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| 1 | Longwall mining “cutting cantilever beam theory” and 110 mining method in China——The third mining science innovation显示文摘With the third innovation in science and technology worldwide, China has also experienced this marvelous progress. Concerning the longwall mining in China, the 'masonry beam theory'(MBT) was first proposed in the 1960 s, illustrating that the transmission and equilibrium method of overburden pressure using reserved coal pillar in mined-out areas can be realized. This forms the so-called '121mining method', which lays a solid foundation for development of mining science and technology in China. The 'transfer rock beam theory'(TRBT) proposed in the 1980 s gives a further understanding for the transmission path of stope overburden pressure and pressure distribution in high-stress areas. In this regard, the advanced 121 mining method was proposed with smaller coal pillar for excavation design,making significant contributions to improvement of the coal recovery rate in that era. In the 21 st century,the traditional mining technologies faced great challenges and, under the theoretical developments pioneered by Profs. Minggao Qian and Zhenqi Song, the 'cutting cantilever beam theory'(CCBT) was proposed in 2008. After that the 110 mining method is formulated subsequently, namely one stope face,after the first mining cycle, needs one advanced gateway excavation, while the other one is automatically formed during the last mining cycle without coal pillars left in the mining area. This method can be implemented using the CCBT by incorporating the key technologies, including the directional presplitting roof cutting, constant resistance and large deformation(CRLD) bolt/anchor supporting system with negative Poisson's ratio(NPR) effect material, and remote real-time monitoring technology. The CCBT and 110 mining method will provide the theoretical and technical basis for the development of mining industry in China. | Manchao He Guolong Zhu Zhibiao Guo | 2015 | Journal of Rock Mechanics and Geotechnical Engineering2015，7，5： | 57 |
| 2 | Effect of two volume responsiveness evaluation methods on fluid resuscitation and prognosis in septic shock patients显示文摘 | Xu Qianghong Yan Jing Cai Guolong Chen Jin Li Li Hu Caibao | 2014 | Chinese Medical Journal2014，，3： | 11 |
| 3 | Dietary modulation of endogenous host defense peptide synthesis as an alternative approach to in-feed antibiotics显示文摘Traditionally, antibiotics are included in animal feed at subtherapeutic levels for growth promotion and disease prevention.However, recent links between in-feed antibiotics and a rise in antibiotic-resistant pathogens have led to a ban of all antibiotics in livestock production by the European Union in January 2006 and a removal of medically important antibiotics in animal feeds in the United States in January 2017.An urgent need arises for antibiotic alternatives capable of maintaining animal health and productivity without triggering antimicrobial resistance.Host defense peptides(HDP) are a critical component of the animal innate immune system with direct antimicrobial and immunomodulatory activities.While in-feed supplementation of recombinant or synthetic HDP appears to be effective in maintaining animal performance and alleviating clinical symptoms in the context of disease, dietary modulation of the synthesis of endogenous host defense peptides has emerged as a cost-effective,antibiotic-alternative approach to disease control and prevention.Several different classes of smallmolecule compounds have been found capable of promoting HDP synthesis.Among the most efficacious compounds are butyrate and vitamin D.Moreover, butyrate and vitamin D synergize with each other in enhancing HDP synthesis.This review will focus on the regulation of HDP synthesis by butyrate and vitamin D in humans, chickens, pigs, and cattle and argue for potential application of HDP-inducing compounds in antibiotic-free livestock production. | Kelsy Robinson Xi Ma Yulan Liu Shiyan Qiao Yongqing Hou Guolong Zhang | 2018 | Animal Nutrition2018，，2： | 9 |
| 4 | A hybrid multi-objective PSO algorithm with local search strategy for VLSI partitioning显示文摘 | Wenzhong GUO Genggeng LIU Guolong CHEN Shaojun PENG | 2014 | Frontiers of Computer Science2014，8，2： | 8 |
