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| 1 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 2 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum显示文摘典型药用的植物的主要成分,蓼 multiflorum (用汉语的 Heshouwu ) ,那导致特质的肝损害仍然保持不清楚。我们的以前的工作证明了有 lipopolysaccharide (LPS ) 的无毒的剂量和 Heshouwu 的治疗学的剂量的 cotreatment 能在老鼠导致肝损害,而独唱治疗不能导致看得见的损害。在现在的工作,用成分大美人和敲门在里面策略,我们发现 Heshouwu 的乙醇醋酸盐(EA ) 摘录在对待 LPS 的老鼠显示了可比较的特质的 hepatotoxicity 到整个摘录。结果显示血浆丙氨酸 aminotransferase, aspartate aminotransferase,和肝 histologic 的重要举起变化,而另外的分开的部分没能导致肝损害。有另外的分开的部分的 EA 摘录的混合在对待 LPS 的老鼠导致了可比较的特质的 hepatotoxicity 到整个摘录。化学分析进一步揭示了那 2,3,5,4-tetrahydroxy trans-stilbene-2-O -- 配糖物(trans-SG ) 和它的 cis 异构体是在 EA 的二主要混合物摘录。而且,孤立的 cis- ,并且不它的 trans 异构体,显示的可比较的特质的 hepatotoxicity 到在对待 LPS 的老鼠的 EA 摘录。cis-SG 的更高的内容从与收集的将军相比与 Heshouwu 联系的实际的肝沉醉病人在 Heshouwu 白酒或准备被检测样品。另外,血浆 metabolomics 分析证明 cis-SG-disturbing 充实显著地不同于的小径在对待 LPS 的老鼠的 trans-SG。所有这些结果建议 cis-SG 仔细与 Heshouwu 的特质的 hepatotoxicity 被联系。认为 trans-SG 的 cis-trans 异构化被紫外光或日光调停,我们的调查结果为在药发现控制 photoisomerization 并且为 Heshouwu 和芪相关的药的临床的使用用作参考。 | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2017 | Frontiers of Medicine2017，11，2： | 41 |
| 3 | LARGE-EDDY SIMULATION OF TURBULENT FLOW CONSIDERING INFLOW WAKES IN A FRANCIS TURBINE BLADE PASSAGE显示文摘Turbulent flow in a 3-D blade passage of a Francis hydro turbine was simulated with the Large Eddy Simulation (LES) to investigate the spatial and temporal distributions of the turbulence when strongly distorted wakes in the inflow sweep over the passage. In a suitable consideration of the energy exchanging mechanism between the large and small scales in the complicated passage with a strong 3-D curvature,one-coefficient dynamic Sub-Grid-Scale (SGS) stress model was used in this article. The simulations show that the strong wakes in the inflow lead to a flow separation at the leading zone of the passage,and to form a primary vortex in the span-wise direction. The primary span-wise vortex evolves and splits into smaller vortex pairs due to the constraint of no-slip wall condition,which triggers losing stability of the flow in the passage. The computed pressures on the pressure and suction sides agree with the measured data for a working test turbine model. | WANG Wen-quan ZHANG Li-xiang YAN Yan GUO Yakun | 2007 | Journal of Hydrodynamics2007，19，2： | 12 |
| 4 | Toward Intelligent Machine Tool显示文摘With the development of modern information technology-and particularly of the new generation of artificial intelligence(AI)technology-new opportunities are available for the development of the intelligent machine tool(IMT).Based on the three classical paradigms of intelligent manufacturing as defined by the Chinese Academy of Engineering,the concept,characteristics,and systemic structure of the IMT are presented in this paper.Three stages of machine tool evolution-from the manually operated machine tool(MOMT)to the IMT-are discussed,including the numerical control machine tool(NCMT),the smart machine tool(SMT),and the IMT.Furthermore,the four intelligent control principles of the IMT-namely,autonomous sensing and connection,autonomous learning and modeling,autonomous optimization and decision-making,and autonomous control and execution-are presented in detail.This paper then points out that the essential characteristic of the IMT is to acquire and accumulate knowledge through learning,and presents original key enabling technologies,including the instruction-domain-based analytical approach,theoretical and big-data-based hybrid modeling technology,and the double-code control method.Based on this research,an intelligent numerical control(INC)system and industrial prototypes of IMTs are developed.Three intelligent practices are conducted,demonstrating that the integration of the new generation of AI technology with advanced manufacturing technology is a feasible and convenient way to advance machine tools toward the IMT. | Jihong Chen Pengcheng Hu Huicheng Zhou Jianzhong Yang Jiejun Xie Yakun Jiang Zhiqiang Gao Chenglei Zhang | 2019 | Engineering2019，5，4： | 12 |
