasegawa Ziheng Yang M. James C. Crabbe Fan Chen Yang Zhong | 2017 | Science Bulletin2017，62，24： | 3 |
| 10 | Global detection of large lunar craters based on the CE-1 digital elevation model显示文摘坑,月亮的表面的最重要的特征之一,因为他们为我们提供表面单位以及关键地质的信息的相对年龄,广泛地被研究了。关于月亮和另外的行星的身体的算法(CDA ) 专注于从形象数据检测他们的坑察觉的研究,而是检测使用的大坑的计算费用想象使这些 CDA 不切实际。这篇论文介绍一条新途径给利用一个数字举起模型而不是图象的坑察觉;这启用大坑的充分自动的全球察觉。坑被地面属性,然后 thresholding 描出地面属性的地图被用来把地志的数据转变成一幅二进制图象,最后,坑被从二进制图象使用 Hough 变换检测。由使用建议算法,我们生产了所有坑的一个目录在月亮的表面上的直径的 10 km 并且分析了他们的分发和人口特征。 | Lei LUO Lingli MU Xinyuan WANG Chao LI Wei JI Jinjin ZHAO Heng CAI | 2013 | Frontiers of Earth Science2013，7，4： | 3 |
| 11 | OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING显示文摘Stimulator of interferon genes(STING)is an adaptor protein that is critical for effective innate antiviral and antitumor immunity.The activity of STING is heavily regulated by protein ubiquitination,which is fine-tuned by both E3 ubiquitin ligases and deubiquitinases.Here,we report that the deubiquitinase OTUD5 interacts with STING,cleaves its K48-linked polyubiquitin chains,and promotes its stability.Consistently,knockout of OTUD5 resulted in faster turnover of STING and subsequently impaired type I IFN signaling following cytosolic DNA stimulation.More importantly,Lyz2-Cre Otud5^(fl/Y) mice and CD11-Cre Otud5^(fl/Y) mice showed more susceptibility to herpes simplex virus type 1(HSV-1)infection and faster development of melanomas than their corresponding control littermates,indicating that OTUD5 is indispensable for STING-mediated antiviral and antitumor immunity.Our data suggest that OTUD5 is a novel checkpoint in the cGAS-STING cytosolic DNA sensing pathway. | Yunyun Guo Fei Jiang Lingli Kong Haifeng Wu Honghai Zhang Xiaorong Chen Jian Zhao Baoshan Cai Yanqi Li Chunhong Ma Fan Yi Lei Zhang Bingyu Liu Yi Zheng Lingqiang Zhang Chengjiang Gao | 2021 | Cellular & Molecular Immunology2021，18，8： | 2 |
| 12 | RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-kB hyper-activation and inflammation显示文摘The ongoing 2019 novel coronavirus disease(COVID-19)caused by SARS-CoV-2 has posed a worldwide pandemic and a major global public health threat.The severity and mortality of COVID-19 are associated with virus-induced dysfunctional inflammatory responses and cytokine storms.However,the interplay between host inflammatory responses and SARS-CoV-2 infection remains largely unknown.Here,we demonstrate that SARS-CoV-2 nucleocapsid(N)protein,the major structural protein of the virion,promotes the virus-triggered activation of NF-kB signaling.After binding to viral RNA,N protein robustly undergoes liquid-liquid phase separation(LLPS),which recruits TAK1 and IKK complex,the key kinases of NF-kB signaling,to enhance NF-kB activation.Moreover,1,6-hexanediol,the inhibitor of LLPS,can attenuate the phase separation of N protein and restrict its regulatory functions in NF-kB activation.These results suggest that LLPS of N protein provides a platform to Induce NF-kB hyper-activation,which could be a potential therapeutic target against COVID-19 severe pneumonia. | Yaoxing Wu Ling Ma Sihui Cai Zhen Zhuang Zhiyao Zhaou Shouheng Jin Weihong Xie Lingli Zhou Lei Zhang Jincun Zhao Jun Cui | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 2 |
| 13 | Targeting lactate dehydrogenase A (LDHA) exerts antileukemic effects on T-cell acute lymphoblastic leukemia显示文摘Background:T-cell acute lymphoblastic leukemia(T-ALL)is an uncommon and aggressive subtype of acute lymphoblastic leukemia(ALL).In the serum of T-ALL patients,the activity of lactate dehydrogenase A(LDHA)is increased.We proposed that targeting LDHA may be a potential strategy to improve T-ALL outcomes.The current study was conducted to investigate the antileukemic effect of LDHA gene-targeting treatment on T-ALL and the underlying molecular mechanism.Methods:Primary T-ALL cell