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| 1 | Structural insights of phosphorylated into the recognition FUNDC1 by LC3B in mitophagy显示文摘 | Mengqi Lv Chongyuan Wang Fudong Li Junhui Peng Bin Wen Qingguo Gong Yunyu Shi Yajun-Tang | 2017 | Protein & Cell2017，8，1： | 21 |
| 2 | Structure of the YTH domain of human YTHDF2 in complex with an m6A mononucleotide reveals an aromatic cage for m6A recognition显示文摘 | Fudong Li Debiao Zhao Jihui Wu Yunyu Shi | 2014 | Cell Research2014，24，12： | 16 |
| 3 | Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation显示文摘在房间期间,分割要求忠诚有丝分裂的锭子汇编和染色体分离的基因信息的稳定的传播。运用了 GTPase 戏在有丝分裂的锭子汇编的一个关键角色。然而,在锭子的 Ran-GTP 的一个化学坡度的产生怎么被联合到有丝分裂的 translational 以后修正,从来没被描绘过。这里,我们解决了复杂结构与核苷酸版本因素 Mog1 跑了并且描出一个新奇有丝分裂特定的调整 acetylation 的 Ran-Mog1 相互作用在染色体分离期间。我们的指导结构的功能的分析表明那 Mog1 与 RCC1 竞争为以一种 GTP/GDP-dependent 方式变有约束力。生物化学的描述表明了那 Mog1 固定跑阻止 RCC1 有约束力、随后的 GTP 装载。令人惊讶地,跑了是 TIP60 的真正的底层,并且由 TIP60 的 Lys134 的 acetylation 解放 Mog1 从在有丝分裂期间变有约束力。重要地,这个得到 acetylation 的开关对 RCC1 变有约束力支持 Ran-GTP 的高水平,它为染色体排列是必要的。这些结果建立一以前 TIP60 由调节在提供 Ran-GTP 水平的 homeostatic 控制的规章的机制运用了的 uncharacterized 为在有丝分裂的染色体分离的受动器绑定。 | Xiaoling Bao Heng Liu Xing Liu Ke Ruan Yonshui Zhang Zhiyong Zhang Qi Hu Ying Liu Saima Akram Jiahai Zhang Qingguo Gong Wenwen wang Xiao Yuan Jian-Li Lingli Zhao Zhen Dou Ruijun Tian Xuebiao Yao Jihui Wu Yunyu Shi | 2018 | Journal of Molecular Cell Biology2018，10，1： | 8 |
| 4 | Insight into the binding properties of MEKK3 PB1 to MEK5 PB1 from Its solution structure显示文摘 | Qi Hu Shen WQ Yunyu Shi | 2007 | Biochemistry2007，46，13： | 1 |
| 5 | Structural basis of protein-protein interaction studied by NMR显示文摘 | Shi Yunyu Wu Jihui | 2007 | Journal of Structural and Functional Genomics2007，8，： | 1 |
| 6 | A computational study on geometries, electronic structures and ionization potentials of MSi15 ( M = Cr, Mo, W ) clusters by density functional method 显示文摘 | Han Juguang Shi Yunyu | 2001 | Chemical Physics2001，266，1： | 1 |
| 7 | Design of new selective inhibitors of cyclooxygenase-2 by dynamic assembly of molecular building blocks显示文摘 | Jiang Zhu Haibo Yu Hao Fan Haiyan Liu Yunyu Shi | 2001 | Journal of Computer - Aided Molecular Design2001，，5： | 1 |
| 8 | Fabrication of porous microspheres and network arrays of Zn-A1 hydrotal- cite-like compounds on A1 substrate via facile hydrothermal method 显示文摘 | Shi Ruixia Yang Ping Yin Yunyu | 2014 | Ceram Int2014，40，5： | 1 |
| 9 | A computational study on geometries,electronic structures and ionization potentials of MSi15(M=Cr,Mo,W)clusters by density functional method显示文摘 | Han Juguang Shi Yunyu | 2001 | Chemical Physics2001，266，1： | 1 |
| 10 | Solution structure of a fragment of the dimerization domain of DP-1 determined by 1 H-nuclear magnetic resonance and distance geometry显示文摘 | Shouhong Guang Jihui Wu Tianning Yu Youlin Xia Yunyu Shi | 1998 | Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular Enzymology1998，，1： | 1 |
| 11 | Quasiequilibrium unfolding thermodynamics of a small protein studied by molecular dynamics simulation with an explicit water model显示文摘 | Jihua Wang Zhiyong Zhang Yunyu Shi | 2003 | Phys Rev E2003，67，： | 1 |
| 12 | A case study for intercomparison of land surface temperature retrieved from GOES and MODIS显示文摘In recent years,algorithms have been developed to derive land surface temperature(LST)from geostationary and polar satellite systems.However,few works have addressed the intercomparison between Geostationary Operational Environmental Satellites(GOES)and the available suite of polar sensors.In this study,differences in LSTs between GOES and MODerate resolution Imaging Spectroradiometer(MODIS)have been compared and also evaluated against ground observations.Due to the lack of split-window(SW)channels in the GOES M(12)-Q era,a dual-window algorithm using a mid-infrared 3.9µm channel is compared with traditional SW algorithm.It is found that the differences in LST between different platforms are