| 5 | The Limiting Effect of Deep Soil Water on Evapotranspiration of a Subtropical Coniferous Plantation Subjected to Seasonal Drought显示文摘Seasonal drought is a common occurrence in humid climates. The year 2003 was the driest year during the period 1985– 2011 in southeastern China. The objective of this study was to elucidate the impact of the exceptional drought in 2003, compared with eddy flux measurements during 2004–11, on the dynamics of evapotranspiration(ET) and related factors, as well as their underlying mechanisms, in a subtropical coniferous plantation in southeastern China. It was found that daily ET decreased from 5.34 to 1.84 mm during the intensive drought period and recovered to 4.80 mm during the subsquent recovering drought period. Path analysis indicated that ET was mainly determined by canopy conductance and deep soil water content(50 cm) during the intensive drought and recovering drought periods, respectively. The canopy conductance offset the positive effect of air vapor pressure deficit on ET when suffering drought stress, while the canopy conductance enhanced the positive effect of air temperature on ET during the late growing season. Because the fine roots of this plantation are mainly distributed in shallow soil, and the soil water in the upper 40 cm did not satisfy the demand for ET, stomatal closure and defoliation were evident as physiological responses to drought stress. | TANG Yakun WEN Xuefa SUN Xiaomin ZHANG Xinyu WANG Huimin | 2014 | Advances in Atmospheric Sciences2014，31，2： | 11 |
| 6 | DEVELOPMENT AND APPLICATION OF A EUTROPHICATION WATER QUALITY MODEL FOR RIVER NETWORKS显示文摘The Preissmann implicit scheme was used to discretize the one-dimensional Saint-Venant equations, the river-junction-river method was applied to resolve the hydrodynamic and water quality model for river networks, and the key issues on the model were expatiated particularly in this article. This water quality module was designed to compute time dependent concentrations of a series of constituents, which are primarily governed by the processes of advection, dispersion and chemical reactions. Based on the theory of Water Quality Analysis Simulation Program (WASP) water quality model, emphasis was given to the simulation of the biogeochemical transformations that determine the fate of nutrients, in particular, the simulation of the aquatic cycles of nitrogen and phosphorus compounds. This model also includes procedures for the determination of growth and death of phytoplankton. This hydrodynamic and water quality model was applied to calculate two river networks. As illustrated by the numerical examples, the calculated water level and discharge agree with the measured data and the simulated trends and magnitudes of water quality constituents are generally in good agreement with field observations. It is concluded that the presented model is useful in the pollutant control and in the determination of pollutant-related problems for river networks. | ZHANG Ming-liang SHEN Yong-ming GUO Yakun | 2008 | Journal of Hydrodynamics2008，20，6： | 8 |
| 7 | Multi-omics analyses of 398 foxtail millet accessions reveal genomic regions associated with domestication,metabolite traits,and antiinflammatory effects显示文摘Foxtail millet(Setaria italica),which was domesticatedfromthewild speciesgreenfoxtail(Setaria viridis),isa richsource of phytonutrientsfor humans.To evaluate how breeding changed themetabolome offoxtail millet grains,we generated and analyzed the datasets encompassing the genomes,transcriptomes,metabolomes,and anti-inflammatory indices from 398 foxtail millet accessions.We identified hundreds of common variants that influence numerous secondary metabolites.We observed tremendous differences in natural variations of the metabolites and their underlying genetic architectures between distinct sub-groups of foxtail millet.Furthermore,we found that the selection of the gene alleles associated with yellow grains led to altered profiles of metabolites such as carotenoids and endogenous phytohormones.Using CRiSPR-mediated genome editing wevalidated the function of PHYTOENE SYNTHASE1(PSY1)gene in affecting milletgrain colorand quality.Interestingly,our in vitro cell inflammation assays showed that 83 metabolites in millet grains have anti-inflammatory effects.Taken together,ourmulti-omics study illustrates how the breeding history of foxtail millet has shaped its metabolite profile.The datasets we generated in this study also provide important resources for further understanding how millet grain quality is affected by different metabolites,laying the foundations for future millet genetic research and metabolome-assisted improvement. | Xukai Li Jianhua Gao Jingyi Song Kai Guo Siyu Hou Xingchun Wang Qiang He Yanyan Zhang Yakun Zhang Yulu Yang Jiaoyan Tang Hailang Wang Staffan Persson Mingquan Huang Lishuai Xu Linlin Zhong Dongqin Li Yongming Liu Hua Wu Xianmin Diao Peng Chen Xiaowen Wang Yuanhuai Han | 2022 | Molecular Plant2022，15，8： | 8 |