lines Jurkat and DU528 were treated with the LDH inhibitor oxamate.MTT,colony formation,apoptosis,and cell cycle assays were performed to investigate the effects of oxamate on T-ALL cells.Quantitative real-time PCR(qPCR)and Western blotting analyses were applied to determine the related signaling pathways.A mitochondrial reactive oxygen species(ROS)assay was performed to evaluate ROS production after T-ALL cells were treated with oxamate.A T-ALL transgenic zebrafish model with LDHA gene knockdown was established using CRISPR/Cas9 gene-editing technology,and then TUNEL,Western blotting,and T-ALL tumor progression analyses were conducted to investigate the effects of LDHA gene knockdown on T-ALL transgenic zebrafish.Results:Oxamate significantly inhibited proliferation and induced apoptosis of Jurkat and DU528 cells.It also arrested Jurkat and DU528 cells in G0/G1 phase and stimulated ROS production(all P<0.001).Blocking LDHA significantly decreased the gene and protein expression of c-Myc,as well as the levels of phosphorylated serine/threonine kinase(AKT)and glycogen synthase kinase 3 beta(GSK-3β)in the phosphatidylinositol 3′-kinase(PI3K)signaling pathway.LDHA gene knockdown delayed disease progression and down-regulated c-Myc mRNA and protein expression in T-ALL transgenic zebrafish.Conclusion:Targeting LDHA exerted an antileukemic effect on T-ALL,representing a potential strategy for T-ALL treatment. | Haizhi Yu Yafei Yin Yifang Yi Zhao Cheng Wenyong Kuang Ruijuan Li Haiying Zhong Yajuan Cui Lingli Yuan Fanjie Gong Zhihua Wang Heng Li Hongling Peng Guangsen Zhang | 2020 | Cancer Communications2020，40，10： | 2 |
| 14 | Divergence in homoeolog expression of the grain length-associated gene GASR7 during wheat allohexaploidization显示文摘Hexaploid wheat has triplicated homoeologs for most of the genes that are located in subgenomes A, B, and D. GASR7, a member of the Snakin/GASA gene family, has been associated with grain length development in wheat. However, little is known about divergence of its homoeolog expression in wheat polyploids. We studied the expression patterns of the GASR7 homoeologs in immature seeds in a synthetic hexaploid wheat line whose kernels are slender like those of its maternal parent(Triticum turgidum, AABB, PI 94655) in contrast to the round seed shape of its paternal progenitor(Aegilops tauschii, DD, AS2404). We found that the B homoeolog of GASR7 was the main contributor to the total expression level of this gene in both the maternal tetraploid progenitor and the hexaploid progeny, whereas the expression levels of the A and D homoeologs were much lower. To understand possible mechanisms regulating different GASR7 homoeologs, we firstly analyzed the promoter sequences of three homoeologous genes and found that all of them contained gibberellic acid(GA) response elements, with the TaG ASR7 B promoter(pT aG ASR7B) uniquely characterized by an additional predicted transcriptional enhancer. This was confirmed by the GA treatment of spikes where all three homoeologs were induced, with a much stronger response for TaG ASR7 B. McrB C enzyme assays showed that the methylation status at pT aG ASR7 D was increased during allohexaploidization, consistent with the repressed expression of TaG ASR7 D. For pT aG ASR7 A, the distribution of repetitive sequence-derived 24-nucleotide(nt) small interfering RNAs(siR NAs) were found which suggests possible epigenetic regulation because 24-nt siR NAs are known to mediate RNA-dependent DNA methylation. Our results thus indicate that both genetic and epigenetic mechanisms may be involved in the divergence of GASR7 homoeolog expression in polyploid wheat. | Dongdong Zhang Bingnan Wang Junmin Zhao Xubo Zhao Lianquan Zhang Dengcai Liu Lingli Dong Daowen Wang Long Mao Aili Li | 2015 | The Crop Journal2015，3，1： | 2 |
