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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Rapid report of the 8 January 2022 M_(S)6.9 Menyuan earthquake,Qinghai,China显示文摘The M_(S)6.9 Menyuan earthquake in Qinghai Province,west China is the largest earthquake by far in 2022.The earthquake occurs in a tectonically active region,with a background b-value of 0.87 within 100 km of the epicenter that we derived from the unified catalog produced by China Earthquake Networks Center since late 2008.Field surveys have revealed surface ruptures extending 22 km along strike,with a maximum ground displacement of 2.1 m.We construct a finite fault model with constraints from In SAR observations,which showed multiple fault segments during the Menyuan earthquake.The major slip asperity is confined within 10 km at depth,with the maximum slip of 3.5 m.Near real-time back-projection results of coseismic radiation indicate a northwest propagating rupture that lasted for~10 s.Intensity estimates from the back-projection results show up to a Mercalli scale of IX near the ruptured area,consistent with instrumental measurements and the observations from the field surveys.Aftershock locations(up to January 21,2022)exhibit two segments,extending to~20 km in depth.The largest one reaches M_(S)5.3,locating near the eastern end of the aftershock zone.Although the location and the approximate magnitude of the mainshock had been indicated by previous studies based on paleoearthquake records and seismic gap,as well as estimated stressing rate on faults,significant surfacebreaching rupture leads to severe damage of the high-speed railway system,which poses a challenge in accurately assessing earthquake hazards and risks,and thus demands further investigations of the rupture behaviors for crustal earthquakes. | Hongfeng Yang Dun Wang Rumeng Guo Mengyu Xie Yang Zang Yue Wang Qiang Yao Chuang Cheng Yanru An Yingying Zhang | 2022 | Earthquake Research Advances2022，2，1： | 14 |
| 3 | MicroRNAs regulate osteogenesis and chondrogenesis显示文摘 | Shiwu Dong Bo Yang Hongfeng Guo Fei Kang | 2012 | Biochemical and Biophysical Research Communications2012，，4： | 2 |
| 4 | Piezoelectric PU/PVDF electrospun scaffolds for wound healing applications显示文摘 | GUO Hongfeng LI Zhensheng DONG Shiwu | 2012 | Colloids and Surfaces B2012，96，： | 1 |
| 5 | Experiments on Exploration of Shallow Fine Structures and the Construction of the 1-D Velocity Model in the Pingtan Island,Fujian显示文摘112 short-period seismographs were set up in the 400 km^2 area of Pingtan Island and its surrounding areas in Fujian.The combined observations of the airgun source and ambient noise source were carried out using a dense array to receive the 387 airgun signals excited around the island and one month of continuous ambient noise recording.The 1-D P-wave and S-wave shallow velocity model of Pingtan Island is obtained by the inversion of the airgun body wave’s first arrival time data,and the reliability of the velocity model is verified by using the surface wave phase velocity dispersion curve,which can provide initial model for subsequent 3-D imaging.The experimental results show that this experiment is a successful demonstration of local scale green non-destructive detection,which can provide basic data for shallow surface structure research and strong vibration simulation of the Pingtan Island. | GUO Yang XU Jiajun LIN Chen JIN Xing YAO Huajian YANG Hongfeng CAI Huiteng | 2019 | Earthquake Research in China2019，33，2： | 1 |
| 6 | On dimensions of dimension-bounded linear systems显示文摘Dear editor,Dimensional-varying dynamic systems,also called crossdimensional systems[1],are often met in actual life,such as electric power generators[2],spacecraft[3],biological systems[4],and internet networks[5,6].However,until now there is little literature about dimension-varying systems[7].The main reason is that dimensional-varying dynamic systems are too complex to find proper mathematic tool to model them. | Peixin ZHAO Hongfeng GUO Yongyuan YU Jun-E FENG | 2021 | Science China(Information Sciences)2021，64，5： | 1 |
