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| 1 | Outbreak of Dengue Fever in Central China,2013显示文摘In 2013,the first dengue fever(DF) outbreak in central China was reported in the central of Henan province,northern temperate regions,although they have been sequentially recorded in Southern China.106 suspected DF cases were reported and 73 patients were confirmed dengue virus type 3(DEN-3) infections.62/392(15.8%) local health persons showed DEN antibodies positive.To this day Henan is the northernmost province in China which has been reported about outbreak of DF and what is important is that it warns us the endemic range of DF has been expanded geographically in China. | HUANG Xue Yong MA Hong Xia WANG Hai Feng DU Yan Hua SU Jia LI Xing Le TANG Xiao Yan MA Hong Peng ZU Bing Can ZHANG Qiao Hong CHEN Hao Min XU Bian Li | 2014 | Biomedical and Environmental Sciences2014，27，11： | 30 |
| 2 | Relationship between expression of CD44v6 and nm23-H1 and tumor invasion and metastasis in hepatocellular carcinoma显示文摘INTRODUCTIONCD44isacelsurfacetransmembraneglycoprotein.Asakindofadhesivemolecule,itparticipatesincelcelandcelmatrixadhesion... | XIAO Cheng Zhi, DAI Yi Min, YU Hong Yu, WANG Jian Jun and NI Can Rong | 1998 | World Journal of Gastroenterology1998，4，5： | 23 |
| 3 | Exosomes from Suxiao Jiuxin pill-treated cardiac mesenchymal stem cells decrease H3K27 demethylase UTX expression in mouse cardiomyocytes in vitro显示文摘Suxiao Jiuxin 药片(SJP ) 是为在中国的急性冠的症候群的处理的繁体中文药,它包含二个主要部件, tetramethylpyrazine (TMP ) 和龙脑(BOR ) 。因此远然而,在心脏的微型环境上位于 SJP 的有益的效果下面的分子的机制是未知的。心脏的间充质的干细胞(C-MSCs ) 通过 microvesicles (exosomes ) 的版本与 cardiomyocytes (厘米) 交流恢复心脏的动态平衡并且得到修理,部分地通过 epigenetic 规章的机制。在这研究,我们检验了 SJP 处理是否改变了 C-MSC-derived exosomes (SJP-Exos ) 引起 epigenetic 在接受者厘米的色彩的改变。从老鼠心孤立的 C-MSC 是有 SJP (SJP-Exos ) 的 pretreated, TMP (TMP-Exos ) 或 BOR (BOR-Exos ) 。然后, HL-1 房间,一根鼠标 cardiomyocyte 线,从控制与 exosomes 被对待 C-MSCs (Ctrl-Exos ) , SJP-Exos, TMP-Exos 或 BOR-Exos。有 SJP-Exos 的处理显著地增加了 histone 的蛋白质层次 3 离氨酸 27 trimethylation (H3K27me3 ) ,为心脏的 transcriptional 抑制的一个关键 epigenetic 染色质标记,在 HL-1 房间。为了推进,探索 SJP-Exo-mediated H3K27me3 upregulation 的机制,我们在对待 exosome 的 HL-1 房间估计了关键 histone methylases (EZH1, EZH2 和 EED ) 和 demethylases (JMJD3 和 UTX ) 的 mRNA 表示层次。有 SJP-Exo 的处理有选择地在接受者 HL-1 房间压制了 UTX 表示。而且, PCNA,房间复制的一个内长的标记,比在 Ctrl-Exo-treated HL-1 房间在 SJP-Exo-treated HL-1 房间是显著地更高的。这些结果证明 SJP-Exos 增加 cardiomyocyte 增长并且证明 SJP 能调制 C-MSC-derived exosomes 引起 epigenetic 染色质在接受者 cardiomyocytes 改变;因而, SJP-Exos 可能被用来支持 cardiomyocyte 增长。 | Xiao-fen RUAN Yongdun LI Cheng-wei JU Yan SHEN Wei LEI Can CHEN Yang LI Hong YU Yu-tao LIU II-man KIM Xiao-long WANG Neal L WEINTRAUB Yaoliang TANG | 2018 | Acta Pharmacologica Sinica2018，39，4： | 23 |
| 4 | Comparative Proteome Analysis of Human Lung Squamous Carcinoma Tissue显示文摘客观:与高分辨率建立二维的电气泳动侧面;从人的肺的重制度有鳞的癌织物;配对的正常肿瘤邻近的支气管的上皮,;识别微分表示由使用 proteome 分析的联系肿瘤的蛋白质。方法:有 20 人的肺的比较 proteome 分析有鳞的癌纸巾;邻近肿瘤的配对的正常支气管的上皮被执行。人的肺的全部的蛋白质有鳞的癌织物;配对的正常肿瘤邻近的支气管的上皮借助于使不能调动的 pH 被分开基于坡度的二维的胶化电气泳动(2-DE ) ;染色的银。微分表示蛋白质被分析;然后到飞行团分光术(MALDI-TOF-MS ) 的帮助矩阵的激光解吸附作用 / 电离时间识别了。结果:(1 ) 人的肺的解决得好的、可再现的 2-DE 模式有鳞的癌;邻近的正常支气管的上皮被获得。为肿瘤织物, 3 胶化的平均的点是 1567 ± 4 6,;4 看到的 1436 ± 5 与 91.6% 的平均匹配率被匹配。为控制, 3 胶化的平均的点是 1349 ± 5 8,;5 看到的 1228 ± 3 与 91.03% 的平均匹配率被匹配。匹配的点的平均位置偏差是在 IEF 的 0.924 ± 0 .128 公里方向,;在 SDS 页方向的 1.022 ± 0 .205 公里;(2 ) 6 看到的 1178 ± 5 的一个总数在 20 人的肺的电泳地图之间被匹配有鳞的癌纸巾;配对正常肿瘤邻近的支气管的上皮。76 差别表示了蛋白质被屏蔽;(3 ) 68 微分蛋白质被 PMF 识别,一些蛋白质是 oncogenes 的产品,;涉及房间的规定的其它骑车;信号转导变异;(4 ) 以便验证识别结果的可靠性, 3 蛋白质 mdm2 的表示, c-jun;EGFR,它与肺被相关有鳞的癌,被免疫检测组织化学的染色;西方的污点分析。结果揭示了那 mdm2, c-jun;EGFR 在肺是起来调整的有鳞的癌而他们在邻近的正常支气管的上皮是下面调整的,正常的肺纸巾;煽动性的假肿瘤,它与我们的 proteome 分析一致结果。结论:人的肺的解决得好的、可再现的 2-DE 模式有鳞的癌;邻近的正常支气管的上皮被建立;68 微分蛋白质被成功地使用比较 proteome 分析描绘。这些结果将为屏蔽使用到 diagnose 的分子的简历标记提供科学基础;对待肺有鳞的癌,以及改进病人的预后;为肺的研究提供新线索有鳞的致癌机制。 | LI Cui TANG Can'e DUAN Chaojun YI Hong XIAO Zhiqiang CHEN Zhuchu | 2006 | The Chinese-German Journal of Clinical Oncology2006，5，4： | 11 |