bigger during daytime than those during nighttime.During daytime,LSTs from GOES with the dualwindow algorithm are warmer than MODIS LSTs,while LSTs from the SW algorithm are close to MODIS LSTs.The difference during daytime is found to be related to anisotropy in satellite viewing geometry,and land surface properties,such as vegetation cover and especially surface emissivity at middle infrared(MIR)channel.When evaluated against ground observations,the standard deviation(precision)error(2.35 K)from the dual window algorithm is worse than that(1.83 K)from the SW algorithm,indicating the lack of split-window channel in the GOES M(12)-Q era may degrade the performance of LST retrievals. | Donglian Sun Yunyue Yu Hequn Yang Li Fang Qinhuo Liu Jiancheng Shi | 2015 | International Journal of Digital Earth2015，8，6： | 1 |
| 13 | Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosome binding显示文摘 | Juncheng Wang Su Qin Fudong Li Sai Li Wei Zhang Junhui Peng Zhiyong Zhang Qingguo Gong Jihui Wu Yunyu Shi | 2014 | Cell Research2014，24，7： | 0 |
| 14 | Pijx confers broad-spectrum seedling and panicle blast resistance by promoting the degradation of ATP β subunit and OsRbohC-mediated ROS burst in rice显示文摘Rice blast,caused by the fungal pathogen Magnaporthe oryzae,is one of the most important diseases of rice.Utilization of blast-resistance genes is the most economical,effective,and environmentally friendly way to control the disease.However,genetic resources with broad-spectrum resistance(BSR)that is effective throughout the rice growth period are rare.In this work,using a genome-wide association study,we identify a new blast-resistance gene,Pijx,which encodes a typical CC-NBS-LRR protein.Pijx is derived from a wild rice species and confers BSR to M.oryzae at both the seedling and panicle stages.The functions of the resistant haplotypes of Pijx are confirmed by gene knockout and overexpression experiments.Mechanistically,the LRR domain in Pijx interacts with and promotes the degradation of the ATP synthase β subunit(ATPb)via the 26S proteasome pathway.ATPb acts as a negative regulator of Pijx-mediated panicle blast resistance,and interacts with OsRbohC to promote its degradation.Consistently,loss of ATPb function causes an increase in NAPDH content and ROS burst.Remarkably,when Pijx is introgressed into two japonica rice varieties,the introgression lines show BSR and increased yields that are approximately 51.59%and 79.31%higher compared with those of their parents in a natural blast disease nursery.In addition,we generate PPL^(Pijx Pigm) and PPL^(Pijx Piz-t) pyramided lines and these lines also have higher BSR to panicle blast compared with Pigm-or Piz-t-containing rice plants.Collectively,this study demonstrates that Pijx not only confers BSR to M.oryzae but also maintains high and stable rice yield,providing new genetic resources and molecular targets for breeding rice varieties with broad-spectrum blast resistance. | Ning Xiao Yunyu Wu Xiaoxiang Zhang Zeyun Hao Zichun Chen Zefeng Yang Yue Cai Ruyi Wang Ling Yu Zhiping Wang Yue Lu Wei Shi Cunhong Pan Yuhong Li Changhai Zhou Jianju Liu Niansheng Huang Guangqing Liu Hongjuan Ji Shuhao Zhu Shuai Fang Yuese Ning Aihong Li | 2023 | Molecular Plant2023，16，11： | 0 |
| 15 | CRISPR-Cas9-mediated editing of the OsHPPD 30 UTR confers enhanced resistance to HPPDinhibiting herbicides in rice显示文摘Dear Editor,Loss of yield because of competition from weeds restricts the production of rice(Oryza sativa L.)(Maeda et al.,2019).Application of chemical herbicides is currently the most effective method for controlling weeds during rice production,especially in modern simplified cultivation systems.However,long-term and extensive use of herbicides,such as inhibitors of the enzymes 5-enolpyruvylshikimate-3-phosphate synthase,acetolactate synthase,and acetyl-coenzyme A carboxylase,has resulted in the emergence of herbicide-resistant weed species as well as soils with high levels of herbicide residues,which limit crop rotation.Therefore,there is an urgent need for alternative herbicides and breeding of corresponding herbicideresistant rice varieties. | Yunyu Wu Ning Xiao Yue Cai Qian Yang Ling Yu Zichun Chen Wei Shi Jianju Liu Cunhong Pan Yuhong Li Xiaoxiang Zhang Changhai Zhou Niansheng Huang Hongjuan Ji Shuhao Zhu Aihong Li | 2023 | Plant Communications2023，4，5： | 0 |