| 8 | Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas显示文摘Invasive nonfunctional pituitary adenomas(NFPAs) are difficult to completely resect and often develop tumor recurrence after initial surgery.Currently,no medications are clinically effective in the control of NFPA.Although radiation therapy and radiosurgery are useful to prevent tumor regrowth,they are frequently withheld because of severe complications.Boron neutron capture therapy(BNCT) is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue.Folate receptor(FR)-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis.In this study,FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas.After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons,the cell viability of NFPAs was significantly decreased,while apoptotic cells were simultaneously increased.However,cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells.The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT.In conclusion,FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs cells for BNCT.Furthermore,our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy,while exploring these new applications of BNCT for tumors,especially benign tumors. | DAI CongXin CAI Feng HWANG Kuo Chu ZHOU YongMao ZHANG ZiZhu LIU XiaoHai MA SiHai YANG YaKun YAO Yong FENG Ming BAO XinJie LI GuiLin WEI JunJi JIAO YongHui WEI ZhenQing MA WenBin WANG RenZhi | 2013 | Science China(Life Sciences)2013，56，2： | 8 |
| 9 | INTRINSIC FEATURES OF TURBULENT FLOW IN STRONGLY 3-D SKEW BLADE PASSAGE OF A FRANCIS TURBINE显示文摘The turbulent flow, with the Reynolds number of 5.9× 105, in the strongly 3-D skew blade passage of a true Francis hydro turbine was simulated by the Large Eddy Simulation (LES) approach to investigate the spatial and temporal distributions of the fully developed turbulence in the passage with strongly 3-D complex geometry. The simulations show that the strong three-dimensionality of the passage has a great amplification effect on the turbulence in the passage, and the distributions of the turbulence are diversely nonuniform, for instance, the rise of turbulent kinetic energy in the lower 1/3 region of the passage is more than 45%, whereas its rise in the upper 1/3 region is less than 1%. With the LES approach, the details of the flow structures at the near-wall surfaces of the blades could be obtained. Several turbulent spots were captured. | ZHANG Li-xiang WANG Wen-quan GUO Yakun | 2007 | Journal of Hydrodynamics2007，19，1： | 7 |
| 10 | Effects of drought stress on photosynthesis and chlorophyll fluorescence images of soybean(Glycine max)seedlings显示文摘The main purpose of this research is to provide a theoretical foundation for the screening of drought-resistant soybean varieties and to establish an efficient method to detect the PSII actual photochemical quantum yields efficiently.Three soybean varieties were compared in this experiment after 15 d when they were planted in a greenhouse.These varieties were then exposed to light drought stress(LD)and serious drought stress(SD)conditions.With five times’measurement,chlorophyll fluorescence and soil-plant analysis development considered as the main basis for this study.Several parameters in SD conditions significantly reduced,such as net photosynthetic rates(Pn),stomatal conductance(Gs),PSII primary light energy conversion efficiency(Fv/FM),PSII actual photochemical quantum yields[Y(II)],photochemical quenching coefficient(qP)and non-photochemical quenching coefficient(qN).The soybeans in the seedling stage adapted to the inhibitory effect of drought stress on photosynthesis through stomatal limitation.Under serious drought stress,non-stomatal limitation damaged the plant photosynthetic system.The amplitudes of Pn and Y(II)of drought-resistant Qihuang 35 were lower than those of the two other varieties.Based on the data of this study,a new method had been developed to detect Y(II)which reflected the photosynthetic capacity of plant,R=0.85989,u=0.048803 when using multiple linear regression,and R=0.84285,u=0.054739 when using partial least square regression. | Wensen Wang Cheng Wang Dayu Pan Yakun Zhang Bin Luo Jianwei Ji | 2018 | International Journal of Agricultural and Biological Engineering2018，11，2： | 7 |