| 15 | The interaction of phenolic acids with Fe(III) in the presence of citrate as studied by isothermal titration calorimetry显示文摘 | Senpei Yang Guangling Bai Lingli Chen Qun Shen Xianmin Diao Guanghua Zhao | 2014 | Food Chemistry2014，，： | 1 |
| 16 | Engineering miniature gold nanorods with tailorable plasmonic wavelength in NIR region via ternary surfactants mediated growth显示文摘Plasmonic nanoparticles are endowed profound capability for sensing,biomedicine,and cancer therapy.However,the inaccessibly adjustable wavelength in near infrared(NIR)region window and size limit for the particles penetration in tumor strongly hinder their developments.Miniature gold nanorods(mini-Au NRs)with diameter less than 12 nm can effectively address this challenge due to the tiny size and tailorable NIR absorption.Herein,we adopt ternary surfactants(hexadecyl trimethyl ammonium bromide(CTAB),sodium oleate(NaOL),and sodium salicylate(NaSal))mediated growth strategy to precisely synthesize miniature Au NRs under micelle space-confinement.Importantly,the selectively dense accumulation of ternary surfactants can efficiently improve the micellar stacking parameters(p)and lower micellar free energy(F),further tends to achieve the formation of Au NRs with tiny diameter and high purity.Compared with that of conventional methods,the purity of mini-Au NRs up to 100%can be dramatically improved via varying the relative concentration of ternary surfactants.The diameter of Au NRs can be dynamically controlled to 6,8,and 11 nm through regulating the concentration of silver nitrate and the mole ratio of ternary surfactants.Such ternary surfactants system is favorable for the aging of tiny Au NRs,and further enables the aspect ratio-tunable in the region from 2.70 to 7.32,as well as tailorable plasmonic wavelength in wide NIR window from 700 to 1,147 nm.Therefore,our findings shed a light on the precise preparation of small sized plasmonic nanoparticles and pave the way to applications in biomedicine,imaging,and cancer therapy. | Xiaoning Luo Xiaoyuan Wang Lingli Zhang Liping Song Zhiwei Sun Yu Zhao Fengmei Su Youju Huang | 2023 | Nano Research2023，16，4： | 1 |
| 17 | Genotypes Diversity of Acute Gastroenteritis Outbreaks Caused by Human Sapovirus-Beijing Municipality,China,2015-2021显示文摘Introduction:Human sapovirus(HuSaV)is an enteric virus responsible for sporadic cases and outbreaks of acute gastroenteritis(AGE)globally.A seven-year active surveillance study was conducted to investigate the molecular epidemiology of HuSaVs associated with AGE outbreaks in Chaoyang District of Beijing Municipality,China from January 2015 to December 2021.Methods:Fecal and anal swab samples were obtained from patients experiencing AGE outbreaks.HuSaVs were identified through reverse transcription polymerase chain reaction(RT-PCR),and partial viral protein 1(VP1)sequences(approximately 434 base pairs)were utilized for genotyping,single nucleotide polymorphism(SNP)analysis,and phylogenetic examination.Results:HuSaVs were identified in 71 AGE outbreaks,demonstrating a detection rate of 10.5%,second only to norovirus.The primary demographic affected by HuSaV were children under the age of 5 in kindergarten settings.Infection rates tended to peak during two distinct periods:May to June and September to December.Upon genotyping,seven distinct genotypes emerged.GII.3 was the most prevalent,accounting for 54.9%of cases,followed by GI.1(12.7%),GI.2(9.9%),GII.5(7.0%),GI.5(2.8%),GI.6(1.4%),GII.1(1.4%),and untyped cases(9.9%).A phylogenetic analysis of GII.3 identified three distinct groups,with 15 notable SNPs observed.Conclusions:This study offers a comprehensive analysis of the persistent prevalence of HuSaV outbreaks in Chaoyang District,Beijing Municipality,China.Over time,the diversity of HuSaV subtypes has shifted,and it is now recognized as the second leading viral agent responsible for AGE outbreaks.This highlights the importance of ongoing surveillance in the future. | Yang Jiao Taoli Han Xiao Qi Yan Gao Jianhong Zhao Yue Zhang Beibei Li Zheng Zhang Jialiang Du Lingli Sun | 2023 | China CDC weekly2023，5，28： | 1 |
