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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 3 | Porphyrin-like Fe-N4 sites with sulfur adjustment on hierarchical porous carbon for different rate-determining steps in oxygen reduction reaction显示文摘We developed a strategy based on coordination polymer to synthesize singleatom site Fe/N and S-codoped hierarchical porous carbon (Fe1/N,S-PC).The as-obtained Fe1/N,S-PC exhibited superior oxygen reduction reaction (ORR) performance with a half-wave potential (Ev2,0.904 V vs.RHE) that was better than that of commercial Pt/C (E1/2,0.86 V vs.RHE),single-atom site Fe/N-doped hierarchical porous carbon (Fe1/N-PC) without S-doped (E1/2,0.85 V vs.RHE),and many other nonprecious metal catalysts in alkaline medium.Moreover,the Fe1/N,S-PC revealed high methanol tolerance and firm stability.The excellent electrocatalytic activity of Fe1/N,S-PC is attributed to the synergistic effects from the atomically dispersed porphyrin-like Fe-N4 active sites,the heteroatom codoping (N and S),and the hierarchical porous structure in the carbon materials.The calculation based on density functional theory further indicates that the catalytic performance of Fe1/N,S-PC is better than that of Fe1/N-PC owing to the sulfur doping that yielded different rate-determining steps. | Konglin Wu Xin Chen Shoujie Liu Yuan Pan Weng-Chon Cheong Wei Zhu Xing Cao Rongan Shen Wenxing Chen Jun LUO Wensheng Yan Lirong Zheng Zheng Chen Dingsheng Wang Qing Peng Chen Chen Yadong Li | 2018 | Nano Research2018，11，12： | 18 |
| 4 | Analysis of CD8+ Treg cells in patients with ovarian cancer: a possible mechanism for immune impairment显示文摘 | Shuping Zhang | 2015 | Cellular & Molecular Immunology2015，12，5： | 17 |
| 5 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 6 | Enhanced mechanical properties and degradation rate of Mg-Ni-Y alloy by introducing LPSO phase for degradable fracturing ball applications显示文摘In this work,as-cast Mg-Ni-Y alloys were proposed to develop a feasible material for fracturing balls,and their mechanical performance and corrosion behavior were systematically investigated.Long period stacking order(LPSO)phase was firstly introduced to improve both the mechanical properties and degradation rate of magnesium alloys.With the increase of LPSO phase,the compressive strength was improved significantly,while the elongation of the alloys decreased owing to the relatively brittle nature of LPSO phase.Due to the higher corrosion potential of LPSO phase,the LPSO phase can accelerate the corrosion process by providing more micro-couples.However,the LPSO phase would serve as the corrosion barrier between the corrosion medium and the matrix when the contents of LPSO phase are too high in Mg92.5Ni3Y4.5 and Mg87.5Ni5Y7.5 alloys.As-cast Mg97.5Ni1Y1.5 alloy with satisfactory mechanical properties and rapid degradation rate was successfully developed,exhibiting a high degradation rate of 6675 mm/a(93℃)in 3 wt.%KCl solution and a favorable ultimate compressive strength of 410 MPa.The degradation rate of Mg97.5Ni1Y1.5 alloy is 2-5 times of the current commercial magnesium alloy fracturing materials. | Jingfeng Wang Shiqing Gao Xiuying Liu Xing Peng Kui Wang Shijie Liu Weiyan Jiang Shengfeng Guo Fusheng Pan | 2020 | Journal of Magnesium and Alloys2020，8，1： | 13 |
| 7 | Efficient InGaN-based yellow-light-emitting diodes显示文摘Realization of efficient yellow-light-emitting diodes(LEDs) has always been a challenge in solid-state lighting.Great effort has been made, but only slight advancements have occurred in the past few decades. After comprehensive work on InGaN-based yellow LEDs on Si substrate, we successfully made a breakthrough and pushed the wall-plug efficiency of 565-nm-yellow LEDs to 24.3% at 20 A∕cm^2 and 33.7% at 3 A∕cm^2. The success of yellow LEDs can be credited to the improved material quality and reduced compressive strain of InGaN quantum wells by a prestrained layer and substrate, as well as enhanced hole injection by a 3 D pn junction with V-pits. | FENGYI JIANG JIANLI ZHANG LONGQUAN XU JIE DING GUANGXU WANG XIAOMING WU XIAOLAN WANG CHUNLAN MO ZHIJUE QUAN XING GUO CHANGDA ZHENG SHUAN PAN JUNLIN LIU | 2019 | Photonics Research2019，7，2： | 13 |