| 11 | STUDY ON TURBULENCE FEATURES NEAR AN OSCILLATING CURVED WALL显示文摘In pursuit of possibly true turbulent characters and for exploring a change in turbulence structures near an oscillating flexible wall-curved surface, a sinusoidal oscillation mode was forced to a curved wall, whose vibrations disturbed the flow with an interacting effort between the fluid and the structure. The methodology used was the Large Eddy Simulation (LES) with fluid-structure interaction. The oscillating configuration was on a Fourier sinusoidal mode from the measurements of a Francis hydro turbine blade vibration. The effects of the vibration on the skin friction coefficient, vortices, turbulent coherent structures, and other statistical quantities were studied. The results showed that the streamwise velocity gradient along the normal direction and the normal velocity gradient along the spanwise direction were considerably increased within the viscous sublayer because of the oscillating wall, which additionally caused the low speed streaks to stay away from the wall and the high-momentum flows to be toward the wall. As a result, the streamwise vortices were much more elongated along the downstream to get an energy balance, and the wall skin friction coefficient or the wall friction velocity rose up. | WANG Wen-quan ZHANG Li-xiang YAN Yan GUO Yakun | 2007 | Journal of Hydrodynamics2007，19，3： | 4 |
| 12 | Study on the FEM design of reinforced earth retaining wall with geogrid显示文摘At present,limit equilibrium method is often adopted in the design of reinforced earth retaining wall. Geotechnical engineers home and abroad have done a lot of work to improve the traditional calculation methods in recent years,while there are lots of defects. This paper first identifies the location of failure surface and safety factor through the finite element program of PLAXIS and then analyses the influencing factors of the stability of reinforced earth retaining wall with geogrid. The authors adopt strength reduction FEM (finite element method)in the design and stability analysis of reinforced earth retaining wall and have achieved some satisfying results. Without any assumptions,the new design method can automatically judge the failure mode of reinforced earth retaining wall,consider the influence of axial tensile stiffness of the reinforcement stripe on the stability of retaining wall,identify reasonable distance and length of the reinforcement stripe,and choose suitable parameters of reinforcement stripe,including strength,stiffness and pseudo-friction coefficient which makes the design optimal. It is proved through the calculation examples that this method is more reasonable,reliable and economical in the design of reinforced earth retaining wall. | Song Yakun Zheng Yingren Tang Xiaosong Zhang Yufang | 2010 | Engineering Sciences2010，8，3： | 4 |
| 13 | Microwave-hydrothermal preparation of a graphene/hierarchy structure MnO_2 composite for a supercapacitor显示文摘Graphene/hierarchy structure manganese dioxide(GN/MnO_2) composites were synthesized using a simple microwave-hydrothermal method.The properties of the prepared composites were analyzed using field emission scanning electron microscopy(FE-SEM),X-ray diffraction(XRD),transmission electron microscopy(TEM),and X-ray photoelectron spectroscopy(XPS) measurements.The electrochemical performances of the composites were analyzed using cyclic voltammetry,electrochemical impedance spectrometry(EIS),and chronopotentiometry.The results showed that GN/MnO_2(10wt% graphene) displayed a specific capacitance of 244F/gat a current density of 100mA/g.An excellent cyclic stability was obtained with a capacity retention of approximately 94.3% after 500 cycles in a 1 mol/L Li_2SO_4 solution.The improved electrochemical performance is attributed to the hierarchy structure of the manganese dioxide,which can enlarge the interface between the active materials and the electrolyte.The preparation route provides a new approach for hierarchy structure graphene composites;this work could be readily extended to the preparation of other graphene-based composites with different structures for use in energy storage devices. | Zhong Chen Jianling Li Yu Chen Yakun Zhang Guofeng Xu Jun Yang Ye Feng | 2014 | Particuology2014，12，4： | 4 |
