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| 1 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 2 | A time-released osmotic pump fabricated by compression-coated method: Formulation screen, mechanism research and pharmacokinetic study显示文摘In this investigation,time-released monolithic osmotic pump(TMOP)tablets containing diltiazem hydrochloride(DIL)were prepared on the basis of osmotic pumping mechanism.The developed dosage forms were coated by Kollidon®SR-Polyethylene Glycol(PEG)mixtures via compression-coated technology instead of spray-coating method to form the outer membrane.For more efficient formulation screening,a three-factor five-level central composite design(CCD)was introduced to explore the optimal TMOP formulation during the experiments.The in vitro tests showed that the optimized formulation of DIL-loaded TMOP had a lag time of 4 h and a following 20-h drug release at an approximate zero-order rate.Moreover,the releasemechanismwas proven based on osmotic pressure and its profile could be well simulated by a dynamic equation.After oral administration by beagle dogs,the comparison of parameters with the TMOP tablets and reference preparations show no significant differences for C_(max)(111.56±20.42,128.38±29.46 ng/ml)and AUC_(0-48 h)(1654.97±283.77,1625.10±313.58 ng h/ml)but show significant differences for T_(max)(13.00±1.16,4.00±0.82 h).These pharmacokinetic parameters were consistent with the dissolution tests that the TMOP tablets had turned out to prolong the lag time of DIL release. | Tiegang Xin Yang Zhao Hengpan Jing Wenji Zhang Yunyun Gao Xinggang Yang Xukai Qu Weisan Pan | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，4： | 4 |
| 3 | Control for the synchronization of Chen system via a single nonlinear input显示文摘这篇论文经由扇区为陈混乱系统的同步探讨控制非线性的输入。基于单身者的反馈控制,适应控制,快滑动模式和柔韧的控制途径声明反馈控制器被调查。在这些情况中,为同步的足够的条件是获得的经分解。数字模拟验证控制表演。 | Tiegang GAO Zengqiang CHEN Zhuzhi YUAN | 2006 | 控制理论与应用(英文版)2006，4，3： | 2 |
| 4 | A hyperchaos generated from Chen's system显示文摘 | GAO Tiegang CHEN Zenqiang YUAN Zhuzhi | 2006 | International Journal of Mordorn Physics C2006，17，4： | 1 |
| 5 | A new image encryption algorithm based on hyper-chaos显示文摘 | Gao Tiegang Chen Zengqiang | 2008 | Physics Letters A2008，372，4： | 1 |
| 6 | Federated transfer learning for disaster classification in social computing networks显示文摘Social media analytics have played an important role in disaster identification.Recent advances in deep learning(DL)technologies have been applied to design disaster classification models.However,the DL-based models are hindered by insufficient training samples,because data collection and labeling are very expensive and time-consuming.To solve this issue,a privacy-preserving federated transfer learning approach for disaster classification(FedTL)is proposed,which can allow distributed social computing nodes to collaboratively train a comprehensive model.In the FedTL,Paillier homomorphic encryption method is used to protect the social computing nodes’data privacy.In particular,the transfer learning technology is adopted as a novel application to reduce the computation and communication costs in the federated learning system.The FedTL is verified by a real disaster image dataset collected from social networks.Theoretical analyses and experiment results show that the FedTL is effective,secure,efficient.In addition,the FedTL is highly extensible and can be easily applied in other transfer learning models. | Zehui Zhang Ningxin He Dongyu Li Hang Gao Tiegang Gao Chuan Zhou | 2022 | Journal of Safety Science and Resilience2022，3，1： | 1 |
| 7 | Pricing management for a closed-loop supply chain显示文摘 | Gu Qiaolun Ji Jianhua Gao Tiegang | | 0，，01： | 1 |
| 8 | A new image encryption algo- rithm based on hyper-chaos 显示文摘 | Gao Tiegang Chen Zengqiang | 2008 | Physics Letters A2008，372，4： | 1 |
| 9 | Pricing Deci- sions for Rverse Supply Chains 显示文摘 | Gu Qiaolun Ji Jianhua Gao Tiegang | 2011 | Kybemetes2011，40，56： | 1 |
| 10 | Activation tagging, an efficient tool for functional analysis of the rice genome显示文摘 | Shuyan Wan Jinxia Wu Zhiguo Zhang Xuehui Sun Yaci Lv Ci Gao Yingda Ning Jun Ma Yupeng Guo Qian Zhang Xia Zheng Caiying Zhang Zhiying Ma Tiegang Lu | 2009 | Plant Molecular Biology (-)2009，，1： | 1 |
| 11 | The Genera- tion and Circuit Implementation of a New Hyper-chaos based Upon Lorenz System显示文摘 | GAO Tiegang CHEN Guanrong CHEN Zengqiang | 2007 | Physics Lette~ A2007，361，1： | 1 |
| 12 | A new image eneryption algorithm based on hyperchaos显示文摘 | Gao Tiegang Chen Zengqiang | 2008 | Physics Letters A2008，372，4： | 1 |
| 13 | Contrast modification forensics algorithm based on merged weight histogram of run length显示文摘 | YANG Liang GAO Tiegang XUAN Yan | 2016 | International Journal of Digital Crime and Forensics2016，8，2： | 1 |
| 14 | The generation and circuit implementation of a new hyper-chaos based upon Lorenz system显示文摘 | Tiegang Gao Guanrong Chen Zengqiang Chen Shijian Cang | 2006 | Physics Letters A2006，，1： | 1 |
| 15 | Management of two competitive closed- loop supply chains 显示文摘 | Gu Qiaolun Gao Tiegang | 2012 | International Journal of Sustainable Engi- neering2012，5，4： | 1 |
| 16 | A New Image EncryptionAlgorithm Based on Hyper chaos显示文摘 | Gao Tiegang Chen Zengqiang | 2008 | Physics Letters A2008，372，39： | 1 |
| 17 | Image encryption basedon a new total shuffling algorithm 显示文摘 | Gao Tiegang Chen Zengqiang | 2008 | Chaos Solutions& Fractals2008，38，1： | 1 |
| 18 | A new image encryption algorithm based on hyper-chaos显示文摘 | GAO TIEGANG CHEN ZENGQIANG | 2008 | Physics Letters A2008，372，4： | 1 |
| 19 | A Bit Level Encryption Scheme Based on Hyper-chaotic System Combing with the Ideology of Central Dogma显示文摘An image encryption scheme based on confusion and diffusion is proposed. In the proposed scheme,original images are transformed into other forms, such as binary streams and ‘hyper-image', firstly. Then the confusion process is achieved by permutation on the pixel level,the binary bit level, and the ‘hyper-image' level respectively. Moreover, the diffusion process is operated on the‘hyper-image' level by bitwise e Xclusive or(XOR) calculation with random sequence generated by a hyper-chaotic system. Furthermore, the central dogma in molecular biology is utilized in the construction of hyper-image, which demonstrates its superiority. Both the theoretical analysis and the experimental results have demonstrated the efficiency and validity of the proposed scheme, and images can be encrypted sufficiently through the three-time permutation and the chaotic substitution. | ZHANG Shun YANG Liang ZHANG Yuan GAO Tiegang | 2018 | Chinese Journal of Electronics2018，27，3： | 1 |
| 20 | The Genera- tion and Circuit Implementation of A New Hyper-chaos Based upon Lorenz System显示文摘 | GAO Tiegang CHEN Guanrong CHEN Zengqiang | 2007 | Physics Letters A2007，361，1： | 1 |
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