| 5 | An Overview of Mineral Dust Modeling over East Asia显示文摘East Asian dust(EAD) exerts considerable impacts on the energy balance and climate/climate change of the earth system through its influence on solar and terrestrial radiation, cloud properties, and precipitation efficiency. Providing an accurate description of the life cycle and climate effects of EAD is therefore critical to better understanding of climate change and socioeconomic development in East Asia and even worldwide. Dust modeling has undergone substantial development since the late 1990 s, associated with improved understanding of the role of EAD in the earth system. Here, we review the achievements and progress made in recent decades in terms of dust modeling research,including dust emissions, long-range transport, radiative forcing(RF), and climate effects of dust particles over East Asia. Numerous efforts in dust/EAD modeling have been directed towards furnishing more sophisticated physical and chemical processes into the models on higher spatial resolutions. Meanwhile, more systematic observations and more advanced retrieval methods for instruments that address EAD related science issues have made it possible to evaluate model results and quantify the role of EAD in the earth system, and to further reduce the uncertainties in EAD simulations. Though much progress has been made, large discrepancies and knowledge gaps still exist among EAD simulations. The deficiencies and limitations that pertain to the performance of the EAD simulations referred to in the present study are also discussed. | Siyu CHEN Jianping HUANG Yun QIAN Chun ZHAO Litai KANG Ben YANG Yong WANG Yuzhi LIU Tiangang YUAN Tianhe WANG Xiaojun MA Guolong ZHANG | 2017 | Journal of Meteorological Research2017，31，4： | 7 |
| 6 | HEMS technique for heat-harm control and geo-thermal utilization in deep mines显示文摘With the increasing exploitation scope and intensity,the shallow resources would be exhausted in the future;and the deep mining will become an essential choice.In deep tunnel engineering,the heat-harm becomes one of the mainbariers.Investigations on high temperature coal mine have been done in Nothem China,with the construting of threemodels of high temperature mines suffering heat-harm,at the Jiahe mine,Sanhejian mine and Zhangshuanglou mine.Thedomestic and abroad cooling technologies of the mine respectively are also summarized after comparatively analyzing theadvantages and disadvantages of each technology.Finally,we find that the high temperature exchange machinery system(HEMS)technology that use mine discharge as the cold source,is excellent to heat-ham control in deep mines.Taking theJiahe coal mine as an example,we systematically introduce this teclnology by disposing three main workstations.HEMStechnology with its operations and functions in different exploitation levels are accomplished,including the extraction ofrefrigerating output,the transportation of chilled water by closed circulation line,the decompression of circulation linesand equipment by pressure transformation machine,and the heat exchange and cooling of workplace by heat exchangebetween wind stream and the chilled water.The exchanged heat source from the workplace is taken to ground heating bythe circulating water which acts as a carrier.It shows that the HEMS-technology benefit in environment protection andemission reduction.Results of this project illustrate that it is efficient in heat-ham control with the temperature decrease ofthe workplace down to 26-29℃,and being 4-6℃ lower than the original,and the relative humidity 5%-15%lowerthan before.It greatly improves the working environment of underground workplace suffering heat-ham of high tem-perature and high humidity.In addition,by the extracting of deep geothermal enery,ground fired boiler for heating hasbeen replaced,reducing environmental pollution.This technology is worth generalization in deep mines and related fields. | Pingye Guo Guolong Zhu Manchao He | 2014 | International Journal of Coal Science & Technology2014，1，3： | 7 |
| 7 | Machining deformation of single-sided component based on finishing allowance optimization显示文摘Owing to reliability and high strength-to-weight ratio,large thin-walled components are widely used in the aviation and aerospace industry.Due to the complex features and sequence involved in the machining process of large thin-walled components,machining deformation of component is easy to exceed the specification.In order to address the problem,it is important to retain the appropriate finishing allowance.To find the overall machining deformation,finishing allowance-induced deformation(web finishing allowance,sidewall finishing allowance)and initial residual stress-induced deformation were considered as major factors.Meanwhile,machined surface residual stress-induced deformation,clamping