| 7 | Regulation of autophagic flux by CHIP显示文摘Autophagy is a major degradation system which processes substrates through the steps of autophagosome formation, autophagosome-lysosome fusion, and substrate degradation. Aberrant autophagic flux is present in many pathological conditions including neurodegeneration and tumors. CHIP/STUB1, an E3 ligase, plays an important role in neurodegeneration. In this study, we identified the regulation of autophagic flux by CHIP(carboxy-terminus of Hsc70-interacting protein). Knockdown of CHIP induced autophagosome formation through increasing the PTEN protein level and decreasing the AKT/m TOR activity as well as decreasing phosphorylation of ULK1 on Ser757. However, degradation of the autophagic substrate p62 was disturbed by knockdown of CHIP, suggesting an abnormality of autophagic flux. Furthermore, knockdown of CHIP increased the susceptibility of cells to autophagic cell death induced by bafilomycin A1. Thus, our data suggest that CHIP plays roles in the regulation of autophagic flux. | Dongkai Guo Zheng Ying Hongfeng Wang Dong Chen Feng Gao Haigang Ren Guanghui Wang | 2015 | Neuroscience Bulletin2015，31，4： | 1 |
| 8 | Efficient low-temperature catalytic combustion of trichloroethylene over flower-like mesoporous Mn-doped CeO 2 microspheres显示文摘 | Hongfeng Li Guanzhong Lu Qiguang Dai Yanqin Wang Yun Guo Yanglong Guo | 2010 | Applied Catalysis B Environmental2010，，3： | 1 |
| 9 | Outcomes of allograft from donor kidney microthrombi and secondary recipient thrombotic microangiopathy: should we consider loosening the belt?显示文摘There is currently a huge worldwide demand for donor kidneys for organ transplantation.Consequently,numerous marginal donor kidneys,such as kidneys with microthrombi,are used to save patients'lives.While some studies have shown an association between the presence of microthrombi in donor kidneys and an increased risk for delayed graft function(DGF)(McCall et al.,2003;Gao et al.,2019),other studies have demonstrated that microthrombi negatively impact the rate of DGF(Batra et al.,2016;Hansen et al.,2018),but not graft survival rate(McCall et al.,2003;Batra et al.,2016;Gao et al.,2019).In contrast,Hansen et al.(2018)concluded that fibrin thrombi were not only associated with reduced graft function six months posttransplantation but also with increased graft loss within the first year of transplantation.On the other hand,Batra et al.(2016)found no significant differences in the DGF rate or one-year graft function between recipients in diffuse and focal microthrombi groups.To date,however,the overall influence of donor kidney microthrombi and the degree of influence on prognosis remain controversial,necessitating further research. | Yamei CHENG Luying GUO Xue REN Zhenzhen YANG Junhao LV Huiping WANG Wenhan PENG Hongfeng HUANG Jianyong WU Jianghua CHEN Rending WANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，6： | 0 |
| 10 | A systematic assessment of hydroxyapatite nanoparticles used in the treatment of melanoma显示文摘Nano Research volume 13,pages2106–2117(2020)Cite this article 106 Accesses 1 Altmetric Metrics details Abstract Melanoma is a highly malignant skin tumor which is prone to recurrence and metastasis.Hydroxyapatite nanoparticles(nHAPs)were reported to possess a suppressive effect on proliferation of various tumor cells in vitro.This study aimed to assess in vitro and in vivo anti-tumor ability and biosafety of the nHAPs used in the treatment of melanoma.Three types of nHAPs with different morphology and crystallinity were synthesized.In vitro cell viability and proliferation studies demonstrated that all three types of nHAPs can inhibit viability and proliferation of A375 and SK-MEL-28 melanoma cells in a concentration-dependent manner.In addition,the rod-shape nHAPs with a crystallinity of 45.60%had the most prominent suppressive effect on the two melanoma cells tested.An important positive regulator of G1/S phase transition in cell cycle,Cyclin D1 protein,was reduced by nHAPs treatment in vivo.We further discovered that the migration ability of the nHAPs treated melanoma cells was greatly decreased.RNA sequencing result revealed that melanoma metastasis related genes were down-regulated by nHAPs,including MMP2,MMP14,ITGA9,ITGB3,ITGB4 and S100B.High concentration of nHAPs treatment in melanoma-bearing nude mice showed a strong inhibitory effect on tumor size and weight.Most importantly,hemolysis,electrolyte disturbance or inflammation response was not discovered in the experimental animals from nHAPs treated groups.We proved that the nHAPs synthesized in the current study has a selective effect to suppress melanoma tumor proliferation and was safe with regard to normal cells and tissue. | Zhongtao Li Jiaoqing Tang Hongfeng Wu Zhixin Ling Siyu Chen Yong Zhou Bo Guo Xiao Yang Xiangdong Zhu Lin Wang Chongqi Tu Xingdong Zhang | 2020 | Nano Research2020，13，8： | 0 |