| 16 | Incorporating density functional potential in classical molecular dynamics simulation显示文摘UNDERSTANDING the properties of reactions in condensed phases, e.g. in solutions or in enzymes, is one of the most challenging questions to both physical chemists and biological chemists. Classical molecular mechanics potential, though widely tested and employed in molecular dynamics simulation, is not feasible to simulating the reaction process where the quantum effects are dominative. Several hybrid approaches have been proposed to combine quantum mechanics (QM) potential with molecular mechanics (MM) potential, in which the reaction site is treated quantum mechanically, and the environment classically.The substantial differences among those hybrid strategies are the QM models employed to treat reaction site, which includes empirical VB models, semi-empirical molecular orbital models (MNDO, AM1,PM3), Hartree-Fock models, etc. Recently, density functional (DF) theory has been tested as the quantum mechanics model in the hybrid method to treat the reaction site. As another 'ab initial' theory,DF | Hao Hu Haiyan Liu Yunyu Shi | 1999 | Chinese Science Bulletin1999，44，3： | 0 |
| 17 | Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4显示文摘 | Aiai Sun Fudong Li Zhonghua Liu, Yiyang Jiang Jiahai Zhang Jihui Wu Yunyu Shi | 2018 | Protein & Cell2018，9，8： | 0 |
| 18 | Structural insights reveal the specific recognition of meiRNA by the Mei2 protein显示文摘In the fission yeast Schizosaccharomyces pombe,Mei2,an RNA-binding protein essential for entry into meiosis,regulates meiosis initiation.Mei2 binds to a specific non-coding RNA species,meiRNA,and accumulates at the sme2 gene locus,which encodes meiRNA.Previous research has shown that the Mei2 C-terminal RNA recognition motif(RRM3)physically interacts with the meiRNA 5'region in vitro and stimulates meiosis in vivo.However,the underlying mechanisms still remain elusive.We first employed an in vitro crosslinking and immunoprecipitation sequencing(CLIP-seq)assay and demonstrated a preference for U-rich motifs of meiRNA by Mei2 RRM3.We then solved the crystal structures of Mei2 RRM3 in the apo form and complex with an 8 mer RNA fragment,derived from meiRNA,as detected by in vitro CLIP-seq.These results provide structural insights into the Mei2 RRM3-meiRNA complex and reveal that Mei2 RRM3 binds specifically to the Uuc(U)sequence.Furthermore,a structure-based Mei2 mutation,Mei2F644A causes defective karyogamy,suggesting an essential role of the RNA-binding ability of Mei2 in regulating meiosis. | Siyuan Shen Yanze jian Zhaokui Cai Fudong Li Mengqi Lv Yongrui Liu Jihui Wu Chuanhai Fu Yunyu Shi | 2022 | Journal of Molecular Cell Biology2022，14，5： | 0 |
| 19 | The 11th C2H2 zinc finger and an adjacent C-terminal arm are responsible for TZAP recognition of telomeric DNA显示文摘 | Yaqing Zhao Guang ,Zhang Chao He Yide Mei Yunyu Shi Fudong Li | 2018 | Cell Research2018，28，1： | 0 |
| 20 | Structural insights into the recognition ofγ-globin gene promoter by BCL11A显示文摘Dear Editor,In humans,theβ-like globin genes are encoded from a single locus comprising five globin genes(ε-,Gγ-,Aγ-,δ-,andβ-globin in sequence)and their expression is under critical developmental control(Fig.1a).Theγ-globin genes(Gγ-and Aγ-)are expressed during fetal life,and then replaced by adultβ-globin after birth. | Yang Yang Ziyan Xu Chao He Beibei Zhang Yunyu Shi Fudong Li | 2019 | Cell Research2019，29，11： | 0 |
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