| 5 | Adsorption of Phosphate onto Ferrihydrite and Ferrihydrite-Humic Acid Complexes显示文摘The adsorption of phosphate onto ferrihydrite(FH) and two FH-humic acid(HA) complexes, obtained by co-precipitating FH with low(FH-HA1) and relatively high amounts of humic acid(FH-HA2), was studied through kinetics and isotherm experiments to determine the differences in phosphate adsorption between FH-HA complexes and FH and to reveal the mechanisms of phosphate adsorption onto two soil compositions. The isoelectric point(IEP) and the specific surface area(SSA) of the mineral decreased as the particle porosity of the mineral increased, which corresponded to an increase in the amount of organic carbon. The adsorption capacity of phosphate was higher on FH than on FH-HA1 and FH-HA2 at the scale of micromoles per kilogram. The initial adsorption rate and adsorption affinity of phosphate decreased with an increase in the amount of HA in the mineral. The sensitivity of phosphate adsorption to the change in the pH was greater for FH than for FH-HA complexes. Ionic strength did not affect the adsorption of phosphate onto FH and FH-HA1 at a lower p H, and the increase in the ionic strength promoted phosphate adsorption at a higher p H.However, for the FH-HA2 complex, the increase in the ionic strength inhibited the adsorption of phosphate onto FH-HA2 at a lower p H and increased the adsorption at a higher pH. | WANG Hui ZHU Jun FU Qing-Ling XIONG Jun-Wei HONG Can HU Hong-Qing Antonio VIOLANTE | 2015 | Pedosphere2015，25，3： | 10 |
| 6 | Cordycepin inhibits pancreatic cancer cell growth in vitro and in vivo via targeting FGFR2 and blocking ERK signaling显示文摘Cordycepin(3′-deoxyadenosine) from Cordyceps militaris has been reported to have anti-tumor effects. However, the molecular target and mechanism underlying cordycepin impeding pancreatic cancer cell growth in vitro and in vivo remain vague. In this study, we reported functional target molecule of cordycepin which inhibited pancreatic cancer cells growth in vitro and in vivo.Cordycepin was confirmed to induce apoptosis by activating caspase-3, caspase-9 and cytochrome c. Further studies suggested that MAPK pathway was blocked by cordycepin via inhibiting the expression of Ras and the phosphorylation of Erk. Moreover, cordycepin caused S-phase arrest and DNA damage associated with activating Chk2(checkpoint kinase 2) pathway and downregulating cyclin A2 and CDK2 phosphorylation. Very interestingly, we showed that cordycepin could bind to FGFR2(KD = 7.77 × 10-9) very potently to inhibit pancreatic cancer cells growth by blocking Ras/Er K pathway. These results suggest that cordycepin could potentially be a leading compound which targeted FGFR2 to inhibit pancreatic cells growth by inducing cell apoptosis and causing cell cycle arrest via blocking FGFR/Ras/ERK signaling for anti-pancreatic cancer new drug development. | LI Xue-Ying TAO Hong JIN Can DU Zhen-Yun LIAO Wen-Feng TANG Qing-Jiu DING Kan | 2020 | Chinese Journal of Natural Medicines2020，18，5： | 10 |
| 7 | Monthly variation in litterfall and the amount of nutrients in an Aleurites montana plantation显示文摘In this study,the dynamics of monthly variation in litterfall and the amount of nutrients,i.e.,organic C,N,P and K,in an Aleurites montana plantation were analyzed,based on a field study and experiments over one year.The results show that the litterfall mass of A.montana collected generally presents an ascending trend with maximum defoliation occurring in the autumn and winter (October-December),accounting for 75.67% of the total amount of annual litterfall.The sequence in the amount of nutrients in A.montana litter was as follows:organic C > N > K > P;their monthly amounts show various dynamic curves.Similar to the dynamics of the mass of monthly litterfall,the monthly returns of C,N,P and K generally show an ascending trend with their peak values all occurring in December.The mass of A.montana litterfall and the dynamics of its monthly nutrient return provide,to a certain degree,a scientific reference for planting and fertilizing A.montana. | LIN Han HONG Tao WU Cheng-zhen CHEN Hui CHEN Can LI Jian LIN Yong-ming FAN Hai-lan | 2012 | Forestry Studies in China2012，14，1： | 10 |