| 8 | Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China显示文摘The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Genetic analysis indicated that the 36 viruses formed two different genotypes: one genotype viruses were widely detected from different wild birds and domestic waterfowls;the other genotype was isolated from a whopper swan. We further revealed the origin and spatiotemporal spread of these two distinct H5N8 virus genotypes in 2020 and 2021. Animal studies indicated that the H5N8 isolates are highly pathogenic to chickens, mildly pathogenic in ducks, but have distinct pathotypes in mice. Moreover, we found that vaccinated poultry in China could be completely protected against H5N8 virus challenge. Given that the H5N8 viruses are likely to continue to spread in wild birds, vaccination of poultry is highly recommended in high-risk countries to prevent H5N8 avian influenza. | Pengfei Cui Xianying Zeng Xuyong Li Yanbing Li Jianzhong Shi Conghui Zhao Zhiyuan Qu Yanwen Wang Jing Guo Wenli Gu Qi Ma Yuancheng Zhang Weipeng Lin Minghui Li Jingman Tian Dongxue Wang Xin Xing Yanjing Liu Shuxin Pan Yaping Zhang Hongmei Bao Liling Liu Guobin Tian Chengjun Li Guohua Deng Hualan Chen | 2022 | Science China(Life Sciences)2022，65，4： | 12 |
| 9 | Liquid propellant analogy technique in dynamic modeling of launch vehicle显示文摘The coupling effects among lateral mode,longitudinal mode and torsional mode of a launch vehicle cannot be taken into account in traditional dynamic analysis using lateral beam model and longitudinal spring-mass model individually.To deal with the problem,propellant analogy methods based on beam model are proposed and coupled mass-matrix of liquid propellant is constructed through additional mass in the present study.Then an integrated model of launch vehicle for free vibration analysis is established,by which research on the interactions between longitudinal and lateral modes,longitudinal and torsional modes of the launch vehicle can be implemented.Numerical examples for tandem tanks validate the present method and its necessity. | PAN ZhongWen 1,2 ,XING YuFeng 1 ,ZHU LiWen 2 ,DONG Kai 2 &SUN Mu 2 1Solid Mechanics Research Center,Beijing University of Aeronautics and Astronautics,Beijing 100191,China 2 Beijing Astronautics Systems Engineering Institute,Beijing 100076,China | 2010 | Science China(Technological Sciences)2010，53，8： | 11 |
| 10 | General solutions of plane problem in one-dimensional quasicrystal piezoelectric materials and its application on fracture mechanics显示文摘Based on the fundamental equations of piezoelasticity of quasicrystals(QCs),with the symmetry operations of point groups, the plane piezoelasticity theory of onedimensional(1D) QCs with all point groups is investigated systematically. The governing equations of the piezoelasticity problem for 1D QCs including monoclinic QCs,orthorhombic QCs, tetragonal QCs, and hexagonal QCs are deduced rigorously. The general solutions of the piezoelasticity problem for these QCs are derived by the operator method and the complex variable function method. As an application, an antiplane crack problem is further considered by the semi-inverse method, and the closed-form solutions of the phonon, phason, and electric fields near the crack tip are obtained. The path-independent integral derived from the conservation integral equals the energy release rate. | Jing YU Junhong GUO Ernian PAN Yongming XING | 2015 | Applied Mathematics and Mechanics(English Edition)2015，36，6： | 10 |