stress-induced deformation,thermal deformation,gravity-induced deformation and inertial force-induced deformation were neglected in the optimization model.Six-peak Gaussian function was introduced to fit the initial residual stress.Based upon the obtained function of initial residual stress,a deformation prediction model between initial residual stress and finishing allowance was established to attain the finishing allowanceinduced deformation.In addition,linear programming optimization model based on the simplex algorithm was developed to optimize the overall machining deformation.Results have concluded that the overall machining deformation reached the minimum value when sidewall finishing allowance and web finishing allowance varied between 1 and 2 mm.Additionally,web finishing allowance-induced deformation and sidewall finishing allowance-induced deformation were1.05 mm and 0.7 mm.Furthermore,the machining deformation decreased to 0.3–0.38 mm with the application of optimized finishing allowance allocation strategy,which made 39–56%reduction of the overall machining deformation compared to that in conventional method. | Xiaoyue LI Liang LI Yinfei YANG Guolong ZHAO Ning HE Xiaocen DING Yaowen SHI Longxin FAN Hui LAN Muhammad JAMIL | 2020 | Chinese Journal of Aeronautics2020，33，9： | 6 |
| 8 | Influences of prolate spheroidal baffle of sound diffraction on spatial directivity of acoustic vector sensor显示文摘The directivity of acoustic vector sensor (AVS) will be distorted by the sound diffraction of the AVS carrier. In this paper,the scattering of a plane acoustic wave from a prolate spheroid baffle is considered. At first,the sound diffraction of prolate spheroidal baffle is established,then the mathematical expressions of sound pressure field and particle vibration velocity field of sound diffraction are derived and the characteristic of the directivity of pressure and velocity of sound diffraction field at different frequencies and distances is analyzed. The directivity of AVS is determined by the amplitude and phase difference of diffraction wave and incident wave,which possesses a close relationship with frequency and incident angle. Finally,the calculated results are compared with the experimental results. | JI JianFei, LIANG GuoLong, WANG Yan & LIN WangSheng National Laboratory of Underwater Acoustic Technology, Harbin Engineering University, Harbin 150001, China | 2010 | Science China(Technological Sciences)2010，53，10： | 6 |
| 9 | Screen-imaging guidance using a modified portable video macroscope for middle cerebral artery occlusion显示文摘The use of operating microscopes is limited by the focal length.Surgeons using these instruments cannot simultaneously view and access the surgical field and must choose one or the other.The longer focal length (more than 1 000 mm) of an operating telescope permits a position away from the operating field,above the surgeon and out of the field of view.This gives the telescope an advantage over an operating microscope.We developed a telescopic system using screen-imaging guidance and a modified portable video macroscope constructed from a Computar MLH-10 × macro lens,a DFK-21AU04 USB CCD Camera and a Dell laptop computer as monitor screen.This system was used to establish a middle cerebral artery occlusion model in rats.Results showed that magnification of the modified portable video macroscope was appropriate (5-20 ×) even though the Computar MLH-10 × macro lens was placed 800 mm away from the operating field rather than at the specified working distance of 152.4 mm with a zoom of 1-40 ×.The screen-imaging telescopic technique was clear,life-like,stereoscopic and matched the actual operation.Screen-imaging guidance led to an accurate,smooth,minimally invasive and comparatively easy surgical procedure.Success rate of the model establishment evaluated by neurological function using the modified neurological score system was 74.07%.There was no significant difference in model establishment time,sensorimotor deficit and infarct volume percentage.Our findings indicate that the telescopic lens is effective in the screen surgical operation mode referred to as 'long distance observation and short distance operation' and that screen-imaging guidance using an modified portable video macroscope can be utilized for the establishment of a middle cerebral artery occlusion model and micro-neurosurgery. | Xingbao Zhu Junli Luo Yun Liu Guolong Chen Song Liu Qiangjin Ruan Xunding Deng Dianchun Wang Quanshui Fan Xinghua Pan | 2012 | Neural Regeneration Research2012，7，12： | 6 |