| 8 | Epigallocatechin-3-gallate induces apoptosis, inhibits proliferation and decreases invasion of glioma cell显示文摘Epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, has been considered a potential therapeutic and chemopreventive agent for cancer. Glioma is a malignant tumor with high mortality but effective therapy has not yet been developed. In this study, we found that EGCG induced apoptosis in U251 glioma cells via the laminin receptor (molecular weight 67kDa) in a time- and dose-dependent manner, decreased their invasiveness and inhibited their proliferation. The mitogen-activated protein kinase pathway was shown to be involved in glioma cell apoptosis and proliferation. Furthermore, the mRNA levels of matrix metalloproteinase (MMP)-2 and MMP-9 were reduced after EGCG treatment. These results suggest that EGCG has important therapeutic effects with low toxicity and side-effects, and could be used in cancer chemoprevention. | Hong Li Zhe Li Ya-Ming Xu Yue Wu Kang-Kang Yu Can Zhang Yong-Hua Ji Gang Ding Fu-Xue Chen | 2014 | Neuroscience Bulletin2014，30，1： | 6 |
| 9 | Preface显示文摘 | Can Li Hong He | 2011 | 催化学报2011，32，5： | 5 |
| 10 | Specific targeting of angiogenesis in lung cancer with RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a 4.7T magnetic resonance scanner显示文摘 | LIU Can LIU Dong-bo LONG Guo-xian WANG Jun-feng MEI Qi HU Guang-yuan QIU Hong HU Guo-qing | 2013 | Chinese Medical Journal2013，，12： | 5 |
| 11 | Pulmonary Toxicity in Rats Caused by Exposure to Intratracheal Instillation of SiO2 Nanoparticles显示文摘Objective The effect of the silica nanoparticles(SNs) on lungs injury in rats was investigated to evaluate the toxicity and possible mechanisms for SNs.Methods Male Wistar rats were instilled intratracheally with 1 mL of saline containing 6.25,12.5,and 25.0 mg of SNs or 25.0 mg of microscale SiO_2 particles suspensions for 30 d,were then sacrificed.Histopathological and ultrastructural change in lungs,and chemical components in the urine excretions were investigated by light microscope,TEM and EDS.MDA,NO and hydroxyproline(Hyp) in lung homogenates were quantified by spectrophotometry.Contents of TNF-α,TGF-β1,IL-1β,and MMP-2 in lung tissue were determined by immunohistochemistry staining.Results There is massive excretion of Si substance in urine.The SNs lead pulmonary lesions of rise in lung/body coefficients,lung inflammation,damaged alveoli,granuloma nodules formation,and collagen metabolized perturbation,and lung tissue damage is milder than those of microscale SiO_2 particles.The SNs also cause increase lipid peroxidation and high expression of cytokines.Conclusion The SNs result into pulmonary fibrosis by means of increase lipid peroxidation and high expression of cytokines.Milder effect of the SNs on pulmonary fibrosis comparing to microscale SiO_2 particles is contributed to its elimination from urine due to their ultrafine particle size. | YANG Hong WU Qiu Yun LI Ming Yue LAO Can Shah ZHANG Ying Jian | 2017 | Biomedical and Environmental Sciences2017，30，4： | 5 |