| 11 | Early initiation renal replacement therapy for fluid management to reduce central venous pressure is more conducive to renal function recovery in patients with acute kidney injury显示文摘Background:Acute kidney injury (AKI) is a serious complication in critically ill patients with septic shock treated in the intensive care unit. Renal replacement therapy (RRT) is a treatment for severe AKI;however, the time of initiation of RRT and factors that affect the recovery of kidney function remains unclear. This study was to explore whether early initiation of RRT treatment for fluid management to reduce central venous pressure (CVP) can help to improve patients5 kidney function recovery. Methods: A retrospective analysis of septic patients who had received RRT treatment was conducted. Patients received RRT either within 12 h after they met the diagnostic criteria of renal failure (early initiation) or after a delay of 48 h if renal recovery had not occurred (delayed initiation). Parameters such as patients5 renal function recovery at discharge, fluid balance, and levels of CVP were assessed. Results: A total of 141 patients were eligible for enrolment: 40.4% of the patients were in the early initiation group (57 of 141 patients), and 59.6% were in the delayed initiation group (84 of 141 patients). There were no significant differences in the characteristics at baseline between the two groups, and there were no differences in 28-day mortality between the two groups (χ^2 = 2.142, P = 0.143);however, there was a significant difference in the recovery rate of renal function between the two groups at discharge (χ^2 = 4.730, P < 0.001). More importantly, early initiation of RRT treatment and dehydration to reduce CVP are more conducive to the recovery of renal function in patients with AKI. Conclusion: Compared with those who received delayed initiation RRT, patients who received early-initiation RRT for dehydration to reduce CVP have enhanced kidney function recovery. | Zhi-Qun Xing Da-Wei Liu Xiao-Ting Wang Yun Long Hong-Min Zhang Pan Pan Long-Xiang Su | 2019 | Chinese Medical Journal2019，，11： | 10 |
| 12 | IGF-1 alleviates ox-LDL-induced inflammation via reducing HMGB1 release in HAECs显示文摘动脉粥样硬化, multifactorial 长期的煽动性的反应,仔细与氧化地修改的低密度的脂蛋白(ox-LDL ) 被联系。(HMGB1 ) 高活动性的组盒子 1 是 DNA 有约束力的蛋白质,它在从房间的版本之上展出有势力煽动性的行动。(IGF-1 ) 像胰岛素的生长因素 1 能包括增长和 anti-apoptosis 得到细胞的回答的一个全部剧目。然而,在发炎的 IGF-1 的角色仍然是不清楚的。在现在的学习,我们试图在发炎和内在的机制调查 IGF-1 的角色。人的大动脉的 endothelial 房间被 ox-LDL (50 g/ml ) 刺激导致发炎。细胞间的粘附分子 1 的表示(ICAM-1 ) 被西方的污点分析和 immunofluorescence 估计。HMGB1 的版本被连接酶的 immunosorbent 试金决定。IGF-1 受体(IGF-1R ) 表示被反向的抄写聚合酶链反应和西方的污点分析估计。IGF-1R phosphorylation 被西方的污点分析决定。Ox-LDL 刺激减少了 IGF-1R mRNA 和蛋白质表示,但是增加了 HMGB1 版本。IGF-1 处理减少了 ox-LDL-induced ICAM-1 表示,潜在地通过减少 HMGB1 释放 picropodophyllin,一个 IGF-1R 特定的禁止者,增加了煽动性的反应。在结论, IGF-1 能由减少 HMGB1 版本减轻 ox-LDL-induced 发炎,建议在煽动性的疾病的 IGF-1 的一个意外有益的角色。 | Xiaofeng Yu Chunyan Xing Yinghua Pan Housheng Ma Jie Zhang Wenjun Li | 2012 | Acta Biochimica et Biophysica Sinica2012，44，9： | 8 |
| 13 | Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction显示文摘 | Xiao-E Jia Ke Ma Tao Xu Lei Gao Shuang Wu Cong Fu Wenjuan Zhang Zhizhang Wang Kaiyu Liu Mei Dong Changbin Jing Chunguang Ren Zhiwei Dong Yi Chen Yi Jin Qiuhua Huang Xing Chang Min Deng Li Li Lingfei Luo Jun Zhu Yongjun Dang Hung-Chun Chang Leonard I Zon Yi Zhou Saijuan Chen Weijun Pan | 2015 | Cell Research2015，25，8： | 8 |
| 14 | P-selectin glycoprotein ligand 1 deficiency prevents development of acute pancreatitis by attenuating leukocyte infiltration显示文摘BACKGROUND Acute pancreatitis(AP) is rapid-onset pancreatic inflammation that causes local and systemic inflammatory response syndrome(SIRS) with high morbidity and mortality, but no approved therapies are currently available. P-selectin glycoprotein ligand 1(PSGL-1) is a transmembrane glycoprotein to initiate inflammatory responses. We hypothesized that PSGL-1 may be involved in the development of AP and would be a new target for the treatment of AP.AIM To investigate the role and mechanism of PSGL-1 in the development of AP.METHODS The PSGL-1 expression on leukocytes was detected in peripheral blood of AP patients and volunteers. Pancreatic injury, inflammatory cytokines expression, and inflammatory cell infiltration was measured in AP mouse models induced with PSGL-1 knockout(PSGL-1-/-) and wild-type(PSGL-1+/+) mice. Leukocyteendothelial cell adhesion was measured in a peripheral blood mononuclear cell(PBMC)-endothelial cell coculture system.RESULTS The expression of PSGL-1 on monocytes and neutrophils was significantly increased in AP patients. Compared with PSGL-1+/+ mice, PSGL-1-/-AP mice induced by caerulein exhibited lower serum amylase, less Interleukin-1 beta(IL-1 beta) and Interleukin-6(IL-6) expression, less neutrophil and macrophage infiltration, and reduced peripheral neutrophil and monocyte accounts. PSGL-1 deficiency alleviated leukocyte-endothelial cell adhesion via IL-6 but not IL-1 beta.CONCLUSION PSGL-1 deficiency effectively inhibits the development of AP by preventing leukocyte-endothelial cell adhesion via IL-6 stimulation and may become a potential therapeutic target for treating AP. | Xu Zhang Ming Zhu Xiao-Liang Jiang Xing Liu Xue Liu Pan Liu Xian-Xian Wu Zhi-Wei Yang Tao Qin | 2020 | World Journal of Gastroenterology2020，26，41： | 8 |