| 10 | Preparation of Tungsten Film and Its Tribological Properties under Boundary Lubrication Conditions显示文摘Tungsten film(W film) is deposited by using the ion beam assisted deposition(IBAD) on the 316 L substrate surface in this experiment. The micro structure and nano-hardness of the film are investigated by scanning electron microscopy(SEM) and nano-indentation tester. The tribological behavior of W film under lubrication by oil with ZDDP and MoDTC is evaluated by a SRV test machine. The tribo-film formed on the worn surfaces is investigated by X-ray photoelectron spectroscopy(XPS) to find out the tribological mechanisms between the W film and the two additional additives. The result shows that the W film lubricated by ZDDP and MoDTC-blended base oil has synergistic effects on the friction reduction property, while the anti-wear property is mainly caused by the hard surface of W film. | Li Xingliang Yue Wen Wang Song Li Guolong Zhao Shiqian | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，3： | 6 |
| 11 | Effect of cold rolling process on microstructure and mechanical properties of high strength β titanium alloy thin sheets显示文摘The microstructure and mechanical properties of Ti-3.5Al-5Mo-6V-3Cr-2Sn-0.5Fe high strength titanium alloy sheets prepared by unidirectional cold rolling and two-step cross cold rolling were investigated. Results showed that the β phase grains were refined significantly by cold rolling followed by solution treatment for a short time.Compared to unidirectional cold rolling, the short time solution treatment after two-step cross rolling could significantly reduce the non-uniformity of the microstructure of the alloy sheets. After aging treatment at 550 ℃,the anisotropy of the mechanical properties still existed in the unidirectional rolled sheets, and the tensile strength was highest along the rolling direction. After solution and aging treatment, the anisotropy of the mechanical properties of the two-step cross rolling process sheet was not obvious than unidirectional cold rolling,and alloy had good strength and plasticity matching. | Yan Ma Zhaoxin Du Xiaoming Cui Jun Cheng Guolong Liu Tianhao Gong Huimin Liu Xiaopeng Wang Yuyong Chen | 2018 | Progress in Natural Science:Materials International2018，28，6： | 6 |
| 12 | One-pot synthesis of Pt-Cu bimetallic nanocrystals with different structures and their enhanced electrocatalytic properties显示文摘 | Daowei Gao Shuna Li Guolong Song Pengfei Zha Cuncheng Li Qin Wei Yipin Lv Guozhu Chen | 2018 | Nano Research2018，11，5： | 5 |
| 13 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 14 | Improved Relief Grinding Method of Gear Hob with Equal Relief Angle显示文摘The regrinding error is the main factor affecting the eligible length of hob tooth,how to decrease the regrinding error is a hot issue in the research area of hob grinding.At present,researches focus on changing the trajectory of relief moving,because of no unified relief grinding path planning method,the research result is restricted in the practical application.For solving the problem,the calculation model of the hob relief angle is established with the Archimedes relieving motion to analyze the interaction between the increasing relief angle of the hob and the accelerating tooth profile errors.Based on it,the improved relief grinding method of gear hob is proposed with equal relief angle(ERA).Furthermore,the relief grinding method with ERA is developed with the following two steps.Firstly,the convergence numerical solution algorithm of the tooth top curve is designed to form the wheel motion path which is compared with that of traditional grinding.The second step is to establish the solution model of ERA grinding wheel.In order to verify the effect of the method,hob grinding simulation system of 3D solid was built under the AutoCAD environment.The regrinding errors is analyzed by intercepting the hob axial profiles of the various regrinding angles with Boolean operations and further converting it to basic rack tooth,then the simulation example of zero rake straight flute hob is used to compare the regrinding errors between ERA grinding and traditional grinding.Finally,the experiments were implemented on the five-axis CNC relief grinder with the relief motion of ERA grinding driven by cam.The results of experiments show that the method can effectively reduce the regrinding errors of hob and grind expediently gear hob of AA rank and over.This research provide an effective model of relief moving path plan reducing regrinding error,and have practicable value in CNC relief grinder. | LI Guolong SUN Menghui LI Xianguang LIU Fei HUANG Chao | 2011 | Chinese Journal of Mechanical Engineering2011，24，5： | 4 |