| 14 | Numerical investigation on critical length of impermeable plate below underwater pipeline under steady current显示文摘This study proposes a new approach in which an impermeable plate is placed under the pipeline to prevent the local scour around the pipeline.In order to understand the performance of this approach,the finite volume method(FVM) and volume of fluid(VOF) method are adopted to simulate the flow field around the pipeline.The pressure distribution along the sandy bed surface is obtained by considering the variation of water surface.Furthermore,the effects of water depth,unidirectional and bidirectional impermeable plates on pressure difference are discussed.The seepage flow field of sandy bed near underwater pipeline is numerically simulated using the laminar and porous media model.On this basis,the effect of the impermeable plate length on hydraulic gradient is investigated and the critical length of impermeable plate is obtained.The simulated results show that when the water depth is smaller than 5.00D(D is the diameter of pipeline),the effect of the water depth on the pressure difference is remarkable.The pressure differences between two endpoints of both the unidirectional and bidirectional plates decrease with the increase of the plate length.The variations of the pressure differences for both the unidirectional and bidirectional plates are similar.With the increase of plate length,the hydraulic gradient decreases and the piping at the seepage exit is avoided effectively as long as it reaches a certain length.Such a critical length of the plate decreases with the increase of the water depth.When water depth is larger than 4.00D,the effect of the water depth on the critical length is small.For the same water depth,the critical length of impermeable plate increases with the increase of the dimensionless flow parameter.Numerical simulation results are in good agreement with the available experimental measurements. | ZHANG ZhiYong SHI Bing GUO YaKun YANG LiPeng | 2013 | Science China(Technological Sciences)2013，56，5： | 4 |
| 15 | The impact of high hydrostatic pressure treatment time on the structure,gelatinization and thermal properties and in vitro digestibility of oat starch显示文摘As a non-thermal processing technology,high hydrostatic pressure(HHP)can be used for starch modification without affecting the quality and flavour constituents.The effect of HHP on starch is closely related to the treatment time of HHP.In this paper,we investigated the impacts of HHP treatment time(0,5,10,15,20,25,30 min)on the microstructure,gelatinization and thermal properties as well as in vitro digestibility of oat starch by scanning electron microscopy,X-ray diffraction,Fourier transform infrared spectroscopy,13C NMR and differential scanning calorimeter.Results showed that 5-min HHP treatment led to deformation and decreases in short-range ordered and doublehelix structures of oat starch granules,and further extending the treatment time to 15 min or above caused the formation of a gelatinous connection zone,increase of particle size,disintegration of short-range ordered and double-helix structures,and crystal structure change from A type to V type,indicating gelatinization occurred.Longer treatment time also resulted in the reduction in both the viscosity and the stability of oat starch.These indicated that HHP treatment time greatly influenced the microstructure of oat starch,and the oat starch experienced crystalline destruction(5 min),crystalline disintegration(15 min)and gelatinization(>15 min)during HHP treatment.Results of in vitro digestibility showed that the rapidly digestible starch(RDS)content declined first after treatment for 5 to 10 min then rose with the time extending from 15 to 30 min,indicating that longer pressure treatment time was unfavourable to the health benefits of oat starch for humans with diabetes and cardiovascular disease.Therefore,the 500-MPa treatment time for oat starch is recommended not more than 15 min.This study provides theoretical guidance for the application of HHP technology in starch modification and development of health foods. | Jing Zhang Meili Zhang Xue Bai Yakun Zhang Chen Wang | 2022 | Grain & Oil Science and Technology2022，5，1： | 4 |