| 15 | Comparison of Magnetic Resonance Elastography and Diffusion-weighted Imaging for Staging Hepatic Fibrosis显示文摘 | Li-Qiu Zou Jie Chen Liang Pan Jin-Zhao Jiang Wei Xing | 2015 | Chinese Medical Journal2015，，5： | 8 |
| 16 | Evaluation of Vaporized Hydrogen Peroxide Fumigation as a Method for the Bio-decontamination of the High Efficiency Particulate Air Filter Unit显示文摘Objective To evaluate the performance of vaporized hydrogen peroxide (VHP) for the bio-decontamination of the high efficiency particulate air (HEPA) filter unit. Methods Self-made or commercially available bioindicators were placed at designated locations in the HEPA filter unit under VHP fumigation. The spores on coupons were then extracted by 0.5 h submergence in eluent followed by 200-time violent knocks. Results Due to the presence of HEPA filter in the box, spore recovery from coupons placed at the bottom of the filter downstream was significantly higher than that from coupons placed at the other locations. The gap of decontamination efficiency between the top and the bottom of the filter downstream became narrower with the exposure time extended. The decontamination efficiency of the bottom of the filter downstream only improved gently with the injection rate of H2O2 increased and the decontamination efficiency decreased instead when the injection rate exceeded 2.5 g/min. The commercially available bioindicators were competent to indicate the disinfection efficiency of VHP for the HEPA filter unit. Conclusion The HEPA filter unit is more difficult than common enclosure to decontaminate using VHP fumigation. Complete decontamination can be achieved by extending fumigation time. VHP fumigation can be applied for in-situ biodecontamination of the HEPA filter unit as an alternative method to formaldehyde fumigation. | JIA Hai Quan LI Yan Ju SUN Bei ZHAO Si Qing YI Ying ZHAO Ming ZHANG Zong Xing PAN Xin QI Jian Cheng | 2013 | Biomedical and Environmental Sciences2013，26，2： | 8 |
| 17 | Effect of pharmacological intervention on MIP-1α,MIP-1β and MCP-1 expression in patients with psoriasis vulgaris显示文摘Objective:To detect the expression level of macrophage inflammatory protein-1(MIP-1)α,MIP-1βand monocyte chemoattractant protein-1(MCP-1)in with psoriasis vulgaris and explore the role in the pathogenesis of psoriasis vulgaris.Methods:The level of MIP-1α,MIP-1βand MCP-1 in peripheral blood from 50 patients with psoriasis vulgaris and 50 normal controls were measured by enzyme linked immunosorbent assay.The correlation with psoriasis area and severity index(PASI)was analyzed.The level of MIP-1α,MIP-1βand MCP-1 was compared between psoriasis vulgaris patients at active stage and resting stage.And the change in MIP-1α,MIP-1βand MCP-1 before and after therapy was also observed.Results:The content of MIP-1α,MIP-1βand MCP-1 in patients with psoriasis vulgaris was(1342.78±210.30),(175.28±28.18)and(266.86±32.75)ng/L,respectively,significantly higher than those in control group(P<0.05).The expression level of MIP-1α,MIP-1βand MCP-1 in peripheral blood of patients with psoriasis vulgaris was positively correlated wilh PASI(P<0.01).After acitretin therapy,expression level of MIP-1α,MIP-1βand MCP-1 in peripheral blood of patients with psoriasis vulgaris was significantly decreased.Conclusions:Chemokine factor MIP-1α,MIP-1βand MCP-1 may be involved in the pathogenesis of psoriasis vulgaris. | Yong-Jiang Dai Yu-Yang Li Hui-Ming Zeng Xiong-An Liang Zhi-Jie Xie Zhi-Ang Zheng Qin-Hui Pan Yi-Xiong Xing | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，7： | 7 |