| 18 | High-step-up and high-efficiency fuel-cell power-generation system with active-clamp flyback-forward converter显示文摘 | Li Wuhua Fan Lingli Zhao Yi | 2012 | IEEE Transactions on Industrial Electronics2012，59，1： | 1 |
| 19 | Optimization of Fermentation Process for Hyaluronic Acid Production by Streptococcus zooepidemicus显示文摘Hyaluronic acid(HA) is a high molecular weight glycosaminoglycan consisting of alternating D-glucuronic acid and N-acetylglucosamine and plays extremely important roles in many biological processes.In this study,we optimized fermentation process for the production of HA by Streptococcus zooepidemicus ATCC35246,including fermentation broth composition and various fermentation parameters.The experimental results showed that the optimal fermentation broth composition was:glucose 45 g/L,yeast extract 10 g/L,tryptone 12 g/L,KH_2PO_42 g/L,K_2HPO_4·3H_2O 2 g/L,MgSO_4 ·7H_2O2 g/L,and(NH_4)_2SO_40.4g/L.The optimal parameters involved in fermentation was:liquid volume 20%,pH 6.0,rotation speed 180 r/min,fermentation temperature 35 °C,fermentation duration 18 h,CTAB concentration 25 mg/L.Under the optimized conditions,the yield of HA was 0.305 g/L,which was dramatically improved by 43.87%compared to that of 0.212 g/L before optimization. | Jing YUAN Zhiping ZHAO Baoqu WANG Lingli WU Li ZHANG | 2015 | Agricultural Biotechnology2015，4，5： | 1 |
| 20 | Acetylation of ezrin regulates membrane–cytoskeleton interaction underlying CCL18-elicited cell migration显示文摘Ezrin,a membrane–cytoskeleton linker protein,plays an essential role in cell polarity establishment,cell migration,and division.Recent studies show that ezrin phosphorylation regulates breast cancer metastasis by promoting cancer cell survivor and promotes intrahepatic metastasis via cell migration.However,it was less characterized whether there are additional post-translational modifications and/or post-translational crosstalks on ezrin underlying context-dependent breast cancer cell migration and invasion.Here we show that ezrin is acetylated by p300/CBP-associated factor(PCAF)in breast cancer cells in response to CCL18 stimulation.Ezrin physically interacts with PCAF and is a cognate substrate of PCAF.The acetylation site of ezrin was mapped by mass spectrometric analyses,and dynamic acetylation of ezrin is essential for CCL18-induced breast cancer cell migration and invasion.Mechanistically,the acetylation reduced the lipid-binding activity of ezrin to ensure a robust and dynamic cycling between the plasma membrane and cytosol in response to CCL18 stimulation.Biochemical analyses show that ezrin acetylation prevents the phosphorylation of Thr567.Using atomic force microscopic measurements,our study revealed that acetylation of ezrin induced its unfolding into a dominant structure,which prevents ezrin phosphorylation at Thr567.Thus,these results present a previously undefined mechanism by which CCL18-elicited crosstalks between the acetylation and phosphorylation on ezrin control breast cancer cell migration and invasion.This suggests that targeting PCAF signaling could be a potential therapeutic strategy for combating hyperactive ezrin-driven cancer progression. | Xiaoyu Song Wanjuan Wang Haowei Wang Xiao Yuan Fengrui Yang Lingli Zhao McKay Mullen Shihao Du Najdat Zohbi Saravanakumar Muthusamy Yalei Cao Jiying Jiang Peng Xia Ping He Mingrui Ding Nerimah Emmett Mingming Ma Quan Wu Hadiyah-Nicole Green Xia Ding Dongmei Wang Fengsong Wang Xing Liu | 2020 | Journal of Molecular Cell Biology2020，12，6： | 1 |
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