| 16 | The construction of personalized virtual landslide disaster environments based on knowledge graphs and deep neural networks显示文摘Virtual Landslide Disaster environments are important for multilevel simulation,analysis and decision-making about Landslide Disasters.However,in the existing related studies,complex disaster scene objects and relationships are not deeply analyzed,and the scene contents are fixed,which is not conducive to meeting multilevel visualization task requirements for diverse users.To resolve the above issues,a construction method for Personalized Virtual Landslide Disaster Environments Based on Knowledge Graphs and Deep Neural networks is proposed in this paper.The characteristics of relationships among users,scenes and data were first discussed in detail;then,a knowledge graph of virtual Landslide Disaster environments was established to clarify the complex relationships among disaster scene objects,and a Deep Neural network was introduced to mine the user history information and the relationships among object entities in the knowledge graph.Therefore,a personalized Landslide Disaster scene data recommendation mechanism was proposed.Finally,a prototype system was developed,and an experimental analysis was conducted.The experimental results show that the method can be used to recommend intelligently appropriate disaster information and scene data to diverse users.The recommendation accuracy stabilizes above 80%–a level able to effectively support The Construction of Personalized Virtual Landslide Disaster environments. | Yunhao Zhang Jun Zhu Qing Zhu Yakun Xie Weilian Li Lin Fu Junxiao Zhang Jianmei Tan | 2020 | International Journal of Digital Earth2020，13，12： | 3 |
| 17 | Sampling Designs for Validating Digital Soil Maps: A Review显示文摘Sampling design(SD) plays a crucial role in providing reliable input for digital soil mapping(DSM) and increasing its efficiency.Sampling design, with a predetermined sample size and consideration of budget and spatial variability, is a selection procedure for identifying a set of sample locations spread over a geographical space or with a good feature space coverage. A good feature space coverage ensures accurate estimation of regression parameters, while spatial coverage contributes to effective spatial interpolation.First, we review several statistical and geometric SDs that mainly optimize the sampling pattern in a geographical space and illustrate the strengths and weaknesses of these SDs by considering spatial coverage, simplicity, accuracy, and efficiency. Furthermore, Latin hypercube sampling, which obtains a full representation of multivariate distribution in geographical space, is described in detail for its development, improvement, and application. In addition, we discuss the fuzzy k-means sampling, response surface sampling, and Kennard-Stone sampling, which optimize sampling patterns in a feature space. We then discuss some practical applications that are mainly addressed by the conditioned Latin hypercube sampling with the flexibility and feasibility of adding multiple optimization criteria. We also discuss different methods of validation, an important stage of DSM, and conclude that an independent dataset selected from the probability sampling is superior for its free model assumptions. For future work, we recommend: 1) exploring SDs with both good spatial coverage and feature space coverage; 2) uncovering the real impacts of an SD on the integral DSM procedure;and 3) testing the feasibility and contribution of SDs in three-dimensional(3 D) DSM with variability for multiple layers. | Asim BISWAS Yakun ZHANG | 2018 | Pedosphere2018，28，1： | 3 |