| 18 | Resilience based importance measure analysis for SoS显示文摘In a system of systems(SoS),resilience is an important factor in maintaining the functionality,stability,and enhancing the operation effectiveness.From the perspective of resilience,this paper studies the importance of the SoS,and a resilience-based importance measure analysis is conducted to provide suggestions in the design and optimization of the structure of the SoS.In this paper,the components of the SoS are simplified as four kinds of network nodes:sensor,decision point,influencer,and target.In this networked SoS,the number of operation loops is used as the performance indicator,and an approximate algorithm,which is based on eigenvalue of the adjacency matrix,is proposed to calculate the number of operation loops.In order to understand the performance change of the SoS during the attack and defense process in the operations,an integral resilience model is proposed to depict the resilience of the SoS.From different perspectives of enhancing the resilience,different measures,parameters and the corresponding algorithms for the resilience importance of components are proposed.Finally,a case study on an SoS is conducted to verify the validity of the network modelling and the resiliencebased importance analysis method. | PAN Xing WANG Huixiong YANG Yanjing ZHANG Guozhong | 2019 | Journal of Systems Engineering and Electronics2019，30，5： | 7 |
| 19 | Development of composite PLGA microspheres containing exenatide-encapsulated lecithin nanoparticles for sustained drug release显示文摘This study aimed to prepare poly(D, L-lactic-co-glycolic acid) microspheres(PLGA-Ms)by a modified solid-in-oil-in-water(S/O/W) multi-emulsion technique in order to achieve sustained release with reduced initial burst and maintain efficient drug concentration for a prolonged period of time. Composite PLGA microspheres containing exenatideencapsulated lecithin nanoparticles(Ex-NPs-PLGA-Ms) were obtained by initial fabrication of exenatide-loaded lecithin nanoparticles(Ex-NPs) via the alcohol injection method,followed by encapsulation of Ex-NPs into PLGA microspheres. Compared to Ms prepared by the conventional water-in-oil-in-water(W/O/W) technique(Ex-PLGA-Ms), Ex-NPs-PLGAMs showed a more uniform particle size distribution, reduced initial burst release, and sustained release for over 60 d in vitro. Cytotoxicity studies showed that Ms prepared by both techniques had superior biocompatibility without causing any detectable cytotoxicity.In pharmacokinetic studies, the effective drug concentration was maintained for over 30 d following a single subcutaneous injection of two types of Ms formulation in rats, potentially prolonging the therapeutic action of Ex. In addition, administration of Ex-NPs-PLGA-Ms resulted in a more smooth plasma concentration-time profile with a higher area under the curve(AUC) compared to that of Ex-PLGA-Ms. Overall, Ex-NPs-PLGA-Ms prepared by the novel S/O/W method could be a promising sustained drug release system with reduced initial burst release and prolonged therapeutic efficacy. | Ni Dong Chune Zhu Junhuang Jiang Di Huang Xing Li Guilan Quan Yang Liu Wen Tan Xin Pan Chuanbin Wu | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，3： | 7 |
| 20 | Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-line treatment: a retrospective study of 251 cases显示文摘有在 2002 和 2008 之间治疗的上皮的卵巢的癌症(EOC ) 的 251 个病人的一个总数回顾地被分析调查长期的结果和这些病人的预示的因素,特别地,经历了主要 debulking 外科的那些由基于铂的化疗列在后面。包括没有前进的幸存(PFS ) 和全面幸存(OS ) , Clinicopathological 参数也被分析。从到 2010 年 6 月的起始的治疗的结束的中部的后续时期是 58 个月。三年的 PFS 率为妇科学和产科学(FIGO ) I-II 的国际联盟是 61.7% , 19.9% 为 FIGO III-IV,并且 33.9% 为所有阶段。由比较,五年的 PFS 率为 FIGO I-II 是 44.6% , 17.7% 为 FIGO III-IV,并且 28.3% 为所有阶段。三年的 OS 率为 FIGO I-II 是 67.9% , 41.7% 为 FIGO III-IV,并且 50.2% 为所有阶段。五年的 OS 率为 FIGO I-II 是 52.7% , 30.8% 为 FIGO III-IV,并且 39.2% 为所有阶段。Univariate 分析表明先进 FIGO 舞台,浆液 CA125,和非最优的 debulking 是影响 PFS 和 OS 的重要因素。在 multivariate 分析, PFS 被 FIGO 舞台和非最优的 debulking 显著地影响。然而, OS 被先进 FIGO 舞台显著地仅仅影响。我们的学习证实外科的功效为 EOC 由基于铂的化疗列在后面。FIGO 舞台与 EOC 被看作病人的预后的最可靠的预言者之一。 | Yunfeng Fu Xinyu Wang Zimin Pan Xing Xie | 2014 | Frontiers of Medicine2014，8，1： | 6 |
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