| 15 | Frequency-invariant robust adaptive beamforming based on interference covariance matrix reconstruction显示文摘Consider the problems of frequency-invariant beampattern optimization and robustness in broadband beamforming.Firstly,a global optimization algorithm,which is based on phase compensation of the array manifolds,is used to construct the frequency-invariant beampattern.Compared with some methods presented recently,the proposed algorithm is not only available to get the global optimal solution,but also simple for physical realization.Meanwhile,a robust adaptive broadband beamforming algorithm is also derived by reconstructing the covariance matrix.The essence of the proposed algorithm is to estimate the space-frequency spectrum using Capon estimator firstly,then integrate over a region separated from the desired signal direction to reconstruct the interference-plus-noise covariance matrix,and finally caleulate the adaptive beamformer weights with the reconstructed matrix.The design of beamformer is formulated as a convex optimization problem to be solved.Simulation results show that the performance of the proposed algorithm is almost always close to the optimal value across a wide range of signal to noise ratios. | FAN Zhan LIANG Guolong | 2014 | Chinese Journal of Acoustics2014，33，4： | 4 |
| 16 | Effect of zinc substitution in hydroxyapatite coating on osteoblast and osteoclast differentiation under osteoblast/osteoclast co-culture显示文摘Zinc is an essential trace element required for bone remodelling process,but its role in such process remains to be elucidated.In particular,inconsistent results have been reported on the effect of Zn on osteoclastic responses,and supplement of receptor activator of nuclear factor kappa-B ligand(RANKL)factors has been commonly adopted.Co-culture is a suitable approach to elucidating the role of Zn in bone remodelling process,by better imitating the cellular environment as the presence of osteoblasts plays critical role in modulating osteoclastic functions.In this study,zincsubstituted HA coatings have been deposited using a liquid precursor plasma spraying process at two different concentrations(1,2 wt.%).The effect of zinc substitution on osteoblastic and osteoclastic differentiation has been studied in vitro.In particular,a cultivation regime was designed to first induce osteoblastic differentiation of rat bone marrow stromal cells(BMSCs)for 14 days,and then induce osteoclastic differentiation of osteoclast-like precursor RAW 264.7 cells through the aid of the osteoblasts formed for additional 14 days,in the absence of the external addition of RANKL.The results showed that Zn substitution moderately promoted the BMSC differentiation into the osteoblasts and reduced the osteoclastic activity in early time(1 day co-culture).However,promotion of the osteoclastic activity were observed at later stages,as indicated by the significantly enhanced expressions of trap5b and IL-1(8-and 15-day co-culture)and moderate stimulation of the nucleus integration and formation of the multinucleated cells(14-day co-culture).Such stimulating effect of the osteoclastic activity was absent under mono-culture of RAW 264.7 cell,with simple RANKL supplementation.The results suggest that both the zinc and the presence of MSC/osteoblast play profound and highly interacted roles on osteoclast differentiation and activity,which is critical in modulating the bone remodelling process. | Guolong Meng Xiaoli Wu Ruijuan Yao Jing He Wu Yao Fang Wu | 2019 | Regenerative Biomaterials2019，6，6： | 4 |
| 17 | Time-space transform:A novel signal processing approach for an acoustic vector-sensor显示文摘A new signal processing method using a single vector hydrophone is proposed for solving the problem of azimuth angle estimation for multiple targets based on a small aperture underwater platform.The method extends the aperture from a single vector hydrophone into a half wavelength distance uniform linear array by decomposing the time-domain sample data from different channels of the hydrophone.The extended array has a narrower space beam pattern than a single vector hydrophone.The azimuths of spatial multiple targets are estimated by using the appended array snapshots under the condition of broadband or narrow band signals.The new method is robust because there is no need to correct the array manifold.Theoretical analysis and computer simulations show that,the new algorithm has the ability to distinguish two incoherent targets with either narrow band or broadband signals in an isotropic noise field.The algorithm provides a non-biased estimate with a high signal-to-noise ratio. | LIANG GuoLong MA Wei WANG YiLin | 2013 | Science China(Information Sciences)2013，56，4： | 3 |