| 18 | Subtyping of type A influenza by sequencing the variable regions of HA gene specifically amplified with RT-PCR显示文摘The outbreak of a novel influenza A(H1N1) virus across the globe poses a threat to human health.It is of paramount importance to develop a rapid,reliable and inexpensive diagnostic procedure.Based on the bioinformatic information from public database,primers specific for influenza A virus surface protein haemagglutinin(HA) of several subtypes(including H1,H2,H3,H5,H7 and H9) were designed.Primer-specific PCR products were subjected to sequencing for accurately distinguishing H1 and H3 subtypes from others.This sequencing-based detection method will not only be applied to rapid detection and simultaneous subtype identification of new influenza A virus H1N1,but also provide the strategies to monitor other new types ofinfluenza virus with explosive potential. | YAN An DING GuoHui ZHOU ZhenFeng DONG Hui ZHANG YaKun ZHU Lei HE YunGang ZHANG GuoQing LI YiXue SUN Bing HUANG Zhong LAN Ke JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenGan ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN WeiRong XIONG Hui | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 19 | Respiratory Control by Phox2b-expressing Neurons in a Locus Coeruleus–pre B?tzinger Complex Circuit显示文摘The locus coeruleus(LC) has been implicated in the control of breathing.Congenital central hypoventilation syndrome results from mutation of the paired-like homeobox 2 b(Phox2 b) gene that is expressed in LC neurons.The present study was designed to address whether stimulation of Phox2 b-expressing LC(Phox2 b~(LC)) neurons affects breathing and to reveal the putative circuit mechanism.A Cre-dependent viral vector encoding a Gqcoupled human M3 muscarinic receptor(hM3 Dq) was delivered into the LC of Phox2 b-Cre mice.The hM3 Dqtransduced neurons were pharmacologically activated while respiratory function was measured by plethysmography.We demonstrated that selective stimulation of Phox2 b~(LC) neurons significantly increased basal ventilation in conscious mice.Genetic ablation of these neurons markedly impaired hypercapnic ventilatory responses.Moreover,stimulation of Phox2 b~(LC) neurons enhanced the activity of preBotzinger complex neurons.Finally,axons of Phox2 b~(LC) neurons projected to the preBotzinger complex.Collectively,Phox2 b~(LC) neurons contribute to the control of breathing most likely via an LC-preBotzinger complex circuit. | Na Liu Congrui Fu Hongxiao Yu Yakun Wang Luo Shi Yinchao Hao Fang Yuan Xiangjian Zhang Sheng Wang | 2021 | Neuroscience Bulletin2021，37，1： | 3 |
| 20 | Evaluation of SARS-CoV-2-Neutralizing Nanobody Using Virus Receptor Binding Domain-Administered Model Mice显示文摘Due to the rapid spread of coronavirus disease 2019(COVID-19),there is an urgent requirement for the development of additional diagnostic tools for further analysis of the disease.The isolated nanobody Nb11-59 binds to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)reeptor-binding domain[RBD]with high afinity to neutralize the virus and block the angiotensin-converting enzyme 2-(ACE2-)RBD interaction.Here,we introduce a novel nanobody-based radiotracer named^(68)Ga-Nb1159.The radiotracer retained high affinity for the RBD and showed reliable radiochemical characteristics both in vitro and in vivo.Predinical positron emission tomography(PET)studies of Ga-Nb1159 in mice revealed is rapid dearance from circulation and robust uptake into the renal and urinary systems.Fortunately,^(68)Ga-Nb1159 could speifcally reveal the distribution of the RBD in mice.This sudy also helped to evaluate the pharmacodynamic efects of the neutralizing nanobody.Moreover,^(68)Ga-Nb1159 may be a promising l0ol lo explore the distribution of the RBD and improve the understanding of the virus.In particular,this study identified a novel molecular radioagent and established a reliable evaluation method for speifially investigating the RBD through noninvasive and visual PET technology. | Song Liu Guanghui Li Lei Ding Jin Ding Qian Zhang Dan Li Xingguo Hou Xiangxing Kong Jing Zou Shiming Zhang Hongbin Han Yakun Wan Zhi Yang Hua Zhu | 2022 | Research2022，，2： | 2 |
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