| 12 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 13 | Influence of MoSi_(2) on oxidation protective ability of TaB_(2)-SiC coating in oxygen-containing environments within a broad temperature range显示文摘TaB_(2)-SiC coating modified by different content of MoSi_(2) was fabricated on graphite substrate with SiC inner coating by liquid phase sintering to elevate the anti-oxidation capability of the TaB_(2)-SiC coatings.As compared to the sample with the TaB_(2)-40wt% SiC coating,the coating sample modified with MoSi_(2) exhibited a weight gain trend at lower temperatures,the fastest weight loss rate went down by 76%,and the relative oxygen permeability value reduced from about 1% to near 0.More importantly,the large amount of SiO_(2) glass phase produced over the coating during oxidation was in contact with the modification of MoSi_(2),which was proved to be beneficial to the dispersion of Ta-oxides.A concomitantly formed continuous Ta-Si-O-B compound glass layer showed excellent capacity to prevent oxygen penetration.However,when the TaB_(2) content was sacrificed to increase the MoSi_(2) content,the relative oxygen permeability of the coating increased instead of decreased.Thus,on the basis of ample TaB_(2) content,increasing the MoSi_(2) content of the coating is conducive to reducing the relative oxygen permeability of the coatings in a broad temperature region. | Xuanru REN Junshuai LV Wei LI Yuwen HU Ke SUN Can MA Hong’ao CHU Weiguang WANG Leihua XU Ziyu LI Peizhong FENG | 2020 | Journal of Advanced Ceramics2020，9，6： | 4 |
| 14 | Seasonal variation and size distribution of biogenic secondary organic aerosols at urban and continental background sites of China显示文摘Size-resolved biogenic secondary organic aerosols(BSOA) derived from isoprene and monoterpene photooxidation in Qinghai Lake, Tibetan Plateau(a continental background site) and five cities of China were measured using gas chromatography/mass spectrometry(GC/MS). Concentrations of the determined BSOA are higher in the cities than in the background and are also higher in summer than in winter. Moreover, strong positive correlations(R2= 0.44–0.90) between BSOA and sulfate were found at the six sites,suggesting that anthropogenic pollution(i.e., sulfate) could enhance SOA formation,because sulfate provides a surface favorable for acid-catalyzed formation of BSOA. Size distribution measurements showed that most of the determined SOA tracers are enriched in the fine mode(< 3.3 μm) except for cis-pinic and cis-pinonic acids, both presented a comparable mass in the fine and coarse(> 3.3 μm) modes, respectively. Mass ratio of oxidation products derived from isoprene to those from monoterpene in the five urban regions during summer are much less than those in Qinghai Lake region. In addition, in the five urban regions relative abundances of monoterpene oxidation products to SOA are much higher than those of isoprene. Such phenomena suggest that BSOA derived from monoterpenes are more abundant than those from isoprene in Chinese urban areas. | Yanqin Ren Gehui Wang Jianjun Li Can Wu Cong Cao Jiayuan Wang Lu Zhang Fan Meng Hong Li | 2018 | Journal of Environmental Sciences2018，30，9： | 4 |
| 15 | Chinese medicine Yu-Ping-Feng-San attenuates allergic inflammation by regulating epithelial derived pro-allergic cytokines显示文摘This study aimed to investigate the mechanisms of Yu-Ping-Feng-San(YPFS) on attenuating allergic inflammation in the initial stage of atopic dermatitis(AD). AD mouse model was established with fluorescein isothiocyanate(FITC) sensitization and elicitation. Epithelial barrier structure was observed with transmission electron microscope. The populations of dendritic cells(DCs)and group 2 innate lymphoid cells(ILC2 s) were detected by flow cytometry. Human immortalized keratinocyte(Ha Ca T) cells were stimulated with Poly(I:C)/TNF-α in vitro to assess thymic stromal lymphopoietin(TSLP), interleukin(IL)-33 and nuclear factor-κB(NF-κB) levels or expressions by immunofluorescence, enzyme linked immunosorbent assay(ELISA) and western blot. In the initial stage of AD, ear swelling and infiltration of