| 18 | Study on forming directivity with constant beam widthin low frequency based on small sensor显示文摘Based on a combined sensor with the size of 10 cm, a narrow beam with a constant receiving beam width of 20 degree has been formed in low frequency from several Hz to thousands of Hz by using simple adaptive algorithm. The results of theoretical simulation, laboratory experiment and lake experiment with one-dimension and two-dimension combined sensors have been given. | HUI Junying,LIU Hong,YU Huabing,LIANG Guolong (Underwater Acoustic Enyineering Dept. Harbin Engineering University Harbin 150001) | 2001 | Chinese Journal of Acoustics2001，20，1： | 3 |
| 19 | Laser-induced oxidation assisted micro milling of high aspect ratio microgroove on WC-Co cemented carbide显示文摘Severe tool wear and poor surface quality are the main problems during micro machining of cemented carbide.In this work,an innovative hybrid process of laser-induced oxidation assisted micro milling(LOMM)was proposed to solve the problems.A nanosecond laser was utilized to induce oxidation of the WC-20%Co material,producing loose oxide which was easy to remove.The micro machinability of the material was improved by laser-induced oxidation.The oxidation mechanisms of cemented carbide were studied.A microgroove with a depth of 2.5 mm and aspect ratio of 5 was fabricated successfully.The milling force,surface quality and tool wear mechanisms were investigated.For comparison,a microgroove was also fabricated with conventional micro milling(COMM)using identical milling parameters.Results revealed that in LOMM the milling force and tool wear rate were extremely low during removing the oxide.The machined surface quality and dimensional accuracy achieved by LOMM were superior to those obtained by COMM.The surface roughness Saof the microgroove bottom reached 88 nm in LOMM,while the cross-sectional geometry of the microgroove was a trapezoid.Perpendicularity of the microgroove sidewall machined by LOMM was better than that by COMM.The tool wear forms in LOMM were coating spalling and slight tool nose breakage.Compared with COMM,the tool life in LOMM was prolonged significantly.It indicates that the proposed hybrid process is an effective and efficient way to fabricate high aspect ratio micro-features with high dimensional accuracy. | Guolong ZHAO Hongjun XIA Yang ZHANG Liang LI Ning HE Hans Nφrgaard HANSEN | 2021 | Chinese Journal of Aeronautics2021，34，4： | 3 |
| 20 | Tissue expression and developmental regulation of chicken cathelicidin antimicrobial peptides显示文摘Cathelicidins are a major family of antimicrobial peptides present in vertebrate animals with potent microbicidal and immunomodulatory activities. Four cathelicidins, namely fowlicidins 1 to 3 and cathelicidin B1, have been identified in chickens. As a first step to understand their role in early innate host defense of chickens, we examined the tissue and developmental expression patterns of all four cathelicidins. Real-time PCR revealed an abundant expression of four cathelicidins throughout the gastrointestinal, respiratory, and urogenital tracts as well as in all primary and secondary immune organs of chickens. Fowlicidins 1 to 3 exhibited a similar tissue expression pattern with the highest expression in the bone marrow and lung, while cathelicidin B1 was synthesized most abundantly in the bursa of Fabricius. Additionally, a tissue-specific regulatory pattern was evident for all four cathelicidins during the first 28 days after hatching. The expression of fowlicidins 1 to 3 showed an age-dependent increase both in the cecal tonsil and lung, whereas all four cathelicidins were peaked in the bursa on day 4 after hatching, with a gradual decline by day 28. An abrupt augmentation in the expression of fowlicidins 1 to 3 was also observed in the cecum on day 28, while the highest expression of cathelicidin B1 was seen in both the lung and cecal tonsil on day 14. Collectively, the presence of cathelicidins in a broad range of tissues and their largely enhanced expression during development are suggestive of their potential important role in early host defense and disease resistance of chickens. | Mallika Achanta Lakshmi T Sunkara Gan Dai Yugendar R Bommineni Weiyu Jiang Guolong Zhang | 2012 | Journal of Animal Science and Biotechnology2012，3，2： | 3 |
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