| 11 | Helper T Cell(CD4^(+))Targeted Tacrolimus Delivery Mediates Precise Suppression of Allogeneic Humoral Immunity显示文摘Antibody-mediated rejection(ABMR)is a major cause of dysfunction and loss of transplanted kidney.The current treatments for ABMR involve nonspecific inhibition and clearance of T/B cells or plasma cells.However,the prognosis of patients following current treatment is poor.T follicular helper cells(Tfh)play an important role in allograft-specific antibodies secreting plasma cell(PC)development.Tfh cells are therefore considered to be important therapeutic targets for the treatment of antibody hypersecretion disorders,such as transplant rejection and autoimmune diseases.Tacrolimus(Tac),the primary immunosuppressant,prevents rejection by reducing T cell activation.However,its administration should be closely monitored to avoid serious side effects.In this study,we investigated whether Tac delivery to helper T(CD4^(+))cells using functionalized mesoporous nanoparticles can block Tfh cell differentiation after alloantigen exposure.Results showed that Tac delivery ameliorated humoral rejection injury in rodent kidney graft by suppressing Tfh cell development,PC,and donor-specific antibody(DSA)generation without causing severe side effects compared with delivery through the drug administration pathway.This study provides a promising therapeutic strategy for preventing humoral rejection in solid organ transplantation.The specific and controllable drug delivery avoids multiple disorder risks and side effects observed in currently used clinical approaches. | Jia Shen Chang Liu Pengpeng Yan Meifang Wang Luying Guo Shuaihui Liu Jianghua Chen Jessica MRosenholm Hongfeng Huang Rending Wang Hongbo Zhang | 2022 | Research2022，，3： | 0 |
| 12 | Pulsar candidate selection using ensemble networks for FAST drift-scan survey显示文摘The Commensal Radio Astronomy Five-hundred-meter Aperture Spherical radio Telescope(FAST) Survey(CRAFTS) utilizes the novel drift-scan commensal survey mode of FAST and can generate billions of pulsar candidate signals. The human experts are not likely to thoroughly examine these signals, and various machine sorting methods are used to aid the classification of the FAST candidates. In this study, we propose a new ensemble classification system for pulsar candidates. This system denotes the further development of the pulsar image-based classification system(PICS), which was used in the Arecibo Telescope pulsar survey, and has been retrained and customized for the FAST drift-scan survey. In this study, we designed a residual network model comprising 15 layers to replace the convolutional neural networks(CNNs) in PICS. The results of this study demonstrate that the new model can sort >96% of real pulsars to belong the top 1% of all candidates and classify >1.6 million candidates per day using a dual-GPU and 24-core computer. This increased speed and efficiency can help to facilitate real-time or quasi-real-time processing of the pulsar-search data stream obtained from CRAFTS. In addition, we have published the labeled FAST data used in this study online, which can aid in the development of new deep learning techniques for performing pulsar searches. | HongFeng Wang WeiWei Zhu Ping Guo Di Li SiBo Feng Qian Yin ChenChen Miao ZhenZhao Tao ZhiChen Pan Pei Wang Xin Zheng XiaoDan Deng ZhiJie Liu XiaoYao Xie XuHong Yu ShanPing You Hui Zhang FAST Collaboration | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，5： | 0 |
| 13 | Modeling of the resilient supply chain system from a perspective of production design changes显示文摘Building an effective resilient supply chain system (RSCS) is critical and necessary to reduce the risk of supply chain disruptions in unexpected scenarios such as COVID-19 pandemic and trade wars. To overcome the impact of insufficient raw material supply on the supply chain in mass disruption scenarios, this study proposes a novel RSCS considering product design changes (PDC). An RSCS domain model is first developed from the perspective of PDC based on a general conceptual framework, i.e., function-context-behavior-principle-state-structure (FCBPSS), which can portray complex systems under unpredictable situations. Specifically, the interaction among the structure, state and behavior of the infrastructure system and substance system is captured, and then a quantitative analysis of the change impact process is presented to evaluate the resilience of both the product and supply chain. Next, a case study is conducted to demonstrate the PDC strategy and to validate the feasibility and effectiveness of the RSCS domain model. The results show that the restructured RSCS based on the proposed strategy and model can remedy the huge losses caused by the unavailability of raw materials. | Shuangshuang ZHANG Hongfeng WANG Guo LI Junwei WANG | 2023 | Frontiers of Engineering Management2023，10，1： | 0 |
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