inflammatory cells in ear tissues were markedly attenuated with YPFS treatments. The damaged structures of ear epithelium and the increased levels of Th2-cytokines induced by FITC were significantly rescued in YPFS-treated mice. The production of pro-allergic cytokines, TSLP and IL-33, as well as the cell populations of their target cells DCs and ILC2 s were decreased in AD model, respectively. Likewise, the levels of TSLP and IL-33 in Poly(I:C)/TNF-α-stimulated HaCaT cells showed the same results. Lower levels of p-NF-κB were detected with YPFS treatment, and the expressions of TSLP and IL-33 could be further decreased with inhibiting of NF-κB. Therefore, YPFS attenuates allergic inflammation in the initial stage of AD probably through regulating NF-κB-TSLP/IL-33 pathway, which may provide a novel effective target for the prevention and treatment of allergic diseases. | WANG Xiao-Tong LIU Hai-Liang YU Xi WANG Can GUI Li-Li WANG Xiao-Yu HUA Yong-Qing ZHENG Jie HONG Min | 2019 | Chinese Journal of Natural Medicines2019，17，7： | 4 |
| 16 | THREE-DIMENSIONAL NUMERICAL MODELINGOF COHESIVE SEDIMENT TRANSPORT BY TIDAL CURRENTIN PEARL RIVER ESTUARV显示文摘A three-dimensional numerical model of suspended sediment transport taking into account the effects of cohesiveness between sediments is presented. An efficient operator splitting scheme is employed to solve the equations of mass conservation, momentum and suspended sediment transport. The splitting method partitions a time step into three fractional time steps according to physical phenomena. In the first step, advection and Coriolis force are solved by Eulerian-Lagrangian method (ELM). Horizontal diffusion is approximated by implicit finite element method (FEM) for each horizontal layer in the second step. In the last step, vertical diffusion and pressure gradient are discretized by implicit finite difference method (FDM) for each nodal column. The continuity equation is solved by implicit FEM within an entire time step. The sigma coordinate system for vertical columns and nine-node isoparameteric finite elements for horizontal planes are employed in the model. Empirical functions specifically developed for cohesive sediments in China have been incorporated into the model. The model has been applied to investigate the suspended sediment concentration and seabed evolution in the Pearl River Estuary (PRE) in China. Computed results show that the distribution of sediment concentration and seabed evolution is in agreement with field measurements. In addition, the effect of the size of time step on result is discussed. The computed result shows that larger time steps can be used in this model for saving computation time without losing much accuracy. | Yong CHEN1, Onyx W.H. WAI2, Y. S. Li3 and Qimiao LU4 (l 2,3 Department of Civil and Structural Engineering, The Hong Kong Polytechnic University. Hung Hom, Kowloon, Hong Kong 4,Department of Civil Engineering, Daltech, Dalhousie University, Halifax, Can | 1999 | International Journal of Sediment Research1999，14，2： | 4 |
| 17 | A male-ABCD algorithm for hepatocellular carcinoma risk prediction in HBs Ag carriers显示文摘Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBs Ag-positive male adults.Methods: HBs Ag-positive males of 35-69 years old(N=6,153) were included from a multi-center populationbased liver cancer screening study. Randomly, three centers were set as training, the other three centers as validation. Within 2 years since initiation, we administrated at least two rounds of HCC screening using Bultrasonography and α-fetoprotein(AFP). We used logistic regression models to determine potential risk factors,built and examined the operating characteristics of a point-based algorithm for HCC risk prediction.Results: With 2 years of follow-up, 302 HCC cases were diagnosed. A male-ABCD algorithm was constructed including participant's age, blood levels of GGT(γ-glutamyl-transpeptidase), counts of platelets, white cells,concentration of DCP(des-γ-carboxy-prothrombin) and AFP, with scores ranging from 0 to 18.3. The area under receiver operating characteristic was 0.91(0.90-0.93), larger than existing models. At 1.5 points of risk score,26.10% of the participants in training cohort and 14.94% in validation cohort were recognized at low risk, with sensitivity of identifying HCC remained 100%. At 2.5 points, 46.51% of the participants in training cohort and 33.68% in validation cohort were recognized at low risk with 99.06% and 97.78% of sensitivity, respectively. At 4.5 points, only 20.86% of participants in training cohort and 23.73% in validation cohort were recognized at high risk,with positive prediction value of 22.85% and 12.35%, respectively.Conclusions: Male-ABCD algorithm identified individual's risk for HCC occurrence within short term for their HCC precision surveillance. | Yuting Wang Minjie Wang He Li Kun Chen Hongmei Zeng Xinyu Bi Zheng Zhu Yuchen Jiao Yong Wang Jian Zhu Hui Zhao Xiang Liu Chunyun Dai Chunsun Fan Can Zhao Deyin Guo Hong Zhao Jianguo Zhou Dongmei Wang Zhiyuan Wu Xinming Zhao Wei Cui Xuehong Zhang Jianqiang Cai Wanqing Chen Chunfeng Qu | 2021 | Chinese Journal of Cancer Research2021，33，3： | 3 |
| 18 | The Effects of Hydrogen-Rich Saline on the Contractile and Structural Changes of Intestine Induced by Ischemia-Reperfusion in Rats显示文摘 | Han Chen Yan Ping Sun Ping Fang Hu Wen Wu Liu Hong Gang Xiang Yang Li Rong Lin Yan Ning Su Can Ping Ruan Xue Jun Sun Qiang Wang | 2011 | Journal of Surgical Research2011，，2： | 2 |
| 19 | Hydrogen-rich saline ameliorates the severity of l -arginine-induced acute pancreatitis in rats显示文摘 | Han Chen Yan Ping Sun Yang Li Wen Wu Liu Hong Gang Xiang Lie Ying Fan Qiang Sun Xin Yun Xu Jian Mei Cai Can Ping Ruan Ning Su Rong Lin Yan Xue Jun Sun Qiang Wang | 2010 | Biochemical and Biophysical Research Communications2010，，2： | 2 |
| 20 | Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization显示文摘Tumor-associated macrophages(TAMs),one of the dominating constituents of tumor microenvironment,are important contributors to cancer progression and treatment resistance.Therefore,regulation of TAMs polarization from M2 phenotype towards M1 phenotype has emerged as a new strategy for tumor immunotherapy.Herein,we successfully initiated antitumor immunotherapy by inhibiting TAMs M2 polarization via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles(PEG-Au NPs).PEG-Au NPs suppressed TAMs M2 polarization in both in vitro and in vivo models,elicited antitumor immunotherapy and inhibited subcutaneous tumor growth in mice.As demonstrated by the m RFP-GFP-LC3 assay and analyzing the autophagy-related proteins(LC3,beclin1 and P62),PEGAu NPs induced autophagic flux inhibition in TAMs,which is attributed to the PEG-Au NPs induced lysosome alkalization and membrane permeabilization.Besides,TAMs were prone to polarize towards M2phenotype following autophagy activation,whereas inhibition of autophagic flux could reduce the M2polarization of TAMs.Our results revealed a mechanism underlying PEG-Au NPs induced antitumor immunotherapy,where PEG-Au NPs reduce TAMs M2 polarization via induction of lysosome dysfunction and autophagic flux inhibition.This study elucidated the biological effects of nanomaterials on TAMs polarization and provided insight into harnessing the intrinsic immunomodulation capacity of nanomaterials for effective cancer treatment. | Siyue Zhang Fangyuan Xie Kaichun Li He Zhang You Yin Yuan Yu Guangzhao Lu Shihao Zhang Yan Wei Ke Xu Yan Wu Hong Jin Lan Xiao Leilei Bao Can Xu Yulin Li Ying Lu Jie Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 2 |
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